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Volumn 369, Issue 21, 2013, Pages 2021-2030

Bilirubin-induced neurologic damage - Mechanisms and management approaches

Author keywords

[No Author keywords available]

Indexed keywords

BILIRUBIN; IMMUNOGLOBULIN; MESOPORPHYRIN; METALLOPORPHYRIN; MINOCYCLINE; MULTIDRUG RESISTANCE PROTEIN 1; PHENOBARBITAL;

EID: 84889805741     PISSN: 00284793     EISSN: 15334406     Source Type: Journal    
DOI: 10.1056/NEJMra1308124     Document Type: Review
Times cited : (296)

References (78)
  • 1
    • 84889781380 scopus 로고    scopus 로고
    • Kernicterus
    • Stevenson DK, Maisels MJ, Watchko JF, eds. New York: McGraw-Hill
    • Shapiro SM. Kernicterus. In: Stevenson DK, Maisels MJ, Watchko JF, eds. Care of the jaundiced neonate. New York: McGraw-Hill, 2012:229-42.
    • (2012) Care of the Jaundiced Neonate , pp. 229-242
    • Shapiro, S.M.1
  • 2
    • 33749636448 scopus 로고    scopus 로고
    • Kernicterus and the molecular mechanisms of bilirubin-induced CNS injury in newborns
    • Watchko JF. Kernicterus and the molecular mechanisms of bilirubin-induced CNS injury in newborns. Neuromolecular Med 2006;8:513-29.
    • (2006) Neuromolecular Med , vol.8 , pp. 513-529
    • Watchko, J.F.1
  • 3
    • 0011324203 scopus 로고    scopus 로고
    • The neuropathology of kernicterus: Definition and debate
    • Maisels MJ, Watchko JF, eds. Newark, NJ: Harwood Academic
    • Ahdab-Barmada M. The neuropathology of kernicterus: definition and debate. In: Maisels MJ, Watchko JF, eds. Neonatal jaundice. Newark, NJ: Harwood Academic, 2000:75-88.
    • (2000) Neonatal Jaundice , pp. 75-88
    • Ahdab-Barmada, M.1
  • 4
    • 1942426424 scopus 로고    scopus 로고
    • Kernicterus: Epidemiological strategies for its prevention through systems-based approaches
    • Bhutani VK, Johnson LH, Jeffrey Maisels M, et al. Kernicterus: epidemiological strategies for its prevention through systems-based approaches. J Perinatol 2004;24:650-62.
    • (2004) J Perinatol , vol.24 , pp. 650-662
    • Bhutani, V.K.1    Johnson, L.H.2    Jeffrey Maisels, M.3
  • 5
    • 59549083204 scopus 로고    scopus 로고
    • Clinical report from the pilot USA Kernicterus Registry (1992 to 2004)
    • Johnson L, Bhutani VK, Karp K, Sivieri EM, Shapiro SM. Clinical report from the pilot USA Kernicterus Registry (1992 to 2004). J Perinatol 2009;29:Suppl 1:S25S-S45.
    • (2009) J Perinatol , vol.29 , Issue.SUPPL. 1
    • Johnson, L.1    Bhutani, V.K.2    Karp, K.3    Sivieri, E.M.4    Shapiro, S.M.5
  • 6
    • 34548805817 scopus 로고    scopus 로고
    • Prospective surveillance study of severe hyperbilirubinaemia in the newborn in the UK and Ireland
    • Manning D, Todd P, Maxwell M, Platt MJ. Prospective surveillance study of severe hyperbilirubinaemia in the newborn in the UK and Ireland. Arch Dis Child Fetal Neonatal Ed 2007;92:F342-F346.
    • (2007) Arch Dis Child Fetal Neonatal Ed , vol.92
    • Manning, D.1    Todd, P.2    Maxwell, M.3    Platt, M.J.4
  • 7
    • 84867184853 scopus 로고    scopus 로고
    • Incidence of chronic bilirubin encephalopathy in Canada, 2007-2008
    • Sgro M, Campbell DM, Kandasamy S, Shah V. Incidence of chronic bilirubin encephalopathy in Canada, 2007-2008. Pediatrics 2012;130(4):e886-e990.
    • (2012) Pediatrics , vol.130 , Issue.4
    • Sgro, M.1    Campbell, D.M.2    Kandasamy, S.3    Shah, V.4
  • 8
    • 84889837636 scopus 로고    scopus 로고
    • Neonatal jaundice in low-and middle-income countries
    • Stevenson DK, Maisels MJ, Watchko JF, eds. New York: McGraw-Hill
    • Slusher TM, Olusaniya BO. Neonatal jaundice in low-and middle-income countries. In: Stevenson DK, Maisels MJ, Watchko JF, eds. Care of the jaundiced neonate. New York: McGraw-Hill, 2012:263-73.
    • (2012) Care of the Jaundiced Neonate , pp. 263-273
    • Slusher, T.M.1    Olusaniya, B.O.2
  • 9
    • 84901829443 scopus 로고    scopus 로고
    • Prevention, screening and postnatal management of neonatal hyperbilirubinemia
    • Stevenson DK, Maisels MJ, Watchko JF, eds. New York: McGraw-Hill
    • Maisels MJ, Newman TB. Prevention, screening and postnatal management of neonatal hyperbilirubinemia. In: Stevenson DK, Maisels MJ, Watchko JF, eds. Care of the jaundiced neonate. New York: McGraw-Hill, 2012:175-94.
    • (2012) Care of the Jaundiced Neonate , pp. 175-194
    • Maisels, M.J.1    Newman, T.B.2
  • 10
    • 38449091850 scopus 로고    scopus 로고
    • The incidence and outcome of bilirubin encephalopathy in Nigeria: A bicentre study
    • Ogunlesi TA, Dedeke IO, Adekanmbi AF, et al. The incidence and outcome of bilirubin encephalopathy in Nigeria: a bicentre study. Niger J Med 2007;16:354-9.
    • (2007) Niger J Med , vol.16 , pp. 354-359
    • Ogunlesi, T.A.1    Dedeke, I.O.2    Adekanmbi, A.F.3
  • 12
    • 64649096636 scopus 로고    scopus 로고
    • The global prevalence of glucose-6-phosphate dehydrogenase deficiency: A systematic review and meta-analysis
    • Nkhoma ET, Poole C, Vannappagari V, Hall SA, Beutler E. The global prevalence of glucose-6-phosphate dehydrogenase deficiency: a systematic review and meta-analysis. Blood Cells Mol Dis 2009;42:267-78.
    • (2009) Blood Cells Mol Dis , vol.42 , pp. 267-278
    • Nkhoma, E.T.1    Poole, C.2    Vannappagari, V.3    Hall, S.A.4    Beutler, E.5
  • 14
    • 80053471686 scopus 로고    scopus 로고
    • Risk factors for neurotoxicity in newborns with severe neonatal hyperbilirubinemia
    • Gamaleldin R, Iskander I, Seoud I, et al. Risk factors for neurotoxicity in newborns with severe neonatal hyperbilirubinemia. Pediatrics 2011;128(4):e925-e931.
    • (2011) Pediatrics , vol.128 , Issue.4
    • Gamaleldin, R.1    Iskander, I.2    Seoud, I.3
  • 15
    • 84876138142 scopus 로고    scopus 로고
    • Bilistick: A low-cost point-of-care system to measure total plasma bilirubin
    • Coda Zabetta CD, Iskander IF, Greco C, et al. Bilistick: a low-cost point-of-care system to measure total plasma bilirubin. Neonatology 2013;103:177-81.
    • (2013) Neonatology , vol.103 , pp. 177-181
    • Coda Zabetta, C.D.1    Iskander, I.F.2    Greco, C.3
  • 16
    • 84864018294 scopus 로고    scopus 로고
    • Bilirubin toxicity
    • Stevenson DK, Maisels MJ, Watchko JF, eds. New York: McGraw-Hill
    • Brites D, Brito MA. Bilirubin toxicity. In: Stevenson DK, Maisels MJ, Watchko JF, eds. Care of the jaundiced neonate. New York: McGraw-Hill, 2012:115-43.
    • (2012) Care of the Jaundiced Neonate , pp. 115-143
    • Brites, D.1    Brito, M.A.2
  • 17
    • 3042776700 scopus 로고    scopus 로고
    • An evidence-based review of important issues concerning neonatal hyperbilirubinemia
    • Ip S, Chung M, Kulig J, et al. An evidence-based review of important issues concerning neonatal hyperbilirubinemia. Pediatrics 2004;114(1):e130-e153.
    • (2004) Pediatrics , vol.114 , Issue.1
    • Ip, S.1    Chung, M.2    Kulig, J.3
  • 18
    • 67650088580 scopus 로고    scopus 로고
    • Unbound (free) bilirubin: Improving the paradigm for evaluating neonatal jaundice
    • Ahlfors CE, Wennberg RP, Ostrow JD, Tiribelli C. Unbound (free) bilirubin: improving the paradigm for evaluating neonatal jaundice. Clin Chem 2009;55:1288-99.
    • (2009) Clin Chem , vol.55 , pp. 1288-1299
    • Ahlfors, C.E.1    Wennberg, R.P.2    Ostrow, J.D.3    Tiribelli, C.4
  • 19
    • 77952257683 scopus 로고    scopus 로고
    • Predicting bilirubin neurotoxicity in jaundiced newborns
    • Ahlfors CE. Predicting bilirubin neurotoxicity in jaundiced newborns. Curr Opin Pediatr 2010;22:129-33.
    • (2010) Curr Opin Pediatr , vol.22 , pp. 129-133
    • Ahlfors, C.E.1
  • 20
    • 33646376962 scopus 로고    scopus 로고
    • Outcomes among newborns with total serum bilirubin levels of 25 mg per deciliter or more
    • Newman TB, Liljestrand P, Jeremy RJ, et al. Outcomes among newborns with total serum bilirubin levels of 25 mg per deciliter or more. N Engl J Med 2006;354:1889-900.
    • (2006) N Engl J Med , vol.354 , pp. 1889-1900
    • Newman, T.B.1    Liljestrand, P.2    Jeremy, R.J.3
  • 21
    • 77950240348 scopus 로고    scopus 로고
    • Influence of clinical status on the association between plasma total and unbound bilirubin and death or adverse neurodevelopmental outcomes in extremely low birth weight infants
    • Erratum, Acta Paediatr 2013;102:326
    • Oh W, Stevenson DK, Tyson JE, et al. Influence of clinical status on the association between plasma total and unbound bilirubin and death or adverse neurodevelopmental outcomes in extremely low birth weight infants. Acta Paediatr 2010;99:673-8. [Erratum, Acta Paediatr 2013;102:326.]
    • (2010) Acta Paediatr , vol.99 , pp. 673-678
    • Oh, W.1    Stevenson, D.K.2    Tyson, J.E.3
  • 22
    • 77956294542 scopus 로고    scopus 로고
    • Bilirubin binding contributes to the increase in total bilirubin concentration in newborns with jaundice
    • Ahlfors CE, Parker AE. Bilirubin binding contributes to the increase in total bilirubin concentration in newborns with jaundice. Pediatrics 2010;126(3):e639-e643.
    • (2010) Pediatrics , vol.126 , Issue.3
    • Ahlfors, C.E.1    Parker, A.E.2
  • 23
    • 0027955615 scopus 로고
    • Criteria for exchange transfusion in jaundiced newborns
    • Ahlfors CE. Criteria for exchange transfusion in jaundiced newborns. Pediatrics 1994;93:488-94.
    • (1994) Pediatrics , vol.93 , pp. 488-494
    • Ahlfors, C.E.1
  • 24
    • 0020533958 scopus 로고
    • Reserve albumin and bilirubin toxicity index in infant serum
    • Cashore WJ, Oh W, Brodersen R. Reserve albumin and bilirubin toxicity index in infant serum. Acta Paediatr Scand 1983;72:415-9.
    • (1983) Acta Paediatr Scand , vol.72 , pp. 415-419
    • Cashore, W.J.1    Oh, W.2    Brodersen, R.3
  • 25
    • 33644864491 scopus 로고    scopus 로고
    • Toward understanding kernicterus: A challenge to improve the management of jaundiced newborns
    • Erratum, Pediatrics 2006;117:1467
    • Wennberg RP, Ahlfors CE, Bhutani VK, Johnson LH, Shapiro SM. Toward understanding kernicterus: a challenge to improve the management of jaundiced newborns. Pediatrics 2006;117:474-85. [Erratum, Pediatrics 2006;117:1467.]
    • (2006) Pediatrics , vol.117 , pp. 474-485
    • Wennberg, R.P.1    Ahlfors, C.E.2    Bhutani, V.K.3    Johnson, L.H.4    Shapiro, S.M.5
  • 26
    • 84860681761 scopus 로고    scopus 로고
    • Measuring free bilirubin: The clinical perspective
    • Wennberg RP. Measuring free bilirubin: the clinical perspective. Clin Chem 2012;58:811-3.
    • (2012) Clin Chem , vol.58 , pp. 811-813
    • Wennberg, R.P.1
  • 27
    • 33644872733 scopus 로고    scopus 로고
    • Bilirubin unbound: Déjà vu all over again?
    • McDonagh AF, Maisels MJ. Bilirubin unbound: déjà vu all over again? Pediatrics 2006;117:523-5.
    • (2006) Pediatrics , vol.117 , pp. 523-525
    • McDonagh, A.F.1    Maisels, M.J.2
  • 28
    • 0035839649 scopus 로고    scopus 로고
    • Affinity of human serum albumin for bilirubin varies with albumin concentration and buffer composition: Results of a novel ultrafiltration method
    • Weisiger RA, Ostrow JD, Koehler RK, et al. Affinity of human serum albumin for bilirubin varies with albumin concentration and buffer composition: results of a novel ultrafiltration method. J Biol Chem 2001;276:29953-60.
    • (2001) J Biol Chem , vol.276 , pp. 29953-29960
    • Weisiger, R.A.1    Ostrow, J.D.2    Koehler, R.K.3
  • 29
    • 33751253746 scopus 로고    scopus 로고
    • Factors affecting the binding of bilirubin to serum albumins: Validation and application of the peroxidase method
    • Roca L, Calligaris S, Wennberg RP, et al. Factors affecting the binding of bilirubin to serum albumins: validation and application of the peroxidase method. Pediatr Res 2006;60:724-8.
    • (2006) Pediatr Res , vol.60 , pp. 724-728
    • Roca, L.1    Calligaris, S.2    Wennberg, R.P.3
  • 30
    • 83655211557 scopus 로고    scopus 로고
    • The effects of aggressive vs. Conservative phototherapy on the brainstem auditory evoked responses of extremely-low-birth-weight infants
    • Lasky RE, Church MW, Orlando MS, et al. The effects of aggressive vs. conservative phototherapy on the brainstem auditory evoked responses of extremely-low-birth-weight infants. Pediatr Res 2012;71:77-84.
    • (2012) Pediatr Res , vol.71 , pp. 77-84
    • Lasky, R.E.1    Church, M.W.2    Orlando, M.S.3
  • 31
    • 33748041670 scopus 로고    scopus 로고
    • Calculated in vivo free bilirubin levels in the central nervous system of Gunn rat pups
    • Daood MJ, Watchko JF. Calculated in vivo free bilirubin levels in the central nervous system of Gunn rat pups. Pediatr Res 2006;60:44-9.
    • (2006) Pediatr Res , vol.60 , pp. 44-49
    • Daood, M.J.1    Watchko, J.F.2
  • 32
    • 59549097623 scopus 로고    scopus 로고
    • Calculated free bilirubin levels and neurotoxicity
    • Daood MJ, McDonagh AF, Watchko JF. Calculated free bilirubin levels and neurotoxicity. J Perinatol 2009;29:Suppl 1:S14-S19.
    • (2009) J Perinatol , vol.29 , Issue.SUPPL. 1
    • Daood, M.J.1    McDonagh, A.F.2    Watchko, J.F.3
  • 33
    • 84861397542 scopus 로고    scopus 로고
    • Bilirubin accumulation and Cyp mRNA expression in selected brain regions of jaundiced Gunn rat pups
    • Erratum, Pediatr Res 2012;71:732
    • Gazzin S, Zelenka J, Zdrahalova L, et al. Bilirubin accumulation and Cyp mRNA expression in selected brain regions of jaundiced Gunn rat pups. Pediatr Res 2012;71:653-60. [Erratum, Pediatr Res 2012;71:732.]
    • (2012) Pediatr Res , vol.71 , pp. 653-660
    • Gazzin, S.1    Zelenka, J.2    Zdrahalova, L.3
  • 34
    • 84866138603 scopus 로고    scopus 로고
    • Transport and metabolism at blood-brain interfaces and in neural cells: Relevance to bilirubin-induced encephalopathy
    • Gazzin S, Strazielle N, Tiribelli C, Ghersi-Egea JF. Transport and metabolism at blood-brain interfaces and in neural cells: relevance to bilirubin-induced encephalopathy. Front Pharmacol 2012;3:89.
    • (2012) Front Pharmacol , vol.3 , pp. 89
    • Gazzin, S.1    Strazielle, N.2    Tiribelli, C.3    Ghersi-Egea, J.F.4
  • 35
    • 70449431474 scopus 로고    scopus 로고
    • Blood-brain interfaces and bilirubin-induced neurological diseases
    • Ghersi-Egea JF, Gazzin S, Strazielle N. Blood-brain interfaces and bilirubin-induced neurological diseases. Curr Pharm Des 2009;15:2893-907.
    • (2009) Curr Pharm des , vol.15 , pp. 2893-2907
    • Ghersi-Egea, J.F.1    Gazzin, S.2    Strazielle, N.3
  • 36
    • 3042814901 scopus 로고    scopus 로고
    • Reassessment of the unbound concentrations of unconjugated bilirubin in relation to neurotoxicity in vitro
    • Ostrow JD, Pascolo L, Tiribelli C. Reassessment of the unbound concentrations of unconjugated bilirubin in relation to neurotoxicity in vitro. Pediatr Res 2003;54:926.
    • (2003) Pediatr Res , vol.54 , pp. 926
    • Ostrow, J.D.1    Pascolo, L.2    Tiribelli, C.3
  • 38
    • 55249101226 scopus 로고    scopus 로고
    • Aggressive vs. Conservative phototherapy for infants with extremely low birth weight
    • Morris BH, Oh W, Tyson JE, et al. Aggressive vs. conservative phototherapy for infants with extremely low birth weight. N Engl J Med 2008;359:1885-96.
    • (2008) N Engl J Med , vol.359 , pp. 1885-1896
    • Morris, B.H.1    Oh, W.2    Tyson, J.E.3
  • 39
    • 36048961367 scopus 로고    scopus 로고
    • Ontogeny of bilirubin-binding capacity and the effect of clinical status in premature infants born at less than 1300 grams
    • Bender GJ, Cashore WJ, Oh W. Ontogeny of bilirubin-binding capacity and the effect of clinical status in premature infants born at less than 1300 grams. Pediatrics 2007;120:1067-73.
    • (2007) Pediatrics , vol.120 , pp. 1067-1073
    • Bender, G.J.1    Cashore, W.J.2    Oh, W.3
  • 40
    • 77952551430 scopus 로고    scopus 로고
    • Early isomerization of bilirubin in phototherapy of neonatal jaundice
    • Mreihil K, McDonagh AF, Nakstad B, Hansen TW. Early isomerization of bilirubin in phototherapy of neonatal jaundice. Pediatr Res 2010;67:656-9.
    • (2010) Pediatr Res , vol.67 , pp. 656-659
    • Mreihil, K.1    McDonagh, A.F.2    Nakstad, B.3    Hansen, T.W.4
  • 41
    • 59449097497 scopus 로고    scopus 로고
    • Photoisomers: Obfuscating factors in clinical peroxidase measurements of unbound bilirubin?
    • McDonagh AF, Vreman HJ, Wong RJ, Stevenson DK. Photoisomers: obfuscating factors in clinical peroxidase measurements of unbound bilirubin? Pediatrics 2009;123:67-76.
    • (2009) Pediatrics , vol.123 , pp. 67-76
    • McDonagh, A.F.1    Vreman, H.J.2    Wong, R.J.3    Stevenson, D.K.4
  • 42
    • 3042718933 scopus 로고    scopus 로고
    • Management of hyperbilirubinemia in the newborn infant 35 or more weeks of gestation
    • American Academy of Pediatrics Subcommittee on Hyperbilirubinemia. Erratum, Pediatrics 2004;114:1138
    • American Academy of Pediatrics Subcommittee on Hyperbilirubinemia. Management of hyperbilirubinemia in the newborn infant 35 or more weeks of gestation. Pediatrics 2004;114:297-316. [Erratum, Pediatrics 2004;114:1138.]
    • (2004) Pediatrics , vol.114 , pp. 297-316
  • 44
    • 0033574696 scopus 로고    scopus 로고
    • Unconjugated bilirubin exhibits spontaneous diffusion through model lipid bilayers and native hepatocyte membranes
    • Zucker SD, Goessling W, Hoppin AG. Unconjugated bilirubin exhibits spontaneous diffusion through model lipid bilayers and native hepatocyte membranes. J Biol Chem 1999;274:10852-62.
    • (1999) J Biol Chem , vol.274 , pp. 10852-10862
    • Zucker, S.D.1    Goessling, W.2    Hoppin, A.G.3
  • 45
    • 70449389954 scopus 로고    scopus 로고
    • Bilirubin chemistry and metabolism; harmful and protective aspects
    • Vítek L, Ostrow JD. Bilirubin chemistry and metabolism; harmful and protective aspects. Curr Pharm Des 2009;15:2869-83.
    • (2009) Curr Pharm des , vol.15 , pp. 2869-2883
    • Vítek, L.1    Ostrow, J.D.2
  • 46
    • 53149117869 scopus 로고    scopus 로고
    • Differential expression of the multidrug resistance-related proteins ABCb1 and ABCc1 between blood-brain interfaces
    • Gazzin S, Strazielle N, Schmitt C, et al. Differential expression of the multidrug resistance-related proteins ABCb1 and ABCc1 between blood-brain interfaces. J Comp Neurol 2008;510:497-507.
    • (2008) J Comp Neurol , vol.510 , pp. 497-507
    • Gazzin, S.1    Strazielle, N.2    Schmitt, C.3
  • 47
    • 59849129439 scopus 로고    scopus 로고
    • ABC transporter (P-gp/ABCB1, MRP1/ABCC1, BCRP/ABCG2) expression in the developing human CNS
    • Daood M, Tsai C, Ahdab-Barmada M, Watchko JF. ABC transporter (P-gp/ABCB1, MRP1/ABCC1, BCRP/ABCG2) expression in the developing human CNS. Neuropediatrics 2008;39:211-8.
    • (2008) Neuropediatrics , vol.39 , pp. 211-218
    • Daood, M.1    Tsai, C.2    Ahdab-Barmada, M.3    Watchko, J.F.4
  • 48
    • 58249089412 scopus 로고    scopus 로고
    • The cytotoxic effect of unconjugated bilirubin in human neuroblastoma SH-SY5Y cells is modulated by the expression level of MRP1 but not MDR1
    • Corich L, Aranda A, Carrassa L, Bellarosa C, Ostrow JD, Tiribelli C. The cytotoxic effect of unconjugated bilirubin in human neuroblastoma SH-SY5Y cells is modulated by the expression level of MRP1 but not MDR1. Biochem J 2009;417:305-12.
    • (2009) Biochem J , vol.417 , pp. 305-312
    • Corich, L.1    Aranda, A.2    Carrassa, L.3    Bellarosa, C.4    Ostrow, J.D.5    Tiribelli, C.6
  • 49
    • 79551647689 scopus 로고    scopus 로고
    • Modulation of Mrp1 (ABCc1) and Pgp (ABCb1) by bilirubin at the blood-CSF and blood-brain barriers in the Gunn rat
    • Gazzin S, Berengeno AL, Strazielle N, et al. Modulation of Mrp1 (ABCc1) and Pgp (ABCb1) by bilirubin at the blood-CSF and blood-brain barriers in the Gunn rat. PLoS One 2011;6(1):e16165.
    • (2011) PLoS One , vol.6 , Issue.1
    • Gazzin, S.1    Berengeno, A.L.2    Strazielle, N.3
  • 50
    • 0027299613 scopus 로고
    • Marked endogenous activation of the CYP1A1 and CYP1A2 genes in the congenitally jaundiced Gunn rat
    • Kapitulnik J, Gonzalez FJ. Marked endogenous activation of the CYP1A1 and CYP1A2 genes in the congenitally jaundiced Gunn rat. Mol Pharmacol 1993;43:722-5.
    • (1993) Mol Pharmacol , vol.43 , pp. 722-725
    • Kapitulnik, J.1    Gonzalez, F.J.2
  • 51
    • 0023125608 scopus 로고
    • Increase in a specific cytochrome P-450 isoenzyme in the liver of congenitally jaundiced Gunn rats
    • Kapitulnik J, Hardwick JP, Ostrow JD, Webster CC, Park SS, Gelboin HV. Increase in a specific cytochrome P-450 isoenzyme in the liver of congenitally jaundiced Gunn rats. Biochem J 1987;242:297-300.
    • (1987) Biochem J , vol.242 , pp. 297-300
    • Kapitulnik, J.1    Hardwick, J.P.2    Ostrow, J.D.3    Webster, C.C.4    Park, S.S.5    Gelboin, H.V.6
  • 52
    • 26944445430 scopus 로고    scopus 로고
    • Evidence for induced microsomal bilirubin degradation by cytochrome P450 2A5
    • Abu-Bakar A, Moore MR, Lang MA. Evidence for induced microsomal bilirubin degradation by cytochrome P450 2A5. Biochem Pharmacol 2005;70:1527-35.
    • (2005) Biochem Pharmacol , vol.70 , pp. 1527-1535
    • Abu-Bakar, A.1    Moore, M.R.2    Lang, M.A.3
  • 53
    • 39749156518 scopus 로고    scopus 로고
    • Bilirubin injury to neurons: Contribution of oxidative stress and rescue by glycoursodeoxycholic acid
    • Brito MA, Lima S, Fernandes A, et al. Bilirubin injury to neurons: contribution of oxidative stress and rescue by glycoursodeoxycholic acid. Neurotoxicology 2008;29:259-69.
    • (2008) Neurotoxicology , vol.29 , pp. 259-269
    • Brito, M.A.1    Lima, S.2    Fernandes, A.3
  • 54
    • 71649114447 scopus 로고    scopus 로고
    • Bilirubin selectively inhibits cytochrome c oxidase activity and induces apoptosis in immature cortical neurons: Assessment of the protective effects of glycoursodeoxycholic acid
    • Vaz AR, Delgado-Esteban M, Brito MA, Bolaños JP, Brites D, Almeida A. Bilirubin selectively inhibits cytochrome c oxidase activity and induces apoptosis in immature cortical neurons: assessment of the protective effects of glycoursodeoxycholic acid. J Neurochem 2010;112:56-65.
    • (2010) J Neurochem , vol.112 , pp. 56-65
    • Vaz, A.R.1    Delgado-Esteban, M.2    Brito, M.A.3    Bolaños, J.P.4    Brites, D.5    Almeida, A.6
  • 55
    • 0036238782 scopus 로고    scopus 로고
    • Bilirubin induces apoptosis via the mitochondrial pathway in developing rat brain neurons
    • Rodrigues CM, Solá S, Brites D. Bilirubin induces apoptosis via the mitochondrial pathway in developing rat brain neurons. Hepatology 2002;35:1186-95.
    • (2002) Hepatology , vol.35 , pp. 1186-1195
    • Rodrigues, C.M.1    Solá, S.2    Brites, D.3
  • 56
    • 67749127695 scopus 로고    scopus 로고
    • Bilirubin as a determinant for altered neurogenesis, neuritogenesis, and synaptogenesis
    • Fernandes A, Falcão AS, Abranches E, et al. Bilirubin as a determinant for altered neurogenesis, neuritogenesis, and synaptogenesis. Dev Neurobiol 2009;69:568-82.
    • (2009) Dev Neurobiol , vol.69 , pp. 568-582
    • Fernandes, A.1    Falcão, A.S.2    Abranches, E.3
  • 57
    • 79957962505 scopus 로고    scopus 로고
    • Bilirubin injury to neurons and glial cells: New players, novel targets, and newer insights
    • Brites D. Bilirubin injury to neurons and glial cells: new players, novel targets, and newer insights. Semin Perinatol 2011;35:114-20.
    • (2011) Semin Perinatol , vol.35 , pp. 114-120
    • Brites, D.1
  • 58
    • 77957807564 scopus 로고    scopus 로고
    • Features of bilirubin-induced reactive microglia: From phagocytosis to inflammation
    • Silva SL, Vaz AR, Barateiro A, et al. Features of bilirubin-induced reactive microglia: from phagocytosis to inflammation. Neurobiol Dis 2010;40:663-75.
    • (2010) Neurobiol Dis , vol.40 , pp. 663-675
    • Silva, S.L.1    Vaz, A.R.2    Barateiro, A.3
  • 59
    • 77951675685 scopus 로고    scopus 로고
    • A proteomic approach to the bilirubin-induced toxicity in neuronal cells reveals a protective function of DJ-1 protein
    • Deganuto M, Cesaratto L, Bellarosa C, et al. A proteomic approach to the bilirubin-induced toxicity in neuronal cells reveals a protective function of DJ-1 protein. Proteomics 2010;10:1645-57.
    • (2010) Proteomics , vol.10 , pp. 1645-1657
    • Deganuto, M.1    Cesaratto, L.2    Bellarosa, C.3
  • 60
    • 34248141645 scopus 로고    scopus 로고
    • Apoptosis and impairment of neurite network by short exposure of immature rat cortical neurons to unconjugated bilirubin increase with cell differentiation and are additionally enhanced by an inflammatory stimulus
    • Falcão AS, Silva RF, Pancadas S, Fernandes A, Brito MA, Brites D. Apoptosis and impairment of neurite network by short exposure of immature rat cortical neurons to unconjugated bilirubin increase with cell differentiation and are additionally enhanced by an inflammatory stimulus. J Neurosci Res 2007;85:1229-39.
    • (2007) J Neurosci Res , vol.85 , pp. 1229-1239
    • Falcão, A.S.1    Silva, R.F.2    Pancadas, S.3    Fernandes, A.4    Brito, M.A.5    Brites, D.6
  • 61
    • 38149097540 scopus 로고    scopus 로고
    • Bilirubin inhibits tumor cell growth via activation of ERK
    • Ollinger R, Kogler P, Troppmair J, et al. Bilirubin inhibits tumor cell growth via activation of ERK. Cell Cycle 2007;6:3078-85.
    • (2007) Cell Cycle , vol.6 , pp. 3078-3085
    • Ollinger, R.1    Kogler, P.2    Troppmair, J.3
  • 62
    • 33846590433 scopus 로고    scopus 로고
    • Bilirubin and biliverdin treatment of atherosclerotic diseases
    • Ollinger R, Yamashita K, Bilban M, et al. Bilirubin and biliverdin treatment of atherosclerotic diseases. Cell Cycle 2007;6:39-43.
    • (2007) Cell Cycle , vol.6 , pp. 39-43
    • Ollinger, R.1    Yamashita, K.2    Bilban, M.3
  • 63
    • 77956632156 scopus 로고    scopus 로고
    • N-methyl-aspartate receptor and neuronal nitric oxide synthase activation mediate bilirubin-induced neurotoxicity
    • Brito MA, Vaz AR, Silva SL, et al. N-methyl-aspartate receptor and neuronal nitric oxide synthase activation mediate bilirubin-induced neurotoxicity. Mol Med 2010;16:372-80.
    • (2010) Mol Med , vol.16 , pp. 372-380
    • Brito, M.A.1    Vaz, A.R.2    Silva, S.L.3
  • 64
    • 84455192791 scopus 로고    scopus 로고
    • Functional induction of the cystine-glutamate exchanger system Xc(-) activity in SH-SY5Y cells by unconjugated bilirubin
    • Giraudi PJ, Bellarosa C, Coda-Zabetta CD, Peruzzo P, Tiribelli C. Functional induction of the cystine-glutamate exchanger system Xc(-) activity in SH-SY5Y cells by unconjugated bilirubin. PLoS One 2011;6(12):e29078.
    • (2011) PLoS One , vol.6 , Issue.12
    • Giraudi, P.J.1    Bellarosa, C.2    Coda-Zabetta, C.D.3    Peruzzo, P.4    Tiribelli, C.5
  • 65
    • 10744221309 scopus 로고    scopus 로고
    • Bilirubin protects astrocytes from its own toxicity by inducing up-regulation and translocation of multidrug resistance-associated protein 1 (Mrp1)
    • Gennuso F, Fernetti C, Tirolo C, et al. Bilirubin protects astrocytes from its own toxicity by inducing up-regulation and translocation of multidrug resistance-associated protein 1 (Mrp1). Proc Natl Acad Sci U S A 2004;101:2470-5.
    • (2004) Proc Natl Acad Sci U S a , vol.101 , pp. 2470-2475
    • Gennuso, F.1    Fernetti, C.2    Tirolo, C.3
  • 66
    • 84866018240 scopus 로고    scopus 로고
    • The evolving landscape of neurotoxicity by unconjugated bilirubin: Role of glial cells and inflammation
    • Brites D. The evolving landscape of neurotoxicity by unconjugated bilirubin: role of glial cells and inflammation. Front Pharmacol 2012;3:88.
    • (2012) Front Pharmacol , vol.3 , pp. 88
    • Brites, D.1
  • 67
    • 77953478352 scopus 로고    scopus 로고
    • Chronic bilirubin encephalopathy: Diagnosis and outcome
    • Shapiro SM. Chronic bilirubin encephalopathy: diagnosis and outcome. Semin Fetal Neonatal Med 2010;15:157-63.
    • (2010) Semin Fetal Neonatal Med , vol.15 , pp. 157-163
    • Shapiro, S.M.1
  • 68
    • 84864003603 scopus 로고    scopus 로고
    • Time-dependent dual effects of high levels of unconjugated bilirubin on the human blood-brain barrier lining
    • Palmela I, Sasaki H, Cardoso FL, et al. Time-dependent dual effects of high levels of unconjugated bilirubin on the human blood-brain barrier lining. Front Cell Neurosci 2012;6:22.
    • (2012) Front Cell Neurosci , vol.6 , pp. 22
    • Palmela, I.1    Sasaki, H.2    Cardoso, F.L.3
  • 69
    • 84876416140 scopus 로고    scopus 로고
    • Cross-talk between neurons and astrocytes in response to bilirubin: Early beneficial effects
    • Falcão AS, Silva RF, Vaz AR, Silva SL, Fernandes A, Brites D. Cross-talk between neurons and astrocytes in response to bilirubin: early beneficial effects. Neurochem Res 2013;38:644-59.
    • (2013) Neurochem Res , vol.38 , pp. 644-659
    • Falcão, A.S.1    Silva, R.F.2    Vaz, A.R.3    Silva, S.L.4    Fernandes, A.5    Brites, D.6
  • 70
    • 84870553767 scopus 로고    scopus 로고
    • Lipid peroxidation is not the primary mechanism of bilirubin-induced neurologic dysfunction in jaundiced Gunn rat pups
    • Daood MJ, Hoyson M, Watchko JF. Lipid peroxidation is not the primary mechanism of bilirubin-induced neurologic dysfunction in jaundiced Gunn rat pups. Pediatr Res 2012;72:455-9.
    • (2012) Pediatr Res , vol.72 , pp. 455-459
    • Daood, M.J.1    Hoyson, M.2    Watchko, J.F.3
  • 71
    • 0027766088 scopus 로고
    • Gunn rat: A model for inherited deficiency of bilirubin glucuronidation
    • Chowdhury JR, Kondapalli R, Chowdhury NR. Gunn rat: a model for inherited deficiency of bilirubin glucuronidation. Adv Vet Sci Comp Med 1993;37:149-73.
    • (1993) Adv Vet Sci Comp Med , vol.37 , pp. 149-173
    • Chowdhury, J.R.1    Kondapalli, R.2    Chowdhury, N.R.3
  • 72
    • 0001130357 scopus 로고
    • Hereditary acholuric jaundice in a new mutant strain of rats
    • Gunn CH. Hereditary acholuric jaundice in a new mutant strain of rats. J Hered 1938;29:137-9.
    • (1938) J Hered , vol.29 , pp. 137-139
    • Gunn, C.H.1
  • 73
    • 84857744956 scopus 로고    scopus 로고
    • Rescue of bilirubin-induced neonatal lethality in a mouse model of Crigler-Najjar syndrome type I by AAV9-mediated gene transfer
    • Bortolussi G, Zentilin L, Baj G, et al. Rescue of bilirubin-induced neonatal lethality in a mouse model of Crigler-Najjar syndrome type I by AAV9-mediated gene transfer. FASEB J 2012;26:1052-63.
    • (2012) FASEB J , vol.26 , pp. 1052-1063
    • Bortolussi, G.1    Zentilin, L.2    Baj, G.3
  • 74
    • 84889858228 scopus 로고    scopus 로고
    • Phototherapy and other treatments
    • Stevenson DK, Maisels MJ, Watchko JF, eds. New York: McGraw-Hill
    • Maisels MJ, Stevenson D, Watchko JF, McDonagh AF. Phototherapy and other treatments. In: Stevenson DK, Maisels MJ, Watchko JF, eds. Care of the jaundiced neonate. New York: McGraw-Hill, 2012:195-227.
    • (2012) Care of the Jaundiced Neonate , pp. 195-227
    • Maisels, M.J.1    Stevenson, D.2    Watchko, J.F.3    McDonagh, A.F.4
  • 75
    • 69749102935 scopus 로고    scopus 로고
    • Reversibility of acute intermediate phase bilirubin encephalopathy
    • Hansen TW, Nietsch L, Norman E, et al. Reversibility of acute intermediate phase bilirubin encephalopathy. Acta Paediatr 2009;98:1689-94.
    • (2009) Acta Paediatr , vol.98 , pp. 1689-1694
    • Hansen, T.W.1    Nietsch, L.2    Norman, E.3
  • 77
    • 23044460297 scopus 로고    scopus 로고
    • Minocycline blocks bilirubin neurotoxicity and prevents hyperbilirubinemia-induced cerebellar hypoplasia in the Gunn rat
    • Lin S, Wei X, Bales KR, et al. Minocycline blocks bilirubin neurotoxicity and prevents hyperbilirubinemia-induced cerebellar hypoplasia in the Gunn rat. Eur J Neurosci 2005;22:21-7.
    • (2005) Eur J Neurosci , vol.22 , pp. 21-27
    • Lin, S.1    Wei, X.2    Bales, K.R.3
  • 78
    • 36248932681 scopus 로고    scopus 로고
    • Minocycline blocks acute bilirubin-induced neurological dysfunction in jaundiced Gunn rats
    • Geiger AS, Rice AC, Shapiro SM. Minocycline blocks acute bilirubin-induced neurological dysfunction in jaundiced Gunn rats. Neonatology 2007;92:219-26.
    • (2007) Neonatology , vol.92 , pp. 219-226
    • Geiger, A.S.1    Rice, A.C.2    Shapiro, S.M.3


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