Genetic polymorphism in the conjugating enzyme UGT1A1 and the risk of head and neck cancer

International Journal of Cancer

Volumn 127, Issue 12, 2010, Pages 2815-2821

  Lacko, Martin ^a   Roelofs, Hennie M J ^b   Te Morsche, Rene H M ^b   Voogd, Adri C ^c   Ophuis, Michel B Oude ^a   Peters, Wilbert H M ^b   Manni, Johannes J ^a  

^a MAASTRICHT UNIVERSITY MEDICAL CENTER   (Netherlands)

^b RADBOUD UNIVERSITY MEDICAL CENTER   (Netherlands)

^c MAASTRICHT UNIVERSITY   (Netherlands)

Author keywords

Bilirubin; Carcinogenesis; Genetic polymorphism; Head and neck carcinoma; UDP glucuronosyltransferase 1A1

Indexed keywords

BENZO[A]PYRENE; BILIRUBIN; GLUCURONOSYLTRANSFERASE 1A1; TOBACCO SMOKE;

ADULT; AGED; ARTICLE; CANCER RISK; CARCINOGENESIS; DNA POLYMORPHISM; ENZYME ACTIVITY; FEMALE; GLUCURONIDATION; HEAD AND NECK CANCER; HUMAN; LARYNX CARCINOMA; LOGISTIC REGRESSION ANALYSIS; MAJOR CLINICAL STUDY; MALE; MOUTH CARCINOMA; PHARYNX CARCINOMA; PRIORITY JOURNAL;

ADULT; AGED; AGED, 80 AND OVER; CARCINOMA, SQUAMOUS CELL; DNA, NEOPLASM; FEMALE; GENE EXPRESSION REGULATION, NEOPLASTIC; GENOTYPE; GLUCURONOSYLTRANSFERASE; HEAD AND NECK NEOPLASMS; HUMANS; MALE; MIDDLE AGED; POLYMERASE CHAIN REACTION; POLYMORPHISM, GENETIC; PROGNOSIS; YOUNG ADULT;

EID: 78249277155     PISSN: 00207136     EISSN: 10970215     Source Type: Journal    
DOI: 10.1002/ijc.25296     Document Type: Article

References (31)

1. Parkin DM, Bray F, Ferlay J, Pisani P,. Global cancer statistics, 2002. CA Cancer J Clin 2005; 55: 74 -108.
2. Hecht SS,. Cigarette smoking: cancer risks, carcinogens, and mechanisms. Langenbecks Arch Surg 2006; 391: 603 -13.
3. Hecht SS,. Tobacco carcinogens, their biomarkers and tobacco-induced cancer. Nat Rev Cancer 2003; 3: 733 -44.
4. Wogan GN, Hecht SS, Felton JS, Conney AH, Loeb LA,. Environmental and chemical carcinogenesis. Semin Cancer Biol 2004; 14: 473 -86.
5. Ames BN,. Dietary carcinogens and anticarcinogens. Oxygen radicals and degenerative diseases. Science 1983; 221: 1256 -64.
6. de Waziers I, Cugnenc PH, Yang CS, Leroux JP, Beaune PH,. Cytochrome P 450 isoenzymes, epoxide hydrolase and glutathione transferases in rat and human hepatic and extrahepatic tissues. Pharmacol Exp Ther 1990; 253: 387 -94.
7. Tukey RH, Strassburg CP,. Genetic multiplicity of the human UDP-glucuronosyltransferases and regulation in the gastrointestinal tract. Mol Pharmacol 2001; 59: 405 -14.
8. Zheng Z, Fang JL, Lazarus P,. Glucuronidation: an important mechanism for detoxification of benzo[a]pyrene metabolites in aerodigestive tract tissues. Drug Metab Dispos 2002; 30: 397 -403.
9. Fang JL, Beland FA, Doerge DR, Wiener D, Guillemette C, Marques MM, Lazarus P,. Characterization of benzo(a) pyrene-trans-7,8-dihydrodiol glucuronidation by human tissue microsomes and overexpressed UDP-glucuronosyltransferase enzymes. Cancer Res 2002; 62: 1978 -86.
10. Zucker SD, Horn PS, Sherman KE,. Serum bilirubin levels in the U.S. population: gender effect and inverse correlation with colorectal cancer. Hepatology 2004; 40: 827 -35.
11. Temme EH, Zhang J, Schouten EG, Kesteloot H,. Serum bilirubin and 10-year mortality risk in a Belgian population. Cancer Causes Control 2001; 12: 887 -94.
12. McCarty MF,. "Iatrogenic Gilbert syndrome"-a strategy for reducing vascular and cancer risk by increasing plasma unconjugated bilirubin. Med Hypotheses 2007; 69: 974 -94.
13. Vitek L, Schwertner HA,. The heme catabolic pathway and its protective effects on oxidative stress-mediated diseases. Adv Clin Chem 2007; 43: 1 -57.
14. Beutler E, Gelbart T, Demina A,. Racial variability in the UDP-glucuronosyltransferase 1 (UGT1A1) promoter: a balanced polymorphism for regulation of bilirubin metabolism? Proc Natl Acad Sci USA 1998; 95: 8170 -4.
15. Bosma PJ, Chowdhury JR, Bakker C, Gantla S, de Boer A, Oostra BA, Lindhout D, Tytgat GN, Jansen PL, Oude Elferink RP, Chowdhury NR,. The genetic basis of the reduced expression of bilirubin UDP-glucuronosyltransferase 1 in Gilbert's syndrome. N Engl J Med 1995; 333: 1171 -5.
16. Monaghan G, Ryan M, Seddon R, Hume R, Burchell B,. Genetic variation in bilirubin UPD-glucuronosyltransferase gene promoter and Gilbert's syndrome. Lancet 1996; 347: 578 -81.
17. Raijmakers MT, Jansen PL, Steegers EA, Peters WH,. Association of human liver bilirubin UDP-glucuronyltransferase activity with a polymorphism in the promoter region of the UGT1A1 gene. J Hepatol 2000; 33: 348 -51.
18. Mercke Odeberg J, Andrade J, Holmberg K, Hoglund P, Malmqvist U, Odeberg J,. UGT1A polymorphisms in a Swedish cohort and a human diversity panel, and the relation to bilirubin plasma levels in males and females. Eur J Clin Pharmacol 2006; 62: 829 -37.
19. Strassburg CP,. Pharmacogenetics of Gilbert's syndrome. Pharmacogenomics 2008; 9: 703 -15.
20. Grant DJ, Bell DA,. Bilirubin UDP-glucuronosyltransferase 1A1 gene polymorphisms: susceptibility to oxidative damage and cancer? Mol Carcinog 2000; 29: 198 -204.
21. Benhamou S, Benhamou E, Flamant R,. Lung cancer risk associated with cigar and pipe smoking. Int J Cancer 1986; 37: 825 -9.
22. Elahi A, Bendaly J, Zheng Z, Muscat JE, Richie JP, Jr., Schantz SP, Lazarus P,. Detection of UGT1A10 polymorphisms and their association with orolaryngeal carcinoma risk. Cancer 2003; 98: 872 -80.
23. Keshavan P, Schwemberger SJ, Smith DL, Babcock GF, Zucker SD,. Unconjugated bilirubin induces apoptosis in colon cancer cells by triggering mitochondrial depolarization. Int J Cancer 2004; 112: 433 -45.
24. Ching S, Ingram D, Hahnel R, Beilby J, Rossi E,. Serum levels of micronutrients, antioxidants and total antioxidant status predict risk of breast cancer in a case control study. J Nutr 2002; 132: 303 -6.
25. Ollinger R, Kogler P, Troppmair J, Hermann M, Wurm M, Drasche A, Konigsrainer I, Amberger A, Weiss H, Ofner D, Bach FH, Margreiter R,. Bilirubin inhibits tumor cell growth via activation of ERK. Cell Cycle 2007; 6: 3078 -85.
26. Novotny L, Vitek L,. Inverse relationship between serum bilirubin and atherosclerosis in men: a meta-analysis of published studies. Exp Biol Med (Maywood) 2003; 228: 568 -71.
27. Lin JP, O'Donnell CJ, Schwaiger JP, Cupples LA, Lingenhel A, Hunt SC, Yang S, Kronenberg F,. Association between the UGT1A128 allele, bilirubin levels, and coronary heart disease in the Framingham Heart Study. Circulation 2006; 114: 1476 -81.
28. Schwertner HA, Vitek L,. Gilbert syndrome, UGT1A128 allele, and cardiovascular disease risk: possible protective effects and therapeutic applications of bilirubin. Atherosclerosis 2008; 198: 1 -11.
29. Kitsiou-Tzeli S, Kanavakis E, Tzetis M, Kavazarakis E, Galla A, Tsezou A,. Gilbert's syndrome as a predisposing factor for idiopathic cholelithiasis in children. Haematologica 2003; 88: 1193 -4.
30. Lacko M, Roelofs HM, Te Morsche RH, Voogd AC, Ophuis MB, Peters WH, Manni JJ,. Genetic polymorphisms in the tobacco smoke carcinogens detoxifying enzyme UGT1A7 and the risk of head and neck cancer. Head Neck 2009; 31: 1274 -81.
31. Kohle C, Mohrle B, Munzel PA, Schwab M, Wernet D, Badary OA, Bock KW,. Frequent co-occurrence of the TATA box mutation associated with Gilbert's syndrome (UGT1A128) with other polymorphisms of the UDP-glucuronosyltransferase- 1 locus (UGT1A62 and UGT1A73) in Caucasians and Egyptians. Biochem Pharmacol 2003; 65: 1521 -7.