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Volumn 3 APR, Issue , 2012, Pages

The role of bilirubin in diabetes, metabolic syndrome, and cardiovascular diseases

Author keywords

Bilirubin; Biliverdin; Biliverdin reductase; Cardiovascular diseases; Diabetes; Heme oxygenase; Metabolic syndrome; UGT1A1

Indexed keywords

8 HYDROXYDEOXYGUANOSINE; ADVANCED GLYCATION END PRODUCT; BILIRUBIN; BILIVERDIN; BILIVERDIN REDUCTASE; CURCUMIN; FIBRONECTIN; GLUCURONOSYLTRANSFERASE 1A1; HEME; HEME OXYGENASE 1; HEME OXYGENASE 2; HEMIN; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INSULIN; NUTRACEUTICAL; OXIDOREDUCTASE; PROTEIN KINASE C BETA; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE OXIDASE; SILYMARIN; TRANSFORMING GROWTH FACTOR BETA1; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG;

EID: 84865984236     PISSN: None     EISSN: 16639812     Source Type: Journal    
DOI: 10.3389/fphar.2012.00055     Document Type: Article
Times cited : (239)

References (92)
  • 3
    • 23444454955 scopus 로고    scopus 로고
    • Heme oxygenase-1: a therapeutic amplification funnel
    • Bach, F. H. (2005). Heme oxygenase-1: a therapeutic amplification funnel. FASEB J. 19, 1216-1219.
    • (2005) FASEB J , vol.19 , pp. 1216-1219
    • Bach, F.H.1
  • 4
    • 77956922366 scopus 로고    scopus 로고
    • Association between heme oxygenase-1 gene promoter polymorphisms and type 2 diabetes mellitus: a HuGE review and metaanalysis
    • Bao, W., Song, F., Li, X., Rong, S., Yang, W., Wang, D., Xu, J., Fu, J., Zhao, Y., and Liu, L. (2010a). Association between heme oxygenase-1 gene promoter polymorphisms and type 2 diabetes mellitus: a HuGE review and metaanalysis. Am. J. Epidemiol. 172, 631-636.
    • (2010) Am. J. Epidemiol. , vol.172 , pp. 631-636
    • Bao, W.1    Song, F.2    Li, X.3    Rong, S.4    Yang, W.5    Wang, D.6    Xu, J.7    Fu, J.8    Zhao, Y.9    Liu, L.10
  • 5
    • 77957882550 scopus 로고    scopus 로고
    • Plasma heme oxygenase-1 concentration is elevated in individuals with type 2 diabetes mellitus
    • doi:10.1371/journal.pone.0012371
    • Bao, W., Song, F., Li, X., Rong, S., Yang, W., Zhang, M., Yao, P., Hao, L., Yang, N., Hu, F. B., and Liu, L. (2010b). Plasma heme oxygenase-1 concentration is elevated in individuals with type 2 diabetes mellitus. PLoS ONE 5, e12371. doi:10.1371/journal.pone.0012371
    • (2010) PLoS ONE , vol.5
    • Bao, W.1    Song, F.2    Li, X.3    Rong, S.4    Yang, W.5    Zhang, M.6    Yao, P.7    Hao, L.8    Yang, N.9    Hu, F.B.10    Liu, L.11
  • 7
    • 84981837007 scopus 로고
    • Über eine biologische bedeutung der gallenfarbstoffe: bilirubin und biliverdin als antioxydantien für das vitamin A und die essentiellen Fettsäuren
    • Bernard, K., Ritzel, G., and Steiner, K. U. (1954). Über eine biologische bedeutung der gallenfarbstoffe: bilirubin und biliverdin als antioxydantien für das vitamin A und die essentiellen Fettsäuren. Helv. Chim. Acta 37, 306-313.
    • (1954) Helv. Chim. Acta , vol.37 , pp. 306-313
    • Bernard, K.1    Ritzel, G.2    Steiner, K.U.3
  • 8
    • 42949118681 scopus 로고    scopus 로고
    • Association of serum bilirubin with pulsatile arterial function in asymptomatic young adults: the Bogalusa Heart Study
    • Bhuiyan, A. R., Srinivasan, S. R., Chen, W., Sultana, A., and Berenson, G. S. (2008). Association of serum bilirubin with pulsatile arterial function in asymptomatic young adults: the Bogalusa Heart Study. Metab. Clin. Exp. 57, 612-616.
    • (2008) Metab. Clin. Exp. , vol.57 , pp. 612-616
    • Bhuiyan, A.R.1    Srinivasan, S.R.2    Chen, W.3    Sultana, A.4    Berenson, G.S.5
  • 9
    • 59849105278 scopus 로고    scopus 로고
    • Effects of silymarin on hepatitis C virus and haem oxygenase-1 gene expression in human hepatoma cells
    • Bonifaz, V., Shan, Y., Lambrecht, R. W., Donohue, S. E., Moschenross, D., and Bonkovsky, H. L. (2009). Effects of silymarin on hepatitis C virus and haem oxygenase-1 gene expression in human hepatoma cells. Liver Int. 29, 366-373.
    • (2009) Liver Int , vol.29 , pp. 366-373
    • Bonifaz, V.1    Shan, Y.2    Lambrecht, R.W.3    Donohue, S.E.4    Moschenross, D.5    Bonkovsky, H.L.6
  • 11
    • 49649107044 scopus 로고    scopus 로고
    • Serum bilirubin and ferritin levels link between heme oxygenase-1 gene promoter polymorphism and susceptibility to coronary artery disease in diabetic patients
    • Chen, Y. H., Chau, L. Y., Chen, J. W., and Lin, S. J. (2008). Serum bilirubin and ferritin levels link between heme oxygenase-1 gene promoter polymorphism and susceptibility to coronary artery disease in diabetic patients. Diabetes Care 31, 1615-1620.
    • (2008) Diabetes Care , vol.31 , pp. 1615-1620
    • Chen, Y.H.1    Chau, L.Y.2    Chen, J.W.3    Lin, S.J.4
  • 12
    • 84864101453 scopus 로고    scopus 로고
    • High total bilirubin as a protective factor for diabetes mellitus: an analysis of NHANES data from 1996-2006
    • Cheriyath, P., Gorrepati, V. S., Peters, I., Nookala, V., Murphy, M. E., Srouji, N., and Fischman, D. (2010). High total bilirubin as a protective factor for diabetes mellitus: an analysis of NHANES data from 1996-2006. J. Clin. Med. Res. 2, 201-206.
    • (2010) J. Clin. Med. Res. , vol.2 , pp. 201-206
    • Cheriyath, P.1    Gorrepati, V.S.2    Peters, I.3    Nookala, V.4    Murphy, M.E.5    Srouji, N.6    Fischman, D.7
  • 13
    • 84872687566 scopus 로고    scopus 로고
    • Relationships between serum total bilirubin levels and metabolic syndrome in Korean adults
    • doi:10.1016/j.numecd.2011.03.001. [Epub ahead of print]
    • Choi, S. H., Yun, K. E., and Choi, H. J. (2011). Relationships between serum total bilirubin levels and metabolic syndrome in Korean adults. Nutr. Metab. Cardiovasc. Dis. doi:10.1016/j.numecd.2011.03.001. [Epub ahead of print].
    • (2011) Nutr. Metab. Cardiovasc. Dis.
    • Choi, S.H.1    Yun, K.E.2    Choi, H.J.3
  • 14
    • 84857048733 scopus 로고    scopus 로고
    • Chronic HO-1 induction with cobalt protoporphyrin (CoPP) treatment increases oxygen consumption, activity, heat production and lowers body weight in obese melanocortin-4 receptor-deficient mice
    • Csongradi, E., Docarmo, J. M., Dubinion, J. H., Vera, T., and Stec, D. E. (2012). Chronic HO-1 induction with cobalt protoporphyrin (CoPP) treatment increases oxygen consumption, activity, heat production and lowers body weight in obese melanocortin-4 receptor-deficient mice. Int. J. Obes. 36, 244-253.
    • (2012) Int. J. Obes. , vol.36 , pp. 244-253
    • Csongradi, E.1    Docarmo, J.M.2    Dubinion, J.H.3    Vera, T.4    Stec, D.E.5
  • 16
    • 0024239038 scopus 로고
    • Antioxidant defenses and lipid peroxidation in human blood plasma
    • Frei, B., Stocker, R., and Ames, B. N. (1988). Antioxidant defenses and lipid peroxidation in human blood plasma. Proc. Natl. Acad. Sci. U.S.A. 85, 9748-9752.
    • (1988) Proc. Natl. Acad. Sci. U. S. A. , vol.85 , pp. 9748-9752
    • Frei, B.1    Stocker, R.2    Ames, B.N.3
  • 17
    • 78650056520 scopus 로고    scopus 로고
    • Hyperbilirubinemia reduces the streptozotocininduced pancreatic damage through attenuating the oxidative stress in the Gunn rat
    • Fu, Y. Y., Kang, K. J., Ahn, J. M., Kim, H. R., Na, K. Y., Chae, D. W., Kim, S., and Chin, H. J. (2010). Hyperbilirubinemia reduces the streptozotocininduced pancreatic damage through attenuating the oxidative stress in the Gunn rat. Tohoku J. Exp. Med. 222, 265-273.
    • (2010) Tohoku J. Exp. Med. , vol.222 , pp. 265-273
    • Fu, Y.Y.1    Kang, K.J.2    Ahn, J.M.3    Kim, H.R.4    Na, K.Y.5    Chae, D.W.6    Kim, S.7    Chin, H.J.8
  • 18
    • 77958086954 scopus 로고    scopus 로고
    • Bilirubin and biliverdin protect rodents against diabetic nephropathy by downregulating NAD(P)H oxidase
    • Fujii, M., Inoguchi, T., Sasaki, S., Maeda, Y., Zheng, J., Kobayashi, K., and Takayanagi, R. (2010). Bilirubin and biliverdin protect rodents against diabetic nephropathy by downregulating NAD(P)H oxidase. Kidney Int. 78, 905-919.
    • (2010) Kidney Int , vol.78 , pp. 905-919
    • Fujii, M.1    Inoguchi, T.2    Sasaki, S.3    Maeda, Y.4    Zheng, J.5    Kobayashi, K.6    Takayanagi, R.7
  • 21
    • 78349297565 scopus 로고    scopus 로고
    • Oxidative stress and diabetic complications
    • Giacco, F., and Brownlee, M. (2010). Oxidative stress and diabetic complications. Circ. Res. 107, 1058-1070.
    • (2010) Circ. Res. , vol.107 , pp. 1058-1070
    • Giacco, F.1    Brownlee, M.2
  • 22
    • 84865248403 scopus 로고    scopus 로고
    • Curcumin-supplemented yoghurt improves physiological and biochemical markers of experimental diabetes
    • doi:10.1017/S0007114511005769.[Epub ahead of print]
    • Gutierres, V. O., Pinheiro, C. M., Assis, R. P., Vendramini, R. C., Pepato, M. T., and Brunetti, I. L. (2011). Curcumin-supplemented yoghurt improves physiological and biochemical markers of experimental diabetes. Br.J.Nutr.1-9. doi:10.1017/S0007114511005769. [Epub ahead of print].
    • (2011) Br .J. Nutr , pp. 1-9
    • Gutierres, V.O.1    Pinheiro, C.M.2    Assis, R.P.3    Vendramini, R.C.4    Pepato, M.T.5    Brunetti, I.L.6
  • 23
    • 77955887671 scopus 로고    scopus 로고
    • High serum bilirubin is associated with the reduced risk of diabetes mellitus and diabetic nephropathy
    • Han, S. S., Na, K. Y., Chae, D. W., Kim, Y. S., and Chin, H. J. (2010). High serum bilirubin is associated with the reduced risk of diabetes mellitus and diabetic nephropathy. Tohoku J. Exp. Med. 221, 133-140.
    • (2010) Tohoku J. Exp. Med. , vol.221 , pp. 133-140
    • Han, S.S.1    Na, K.Y.2    Chae, D.W.3    Kim, Y.S.4    Chin, H.J.5
  • 24
    • 3042799349 scopus 로고    scopus 로고
    • Characterization of rat heme oxygenase-3 gene. Implication of processed pseudogenes derived from heme oxygenase2 gene
    • Hayashi, S., Omata, Y., Sakamoto, H., Higashimoto, Y., Hara, T., Sagara, Y., and Noguchi,M. (2004). Characterization of rat heme oxygenase-3 gene. Implication of processed pseudogenes derived from heme oxygenase2 gene. Gene 336, 241-250.
    • (2004) Gene , vol.336 , pp. 241-250
    • Hayashi, S.1    Omata, Y.2    Sakamoto, H.3    Higashimoto, Y.4    Hara, T.5    Sagara, Y.6    Noguchi, M.7
  • 25
    • 0032961802 scopus 로고    scopus 로고
    • Heme oxygenase and carbon monoxide: regulatory roles in islet hormone release: a biochemical, immunohistochemical, and confocal microscopic study
    • Henningsson, R., Alm, P., Ekstrom, P., and Lundquist, I. (1999). Heme oxygenase and carbon monoxide: regulatory roles in islet hormone release: a biochemical, immunohistochemical, and confocal microscopic study. Diabetes 48, 66-76.
    • (1999) Diabetes , vol.48 , pp. 66-76
    • Henningsson, R.1    Alm, P.2    Ekstrom, P.3    Lundquist, I.4
  • 26
    • 77954692327 scopus 로고    scopus 로고
    • Serum bilirubin predicts long-term clinical outcomes in patients with cardiac syndrome X
    • Huang, S. S., Huang, P. H., Leu, H. B., Wu, T. C., Lin, S. J., and Chen, J. W. (2010). Serum bilirubin predicts long-term clinical outcomes in patients with cardiac syndrome X. Heart 96, 1227-1232.
    • (2010) Heart , vol.96 , pp. 1227-1232
    • Huang, S.S.1    Huang, P.H.2    Leu, H.B.3    Wu, T.C.4    Lin, S.J.5    Chen, J.W.6
  • 27
    • 80755187935 scopus 로고    scopus 로고
    • Relationship between bilirubin and C-reactive protein
    • Hwang, H. J., Lee, S. W., and Kim, S. H. (2011). Relationship between bilirubin and C-reactive protein. Clin. Chem. Lab. Med. 49, 1823-1828.
    • (2011) Clin. Chem. Lab. Med. , vol.49 , pp. 1823-1828
    • Hwang, H.J.1    Lee, S.W.2    Kim, S.H.3
  • 29
    • 34748876803 scopus 로고    scopus 로고
    • Relationship between Gilbert syndrome and prevalence of vascular complications in patients with diabetes
    • Inoguchi, T., Sasaki, S., Kobayashi, K., Takayanagi, R., and Yamada, T. (2007). Relationship between Gilbert syndrome and prevalence of vascular complications in patients with diabetes. JAMA 298, 1398-1400.
    • (2007) JAMA , vol.298 , pp. 1398-1400
    • Inoguchi, T.1    Sasaki, S.2    Kobayashi, K.3    Takayanagi, R.4    Yamada, T.5
  • 30
    • 84874950329 scopus 로고    scopus 로고
    • Association of low bilirubin levels and promoter variations in UGT1A1 gene with diabetes mellitus type 2 (abstract)
    • Jirásková, A., Jovanovská, J., Škrha, J., and Vítek, L. (2011). Association of low bilirubin levels and promoter variations in UGT1A1 gene with diabetes mellitus type 2 (abstract). Hepatol. Int. 5, 37.
    • (2011) Hepatol. Int. , vol.5 , pp. 37
    • Jirásková, A.1    Jovanovská, J.2    Škrha, J.3    Vítek, L.4
  • 31
    • 0141483051 scopus 로고    scopus 로고
    • Haeme-oxygenase 1 expression in rat pancreatic beta cells is stimulated by supraphysiological glucose concentrations and by cyclic AMP
    • Jonas, J. C., Guiot, Y., Rahier, J., and Henquin, J. C. (2003). Haeme-oxygenase 1 expression in rat pancreatic beta cells is stimulated by supraphysiological glucose concentrations and by cyclic AMP. Diabetologia 46, 1234-1244.
    • (2003) Diabetologia , vol.46 , pp. 1234-1244
    • Jonas, J.C.1    Guiot, Y.2    Rahier, J.3    Henquin, J.C.4
  • 32
    • 27744588300 scopus 로고    scopus 로고
    • Decreased levels of advanced glycation end-products in patients with Gilbert syndrome
    • Kalousová, M., Novotný, L., Zima, T., Braun, M., and Vítek, L. (2005). Decreased levels of advanced glycation end-products in patients with Gilbert syndrome. Cell. Mol. Biol. 51, 387-392.
    • (2005) Cell. Mol. Biol. , vol.51 , pp. 387-392
    • Kalousová, M.1    Novotný, L.2    Zima, T.3    Braun, M.4    Vítek, L.5
  • 33
    • 61549122310 scopus 로고    scopus 로고
    • Pleiotropic functions of biliverdin reductase: cellular signaling and generation of cytoprotective and cytotoxic bilirubin
    • Kapitulnik, J., and Maines, M. D. (2009). Pleiotropic functions of biliverdin reductase: cellular signaling and generation of cytoprotective and cytotoxic bilirubin. Trends Pharmacol. Sci. 30, 129-137.
    • (2009) Trends Pharmacol. Sci. , vol.30 , pp. 129-137
    • Kapitulnik, J.1    Maines, M.D.2
  • 34
    • 70350558555 scopus 로고    scopus 로고
    • Low serum bilirubin levelasanindependentpredictorof stroke incidence: a prospective study in Korean men and women
    • Kimm, H., Yun, J. E., Jo, J., and Jee, S. H. (2009). Low serum bilirubin levelasanindependentpredictorof stroke incidence: a prospective study in Korean men and women. Stroke 40, 3422-3427.
    • (2009) Stroke , vol.40 , pp. 3422-3427
    • Kimm, H.1    Yun, J.E.2    Jo, J.3    Jee, S.H.4
  • 37
    • 0030033619 scopus 로고    scopus 로고
    • Downregulation of the human heme oxygenase gene by glucocorticoids and identification of 56b regulatory elements
    • Lavrovsky, Y., Drummond, G. S., and Abraham, N. G. (1996). Downregulation of the human heme oxygenase gene by glucocorticoids and identification of 56b regulatory elements. Biochem. Biophys. Res. Commun. 218, 759-765.
    • (1996) Biochem. Biophys. Res. Commun. , vol.218 , pp. 759-765
    • Lavrovsky, Y.1    Drummond, G.S.2    Abraham, N.G.3
  • 38
    • 77954373540 scopus 로고    scopus 로고
    • A randomized study to establish the effects of spirulina in type 2 diabetes mellitus patients
    • Lee, E. H., Park, J. E., Choi, Y. J., Huh, K. B., and Kim,W.Y. (2008).A randomized study to establish the effects of spirulina in type 2 diabetes mellitus patients. Nutr. Res. Pract. 2, 295-300.
    • (2008) Nutr. Res. Pract. , vol.2 , pp. 295-300
    • Lee, E.H.1    Park, J.E.2    Choi, Y.J.3    Huh, K.B.4    Kim, W.Y.5
  • 39
    • 36849045105 scopus 로고    scopus 로고
    • Regulation of TNF-alphaactivated PKC-zeta signaling by the human biliverdin reductase: identification of activating and inhibitory domains of the reductase
    • Lerner-Marmarosh, N., Miralem, T., Gibbs, P. E., and Maines, M. D. (2007). Regulation of TNF-alphaactivated PKC-zeta signaling by the human biliverdin reductase: identification of activating and inhibitory domains of the reductase. FASEB J. 21, 3949-3962.
    • (2007) FASEB J , vol.21 , pp. 3949-3962
    • Lerner-Marmarosh, N.1    Miralem, T.2    Gibbs, P.E.3    Maines, M.D.4
  • 40
    • 44349190488 scopus 로고    scopus 로고
    • Human biliverdin reductase is an ERK activator; hBVR is an ERK nuclear transporter and is required for MAPK signaling
    • Lerner-Marmarosh, N., Miralem, T., Gibbs, P. E., and Maines, M. D. (2008). Human biliverdin reductase is an ERK activator; hBVR is an ERK nuclear transporter and is required for MAPK signaling. Proc. Natl. Acad. Sci. U.S.A. 105, 6870-6875.
    • (2008) Proc. Natl. Acad. Sci. U. S. A. , vol.105 , pp. 6870-6875
    • Lerner-Marmarosh, N.1    Miralem, T.2    Gibbs, P.E.3    Maines, M.D.4
  • 41
    • 18844371482 scopus 로고    scopus 로고
    • Human biliverdin reductase: a member of the insulin receptor substrate family with serine/threonine/tyrosine kinase activity
    • Lerner-Marmarosh, N., Shen, J., Torno, M. D., Kravets, A., Hu, Z., and Maines, M. D. (2005). Human biliverdin reductase: a member of the insulin receptor substrate family with serine/threonine/tyrosine kinase activity. Proc. Natl. Acad. Sci. U.S.A. 102, 7109-7114.
    • (2005) Proc. Natl. Acad. Sci. U. S. A. , vol.102 , pp. 7109-7114
    • Lerner-Marmarosh, N.1    Shen, J.2    Torno, M.D.3    Kravets, A.4    Hu, Z.5    Maines, M.D.6
  • 42
    • 41149155892 scopus 로고    scopus 로고
    • Treatment of obese diabetic mice with a heme oxygenase inducer reduces visceral and subcutaneous adiposity, increases adiponectin levels, and improves insulin sensitivity and glucose tolerance
    • Li, M., Kim, D. H., Tsenovoy, P. L., Peterson, S. J., Rezzani, R., Rodella, L. F., Aronow,W. S., Ikehara, S., and Abraham, N. G. (2008). Treatment of obese diabetic mice with a heme oxygenase inducer reduces visceral and subcutaneous adiposity, increases adiponectin levels, and improves insulin sensitivity and glucose tolerance. Diabetes 57, 1526-1535.
    • (2008) Diabetes , vol.57 , pp. 1526-1535
    • Li, M.1    Kim, D.H.2    Tsenovoy, P.L.3    Peterson, S.J.4    Rezzani, R.5    Rodella, L.F.6    Aronow, W.S.7    Ikehara, S.8    Abraham, N.G.9
  • 43
    • 77957735569 scopus 로고    scopus 로고
    • Serum bilirubin and genes controlling bilirubin concentrations as biomarkers for cardiovascular disease
    • Lin, J. P., Vítek, L., and Schwertner, H. A. (2010). Serum bilirubin and genes controlling bilirubin concentrations as biomarkers for cardiovascular disease. Clin. Chem. 56, 1535-1543
    • (2010) Clin. Chem. , vol.56 , pp. 1535-1543
    • Lin, J.P.1    Vítek, L.2    Schwertner, H.A.3
  • 44
    • 62749195623 scopus 로고    scopus 로고
    • Serum bilirubin is inversely associated with insulin resistance and metabolic syndrome among children and adolescents
    • Lin, L. Y., Kuo, H. K., Hwang, J. J., Lai, L. P., Chiang, F. T., Tseng, C. D., and Lin, J. L. (2009a). Serum bilirubin is inversely associated with insulin resistance and metabolic syndrome among children and adolescents. Atherosclerosis 203, 563-568.
    • (2009) Atherosclerosis , vol.203 , pp. 563-568
    • Lin, L.Y.1    Kuo, H.K.2    Hwang, J.J.3    Lai, L.P.4    Chiang, F.T.5    Tseng, C.D.6    Lin, J.L.7
  • 45
    • 71949122207 scopus 로고    scopus 로고
    • Variants in the UGT1A1 gene and the risk of pediatric nonalcoholic fatty liver disease
    • Lin, Y. C., Chang, P. F., Hu, F. C., Chang, M. H., and Ni, Y. H. (2009b). Variants in the UGT1A1 gene and the risk of pediatric nonalcoholic fatty liver disease. Pediatrics 124, e1221-e1227.
    • (2009) Pediatrics , vol.124
    • Lin, Y.C.1    Chang, P.F.2    Hu, F.C.3    Chang, M.H.4    Ni, Y.H.5
  • 46
    • 79960940574 scopus 로고    scopus 로고
    • Association of a BLVRA common polymorphism with essential hypertension and blood pressure in Kazaks
    • Lin, R., Wang, X., Zhou, W., Fu, W., Wang, Y., Huang, W., and Jin, L. (2011). Association of a BLVRA common polymorphism with essential hypertension and blood pressure in Kazaks. Clin. Exp. Hypertens. 33, 294-298.
    • (2011) Clin. Exp. Hypertens. , vol.33 , pp. 294-298
    • Lin, R.1    Wang, X.2    Zhou, W.3    Fu, W.4    Wang, Y.5    Huang, W.6    Jin, L.7
  • 47
    • 28844493391 scopus 로고    scopus 로고
    • New insights into biliverdin reductase functions: linking heme metabolism to cell signaling
    • Maines, M. D. (2005). New insights into biliverdin reductase functions: linking heme metabolism to cell signaling. Physiology (Bethesda) 20, 382-389.
    • (2005) Physiology (Bethesda) , vol.20 , pp. 382-389
    • Maines, M.D.1
  • 48
    • 79952277022 scopus 로고    scopus 로고
    • Potential application of biliverdin reductase and its fragments to modulate insulin/IGF1/MAPK/PI3-K signaling pathways in therapeutic settings
    • Maines, M. D. (2010). Potential application of biliverdin reductase and its fragments to modulate insulin/IGF1/MAPK/PI3-K signaling pathways in therapeutic settings. Curr. Drug Targets 11, 1586-1594.
    • (2010) Curr. Drug Targets , vol.11 , pp. 1586-1594
    • Maines, M.D.1
  • 49
    • 34247259885 scopus 로고    scopus 로고
    • Human biliverdin reductase, a previously unknown activator of protein kinase C betaII
    • Maines, M. D., Miralem, T., Lerner Marmarosh, N., Shen, J., and Gibbs, P. E. (2007). Human biliverdin reductase, a previously unknown activator of protein kinase C betaII. J. Biol. Chem. 282, 8110-8122.
    • (2007) J. Biol. Chem. , vol.282 , pp. 8110-8122
    • Maines, M.D.1    Miralem, T.2    Lerner Marmarosh, N.3    Shen, J.4    Gibbs, P.E.5
  • 51
    • 34548761301 scopus 로고    scopus 로고
    • "Iatrogenic Gilbert syndrome" - a strategy for reducing vascular and cancer risk by increasing plasma unconjugated bilirubin
    • McCarty, M. F. (2007). "Iatrogenic Gilbert syndrome" - a strategy for reducing vascular and cancer risk by increasing plasma unconjugated bilirubin. Med. Hypotheses 69, 974-994.
    • (2007) Med. Hypotheses , vol.69 , pp. 974-994
    • McCarty, M.F.1
  • 52
    • 79955876279 scopus 로고    scopus 로고
    • Exercise and spirulina control non-alcoholic hepatic steatosis and lipid profile in diabetic Wistar rats
    • Moura, L. P., Puga, G. M., Beck, W. R., Teixeira, I. P., Ghezzi, A. C., Silva, G. A., and Mello, M. A. (2011). Exercise and spirulina control non-alcoholic hepatic steatosis and lipid profile in diabetic Wistar rats. Lipids Health Dis. 10, 77.
    • (2011) Lipids Health Dis , vol.10 , pp. 77
    • Moura, L.P.1    Puga, G.M.2    Beck, W.R.3    Teixeira, I.P.4    Ghezzi, A.C.5    Silva, G.A.6    Mello, M.A.7
  • 53
    • 36348957437 scopus 로고    scopus 로고
    • Statin treatment increases formation of carbon monoxide and bilirubin in mice: a novel mechanism of in vivo antioxidant protection
    • Muchová, L., Wong, R. J., Hsu, M., Morioka, I., Vítek, L., Zelenka, J., Schroder, H., and Stevenson, D. K. (2007). Statin treatment increases formation of carbon monoxide and bilirubin in mice: a novel mechanism of in vivo antioxidant protection. Can. J. Physiol. Pharmacol. 85, 800-810.
    • (2007) Can. J. Physiol. Pharmacol. , vol.85 , pp. 800-810
    • Muchová, L.1    Wong, R.J.2    Hsu, M.3    Morioka, I.4    Vítek, L.5    Zelenka, J.6    Schroder, H.7    Stevenson, D.K.8
  • 54
    • 77953527349 scopus 로고    scopus 로고
    • Role of heme oxygenase in inflammation, insulin-signalling, diabetes and obesity
    • doi:10.1155/2010/359732. [Epub 2010 May 18]
    • Ndisang, J. F. (2010). Role of heme oxygenase in inflammation, insulin-signalling, diabetes and obesity. Mediators Inflamm. doi:10.1155/2010/359732. [Epub 2010 May 18].
    • (2010) Mediators Inflamm
    • Ndisang, J.F.1
  • 55
    • 65649110522 scopus 로고    scopus 로고
    • Heme oxygenase system enhances insulin sensitivity and glucose metabolism in streptozotocininduced diabetes
    • Ndisang, J. F., and Jadhav, A. (2009a). Heme oxygenase system enhances insulin sensitivity and glucose metabolism in streptozotocininduced diabetes. Am. J. Physiol. Endocrinol. Metab. 296, E829-E841.
    • (2009) Am. J. Physiol. Endocrinol. Metab. , vol.296
    • Ndisang, J.F.1    Jadhav, A.2
  • 56
    • 66649132533 scopus 로고    scopus 로고
    • Up-regulating the hemeoxygenase system enhances insulin sensitivity and improves glucose metabolism in insulin-resistant diabetes in GotoKakizaki rats
    • Ndisang, J. F., and Jadhav, A. (2009b). Up-regulating the hemeoxygenase system enhances insulin sensitivity and improves glucose metabolism in insulin-resistant diabetes in GotoKakizaki rats. Endocrinology 150, 2627-2636.
    • (2009) Endocrinology , vol.150 , pp. 2627-2636
    • Ndisang, J.F.1    Jadhav, A.2
  • 57
    • 73549113296 scopus 로고    scopus 로고
    • The heme oxygenase system attenuates pancreatic lesions and improves insulin sensitivity and glucose metabolism in deoxycorticosterone acetate hypertension
    • Ndisang, J. F., and Jadhav, A. (2010a). The heme oxygenase system attenuates pancreatic lesions and improves insulin sensitivity and glucose metabolism in deoxycorticosterone acetate hypertension. Am. J. Physiol. Regul. Integr. Comp. Physiol. 298, R211-R223.
    • (2010) Am. J. Physiol. Regul. Integr. Comp. Physiol. , vol.298
    • Ndisang, J.F.1    Jadhav, A.2
  • 58
    • 74949102157 scopus 로고    scopus 로고
    • Up-regulating the heme oxygenase system with hemin improves insulin sensitivity and glucose metabolism in adult spontaneously hypertensive rats
    • Ndisang, J. F., Lane, N., Syed, N., and Jadhav, A. (2010b). Up-regulating the heme oxygenase system with hemin improves insulin sensitivity and glucose metabolism in adult spontaneously hypertensive rats. Endocrinology 151, 549-560.
    • (2010) Endocrinology , vol.151 , pp. 549-560
    • Ndisang, J.F.1    Lane, N.2    Syed, N.3    Jadhav, A.4
  • 60
    • 0038047678 scopus 로고    scopus 로고
    • Inverse relationship between serum bilirubin and atherosclerosis in men: a meta-analysis of published studies
    • Novotný, L., and Vítek, L. (2003). Inverse relationship between serum bilirubin and atherosclerosis in men: a meta-analysis of published studies. Exp. Biol. Med. 228, 568-571.
    • (2003) Exp. Biol. Med. , vol.228 , pp. 568-571
    • Novotný, L.1    Vítek, L.2
  • 61
    • 78751490191 scopus 로고    scopus 로고
    • Bilirubin is negatively associated with A1C independently of fasting plasma glucose, age, obesity, inflammation, hemoglobin, and iron in apparently healthy Japanese men and women
    • Oda, E. (2010). Bilirubin is negatively associated with A1C independently of fasting plasma glucose, age, obesity, inflammation, hemoglobin, and iron in apparently healthy Japanese men and women. Diabetes Care 33, e131.
    • (2010) Diabetes Care , vol.33
    • Oda, E.1
  • 62
    • 78651238873 scopus 로고    scopus 로고
    • Bilirubin is negatively associated with hemoglobin a(1c) independently of other cardiovascular risk factors in apparently healthy Japanese men and women
    • Oda, E., and Kawai, R. (2010). Bilirubin is negatively associated with hemoglobin a(1c) independently of other cardiovascular risk factors in apparently healthy Japanese men and women. Circ. J. 75, 190-195.
    • (2010) Circ. J. , vol.75 , pp. 190-195
    • Oda, E.1    Kawai, R.2
  • 63
    • 77649232070 scopus 로고    scopus 로고
    • Inverse associations of serum bilirubin with high sensitivity C-reactive protein, glycated hemoglobin, and prevalence of type 2 diabetes in middle-aged and elderly Japanese men and women
    • Ohnaka, K., Kono, S., Inoguchi, T., Yin, G., Morita, M., Adachi, M., Kawate, H., and Takayanagi, R. (2010). Inverse associations of serum bilirubin with high sensitivity C-reactive protein, glycated hemoglobin, and prevalence of type 2 diabetes in middle-aged and elderly Japanese men and women. Diabetes Res. Clin. Pract. 88, 103-110.
    • (2010) Diabetes Res. Clin. Pract. , vol.88 , pp. 103-110
    • Ohnaka, K.1    Kono, S.2    Inoguchi, T.3    Yin, G.4    Morita, M.5    Adachi, M.6    Kawate, H.7    Takayanagi, R.8
  • 64
    • 35349023691 scopus 로고    scopus 로고
    • Hemeoxygenase-1-induced protection against hypoxia/reoxygenation is dependent on biliverdin reductase and its interaction with PI3K/Akt pathway
    • Pachori, A. S., Smith, A., McDonald, P., Zhang, L., Dzau, V. J., and Melo, L. G. (2007). Hemeoxygenase-1-induced protection against hypoxia/reoxygenation is dependent on biliverdin reductase and its interaction with PI3K/Akt pathway. J. Mol. Cell. Cardiol. 43, 580-592.
    • (2007) J. Mol. Cell. Cardiol. , vol.43 , pp. 580-592
    • Pachori, A.S.1    Smith, A.2    McDonald, P.3    Zhang, L.4    Dzau, V.J.5    Melo, L.G.6
  • 65
    • 79955035120 scopus 로고    scopus 로고
    • Pseudogenes: pseudofunctional or key regulators in health and disease?
    • Pink, R. C., Wicks, K., Caley, D. P., Punch, E. K., Jacobs, L., and Carter, D. R. (2011). Pseudogenes: pseudofunctional or key regulators in health and disease? RNA. 17, 792-798.
    • (2011) RNA , vol.17 , pp. 792-798
    • Pink, R.C.1    Wicks, K.2    Caley, D.P.3    Punch, E.K.4    Jacobs, L.5    Carter, D.R.6
  • 68
    • 0028084319 scopus 로고
    • Association of low serum concentration of bilirubin with increased risk of coronary artery disease
    • Schwertner, H. A., Jackson, W. G., and Tolan, G. (1994). Association of low serum concentration of bilirubin with increased risk of coronary artery disease. Clin. Chem. 40, 18-23.
    • (1994) Clin. Chem. , vol.40 , pp. 18-23
    • Schwertner, H.A.1    Jackson, W.G.2    Tolan, G.3
  • 69
    • 41049098411 scopus 로고    scopus 로고
    • Gilbert syndrome, UGT1A1*28 allele, and cardiovascular disease risk: possible protective effects and therapeutic applications of bilirubin
    • Schwertner, H. A., and Vítek, L. (2008). Gilbert syndrome, UGT1A1*28 allele, and cardiovascular disease risk: possible protective effects and therapeutic applications of bilirubin. Atherosclerosis 198, 1-11.
    • (2008) Atherosclerosis , vol.198 , pp. 1-11
    • Schwertner, H.A.1    Vítek, L.2
  • 73
    • 0023132858 scopus 로고
    • Bilirubin is an antioxidant of possible physiological importance
    • Stocker, R., Yamamoto, Y., McDonagh, A. F., Glazer, A. N., and Ames, B. N. (1987). Bilirubin is an antioxidant of possible physiological importance. Science 235, 1043-1046.
    • (1987) Science , vol.235 , pp. 1043-1046
    • Stocker, R.1    Yamamoto, Y.2    McDonagh, A.F.3    Glazer, A.N.4    Ames, B.N.5
  • 75
    • 67349088999 scopus 로고    scopus 로고
    • Soluble CD40 ligand and soluble P-selectin levels in Gilbert's syndrome: a link to protection against atherosclerosis?
    • Tapan, S., Dogru, T., Tasci, I., Ercin, C. N., Ozgurtas, T., and Erbil, M. K. (2009). Soluble CD40 ligand and soluble P-selectin levels in Gilbert's syndrome: a link to protection against atherosclerosis? Clin. Biochem. 42,791-795.
    • (2009) Clin. Biochem. , vol.42 , pp. 791-795
    • Tapan, S.1    Dogru, T.2    Tasci, I.3    Ercin, C.N.4    Ozgurtas, T.5    Erbil, M.K.6
  • 77
    • 65949112939 scopus 로고    scopus 로고
    • Type of vegetarian diet, body weight, and prevalence of type 2 diabetes
    • Tonstad, S., Butler, T., Yan, R., and Fraser, G. E. (2009). Type of vegetarian diet, body weight, and prevalence of type 2 diabetes. Diabetes Care 32, 791-796.
    • (2009) Diabetes Care , vol.32 , pp. 791-796
    • Tonstad, S.1    Butler, T.2    Yan, R.3    Fraser, G.E.4
  • 78
    • 44449114217 scopus 로고    scopus 로고
    • Advanced glycation end products and insulin resistance
    • Unoki, H., and Yamagishi, S. (2008). Advanced glycation end products and insulin resistance. Curr. Pharm. Des. 14, 987-989.
    • (2008) Curr. Pharm. Des. , vol.14 , pp. 987-989
    • Unoki, H.1    Yamagishi, S.2
  • 79
    • 77953570914 scopus 로고    scopus 로고
    • Silymarin and milk thistle extract may prevent the progression of diabetic nephropathy in streptozotocin-induced diabetic rats
    • Vessal, G., Akmali, M., Najafi, P., Moein, M. R., and Sagheb, M. M. (2010). Silymarin and milk thistle extract may prevent the progression of diabetic nephropathy in streptozotocin-induced diabetic rats. Ren. Fail. 32, 733-739.
    • (2010) Ren. Fail. , vol.32 , pp. 733-739
    • Vessal, G.1    Akmali, M.2    Najafi, P.3    Moein, M.R.4    Sagheb, M.M.5
  • 82
    • 33748445757 scopus 로고    scopus 로고
    • The inverse association of elevated serum bilirubin levels with subclinical carotid atherosclerosis
    • Vítek, L., Novotný, L, Šperl, M., Holaj, R., and Spáčil, J. (2006). The inverse association of elevated serum bilirubin levels with subclinical carotid atherosclerosis. Cerebrovasc. Dis. 21, 408 -414.
    • (2006) Cerebrovasc. Dis. , vol.21 , pp. 408-414
    • Vítek, L.1    Novotný, L.2    Šperl, M.3    Holaj, R.4    Spáčil, J.5
  • 83
    • 70449389954 scopus 로고    scopus 로고
    • Bilirubin chemistry and metabolism; harmful and protective aspects
    • Vítek, L., and Ostrow, J. D. (2009). Bilirubin chemistry and metabolism; harmful and protective aspects. Curr. Pharm. Des. 15, 2869-2883.
    • (2009) Curr. Pharm. Des. , vol.15 , pp. 2869-2883
    • Vítek, L.1    Ostrow, J.D.2
  • 84
    • 33845613215 scopus 로고    scopus 로고
    • The heme catabolic pathway and its protective effects on oxidative stressmediated diseases
    • Vítek,L.,and Schwertner,H. A. (2007b). The heme catabolic pathway and its protective effects on oxidative stressmediated diseases. Adv. Clin. Chem. 43, 1-57.
    • (2007) Adv. Clin. Chem. , vol.43 , pp. 1-57
    • Vítek, L.1    Schwertner, H.A.2
  • 86
    • 33745244769 scopus 로고    scopus 로고
    • A protective role for heme oxygenase1 in INS-1 cells and rat islets that are exposed to high glucose conditions
    • Won, K. C., Moon, J. S., Eun, M. J., Yoon, J. S., Chun, K. A., Cho, I. H., Kim, Y. W., and Lee, H. W. (2006). A protective role for heme oxygenase1 in INS-1 cells and rat islets that are exposed to high glucose conditions. J. Korean Med. Sci. 21, 418-424.
    • (2006) J. Korean Med. Sci. , vol.21 , pp. 418-424
    • Won, K.C.1    Moon, J.S.2    Eun, M.J.3    Yoon, J.S.4    Chun, K.A.5    Cho, I.H.6    Kim, Y.W.7    Lee, H.W.8
  • 87
    • 84855381655 scopus 로고    scopus 로고
    • Niacin inhibits vascular inflammation via the induction of heme oxygenase-1
    • Wu, B. J., Chen, K., Barter, P. J., and Rye, K.A. (2012). Niacin inhibits vascular inflammation via the induction of heme oxygenase-1. Circulation 125, 150-158.
    • (2012) Circulation , vol.125 , pp. 150-158
    • Wu, B.J.1    Chen, K.2    Barter, P.J.3    Rye, K.A.4
  • 88
    • 0028313015 scopus 로고
    • Unconjugated bilirubin inhibits the oxidation of human low density lipoprotein better than Trolox
    • Wu, T. W., Fung, K. P., and Yang, C. C. (1994). Unconjugated bilirubin inhibits the oxidation of human low density lipoprotein better than Trolox. Life Sci. 54, 477-481.
    • (1994) Life Sci , vol.54 , pp. 477-481
    • Wu, T.W.1    Fung, K.P.2    Yang, C.C.3
  • 89
    • 80051819472 scopus 로고    scopus 로고
    • Low serum total bilirubin concentrations are associated with increased prevalence of metabolic syndrome in Chinese
    • Wu, Y., Li, M., Xu, M., Bi, Y., Li, X., Chen, Y., Ning, G., and Wang, W. (2011). Low serum total bilirubin concentrations are associated with increased prevalence of metabolic syndrome in Chinese. J. Diabetes 3, 217-224.
    • (2011) J. Diabetes , vol.3 , pp. 217-224
    • Wu, Y.1    Li, M.2    Xu, M.3    Bi, Y.4    Li, X.5    Chen, Y.6    Ning, G.7    Wang, W.8
  • 90
    • 84859343649 scopus 로고    scopus 로고
    • Role of advanced glycation end products (AGEs) and oxidative stress in vascular complications in diabetes
    • doi:10.1016/j.bbagen.2011.03.014. [Epub ahead of print]
    • Yamagishi, S. I., Maeda, S., Matsui, T., Ueda, S., Fukami, K., and Okuda, S. (2011). Role of advanced glycation end products (AGEs) and oxidative stress in vascular complications in diabetes. Biochim. Biophys. Acta. doi:10.1016/j.bbagen.2011.03.014. [Epub ahead of print].
    • (2011) Biochim. Biophys. Acta
    • Yamagishi, S.I.1    Maeda, S.2    Matsui, T.3    Ueda, S.4    Fukami, K.5    Okuda, S.6


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