Serum bilirubin links UGT1A1*28 polymorphism and predicts long-term cardiovascular events and mortality in chronic hemodialysis patients

Clinical Journal of the American Society of Nephrology

Volumn 6, Issue 3, 2011, Pages 567-574

  Chen, Ying Hwa ^a,b   Hung, Szu Chun ^c   Tarng, Der Cherng ^a,b  

^a NATIONAL YANG MING UNIVERSITY   (Taiwan)

^b TAIPEI VETERANS GENERAL HOSPITAL   (Taiwan)

^c Taipei Branch   (Taiwan)

Author keywords

[No Author keywords available]

Indexed keywords

BILIRUBIN; GLUCURONOSYLTRANSFERASE 1A1;

ADULT; ALLELE; ARTICLE; BILIRUBIN BLOOD LEVEL; CARDIOVASCULAR DISEASE; CAUSE OF DEATH; DNA POLYMORPHISM; FEMALE; FOLLOW UP; GENE FREQUENCY; GENOTYPE; HEMODIALYSIS; HEMODIALYSIS PATIENT; HOMOZYGOTE; HUMAN; MAJOR CLINICAL STUDY; MALE; MORTALITY; PROSPECTIVE STUDY; RISK FACTOR; TREATMENT OUTCOME;

AGED; ANALYSIS OF VARIANCE; BILIRUBIN; BIOLOGICAL MARKERS; CARDIOVASCULAR DISEASES; CHI-SQUARE DISTRIBUTION; CHRONIC DISEASE; FEMALE; FOLLOW-UP STUDIES; GENE FREQUENCY; GENETIC PREDISPOSITION TO DISEASE; GLUCURONOSYLTRANSFERASE; HOMOZYGOTE; HUMANS; KAPLAN-MEIER ESTIMATE; KIDNEY DISEASES; MALE; MIDDLE AGED; PHENOTYPE; POLYMORPHISM, GENETIC; PROPORTIONAL HAZARDS MODELS; PROSPECTIVE STUDIES; RENAL DIALYSIS; RISK ASSESSMENT; RISK FACTORS; TAIWAN; TIME FACTORS;

EID: 79953004070     PISSN: 15559041     EISSN: 1555905X     Source Type: Journal    
DOI: 10.2215/CJN.06130710     Document Type: Article

References (31)

1. de Jager DJ, Grootendorst DC, Jager KJ, van Dijk PC, Tomas LM, Ansell D, Collart F, Finne P, Heaf JG, De Meester J, Wetzels JF, Rosendaal FR, Dekker FW: Cardiovascular and non-cardiovascular mortality among patients starting dialysis. JAMA 302: 1782-1789, 2009
2. Rattazzi M, Puato M, Faggin E, Bertipaglia B, Grego F, Pauletto P: New markers of accelerated atherosclerosis in endstage renal disease. J Nephrol 16: 11-20, 2003
3. Clermont G, Lecour S, Lahet J, Siohan P, Vergely C, Chevet D, Rifle G, Rochette L: Alteration in plasma antioxidant capacities in chronic renal failure and haemodialysis patients: A possible explanation for the increased cardiovascular risk in these patients. Cardiovasc Res 47: 618-623, 2000 (Pubitemid 30646084)
4. Stocker R, Yamamoto Y, McDonagh A, Glazer A: Bilirubin is an antioxidant of possible physiological importance. Science 235: 1043-1046, 1987 (Pubitemid 17049750)
5. Stocker R, Keaney JF Jr: Role of oxidative modifications in atherosclerosis. Physiol Rev 84: 1381-1478, 2004 (Pubitemid 39302636)
6. Willis D, Moore AR, Frederik R, Willoughby DA: Heme oxygenase: A novel target for the modulation of the inflammatory response. Nat Med 2: 87-90, 1996 (Pubitemid 26029572)
7. Nakagami T, Toyomura K, Kinoshita T, Morisawa S: A beneficial role of bile pigments as an endogenous tissue protector: Anticomplement effects of biliverdin and conjugated bilirubin. Biochim Biophys Acta 1158: 189-193, 1993 (Pubitemid 23291461)
8. Neuzil J, Stocker R: Free and albumin-bound bilirubin are efficient co-antioxidants for α-tocopherol, inhibiting plasma low density lipoprotein lipid peroxidation. J Biol Chem 269: 16712-16719, 1994
9. Wu TW, Fung KP, Wu J, Yang CC, Weisel RD: Antioxidation of human low density lipoprotein by unconjugated and conjugated bilirubins. Biochem Pharmacol 51: 859-862, 1996 (Pubitemid 26096296)
10. Schwertner HA: Association of smoking and low serum bilirubin antioxidant concentrations. Atherosclerosis 136: 383-387, 1998
11. Vítek L, Jirsa M, Brodanová M, Kalab M, Marecek Z, Danzig V, Novotný L, Kotal P: Gilbert syndrome and ischemic heart disease: A protective effect of elevated bilirubin levels. Atherosclerosis 160: 449-456, 2002 (Pubitemid 34159340)
12. Schwertner HA, Jackson WG, Tolan G: Association of low serum concentration of bilirubin with increased risk of coronary artery disease. Clin Chem 40: 18-23, 1994 (Pubitemid 24050206)
13. Djoussé L, Levy D, Cupples LA, Evans JC, D'Agostino RB, Ellison RC: Total serum bilirubin and risk of cardiovascular disease in the Framingham offspring study. Am J Cardiol 87: 1196-1200, 2001 (Pubitemid 32453243)
14. Perlstein TS, Pande R, Beckman JA, Creager MA: Serum total bilirubin level and prevalent lower-extremity peripheral arterial disease: National Health and Nutrition Examination Survey (NHANES) 1999 to 2004. Arteriocler Thromb Vasc Biol 28: 166-172, 2008
15. Kimm H, Yun JE, Jo J, Jee SH: Low serum bilirubin level as an independent predictor of stroke incidence: A prospective study in Korean men and women. Stroke 40: 3422-3427, 2009
16. Lin JP, Cupples LA, Wilson PW, Heard-Costa N, O'Donnell CJ: Evidence for a gene influencing serum bilirubin on chromosome 2q telomere: A genomewide scan in the Framingham study. Am J Hum Genet 72: 1029-1034, 2003 (Pubitemid 36403322)
17. Kronenberg F, Coon H, Gutin A, Abkevich V, Samuels ME, Ballinger DG, Hopkins PN, Hunt SC: A genome scan for loci influencing anti-atherogenic serum bilirubin levels. Eur J Hum Genet 10: 539-546, 2002 (Pubitemid 35012308)
18. Bosma PL, Chowdhury JR, Bakker C, Gantla S, de Boer A, Oostra BA, Lindhout D, Tytgat GNJ, Hansen PLM, Oude Elferick RPJ, Chowdhury NR: The genetic basis of the reduced expression of bilirubin UDP glucuronosyltransferase in Gilbert's syndrome. N Engl J Med 333: 1171-1175, 1995
19. Monaghan G, Ryan M, Seddon R, Burchell B: Genetic variation in bilirubin UDP-glucuronosyltransferase gene promoter and Gilbert syndrome. Lancet 347: 578-581, 1996 (Pubitemid 26070740)
20. Beutler E, Gelbart T, Demina A: Racial variability in the UDP glucuronosyltransferase 1 (UGT1A1) promoter: A balanced polymorphism for regulation of bilirubin metabolism. Proc Natl Acad Sci U S A 95: 8170-8174, 1998 (Pubitemid 28326085)
21. Premawardhena A, Fisher CA, Liu YT, Verma IC, de Silva S, Arambepola M, Clegg JB, Weatherall DJ: The global distribution of length polymorphisms of the promoters of the glucuronosyltransferase 1 gene (UGT1A1): Hematologic and evolutionary implications. Blood Cells Mol Dis 31: 98-101, 2003 (Pubitemid 36802250)
22. Lin JP, O'Donnell CJ, Schwaiger JP, Cupples LA, Lingenhel A, Hunt SC, Yang S, Kronenberg F: Association between the UGT1A1*28 allele, bilirubin levels, and coronary heart disease in the Framingham Heart Study. Circulation 114: 1476-1481, 2006 (Pubitemid 44527002)
23. Rantner B, Kollerits B, Anderwald-Stadler M, Klein-Weigel P, Gruber I, Gehringer A, Haak M, Schnapka-Köpf M, Fraedrich G, Kronenberg F: Association between the UGT1A1 TA-repeat polymorphism and bilirubin concentration in patients with intermittent claudication: Results from the CAVASIC Study. Clin Chem 54: 851-857, 2008 (Pubitemid 351671602)
24. Lingenhel A, Kollerits B, Schwaiger JP, Hunt SC, Gress R, Hopkins PN, Schoenborn V, Heid IM, Kronenberg F: Serum bilirubin levels, UGT1A1 polymorphisms and risk for coronary artery disease. Exp Gerontol 43: 1102-1107, 2008
25. Bosma PJ, van der Meer IM, Bakker CT, Hofman A, Paul-Abrahamse M, Witteman JC: UGT1A1*28 allele and coronary heart disease: The Rotterdam Study. Clin Chem 49: 1180-1181, 2003 (Pubitemid 36751106)
26. Gajdos V, Petit FM, Perret C, Mollet-Boudjemline A, Colin P, Capel L, Nicaud V, Evans A, Arveiler D, Parisot F, Francoual J, Genin E, Cambien F, Labrune P: Further evidence that the UGT1A1*28 allele is not associated with coronary heart disease: The ECTIM Study. Clin Chem 52: 2313-2314, 2006 (Pubitemid 44925016)
27. Daugirdas JT: Second generation logarithmic estimates of single-pool variable volume Kt/V: An analysis of errors. J Am Soc Nephrol 4: 1205-1213, 1993
28. U.S. Renal Data System: USRDS 2008 Annual Data Report: Atlas of Chronic Kidney Disease and End-Stage Renal Disease in the United States, Bethesda, MD, National Institute of Health, National Institute of Diabetes and Digestive and Kidney Disease, 2008
29. Stenvinkel P, Heimburger O, Paultre F, Diczfalusy U, Wang T, Berglund L, Jogestrand T: Strong association between malnutrition, inflammation, and atherosclerosis in chronic renal failure. Kidney Int 55: 1899-1911, 1999
30. Gunnell J, Jane Y: Yeun JY, Thomas A Depner TA, George A Kaysen GA: Acute phase response predicts erythropoietin resistance in hemodialysis and peritoneal dialysis patients. Am J Kidney Dis 33: 63-72, 1999 (Pubitemid 29031210)
31. Kalantar-Zadeh K, Block G, Humphreys MH, Kopple JD: Reverse epidemiology of cardiovascular risk factors in maintenance dialysis patients. Kidney Int 63: 793-808, 2003 (Pubitemid 36315558)