Essential roles of Raf/extracellular signal-regulated kinase/mitogen- activated protein kinase pathway, YY1, and Ca2+ influx in growth arrest of human vascular smooth muscle cells by bilirubin

Journal of Biological Chemistry

Volumn 287, Issue 19, 2012, Pages 15418-15426

  Stoeckius, Marlon ^a   Erat, Anna ^a,f   Fujikawa, Tatsuya ^a   Hiromura, Makoto ^a,c   Koulova, Anna ^a,d   Otterbein, Leo ^b   Bianchi, Cesario ^c   Tobiasch, Edda ^e   Dagon, Yossi ^a   Sellke, Frank W ^c   Usheva, Anny ^a  

^a BETH ISRAEL DEACONESS MEDICAL CENTER   (United States)

^b HARVARD MEDICAL SCHOOL   (United States)

^c BROWN UNIVERSITY   (United States)

^d RIKEN KOBE INSTITUTE   (Japan)

^e BONN RHEIN SIEG UNIVERSITY OF APPLIED SCIENCES   (Germany)

^f UNIVERSITY HOSPITAL ZURICH   (Switzerland)

Author keywords

[No Author keywords available]

Indexed keywords

BINARY ALLOYS; CALCIUM; CELL CULTURE; CELL PROLIFERATION; CHEMICAL ACTIVATION; ENZYME ACTIVITY; MUSCLE; TRANSCRIPTION;

CELLULAR PROLIFERATIONS; CONCENTRATION-DEPENDENT; HUMAN CORONARY ARTERIES; HUMAN VASCULAR SMOOTH MUSCLE CELLS; PHYSIOLOGICAL CONCENTRATIONS; RETINOBLASTOMA PROTEIN; SIGNAL-REGULATED KINASE; VASCULAR SMOOTH MUSCLES;

CALCIUM ALLOYS;

BILIRUBIN; CALCIUM ION; CYCLIN D1; DNA DIRECTED RNA POLYMERASE; DNA DIRECTED RNA POLYMERASE III; MITOGEN ACTIVATED PROTEIN KINASE; RAF PROTEIN; RNA POLYMERASE II; TRANSCRIPTION FACTOR YY1;

APOPTOSIS; ARTICLE; CALCIUM TRANSPORT; CELL CYCLE ARREST; CELL CYCLE G0 PHASE; CELL CYCLE G1 PHASE; CELL GROWTH; CELL PROLIFERATION; CONTROLLED STUDY; GENE EXPRESSION; GROWTH INHIBITION; HUMAN; HUMAN CELL; PHENOTYPE; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN CLEAVAGE; PROTEIN CONTENT; PROTEIN INTERACTION; PROTEIN PHOSPHORYLATION; RNA SYNTHESIS; SMOOTH MUSCLE FIBER; VASCULAR SMOOTH MUSCLE;

EID: 84860847500     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M111.266510     Document Type: Article

References (24)

1. Mustafa, M. G., Cowger, M. L., and King, T. E. (1969) Effects of bilirubin on mitochondrial reactions. J. Biol. Chem. 244, 6403-6414
2. Hahm, J. S., Sung, I. K., Yang, S. C., Rhee, J. C., Lee, M. H., Kee, C. S., and Park, K. N. (1992) Biliary proteins in patients with and without gallstones. Korean J. Intern Med. 7, 18-24
3. Grojean, S., Koziel, V., Vert, P., and Daval, J. L. (2000) Bilirubin induces apoptosis via activation of NMDA receptors in developing rat brain neurons. Exp. Neurol. 166, 334-341
4. Stocker, R., Yamamoto, Y., McDonagh, A. F., Glazer, A. N., and Ames, B. N. (1987) Bilirubin is an antioxidant of possible physiological importance. Science 235, 1043-1046 (Pubitemid 17049750)
5. Perlstein, T. S., Pande, R. L., Beckman, J. A., and Creager, M. A. (2008) Serum total bilirubin level and prevalent lower-extremity peripheral arterial disease: National Health and Nutrition Examination Survey (NHANES) 1999 to 2004. Arterioscler. Thromb. Vasc. Biol. 28, 166 -172
6. Troughton, J. A., Woodside, J. V., Young, I. S., Arveiler, D., Amouyel, P., Ferrières, J., Ducimetière, P., Patterson, C. C., Kee, F., Yarnell, J. W., Evans, A., and PRIME Study Group (2007) Bilirubin and coronary heart disease risk in the Prospective Epidemiological Study of Myocardial Infarction (PRIME). Eur. J. Cardiovasc Prev. Rehabil. 14, 79-84
7. Vítek, L., Jirsa, M., Brodanová, M., Kalab, M., Marecek, Z., Danzig, V., Novotný, L., and Kotal, P. (2002) Gilbert syndrome and ischemic heart disease.Aprotective effect of elevated bilirubin levels. Atherosclerosis 160, 449-456 (Pubitemid 34159340)
8. Petkova, V., Romanowski, M. J., Sulijoadikusumo, I., Rohne, D., Kang, P., Shenk, T., and Usheva, A. (2001) Interaction between YY1 and the retinoblastoma protein. Regulation of cell cycle progression in differentiated cells. J. Biol. Chem. 276, 7932-7936
9. Ollinger, R., Bilban, M., Erat, A., Froio, A., McDaid, J., Tyagi, S., Csizmadia, E., Graça-Souza, A. V., Liloia, A., Soares, M. P., Otterbein, L. E., Usheva, A., Yamashita, K., and Bach, F. H. (2005) Bilirubin. A natural inhibitor of vascular smooth muscle cell proliferation. Circulation 112, 1030-1039 (Pubitemid 41170272)
10. Chau, B. N., and Wang, J. Y. (2003) Coordinated regulation of life and death by RB. Nat. Rev. Cancer 3, 130-138 (Pubitemid 37328880)
11. Sherr, C. J. (1994) G1 phase progression. Cycling on cue. Cell 79, 551-555
12. Zhu, L. (2005) Tumour suppressor retinoblastoma protein Rb. A transcriptional regulator. Eur. J. Cancer 41, 2415-2427
13. Walowitz, J. L., Bradley, M. E., Chen, S., and Lee, T. (1998) Proteolytic regulation of the zinc finger transcription factor YY1, a repressor of muscle-restricted gene expression. J. Biol. Chem. 273, 6656-6661 (Pubitemid 28160323)
14. 2+ in oxidant-induced NF-κB activation. FEBS Lett. 385, 58-62
15. Grummt, I. (2003) Life on a planet of its own. Regulation of RNA polymerase I transcription in the nucleolus. Genes Dev. 17, 1691-1702
16. Moss, T., and Stefanovsky, V. Y. (2002) At the center of eukaryotic life. Cell 109, 545-548 (Pubitemid 34628718)
17. Felton-Edkins, Z. A., Kenneth, N. S., Brown, T. R., Daly, N. L., Gomez- Roman, N., Grandori, C., Eisenman, R. N., and White, R. J. (2003) Direct regulation of RNA polymerase III transcription by RB, p53 and c-Myc. Cell Cycle 2, 181-184
18. Kurose, K., Hata, K., Hattori, M., and Sakaki, Y. (1995)RNApolymerase III dependence of the human L1 promoter and possible participation of the RNA polymerase II factor YY1 in the RNA polymerase III transcription system. Nucleic Acids Res. 23, 3704-3709
19. Leicht, D. T., Balan, V., Kaplun, A., Singh-Gupta, V., Kaplun, L., Dobson, M., and Tzivion, G. (2007) Raf kinases. Function, regulation and role in human cancer. Biochim. Biophys. Acta 1773, 1196-1212 (Pubitemid 47161035)
20. Beohar, N., Flaherty, J. D., Davidson, C. J., Maynard, R. C., Robbins, J. D., Shah, A. P., Choi, J. W., MacDonald, L. A., Jorgensen, J. P., Pinto, J. V., Chandra, S., Klaus, H. M., Wang, N. C., Harris, K. R., Decker, R., and Bonow, R. O. (2004) Antirestenotic effects of a locally delivered caspase inhibitor in a balloon injury model. Circulation 109, 108-113 (Pubitemid 38056030)
21. Garnovskaya, M. N., Mukhin, Y. V., Vlasova, T. M., Grewal, J. S., Ullian, M. E., Tholanikunnel, B. G., and Raymond, J. R. (2004) Mitogen-induced rapid phosphorylation of serine 795 of the retinoblastoma gene product in vascular smooth muscle cells involves ERK activation. J. Biol. Chem. 279, 24899-24905 (Pubitemid 38725359)
22. Dumaz, N., and Marais, R. (2005) Raf phosphorylation one step forward and two steps back. Mol. Cell. 17, 164-166 (Pubitemid 40138610)
23. Taillé, C., Almolki, A., Benhamed, M., Zedda, C., Mégret, J., Berger, P., Lesèche, G., Fadel, E., Yamaguchi, T., Marthan, R., Aubier, M., and Boczkowski, J. (2003) Heme oxygenase inhibits human airway smooth muscle proliferation via a bilirubin-dependent modulation of ERK1/2 phosphorylation. J. Biol. Chem. 278, 27160-27168 (Pubitemid 36876872)
24. Musgrove, E. A., Caldon, C. E., Barraclough, J., Stone, A., and Sutherland, R. L. (2011) CyclinDas a therapeutic target in cancer. Nat. Rev. Cancer 11, 558-572