메뉴 건너뛰기




Volumn 7, Issue 7, 2015, Pages 3910-3936

Bone marrow gene therapy for HIV/AIDS

Author keywords

Antiviral; Bone marrow; Gene therapy; Hematopoietic stem cell (HSC); HIV 1; Lentiviral vector; RNAi; Virus

Indexed keywords

CHEMOKINE RECEPTOR CCR5; CHEMOKINE RECEPTOR CXCR4; CHIMERIC ANTIGEN RECEPTOR; ENHANCED GREEN FLUORESCENT PROTEIN; GRANULOCYTE COLONY STIMULATING FACTOR RECEPTOR; RNA INDUCED SILENCING COMPLEX; T LYMPHOCYTE RECEPTOR; TRANSCRIPTION ACTIVATOR LIKE EFFECTOR NUCLEASE; ZINC FINGER NUCLEASE;

EID: 84937413297     PISSN: 19994915     EISSN: 19994915     Source Type: Journal    
DOI: 10.3390/v7072804     Document Type: Review
Times cited : (19)

References (146)
  • 1
    • 84937479213 scopus 로고    scopus 로고
    • UNAIDS. Reports on the Global AIDS Epidemic; UNAIDS: Geneva, Switzerland
    • UNAIDS. Reports on the Global AIDS Epidemic; UNAIDS: Geneva, Switzerland, 2013.
    • (2013)
  • 2
    • 79959301474 scopus 로고    scopus 로고
    • Safety and efficacy of the HVTN 503/Phambili study of a clade-B-based HIV-1 vaccine in South Africa: A double-blind, randomised, placebo-controlled test-of-concept phase 2b study
    • [CrossRef]
    • Gray, G.E.; Allen, M.; Moodie, Z.; Churchyard, G.; Bekker, L.G.; Nchabeleng, M.; Mlisana, K.; Metch, B.; De, B.G.; Latka, M.H., et al. Safety and efficacy of the HVTN 503/Phambili study of a clade-B-based HIV-1 vaccine in South Africa: A double-blind, randomised, placebo-controlled test-of-concept phase 2b study. Lancet Infect. Dis. 2011, 11, 507–515. [CrossRef]
    • (2011) Lancet Infect. Dis , vol.11 , pp. 507-515
    • Gray, G.E.1    Allen, M.2    Moodie, Z.3    Churchyard, G.4    Bekker, L.G.5    Nchabeleng, M.6    Mlisana, K.7    Metch, B.8    De, B.G.9    Latka, M.H.10
  • 6
    • 84860345691 scopus 로고    scopus 로고
    • Treatment intensification with raltegravir in subjects with sustained HIV-1 viraemia suppression: A randomized 48-week study
    • [CrossRef] [PubMed]
    • Llibre, J.M.; Buzon, M.J.; Massanella, M.; Esteve, A.; Dahl, V.; Puertas, M.C.; Domingo, P.; Gatell, J.M.; Larrouse, M.; Gutierrez, M., et al. Treatment intensification with raltegravir in subjects with sustained HIV-1 viraemia suppression: A randomized 48-week study. Antivir. Ther. 2012, 17, 355–364. [CrossRef] [PubMed]
    • (2012) Antivir. Ther , vol.17 , pp. 355-364
    • Llibre, J.M.1    Buzon, M.J.2    Massanella, M.3    Esteve, A.4    Dahl, V.5    Puertas, M.C.6    Domingo, P.7    Gatell, J.M.8    Larrouse, M.9    Gutierrez, M.10
  • 7
    • 40549100332 scopus 로고    scopus 로고
    • Overcoming resistance to existing therapies in HIV-infected patients: The role of new antiretroviral drugs
    • [CrossRef] [PubMed]
    • Perno, C.F.; Moyle, G.; Tsoukas, C.; Ratanasuwan, W.; Gatell, J.; Schechter, M. Overcoming resistance to existing therapies in HIV-infected patients: The role of new antiretroviral drugs. J. Med. Virol. 2008, 80, 565–576. [CrossRef] [PubMed]
    • (2008) J. Med. Virol , vol.80 , pp. 565-576
    • Perno, C.F.1    Moyle, G.2    Tsoukas, C.3    Ratanasuwan, W.4    Gatell, J.5    Schechter, M.6
  • 9
    • 78650881417 scopus 로고    scopus 로고
    • Allogeneic transplantation of CCR5-deficient progenitor cells in a patient with HIV infection: An update after 3 years and the search for patient No. 2
    • [CrossRef] [PubMed]
    • Hutter, G.; Thiel, E. Allogeneic transplantation of CCR5-deficient progenitor cells in a patient with HIV infection: An update after 3 years and the search for patient No. 2. AIDS 2011, 25, 273–274. [CrossRef] [PubMed]
    • (2011) AIDS , vol.25 , pp. 273-274
    • Hutter, G.1    Thiel, E.2
  • 10
    • 0024299563 scopus 로고
    • Gene therapy. Intracellular immunization
    • [CrossRef] [PubMed]
    • Baltimore, D. Gene therapy. Intracellular immunization. Nature 1988, 335, 395–396. [CrossRef] [PubMed]
    • (1988) Nature , vol.335 , pp. 395-396
    • Baltimore, D.1
  • 11
    • 40149106131 scopus 로고    scopus 로고
    • Lentiviral vectors encoding human immunodeficiency virus type 1 (HIV-1)-specific T-cell receptor genes efficiently convert peripheral blood CD8 T lymphocytes into cytotoxic T lymphocytes with potent in vitro and in vivo HIV-1-specific inhibitory activity
    • [CrossRef] [PubMed]
    • Joseph, A.; Zheng, J.H.; Follenzi, A.; Dilorenzo, T.; Sango, K.; Hyman, J.; Chen, K.; Piechocka-Trocha, A.; Brander, C.; Hooijberg, E., et al. Lentiviral vectors encoding human immunodeficiency virus type 1 (HIV-1)-specific T-cell receptor genes efficiently convert peripheral blood CD8 T lymphocytes into cytotoxic T lymphocytes with potent in vitro and in vivo HIV-1-specific inhibitory activity. J. Virol. 2008, 82, 3078–3089. [CrossRef] [PubMed]
    • (2008) J. Virol , vol.82 , pp. 3078-3089
    • Joseph, A.1    Zheng, J.H.2    Follenzi, A.3    Dilorenzo, T.4    Sango, K.5    Hyman, J.6    Chen, K.7    Piechocka-Trocha, A.8    Brander, C.9    Hooijberg, E.10
  • 12
    • 0034254611 scopus 로고    scopus 로고
    • Prolonged survival and tissue trafficking following adoptive transfer of CD4ζ gene-modified autologous CD4+ and CD8+ T cells in human immunodeficiency virus-infected subjects
    • [PubMed]
    • Mitsuyasu, R.T.; Anton, P.A.; Deeks, S.G.; Scadden, D.T.; Connick, E.; Downs, M.T.; Bakker, A.; Roberts, M.R.; June, C.H.; Jalali, S., et al. Prolonged survival and tissue trafficking following adoptive transfer of CD4ζ gene-modified autologous CD4+ and CD8+ T cells in human immunodeficiency virus-infected subjects. Blood 2000, 96, 785–793. [PubMed]
    • (2000) Blood , vol.96 , pp. 785-793
    • Mitsuyasu, R.T.1    Anton, P.A.2    Deeks, S.G.3    Scadden, D.T.4    Connick, E.5    Downs, M.T.6    Bakker, A.7    Roberts, M.R.8    June, C.H.9    Jalali, S.10
  • 13
    • 18344406935 scopus 로고    scopus 로고
    • Long-term in vivo survival of receptor-modified syngeneic T cells in patients with human immunodeficiency virus infection
    • [PubMed]
    • Walker, R.E.; Bechtel, C.M.; Natarajan, V.; Baseler, M.; Hege, K.M.; Metcalf, J.A.; Stevens, R.; Hazen, A.; Blaese, R.M.; Chen, C.C., et al. Long-term in vivo survival of receptor-modified syngeneic T cells in patients with human immunodeficiency virus infection. Blood 2000, 96, 467–474. [PubMed]
    • (2000) Blood , vol.96 , pp. 467-474
    • Walker, R.E.1    Bechtel, C.M.2    Natarajan, V.3    Baseler, M.4    Hege, K.M.5    Metcalf, J.A.6    Stevens, R.7    Hazen, A.8    Blaese, R.M.9    Chen, C.C.10
  • 14
    • 0035989039 scopus 로고    scopus 로고
    • A phase II randomized study of HIV-specific T-cell gene therapy in subjects with undetectable plasma viremia on combination antiretroviral therapy
    • [CrossRef] [PubMed]
    • Deeks, S.G.; Wagner, B.; Anton, P.A.; Mitsuyasu, R.T.; Scadden, D.T.; Huang, C.; Macken, C.; Richman, D.D.; Christopherson, C.; June, C.H., et al. A phase II randomized study of HIV-specific T-cell gene therapy in subjects with undetectable plasma viremia on combination antiretroviral therapy. Mol. Ther. 2002, 5, 788–797. [CrossRef] [PubMed]
    • (2002) Mol. Ther , vol.5 , pp. 788-797
    • Deeks, S.G.1    Wagner, B.2    Anton, P.A.3    Mitsuyasu, R.T.4    Scadden, D.T.5    Huang, C.6    Macken, C.7    Richman, D.D.8    Christopherson, C.9    June, C.H.10
  • 16
    • 0036157376 scopus 로고    scopus 로고
    • Adoptive transfer of costimulated CD4+ T cells induces expansion of peripheral T cells and decreased CCR5 expression in HIV infection
    • [CrossRef] [PubMed]
    • Levine, B.L.; Bernstein, W.B.; Aronson, N.E.; Schlienger, K.; Cotte, J.; Perfetto, S.; Humphries, M.J.; Ratto-Kim, S.; Birx, D.L.; Steffens, C., et al. Adoptive transfer of costimulated CD4+ T cells induces expansion of peripheral T cells and decreased CCR5 expression in HIV infection. Nat. Med. 2002, 8, 47–53. [CrossRef] [PubMed]
    • (2002) Nat. Med , vol.8 , pp. 47-53
    • Levine, B.L.1    Bernstein, W.B.2    Aronson, N.E.3    Schlienger, K.4    Cotte, J.5    Perfetto, S.6    Humphries, M.J.7    Ratto-Kim, S.8    Birx, D.L.9    Steffens, C.10
  • 17
    • 84877030619 scopus 로고    scopus 로고
    • Introduction of exogenous T-cell receptors into human hematopoietic progenitors results in exclusion of endogenous T-cell receptor expression
    • [CrossRef] [PubMed]
    • Vatakis, D.N.; Arumugam, B.; Kim, S.G.; Bristol, G.; Yang, O.; Zack, J.A. Introduction of exogenous T-cell receptors into human hematopoietic progenitors results in exclusion of endogenous T-cell receptor expression. Mol. Ther. 2013, 21, 1055–1063. [CrossRef] [PubMed]
    • (2013) Mol. Ther , vol.21 , pp. 1055-1063
    • Vatakis, D.N.1    Arumugam, B.2    Kim, S.G.3    Bristol, G.4    Yang, O.5    Zack, J.A.6
  • 18
    • 0024382709 scopus 로고
    • Functional dissection of the HIV-1 Rev trans-activator-derivation of a trans-dominant repressor of Rev function
    • CrossRef
    • Malim, M.H.; Bohnlein, S.; Hauber, J.; Cullen, B.R. Functional dissection of the HIV-1 Rev trans-activator-derivation of a trans-dominant repressor of Rev function. Cell 1989, 58, 205–214. [CrossRef]
    • (1989) Cell , vol.58 , pp. 205-214
    • Malim, M.H.1    Bohnlein, S.2    Hauber, J.3    Cullen, B.R.4
  • 19
    • 0026661059 scopus 로고
    • Stable expression of transdominant Rev protein in human T cells inhibits human immunodeficiency virus replication
    • [CrossRef] [PubMed]
    • Malim, M.H.; Freimuth, W.W.; Liu, J.; Boyle, T.J.; Lyerly, H.K.; Cullen, B.R.; Nabel, G.J. Stable expression of transdominant Rev protein in human T cells inhibits human immunodeficiency virus replication. J. Exp. Med. 1992, 176, 1197–1201. [CrossRef] [PubMed]
    • (1992) J. Exp. Med , vol.176 , pp. 1197-1201
    • Malim, M.H.1    Freimuth, W.W.2    Liu, J.3    Boyle, T.J.4    Lyerly, H.K.5    Cullen, B.R.6    Nabel, G.J.7
  • 20
    • 33845994066 scopus 로고    scopus 로고
    • Lentiviral vector transduction of a dominant-negative Rev gene into human CD34+ hematopoietic progenitor cells potently inhibits human immunodeficiency virus-1 replication
    • [CrossRef] [PubMed]
    • Bahner, I.; Sumiyoshi, T.; Kagoda, M.; Swartout, R.; Peterson, D.; Pepper, K.; Dorey, F.; Reiser, J.; Kohn, D.B. Lentiviral vector transduction of a dominant-negative Rev gene into human CD34+ hematopoietic progenitor cells potently inhibits human immunodeficiency virus-1 replication. Mol. Ther. 2007, 15, 76–85. [CrossRef] [PubMed]
    • (2007) Mol. Ther , vol.15 , pp. 76-85
    • Bahner, I.1    Sumiyoshi, T.2    Kagoda, M.3    Swartout, R.4    Peterson, D.5    Pepper, K.6    Dorey, F.7    Reiser, J.8    Kohn, D.B.9
  • 21
    • 24944441656 scopus 로고    scopus 로고
    • Preferential survival of CD4+ T lymphocytes engineered with anti-human immunodeficiency virus (HIV) genes in HIV-infected individuals
    • [CrossRef] [PubMed]
    • Morgan, R.A.; Walker, R.; Carter, C.S.; Natarajan, V.; Tavel, J.A.; Bechtel, C.; Herpin, B.; Muul, L.; Zheng, Z.; Jagannatha, S., et al. Preferential survival of CD4+ T lymphocytes engineered with anti-human immunodeficiency virus (HIV) genes in HIV-infected individuals. Hum. Gene Ther. 2005, 16, 1065–1074. [CrossRef] [PubMed]
    • (2005) Hum. Gene Ther , vol.16 , pp. 1065-1074
    • Morgan, R.A.1    Walker, R.2    Carter, C.S.3    Natarajan, V.4    Tavel, J.A.5    Bechtel, C.6    Herpin, B.7    Muul, L.8    Zheng, Z.9    Jagannatha, S.10
  • 23
    • 84875454096 scopus 로고    scopus 로고
    • Mutant Tat protein provides strong protection from HIV-1 infection in human CD4+ T cells
    • [CrossRef] [PubMed]
    • Apolloni, A.; Lin, M.H.; Sivakumaran, H.; Li, D.; Kershaw, M.H.; Harrich, D. A mutant Tat protein provides strong protection from HIV-1 infection in human CD4+ T cells. Hum. Gene Ther. 2013, 24, 270–282. [CrossRef] [PubMed]
    • (2013) Hum. Gene Ther , vol.24 , pp. 270-282
    • Apolloni, A.1    Lin, M.H.2    Sivakumaran, H.3    Li, D.4    Kershaw, M.H.5    Harrich, D.A.6
  • 24
    • 65349148559 scopus 로고    scopus 로고
    • The F12-Vif derivative Chim3 inhibits HIV-1 replication in CD4+ T lymphocytes and CD34+-derived macrophages by blocking HIV-1 DNA integration
    • [CrossRef] [PubMed]
    • Porcellini, S.; Alberici, L.; Gubinelli, F.; Lupo, R.; Olgiati, C.; Rizzardi, G.P.; Bovolenta, C. The F12-Vif derivative Chim3 inhibits HIV-1 replication in CD4+ T lymphocytes and CD34+-derived macrophages by blocking HIV-1 DNA integration. Blood 2009, 113, 3443–3452. [CrossRef] [PubMed]
    • (2009) Blood , vol.113 , pp. 3443-3452
    • Porcellini, S.1    Alberici, L.2    Gubinelli, F.3    Lupo, R.4    Olgiati, C.5    Rizzardi, G.P.6    Bovolenta, C.7
  • 25
    • 77951460356 scopus 로고    scopus 로고
    • Identification of dominant negative human immunodeficiency virus type 1 Vif mutants that interfere with the functional inactivation of APOBEC3G by virus-encoded Vif
    • [CrossRef] [PubMed]
    • Walker, R.C., Jr.; Khan, M.A.; Kao, S.; Goila-Gaur, R.; Miyagi, E.; Strebel, K. Identification of dominant negative human immunodeficiency virus type 1 Vif mutants that interfere with the functional inactivation of APOBEC3G by virus-encoded Vif. J. Virol. 2010, 84, 5201–5211. [CrossRef] [PubMed]
    • (2010) J. Virol , vol.84 , pp. 5201-5211
    • Walker, R.C.1    Khan, M.A.2    Kao, S.3    Goila-Gaur, R.4    Miyagi, E.5    Strebel, K.6
  • 26
    • 0031963348 scopus 로고    scopus 로고
    • Inhibition of HIV-1 replication by combined expression of gag dominant negative mutant and a human ribonuclease in a tightly controlled HIV-1 inducible vector
    • [CrossRef] [PubMed]
    • Cara, A.; Rybak, S.M.; Newton, D.L.; Crowley, R.; Rottschafer, S.E.; Reitz, M.S., Jr.; Gusella, G.L. Inhibition of HIV-1 replication by combined expression of gag dominant negative mutant and a human ribonuclease in a tightly controlled HIV-1 inducible vector. Gene Ther. 1998, 5, 65–75. [CrossRef] [PubMed]
    • (1998) Gene Ther , vol.5 , pp. 65-75
    • Cara, A.1    Rybak, S.M.2    Newton, D.L.3    Crowley, R.4    Rottschafer, S.E.5    Reitz, M.S.6    Gusella, G.L.7
  • 27
    • 0024443873 scopus 로고
    • HIV-1 Gag mutants can dominantly interfere with the replication of the wild-type virus
    • CrossRef
    • Trono, D.; Feinberg, M.B.; Baltimore, D. HIV-1 Gag mutants can dominantly interfere with the replication of the wild-type virus. Cell 1989, 59, 113–120. [CrossRef]
    • (1989) Cell , vol.59 , pp. 113-120
    • Trono, D.1    Feinberg, M.B.2    Baltimore, D.3
  • 28
    • 79551706989 scopus 로고    scopus 로고
    • Inhibition of early stages of HIV-1 assembly by INI1/hSNF5 transdominant negative mutant S6
    • [CrossRef] [PubMed]
    • Cano, J.; Kalpana, G.V. Inhibition of early stages of HIV-1 assembly by INI1/hSNF5 transdominant negative mutant S6. J. Virol. 2011, 85, 2254–2265. [CrossRef] [PubMed]
    • (2011) J. Virol , vol.85 , pp. 2254-2265
    • Cano, J.1    Kalpana, G.V.2
  • 29
    • 0033066668 scopus 로고    scopus 로고
    • Inhibition of HIV replication by dominant negative mutants of Sam68, a functional homolog of HIV-1
    • [CrossRef] [PubMed]
    • Reddy, T.R.; Xu, W.; Mau, J.K.; Goodwin, C.D.; Suhasini, M.; Tang, H.; Frimpong, K.; Rose, D.W.; Wong-Staal, F. Inhibition of HIV replication by dominant negative mutants of Sam68, a functional homolog of HIV-1 Rev. Nat. Med. 1999, 5, 635–642. [CrossRef] [PubMed]
    • (1999) Rev. Nat. Med , vol.5 , pp. 635-642
    • Reddy, T.R.1    Xu, W.2    Mau, J.K.3    Goodwin, C.D.4    Suhasini, M.5    Tang, H.6    Frimpong, K.7    Rose, D.W.8    Wong-Staal, F.9
  • 30
    • 56449127254 scopus 로고    scopus 로고
    • Selective translational repression of HIV-1 RNA by Sam68DeltaC occurs by altering PABP1 binding to unspliced viral RNA
    • [CrossRef] [PubMed]
    • Marsh, K.; Soros, V.; Cochrane, A. Selective translational repression of HIV-1 RNA by Sam68DeltaC occurs by altering PABP1 binding to unspliced viral RNA. Retrovirology 2008, 5, 97. [CrossRef] [PubMed]
    • (2008) Retrovirology , vol.5
    • Marsh, K.1    Soros, V.2    Cochrane, A.3
  • 31
    • 67650895835 scopus 로고    scopus 로고
    • Recruitment of a SAP18-HDAC1 complex into HIV-1 virions and its requirement for viral replication
    • [CrossRef] [PubMed]
    • Sorin, M.; Cano, J.; Das, S.; Mathew, S.; Wu, X.; Davies, K.P.; Shi, X.; Cheng, S.W.; Ott, D.; Kalpana, G.V. Recruitment of a SAP18-HDAC1 complex into HIV-1 virions and its requirement for viral replication. PLoS Pathog. 2009, 5, e1000463. [CrossRef] [PubMed]
    • (2009) Plos Pathog , vol.5
    • Sorin, M.1    Cano, J.2    Das, S.3    Mathew, S.4    Wu, X.5    Davies, K.P.6    Shi, X.7    Cheng, S.W.8    Ott, D.9    Kalpana, G.V.10
  • 32
    • 0025794308 scopus 로고
    • Relative resistance of primary HIV-1 isolates to neutralization by soluble CD4
    • [CrossRef]
    • Daar, E.S.; Ho, D.D. Relative resistance of primary HIV-1 isolates to neutralization by soluble CD4. Am. J. Med. 1991, 90, 22S–26S. [CrossRef]
    • (1991) Am. J. Med , vol.90
    • Daar, E.S.1    Ho, D.D.2
  • 33
    • 84893770462 scopus 로고    scopus 로고
    • A novel gene therapy strategy using secreted multifunctional anti-HIV proteins to confer protection to gene-modified and unmodified target cells
    • [CrossRef] [PubMed]
    • Falkenhagen, A.; Ameli, M.; Asad, S.; Read, S.E.; Joshi, S. A novel gene therapy strategy using secreted multifunctional anti-HIV proteins to confer protection to gene-modified and unmodified target cells. Gene Ther. 2014, 21, 175–187. [CrossRef] [PubMed]
    • (2014) Gene Ther , vol.21 , pp. 175-187
    • Falkenhagen, A.1    Ameli, M.2    Asad, S.3    Read, S.E.4    Joshi, S.5
  • 34
    • 0027985209 scopus 로고
    • Further evaluation of soluble CD4 as an anti-HIV type 1 gene therapy: Demonstration of protection of primary human peripheral blood lymphocytes from infection by HIV type 1
    • [CrossRef] [PubMed]
    • Morgan, R.A.; Baler-Bitterlich, G.; Ragheb, J.A.; Wong-Staal, F.; Gallo, R.C.; Anderson, W.F. Further evaluation of soluble CD4 as an anti-HIV type 1 gene therapy: Demonstration of protection of primary human peripheral blood lymphocytes from infection by HIV type 1. AIDS Res. Hum. Retroviruses 1994, 10, 1507–1515. [CrossRef] [PubMed]
    • (1994) AIDS Res. Hum. Retroviruses , vol.10 , pp. 1507-1515
    • Morgan, R.A.1    Baler-Bitterlich, G.2    Ragheb, J.A.3    Wong-Staal, F.4    Gallo, R.C.5    Anderson, W.F.6
  • 35
    • 79959953799 scopus 로고    scopus 로고
    • Secreted antiviral entry inhibitory (SAVE) peptides for gene therapy of HIV infection
    • [CrossRef] [PubMed]
    • Egerer, L.; Volk, A.; Kahle, J.; Kimpel, J.; Brauer, F.; Hermann, F.G.; von, L.D. Secreted antiviral entry inhibitory (SAVE) peptides for gene therapy of HIV infection. Mol. Ther. 2011, 19, 1236–1244. [CrossRef] [PubMed]
    • (2011) Mol. Ther , vol.19 , pp. 1236-1244
    • Egerer, L.1    Volk, A.2    Kahle, J.3    Kimpel, J.4    Brauer, F.5    Hermann, F.G.6    Von, L.D.7
  • 37
    • 18144380714 scopus 로고    scopus 로고
    • Suppression of HIV-1 infection in primary CD4 T cells transduced with a self-inactivating lentiviral vector encoding a membrane expressed GP41-derived fusion inhibitor
    • [CrossRef] [PubMed]
    • Perez, E.E.; Riley, J.L.; Carroll, R.G.; von, L.D.; June, C.H. Suppression of HIV-1 infection in primary CD4 T cells transduced with a self-inactivating lentiviral vector encoding a membrane expressed GP41-derived fusion inhibitor. Clin. Immunol. 2005, 115, 26–32. [CrossRef] [PubMed]
    • (2005) Clin. Immunol , vol.115 , pp. 26-32
    • Perez, E.E.1    Riley, J.L.2    Carroll, R.G.3    Von, L.D.4    June, C.H.5
  • 38
    • 34247208235 scopus 로고    scopus 로고
    • Transfer of autologous gene-modified T cells in HIV-infected patients with advanced immunodeficiency and drug-resistant virus
    • [CrossRef] [PubMed]
    • van Lunzen, J.; Glaunsinger, T.; Stahmer, I.; von Baehr, V.; Baum, C.; Schilz, A.; Kuehlcke, K.; Naundorf, S.; Martinius, H.; Hermann, F., et al. Transfer of autologous gene-modified T cells in HIV-infected patients with advanced immunodeficiency and drug-resistant virus. Mol. Ther. 2007, 15, 1024–1033. [CrossRef] [PubMed]
    • (2007) Mol. Ther , vol.15 , pp. 1024-1033
    • Van Lunzen, J.1    Glaunsinger, T.2    Stahmer, I.3    Von Baehr, V.4    Baum, C.5    Schilz, A.6    Kuehlcke, K.7    Naundorf, S.8    Martinius, H.9    Hermann, F.10
  • 39
    • 0037199960 scopus 로고    scopus 로고
    • III. Functional neutralization of HIV-1 VIF protein by intracellular immunization inhibits reverse transcription and viral replication
    • [CrossRef] [PubMed]
    • Goncalves, J.; Silva, F.; Freitas-Vieira, A.; Santa-Marta, M.; Malho, R.; Yang, X.; Gabuzda, D.; Barbas, C., III. Functional neutralization of HIV-1 VIF protein by intracellular immunization inhibits reverse transcription and viral replication. J. Biol. Chem. 2002, 277, 32036–32045. [CrossRef] [PubMed]
    • (2002) J. Biol. Chem , vol.277 , pp. 32036-32045
    • Goncalves, J.1    Silva, F.2    Freitas-Vieira, A.3    Santa-Marta, M.4    Malho, R.5    Yang, X.6    Gabuzda, D.7    Barbas, C.8
  • 40
    • 0033080821 scopus 로고    scopus 로고
    • Inhibition of replication of HIV-1 at both early and late stages of the viral life cycle by single-chain antibody against viral integrase
    • [CrossRef] [PubMed]
    • Kitamura, Y.; Ishikawa, T.; Okui, N.; Kobayashi, N.; Kanda, T.; Shimada, T.; Miyake, K.; Yoshiike, K. Inhibition of replication of HIV-1 at both early and late stages of the viral life cycle by single-chain antibody against viral integrase. J. Acquir. Immune Defic. Syndr. Hum. Retrovirol. 1999, 20, 105–114. [CrossRef] [PubMed]
    • (1999) J. Acquir. Immune Defic. Syndr. Hum. Retrovirol , vol.20 , pp. 105-114
    • Kitamura, Y.1    Ishikawa, T.2    Okui, N.3    Kobayashi, N.4    Kanda, T.5    Shimada, T.6    Miyake, K.7    Yoshiike, K.8
  • 41
    • 10344256143 scopus 로고    scopus 로고
    • Intracellular expression of single-chain variable fragments to inhibit early stages of the viral life cycle by targeting human immunodeficiency virus type 1 integrase
    • [PubMed]
    • Levy-Mintz, P.; Duan, L.; Zhang, H.; Hu, B.; Dornadula, G.; Zhu, M.; Kulkosky, J.; Bizub-Bender, D.; Skalka, A.M.; Pomerantz, R.J. Intracellular expression of single-chain variable fragments to inhibit early stages of the viral life cycle by targeting human immunodeficiency virus type 1 integrase. J. Virol. 1996, 70, 8821–8832. [PubMed]
    • (1996) J. Virol , vol.70 , pp. 8821-8832
    • Levy-Mintz, P.1    Duan, L.2    Zhang, H.3    Hu, B.4    Dornadula, G.5    Zhu, M.6    Kulkosky, J.7    Bizub-Bender, D.8    Skalka, A.M.9    Pomerantz, R.J.10
  • 42
    • 0028914482 scopus 로고
    • Inhibition of HIV-1 Tat-mediated LTR transactivation and HIV-1 infection by anti-Tat single chain intrabodies
    • [PubMed]
    • Mhashilkar, A.M.; Bagley, J.; Chen, S.Y.; Szilvay, A.M.; Helland, D.G.; Marasco, W.A. Inhibition of HIV-1 Tat-mediated LTR transactivation and HIV-1 infection by anti-Tat single chain intrabodies. EMBO J. 1995, 14, 1542–1551. [PubMed]
    • (1995) EMBO J , vol.14 , pp. 1542-1551
    • Mhashilkar, A.M.1    Bagley, J.2    Chen, S.Y.3    Szilvay, A.M.4    Helland, D.G.5    Marasco, W.A.6
  • 43
    • 9344264608 scopus 로고    scopus 로고
    • Targeting human immunodeficiency virus type 1 reverse transcriptase by intracellular expression of single-chain variable fragments to inhibit early stages of the viral life cycle
    • [PubMed]
    • Shaheen, F.; Duan, L.; Zhu, M.; Bagasra, O.; Pomerantz, R.J. Targeting human immunodeficiency virus type 1 reverse transcriptase by intracellular expression of single-chain variable fragments to inhibit early stages of the viral life cycle. J. Virol. 1996, 70, 3392–3400. [PubMed]
    • (1996) J. Virol , vol.70 , pp. 3392-3400
    • Shaheen, F.1    Duan, L.2    Zhu, M.3    Bagasra, O.4    Pomerantz, R.J.5
  • 44
    • 84866308671 scopus 로고    scopus 로고
    • In vivo selection of CD4γ T cells transduced with a -retroviral vector expressing a single-chain intrabody targeting HIV-1 tat
    • [CrossRef] [PubMed]
    • Braun, S.E.; Taube, R.; Zhu, Q.; Wong, F.E.; Murakami, A.; Kamau, E.; Dwyer, M.; Qiu, G.; Daigle, J.; Carville, A., et al. In vivo selection of CD4γ T cells transduced with a -retroviral vector expressing a single-chain intrabody targeting HIV-1 tat. Hum. Gene Ther. 2012, 23, 917–931. [CrossRef] [PubMed]
    • (2012) Hum. Gene Ther , vol.23 , pp. 917-931
    • Braun, S.E.1    Taube, R.2    Zhu, Q.3    Wong, F.E.4    Murakami, A.5    Kamau, E.6    Dwyer, M.7    Qiu, G.8    Daigle, J.9    Carville, A.10
  • 45
    • 0036290645 scopus 로고    scopus 로고
    • Lentiviral transduction of human T-lymphocytes with a RANTES intrakine inhibits human immunodeficiency virus type 1 infection
    • [PubMed]
    • Schroers, R.; Davis, C.M.; Wagner, H.J.; Chen, S.Y. Lentiviral transduction of human T-lymphocytes with a RANTES intrakine inhibits human immunodeficiency virus type 1 infection. Gene Ther. 2002, 9, 889–897. [PubMed]
    • (2002) Gene Ther , vol.9 , pp. 889-897
    • Schroers, R.1    Davis, C.M.2    Wagner, H.J.3    Chen, S.Y.4
  • 46
    • 0033659687 scopus 로고    scopus 로고
    • Co-receptor use by HIV and inhibition of HIV infection by chemokine receptor ligands
    • [CrossRef] [PubMed]
    • Simmons, G.; Reeves, J.D.; Hibbitts, S.; Stine, J.T.; Gray, P.W.; Proudfoot, A.E.; Clapham, P.R. Co-receptor use by HIV and inhibition of HIV infection by chemokine receptor ligands. Immunol. Rev. 2000, 177, 112–126. [CrossRef] [PubMed]
    • (2000) Immunol. Rev , vol.177 , pp. 112-126
    • Simmons, G.1    Reeves, J.D.2    Hibbitts, S.3    Stine, J.T.4    Gray, P.W.5    Proudfoot, A.E.6    Clapham, P.R.7
  • 47
    • 0032552429 scopus 로고    scopus 로고
    • Anti-HIV type 1 activity of wild-type and functional defective RANTES intrakine in primary human lymphocytes
    • [CrossRef] [PubMed]
    • Yang, A.G.; Zhang, X.; Torti, F.; Chen, S.Y. Anti-HIV type 1 activity of wild-type and functional defective RANTES intrakine in primary human lymphocytes. Hum. Gene Ther. 1998, 9, 2005–2018. [CrossRef] [PubMed]
    • (1998) Hum. Gene Ther , vol.9 , pp. 2005-2018
    • Yang, A.G.1    Zhang, X.2    Torti, F.3    Chen, S.Y.4
  • 48
    • 84891772031 scopus 로고    scopus 로고
    • Simultaneous zinc-finger nuclease editing of the HIV coreceptors CCR5 and CXCR4 protects CD4+ T cells from HIV-1 infection
    • [CrossRef] [PubMed]
    • Didigu, C.A.; Wilen, C.B.; Wang, J.; Duong, J.; Secreto, A.J.; Danet-Desnoyers, G.A.; Riley, J.L.; Gregory, P.D.; June, C.H.; Holmes, M.C., et al. Simultaneous zinc-finger nuclease editing of the HIV coreceptors CCR5 and CXCR4 protects CD4+ T cells from HIV-1 infection. Blood 2014, 123, 61–69. [CrossRef] [PubMed]
    • (2014) Blood , vol.123 , pp. 61-69
    • Didigu, C.A.1    Wilen, C.B.2    Wang, J.3    Duong, J.4    Secreto, A.J.5    Danet-Desnoyers, G.A.6    Riley, J.L.7    Gregory, P.D.8    June, C.H.9    Holmes, M.C.10
  • 51
    • 84862777608 scopus 로고    scopus 로고
    • Zinc-finger nuclease editing of human CXCR4 promotes HIV-1 CD4+ T cell resistance and enrichment
    • [CrossRef] [PubMed]
    • Yuan, J.; Wang, J.; Crain, K.; Fearns, C.; Kim, K.A.; Hua, K.L.; Gregory, P.D.; Holmes, M.C., Torbett, B.E. Zinc-finger nuclease editing of human CXCR4 promotes HIV-1 CD4+ T cell resistance and enrichment. Mol. Ther. 2012, 20, 849–859. [CrossRef] [PubMed]
    • (2012) Mol. Ther , vol.20 , pp. 849-859
    • Yuan, J.1    Wang, J.2    Crain, K.3    Fearns, C.4    Kim, K.A.5    Hua, K.L.6    Gregory, P.D.7    Holmes, M.C.8    Torbett, B.E.9
  • 52
    • 84885008722 scopus 로고    scopus 로고
    • Zinc-finger-nucleases mediate specific and efficient excision of HIV-1 proviral DNA from infected and latently infected human T cells
    • [CrossRef] [PubMed]
    • Qu, X.; Wang, P.; Ding, D.; Li, L.; Wang, H.; Ma, L.; Zhou, X.; Liu, S.; Lin, S.; Wang, X., et al. Zinc-finger-nucleases mediate specific and efficient excision of HIV-1 proviral DNA from infected and latently infected human T cells. Nucleic Acids Res. 2013, 41, 7771–7782. [CrossRef] [PubMed]
    • (2013) Nucleic Acids Res , vol.41 , pp. 7771-7782
    • Qu, X.1    Wang, P.2    Ding, D.3    Li, L.4    Wang, H.5    Ma, L.6    Zhou, X.7    Liu, S.8    Lin, S.9    Wang, X.10
  • 54
    • 80053039555 scopus 로고    scopus 로고
    • Nuclease scaffold enables high genome editing activity in combination with low toxicity
    • [CrossRef] [PubMed]
    • Mussolino, C.; Morbitzer, R.; Lutge, F.; Dannemann, N.; Lahaye, T.; Cathomen, T. A novel TALE nuclease scaffold enables high genome editing activity in combination with low toxicity. Nucleic Acids Res. 2011, 39, 9283–9293. [CrossRef] [PubMed]
    • (2011) Nucleic Acids Res , vol.39 , pp. 9283-9293
    • Mussolino, C.1    Morbitzer, R.2    Lutge, F.3    Dannemann, N.4    Lahaye, T.5    Cathomen, T.A.6    Novel, T.7
  • 56
    • 84907224797 scopus 로고    scopus 로고
    • TALEN knockout of the PSIP1 gene in human cells: Analyses of HIV-1 replication and allosteric integrase inhibitor mechanism
    • [CrossRef] [PubMed]
    • Fadel, H.J.; Morrison, J.H.; Saenz, D.T.; Fuchs, J.R.; Kvaratskhelia, M.; Ekker, S.C.; Poeschla, E.M. TALEN knockout of the PSIP1 gene in human cells: Analyses of HIV-1 replication and allosteric integrase inhibitor mechanism. J. Virol. 2014, 88, 9704–9717. [CrossRef] [PubMed]
    • (2014) J. Virol , vol.88 , pp. 9704-9717
    • Fadel, H.J.1    Morrison, J.H.2    Saenz, D.T.3    Fuchs, J.R.4    Kvaratskhelia, M.5    Ekker, S.C.6    Poeschla, E.M.7
  • 57
    • 84892615613 scopus 로고    scopus 로고
    • Gene therapy strategies to exploit TRIM derived restriction factors against HIV-1
    • [CrossRef] [PubMed]
    • Chan, E.; Towers, G.J.; Qasim, W. Gene therapy strategies to exploit TRIM derived restriction factors against HIV-1. Viruses 2014, 6, 243–263. [CrossRef] [PubMed]
    • (2014) Viruses , vol.6 , pp. 243-263
    • Chan, E.1    Towers, G.J.2    Qasim, W.3
  • 59
    • 84937421013 scopus 로고    scopus 로고
    • Broadly neutralizing human immunodeficiency virus type 1 antibody gene transfer protects non-human primates from mucosal simian-human immunodeficiency virus infection
    • [CrossRef] [PubMed]
    • Saunders, K.O.; Wang, L.; Joyce, M.G.; Yang, Z.Y.; Balazs, A.B.; Cheng, C.; Ko, S.Y.; Kong, W.P.; Rudicell, R.S.; Georgiev, I.S., et al. Broadly neutralizing human immunodeficiency virus type 1 antibody gene transfer protects non-human primates from mucosal simian-human immunodeficiency virus infection. J. Virol. 2015. [CrossRef] [PubMed]
    • (2015) J. Virol
    • Saunders, K.O.1    Wang, L.2    Joyce, M.G.3    Yang, Z.Y.4    Balazs, A.B.5    Cheng, C.6    Ko, S.Y.7    Kong, W.P.8    Rudicell, R.S.9    Georgiev, I.S.10
  • 61
    • 84866250119 scopus 로고    scopus 로고
    • Gene therapy as a vaccine for HIV-1
    • [CrossRef] [PubMed]
    • Berkhout, B.; Sanders, R.W. Gene therapy as a vaccine for HIV-1. Expert Opin. Biol. Ther. 2012, 12, 1315–1321. [CrossRef] [PubMed]
    • (2012) Expert Opin. Biol. Ther , vol.12 , pp. 1315-1321
    • Berkhout, B.1    Sanders, R.W.2
  • 62
    • 84855466746 scopus 로고    scopus 로고
    • Antibody-based protection against HIV infection by vectored immunoprophylaxis
    • [CrossRef] [PubMed]
    • Balazs, A.B.; Chen, J.; Hong, C.M.; Rao, D.S.; Yang, L.; Baltimore, D. Antibody-based protection against HIV infection by vectored immunoprophylaxis. Nature 2012, 481, 81–84. [CrossRef] [PubMed]
    • (2012) Nature , vol.481 , pp. 81-84
    • Balazs, A.B.1    Chen, J.2    Hong, C.M.3    Rao, D.S.4    Yang, L.5    Baltimore, D.6
  • 63
    • 84896120124 scopus 로고    scopus 로고
    • Vectored immunoprophylaxis protects humanized mice from mucosal HIV transmission
    • [CrossRef] [PubMed]
    • Balazs, A.B.; Ouyang, Y.; Hong, C.M.; Chen, J.; Nguyen, S.M.; Rao, D.S.; An, D.S.; Baltimore, D. Vectored immunoprophylaxis protects humanized mice from mucosal HIV transmission. Nat. Med. 2014, 20, 296–300. [CrossRef] [PubMed]
    • (2014) Nat. Med , vol.20 , pp. 296-300
    • Balazs, A.B.1    Ouyang, Y.2    Hong, C.M.3    Chen, J.4    Nguyen, S.M.5    Rao, D.S.6    An, D.S.7    Baltimore, D.8
  • 64
    • 3042735441 scopus 로고    scopus 로고
    • Efficient lentiviral vector-mediated control of HIV-1 replication in CD4 lymphocytes from diverse HIV+ infected patients grouped according to CD4 count and viral load
    • [CrossRef] [PubMed]
    • Humeau, L.M.; Binder, G.K.; Lu, X.; Slepushkin, V.; Merling, R.; Echeagaray, P.; Pereira, M.; Slepushkina, T.; Barnett, S.; Dropulic, L.K., et al. Efficient lentiviral vector-mediated control of HIV-1 replication in CD4 lymphocytes from diverse HIV+ infected patients grouped according to CD4 count and viral load. Mol. Ther. 2004, 9, 902–913. [CrossRef] [PubMed]
    • (2004) Mol. Ther , vol.9 , pp. 902-913
    • Humeau, L.M.1    Binder, G.K.2    Lu, X.3    Slepushkin, V.4    Merling, R.5    Echeagaray, P.6    Pereira, M.7    Slepushkina, T.8    Barnett, S.9    Dropulic, L.K.10
  • 65
    • 2942639506 scopus 로고    scopus 로고
    • Antisense-mediated inhibition of human immunodeficiency virus (HIV) replication by use of an HIV type 1-based vector results in severely attenuated mutants incapable of developing resistance
    • [CrossRef] [PubMed]
    • Lu, X.; Yu, Q.; Binder, G.K.; Chen, Z.; Slepushkina, T.; Rossi, J.; Dropulic, B. Antisense-mediated inhibition of human immunodeficiency virus (HIV) replication by use of an HIV type 1-based vector results in severely attenuated mutants incapable of developing resistance. J. Virol. 2004, 78, 7079–7088. [CrossRef] [PubMed]
    • (2004) J. Virol , vol.78 , pp. 7079-7088
    • Lu, X.1    Yu, Q.2    Binder, G.K.3    Chen, Z.4    Slepushkina, T.5    Rossi, J.6    Dropulic, B.7
  • 66
    • 0025834035 scopus 로고
    • Inhibition of HIV-LTR gene expression by oligonucleotides targeted to the TAR element
    • [CrossRef] [PubMed]
    • Vickers, T.; Baker, B.F.; Cook, P.D.; Zounes, M.; Buckheit, R.W., Jr.; Germany, J.; Ecker, D.J. Inhibition of HIV-LTR gene expression by oligonucleotides targeted to the TAR element. Nucleic Acids Res. 1991, 19, 3359–3368. [CrossRef] [PubMed]
    • (1991) Nucleic Acids Res , vol.19 , pp. 3359-3368
    • Vickers, T.1    Baker, B.F.2    Cook, P.D.3    Zounes, M.4    Buckheit, R.W.5    Germany, J.6    Ecker, D.J.7
  • 67
    • 12144291445 scopus 로고    scopus 로고
    • Anti-human immunodeficiency virus hematopoietic progenitor cell-delivered ribozyme in a phase I study: Myeloid and lymphoid reconstitution in human immunodeficiency virus type-1-infected patients
    • [CrossRef] [PubMed]
    • Amado, R.G.; Mitsuyasu, R.T.; Rosenblatt, J.D.; Ngok, F.K.; Bakker, A.; Cole, S.; Chorn, N.; Lin, L.S.; Bristol, G.; Boyd, M.P., et al. Anti-human immunodeficiency virus hematopoietic progenitor cell-delivered ribozyme in a phase I study: Myeloid and lymphoid reconstitution in human immunodeficiency virus type-1-infected patients. Hum. Gene Ther. 2004, 15, 251–262. [CrossRef] [PubMed]
    • (2004) Hum. Gene Ther , vol.15 , pp. 251-262
    • Amado, R.G.1    Mitsuyasu, R.T.2    Rosenblatt, J.D.3    Ngok, F.K.4    Bakker, A.5    Cole, S.6    Chorn, N.7    Lin, L.S.8    Bristol, G.9    Boyd, M.P.10
  • 68
    • 21144470101 scopus 로고    scopus 로고
    • Long-term survival and concomitant gene expression of ribozyme-transduced CD4+ T-lymphocytes in HIV-infected patients
    • [CrossRef] [PubMed]
    • MacPherson, J.L.; Boyd, M.P.; Arndt, A.J.; Todd, A.V.; Fanning, G.C.; Ely, J.A.; Elliott, F.; Knop, A.; Raponi, M.; Murray, J., et al. Long-term survival and concomitant gene expression of ribozyme-transduced CD4+ T-lymphocytes in HIV-infected patients. J. Gene Med. 2005, 7, 552–564. [CrossRef] [PubMed]
    • (2005) J. Gene Med , vol.7 , pp. 552-564
    • Macpherson, J.L.1    Boyd, M.P.2    Arndt, A.J.3    Todd, A.V.4    Fanning, G.C.5    Ely, J.A.6    Elliott, F.7    Knop, A.8    Raponi, M.9    Murray, J.10
  • 71
    • 0032211255 scopus 로고    scopus 로고
    • A controlled, Phase 1 clinical trial to evaluate the safety and effects in HIV-1 infected humans of autologous lymphocytes transduced with a ribozyme that cleaves HIV-1 RNA
    • [CrossRef] [PubMed]
    • Wong-Staal, F.; Poeschla, E.M.; Looney, D.J. A controlled, Phase 1 clinical trial to evaluate the safety and effects in HIV-1 infected humans of autologous lymphocytes transduced with a ribozyme that cleaves HIV-1 RNA. Hum. Gene Ther. 1998, 9, 2407–2425. [CrossRef] [PubMed]
    • (1998) Hum. Gene Ther , vol.9 , pp. 2407-2425
    • Wong-Staal, F.1    Poeschla, E.M.2    Looney, D.J.3
  • 72
    • 3042818032 scopus 로고    scopus 로고
    • Efficacy and mode of action of hammerhead and hairpin ribozymes against various HIV-1 target sites
    • [CrossRef] [PubMed]
    • Hotchkiss, G.; Maijgren-Steffensson, C.; Ahrlund-Richter, L. Efficacy and mode of action of hammerhead and hairpin ribozymes against various HIV-1 target sites. Mol. Ther. 2004, 10, 172–180. [CrossRef] [PubMed]
    • (2004) Mol. Ther , vol.10 , pp. 172-180
    • Hotchkiss, G.1    Maijgren-Steffensson, C.2    Ahrlund-Richter, L.3
  • 73
    • 0030051703 scopus 로고    scopus 로고
    • A chimeric human immunodeficiency virus type 1 (HIV-1) minimal Rev response element-ribozyme molecule exhibits dual antiviral function and inhibits cell-cell transmission of HIV-1
    • [PubMed]
    • Yamada, O.; Kraus, G.; Luznik, L.; Yu, M.; Wong-Staal, F. A chimeric human immunodeficiency virus type 1 (HIV-1) minimal Rev response element-ribozyme molecule exhibits dual antiviral function and inhibits cell-cell transmission of HIV-1. J. Virol. 1996, 70, 1596–1601. [PubMed]
    • (1996) J. Virol , vol.70 , pp. 1596-1601
    • Yamada, O.1    Kraus, G.2    Luznik, L.3    Yu, M.4    Wong-Staal, F.5
  • 74
    • 0025837282 scopus 로고
    • Analysis of trans-acting response decoy RNA-mediated inhibition of human immunodeficiency virus type 1 transactivation
    • [PubMed]
    • Sullenger, B.A.; Gallardo, H.F.; Ungers, G.E.; Gilboa, E. Analysis of trans-acting response decoy RNA-mediated inhibition of human immunodeficiency virus type 1 transactivation. J. Virol. 1991, 65, 6811–6816. [PubMed]
    • (1991) J. Virol , vol.65 , pp. 6811-6816
    • Sullenger, B.A.1    Gallardo, H.F.2    Ungers, G.E.3    Gilboa, E.4
  • 75
    • 0025188193 scopus 로고
    • Overexpression of TAR sequences renders cells resistant to human immunodeficiency virus replication
    • CrossRef
    • Sullenger, B.A.; Gallardo, H.F.; Ungers, G.E.; Gilboa, E. Overexpression of TAR sequences renders cells resistant to human immunodeficiency virus replication. Cell 1990, 63, 601–608. [CrossRef]
    • (1990) Cell , vol.63 , pp. 601-608
    • Sullenger, B.A.1    Gallardo, H.F.2    Ungers, G.E.3    Gilboa, E.4
  • 76
    • 0026521479 scopus 로고
    • Overexpression of RRE-derived sequences inhibits HIV-1 replication in CEM cells
    • [PubMed]
    • Lee, T.C.; Sullenger, B.A.; Gallardo, H.F.; Ungers, G.E.; Gilboa, E. Overexpression of RRE-derived sequences inhibits HIV-1 replication in CEM cells. New Biol. 1992, 4, 66–74. [PubMed]
    • (1992) New Biol , vol.4 , pp. 66-74
    • Lee, T.C.1    Sullenger, B.A.2    Gallardo, H.F.3    Ungers, G.E.4    Gilboa, E.5
  • 78
    • 0036940586 scopus 로고    scopus 로고
    • RNA-based anti-HIV-1 gene therapeutic constructs in SCID-hu mouse model
    • [CrossRef] [PubMed]
    • Bai, J.; Banda, N.; Lee, N.S.; Rossi, J.; Akkina, R. RNA-based anti-HIV-1 gene therapeutic constructs in SCID-hu mouse model. Mol. Ther. 2002, 6, 770–782. [CrossRef] [PubMed]
    • (2002) Mol. Ther , vol.6 , pp. 770-782
    • Bai, J.1    Banda, N.2    Lee, N.S.3    Rossi, J.4    Akkina, R.5
  • 79
    • 23644454894 scopus 로고    scopus 로고
    • Lentiviral transduction of Tar Decoy and CCR5 ribozyme into CD34+ progenitor cells and derivation of HIV-1 resistant T cells and macrophages
    • [CrossRef] [PubMed]
    • Banerjea, A.; Li, M.J.; Remling, L.; Rossi, J.; Akkina, R. Lentiviral transduction of Tar Decoy and CCR5 ribozyme into CD34+ progenitor cells and derivation of HIV-1 resistant T cells and macrophages. AIDS Res. Ther. 2004, 1. [CrossRef] [PubMed]
    • (2004) AIDS Res. Ther
    • Banerjea, A.1    Li, M.J.2    Remling, L.3    Rossi, J.4    Akkina, R.5
  • 80
    • 0033168686 scopus 로고    scopus 로고
    • A clinical trial of retroviral-mediated transfer of a rev-responsive element decoy gene into CD34+ cells from the bone marrow of human immunodeficiency virus-1-infected children
    • [PubMed]
    • Kohn, D.B.; Bauer, G.; Rice, C.R.; Rothschild, J.C.; Carbonaro, D.A.; Valdez, P.; Hao, Q.; Zhou, C.; Bahner, I.; Kearns, K., et al. A clinical trial of retroviral-mediated transfer of a rev-responsive element decoy gene into CD34+ cells from the bone marrow of human immunodeficiency virus-1-infected children. Blood 1999, 94, 368–371. [PubMed]
    • (1999) Blood , vol.94 , pp. 368-371
    • Kohn, D.B.1    Bauer, G.2    Rice, C.R.3    Rothschild, J.C.4    Carbonaro, D.A.5    Valdez, P.6    Hao, Q.7    Zhou, C.8    Bahner, I.9    Kearns, K.10
  • 81
  • 82
    • 0035942736 scopus 로고    scopus 로고
    • Duplexes of 21-nucleotide RNAs mediate RNA interference in cultured mammalian cells
    • [CrossRef] [PubMed]
    • Elbashir, S.M.; Harborth, J.; Lendeckel, W.; Yalcin, A.; Weber, K.; Tuschl, T. Duplexes of 21-nucleotide RNAs mediate RNA interference in cultured mammalian cells. Nature 2001, 411, 494–498. [CrossRef] [PubMed]
    • (2001) Nature , vol.411 , pp. 494-498
    • Elbashir, S.M.1    Harborth, J.2    Lendeckel, W.3    Yalcin, A.4    Weber, K.5    Tuschl, T.6
  • 83
    • 1642564331 scopus 로고    scopus 로고
    • Bispecific short hairpin siRNA constructs targeted to CD4, CXCR4, and CCR5 confer HIV-1 resistance
    • [CrossRef] [PubMed]
    • Anderson, J.; Banerjea, A.; Akkina, R. Bispecific short hairpin siRNA constructs targeted to CD4, CXCR4, and CCR5 confer HIV-1 resistance. Oligonucleotides 2003, 13, 303–312. [CrossRef] [PubMed]
    • (2003) Oligonucleotides , vol.13 , pp. 303-312
    • Anderson, J.1    Banerjea, A.2    Akkina, R.3
  • 84
    • 22744451729 scopus 로고    scopus 로고
    • Lentiviral siRNAs targeting multiple highly conserved RNA sequences of human immunodeficiency virus type 1
    • [CrossRef] [PubMed]
    • Chang, L.J.; Liu, X.; He, J. Lentiviral siRNAs targeting multiple highly conserved RNA sequences of human immunodeficiency virus type 1. Gene Ther. 2005, 12, 1133–1144. [CrossRef] [PubMed]
    • (2005) Gene Ther , vol.12 , pp. 1133-1144
    • Chang, L.J.1    Liu, X.2    He, J.3
  • 85
    • 78650904206 scopus 로고    scopus 로고
    • Long-term inhibition of HIV-1 replication with RNA interference against cellular co-factors
    • [CrossRef] [PubMed]
    • Eekels, J.J.; Geerts, D.; Jeeninga, R.E.; Berkhout, B. Long-term inhibition of HIV-1 replication with RNA interference against cellular co-factors. Antiviral Res. 2011, 89, 43–53. [CrossRef] [PubMed]
    • (2011) Antiviral Res , vol.89 , pp. 43-53
    • Eekels, J.J.1    Geerts, D.2    Jeeninga, R.E.3    Berkhout, B.4
  • 86
    • 0036891843 scopus 로고    scopus 로고
    • RNA interference directed against viral and cellular targets inhibits human immunodeficiency virus type 1 replication
    • [CrossRef] [PubMed]
    • Surabhi, R.M.; Gaynor, R.B. RNA interference directed against viral and cellular targets inhibits human immunodeficiency virus type 1 replication. J. Virol. 2002, 76, 12963–12973. [CrossRef] [PubMed]
    • (2002) J. Virol , vol.76 , pp. 12963-12973
    • Surabhi, R.M.1    Gaynor, R.B.2
  • 87
    • 65949091600 scopus 로고    scopus 로고
    • Stringent testing identifies highly potent and escape-proof anti-HIV short hairpin RNAs
    • [CrossRef] [PubMed]
    • Von Eije, K.J.; Ter Brake, O.; Berkhout, B. Stringent testing identifies highly potent and escape-proof anti-HIV short hairpin RNAs. J. Gene Med. 2009, 11, 459–467. [CrossRef] [PubMed]
    • (2009) J. Gene Med , vol.11 , pp. 459-467
    • Von Eije, K.J.1    Ter Brake, O.2    Berkhout, B.3
  • 88
    • 33745384405 scopus 로고    scopus 로고
    • Conditionally replicating HIV-based vector that stably expresses an antiviral shRNA against HIV-1 replication
    • [CrossRef] [PubMed]
    • Westerhout, E.M.; Vink, M.; Haasnoot, P.C.; Das, A.T.; Berkhout, B. A conditionally replicating HIV-based vector that stably expresses an antiviral shRNA against HIV-1 replication. Mol. Ther. 2006, 14, 268–275. [CrossRef] [PubMed]
    • (2006) Mol. Ther , vol.14 , pp. 268-275
    • Westerhout, E.M.1    Vink, M.2    Haasnoot, P.C.3    Das, A.T.4    Berkhout, B.A.5
  • 90
    • 33751001588 scopus 로고    scopus 로고
    • Silencing of HIV-1 with RNA interference: A multiple shRNA approach
    • [CrossRef] [PubMed]
    • Ter Brake, O.; Konstantinova, P.; Ceylan, M.; Berkhout, B. Silencing of HIV-1 with RNA interference: A multiple shRNA approach. Mol. Ther. 2006, 14, 883–892. [CrossRef] [PubMed]
    • (2006) Mol. Ther , vol.14 , pp. 883-892
    • Ter Brake, O.1    Konstantinova, P.2    Ceylan, M.3    Berkhout, B.4
  • 91
    • 0034673638 scopus 로고    scopus 로고
    • An RNA-directed nuclease mediates post-transcriptional gene silencing in Drosophila cells
    • [PubMed]
    • Hammond, S.M.; Bernstein, E.; Beach, D.; Hannon, G.J. An RNA-directed nuclease mediates post-transcriptional gene silencing in Drosophila cells. Nature 2000, 404, 293–296. [PubMed]
    • (2000) Nature , vol.404 , pp. 293-296
    • Hammond, S.M.1    Bernstein, E.2    Beach, D.3    Hannon, G.J.4
  • 92
    • 84900321291 scopus 로고    scopus 로고
    • Towards improved shRNA and miRNA reagents as inhibitors of HIV-1 replication
    • [CrossRef] [PubMed]
    • Berkhout, B.; Liu, Y.P. Towards improved shRNA and miRNA reagents as inhibitors of HIV-1 replication. Future Microbiol. 2014, 9, 561–571. [CrossRef] [PubMed]
    • (2014) Future Microbiol , vol.9 , pp. 561-571
    • Berkhout, B.1    Liu, Y.P.2
  • 93
    • 84876030403 scopus 로고    scopus 로고
    • Dicer-independent processing of short hairpin RNAs
    • [CrossRef] [PubMed]
    • Liu, Y.P.; Schopman, N.C.; Berkhout, B. Dicer-independent processing of short hairpin RNAs. Nucleic Acids Res. 2013, 41, 3723–3733. [CrossRef] [PubMed]
    • (2013) Nucleic Acids Res , vol.41 , pp. 3723-3733
    • Liu, Y.P.1    Schopman, N.C.2    Berkhout, B.3
  • 94
    • 84928266443 scopus 로고    scopus 로고
    • Mechanistic insights on the dicer-independent Ago2-mediated processing of AgoshRNAs
    • [CrossRef] [PubMed]
    • Liu, Y.P.; Karg, M.; Harwig, A.; Herrera-Carrillo, E.; Jongejan, A.; van kampen, A.; Berkhout, B. Mechanistic insights on the dicer-independent Ago2-mediated processing of AgoshRNAs. RNA Biol. 2014, 12, 92–100. [CrossRef] [PubMed]
    • (2014) RNA Biol , vol.12 , pp. 92-100
    • Liu, Y.P.1    Karg, M.2    Harwig, A.3    Herrera-Carrillo, E.4    Jongejan, A.5    Van Kampen, A.6    Berkhout, B.7
  • 97
    • 84869037267 scopus 로고    scopus 로고
    • The loop position of shRNAs and pre-miRNAs is critical for the accuracy of Dicer processing in vivo
    • [CrossRef] [PubMed]
    • Gu, S.; Jin, L.; Zhang, Y.; Huang, Y.; Zhang, F.; Valdmanis, P.N.; Kay, M.A. The loop position of shRNAs and pre-miRNAs is critical for the accuracy of Dicer processing in vivo. Cell 2012, 151, 900–911. [CrossRef] [PubMed]
    • (2012) Cell , vol.151 , pp. 900-911
    • Gu, S.1    Jin, L.2    Zhang, Y.3    Huang, Y.4    Zhang, F.5    Valdmanis, P.N.6    Kay, M.A.7
  • 98
    • 84868097965 scopus 로고    scopus 로고
    • MicroRNAs associated with the different human Argonaute proteins
    • [CrossRef] [PubMed]
    • Dueck, A.; Ziegler, C.; Eichner, A.; Berezikov, E.; Meister, G. MicroRNAs associated with the different human Argonaute proteins. Nucleic Acids Res. 2012, 40, 9850–9862. [CrossRef] [PubMed]
    • (2012) Nucleic Acids Res , vol.40 , pp. 9850-9862
    • Dueck, A.1    Ziegler, C.2    Eichner, A.3    Berezikov, E.4    Meister, G.5
  • 99
    • 84906851063 scopus 로고    scopus 로고
    • Probing the shRNA characteristics that hinder Dicer recognition and consequently allow Ago-mediated processing and AgoshRNA activity
    • [CrossRef] [PubMed]
    • Herrera-Carrillo, E.; Harwig, A.; Liu, Y.P.; Berkhout, B. Probing the shRNA characteristics that hinder Dicer recognition and consequently allow Ago-mediated processing and AgoshRNA activity. RNA 2014, 20, 1410–1418. [CrossRef] [PubMed]
    • (2014) RNA , vol.20 , pp. 1410-1418
    • Herrera-Carrillo, E.1    Harwig, A.2    Liu, Y.P.3    Berkhout, B.4
  • 100
    • 84928267272 scopus 로고    scopus 로고
    • Towards optimization of AgoshRNA molecules that use a non-canonical RNAi pathway: Variations in the top and bottom base pairs
    • [CrossRef] [PubMed]
    • Herrera-Carrillo, E.; Harwig, A.; Berkhout, B. Towards optimization of AgoshRNA molecules that use a non-canonical RNAi pathway: Variations in the top and bottom base pairs. RNA Biol. 2015, 12, 447–456. [CrossRef] [PubMed]
    • (2015) RNA Biol , vol.12 , pp. 447-456
    • Herrera-Carrillo, E.1    Harwig, A.2    Berkhout, B.3
  • 101
    • 41149134501 scopus 로고    scopus 로고
    • Human immunodeficiency virus type 1 restriction by human-rhesus chimeric tripartite motif 5α (TRIM 5α) in CD34+ cell-derived macrophages in vitro and in T cells in vivo in severe combined immunodeficient (SCID-hu) mice transplanted with human fetal tissue
    • [CrossRef] [PubMed]
    • Anderson, J.; Akkina, R. Human immunodeficiency virus type 1 restriction by human-rhesus chimeric tripartite motif 5α (TRIM 5α) in CD34+ cell-derived macrophages in vitro and in T cells in vivo in severe combined immunodeficient (SCID-hu) mice transplanted with human fetal tissue. Hum. Gene Ther. 2008, 19, 217–228. [CrossRef] [PubMed]
    • (2008) Hum. Gene Ther , vol.19 , pp. 217-228
    • Anderson, J.1    Akkina, R.2
  • 102
    • 77955608799 scopus 로고    scopus 로고
    • RNA-based gene therapy for HIV with lentiviral vector-modified CD34+ cells in patients undergoing transplantation for AIDS-related lymphoma
    • [CrossRef] [PubMed]
    • DiGiusto, D.L.; Krishnan, A.; Li, L.; Li, H.; Li, S.; Rao, A.; Mi, S.; Yam, P.; Stinson, S.; Kalos, M., et al. RNA-based gene therapy for HIV with lentiviral vector-modified CD34+ cells in patients undergoing transplantation for AIDS-related lymphoma. Sci. Transl. Med. 2010, 2, 36–43. [CrossRef] [PubMed]
    • (2010) Sci. Transl. Med , vol.2 , pp. 36-43
    • Digiusto, D.L.1    Krishnan, A.2    Li, L.3    Li, H.4    Li, S.5    Rao, A.6    Mi, S.7    Yam, P.8    Stinson, S.9    Kalos, M.10
  • 103
    • 39849108343 scopus 로고    scopus 로고
    • Lentiviral vector design for multiple shRNA expression and durable HIV-1 inhibition
    • [CrossRef] [PubMed]
    • Ter Brake, O.; ‘t Hooft, K.; Liu, Y.P.; Centlivre, M.; von Eije, K.J.; Berkhout, B. Lentiviral vector design for multiple shRNA expression and durable HIV-1 inhibition. Mol. Ther. 2008, 16, 557–564. [CrossRef] [PubMed]
    • (2008) Mol. Ther , vol.16 , pp. 557-564
    • Ter Brake, O.1    ‘T Hooft, K.2    Liu, Y.P.3    Centlivre, M.4    Von Eije, K.J.5    Berkhout, B.6
  • 104
    • 44349164025 scopus 로고    scopus 로고
    • Inhibition of HIV-1 by multiple siRNAs expressed from a single microRNA polycistron
    • [CrossRef] [PubMed]
    • Liu, Y.P.; Haasnoot, J.; Ter Brake, O.; Berkhout, B.; Konstantinova, P. Inhibition of HIV-1 by multiple siRNAs expressed from a single microRNA polycistron. Nucleic Acids Res. 2008, 36, 2811–2824. [CrossRef] [PubMed]
    • (2008) Nucleic Acids Res , vol.36 , pp. 2811-2824
    • Liu, Y.P.1    Haasnoot, J.2    Ter Brake, O.3    Berkhout, B.4    Konstantinova, P.5
  • 105
    • 71049186345 scopus 로고    scopus 로고
    • RNA polymerase III can drive polycistronic expression of functional interfering RNAs designed to resemble microRNAs
    • [CrossRef] [PubMed]
    • Snyder, L.L.; Ahmed, I.; Steel, L.F. RNA polymerase III can drive polycistronic expression of functional interfering RNAs designed to resemble microRNAs. Nucleic Acids Res. 2009, 37. [CrossRef] [PubMed]
    • (2009) Nucleic Acids Res
    • Snyder, L.L.1    Ahmed, I.2    Steel, L.F.3
  • 108
    • 34848814237 scopus 로고    scopus 로고
    • Design of extended short hairpin RNAs for HIV-1 inhibition
    • [CrossRef] [PubMed]
    • Liu, Y.P.; Haasnoot, J.; Berkhout, B. Design of extended short hairpin RNAs for HIV-1 inhibition. Nucleic Acids Res. 2007, 35, 5683–5693. [CrossRef] [PubMed]
    • (2007) Nucleic Acids Res , vol.35 , pp. 5683-5693
    • Liu, Y.P.1    Haasnoot, J.2    Berkhout, B.3
  • 109
    • 33748850724 scopus 로고    scopus 로고
    • Inhibition of human immunodeficiency virus type 1 by RNA interference using long-hairpin RNA
    • [CrossRef] [PubMed]
    • Konstantinova, P.; de Vries, W.; Haasnoot, J.; Ter Brake, O.; de Haan, P.; Berkhout, B. Inhibition of human immunodeficiency virus type 1 by RNA interference using long-hairpin RNA. Gene Ther. 2006, 13, 1403–1413. [CrossRef] [PubMed]
    • (2006) Gene Ther , vol.13 , pp. 1403-1413
    • Konstantinova, P.1    De Vries, W.2    Haasnoot, J.3    Ter Brake, O.4    De Haan, P.5    Berkhout, B.6
  • 110
    • 77957807722 scopus 로고    scopus 로고
    • Deriving four functional anti-HIV siRNAs from a single Pol III-generated transcript comprising two adjacent long hairpin RNA precursors
    • [CrossRef] [PubMed]
    • Saayman, S.; Arbuthnot, P.; Weinberg, M.S. Deriving four functional anti-HIV siRNAs from a single Pol III-generated transcript comprising two adjacent long hairpin RNA precursors. Nucleic Acids Res. 2010, 38, 6652–6663. [CrossRef] [PubMed]
    • (2010) Nucleic Acids Res , vol.38 , pp. 6652-6663
    • Saayman, S.1    Arbuthnot, P.2    Weinberg, M.S.3
  • 111
    • 67149100493 scopus 로고    scopus 로고
    • Combinatorial RNAi strategies against HIV-1 and other escape-prone viruses
    • Liu, Y.P.; Berkhout, B. Combinatorial RNAi strategies against HIV-1 and other escape-prone viruses. Int. J. BioSci. Technol. 2008, 1, 1–10.
    • (2008) Int. J. Biosci. Technol , vol.1 , pp. 1-10
    • Liu, Y.P.1    Berkhout, B.2
  • 112
    • 84875311939 scopus 로고    scopus 로고
    • Antiviral strategies combining antiretroviral drugs with RNAi-mediated attack on HIV-1 and cellular co-factors
    • [CrossRef] [PubMed]
    • Boutimah, F.; Eekels, J.J.; Liu, Y.P.; Berkhout, B. Antiviral strategies combining antiretroviral drugs with RNAi-mediated attack on HIV-1 and cellular co-factors. Antiviral Res. 2013, 98, 121–129. [CrossRef] [PubMed]
    • (2013) Antiviral Res , vol.98 , pp. 121-129
    • Boutimah, F.1    Eekels, J.J.2    Liu, Y.P.3    Berkhout, B.4
  • 113
    • 84455169971 scopus 로고    scopus 로고
    • Directed HIV-1 evolution of protease inhibitor resistance by second-generation short hairpin RNAs
    • [CrossRef] [PubMed]
    • Schopman, N.C.; Braun, A.; Berkhout, B. Directed HIV-1 evolution of protease inhibitor resistance by second-generation short hairpin RNAs. Antimicrob. Agents Chemother. 2012, 56, 479–486. [CrossRef] [PubMed]
    • (2012) Antimicrob. Agents Chemother , vol.56 , pp. 479-486
    • Schopman, N.C.1    Braun, A.2    Berkhout, B.3
  • 114
    • 34249336747 scopus 로고    scopus 로고
    • Safety and efficacy of a lentiviral vector containing three anti-HIV genes—CCR5 ribozyme, Tat-Rev siRNA, and TAR decoy—In SCID-hu mouse-derived T cells
    • [CrossRef] [PubMed]
    • Anderson, J.; Li, M.J.; Palmer, B.; Remling, L.; Li, S.; Yam, P.; Yee, J.K.; Rossi, J.; Zaia, J.; Akkina, R. Safety and efficacy of a lentiviral vector containing three anti-HIV genes—CCR5 ribozyme, Tat-Rev siRNA, and TAR decoy—In SCID-hu mouse-derived T cells. Mol. Ther. 2007, 15, 1182–1188. [CrossRef] [PubMed]
    • (2007) Mol. Ther , vol.15 , pp. 1182-1188
    • Anderson, J.1    Li, M.J.2    Palmer, B.3    Remling, L.4    Li, S.5    Yam, P.6    Yee, J.K.7    Rossi, J.8    Zaia, J.9    Akkina, R.10
  • 115
    • 84861309293 scopus 로고    scopus 로고
    • Generation of an HIV-1-resistant immune system with CD34+ hematopoietic stem cells transduced with a triple-combination anti-HIV lentiviral vector
    • [CrossRef] [PubMed]
    • Walker, J.E.; Chen, R.X.; McGee, J.; Nacey, C.; Pollard, R.B.; Abedi, M.; Bauer, G.; Nolta, J.A.; Anderson, J.S. Generation of an HIV-1-resistant immune system with CD34+ hematopoietic stem cells transduced with a triple-combination anti-HIV lentiviral vector. J. Virol. 2012, 86, 5719–5729. [CrossRef] [PubMed]
    • (2012) J. Virol , vol.86 , pp. 5719-5729
    • Walker, J.E.1    Chen, R.X.2    McGee, J.3    Nacey, C.4    Pollard, R.B.5    Abedi, M.6    Bauer, G.7    Nolta, J.A.8    Anderson, J.S.9
  • 116
    • 74349091890 scopus 로고    scopus 로고
    • Foamy combinatorial anti-HIV vectors with MGMTP140K potently inhibit HIV-1 and SHIV replication and mediate selection in vivo
    • [CrossRef] [PubMed]
    • Kiem, H.P.; Wu, R.A.; Sun, G.; von, L.D.; Rossi, J.J.; Trobridge, G.D. Foamy combinatorial anti-HIV vectors with MGMTP140K potently inhibit HIV-1 and SHIV replication and mediate selection in vivo. Gene Ther. 2010, 17, 37–49. [CrossRef] [PubMed]
    • (2010) Gene Ther , vol.17 , pp. 37-49
    • Kiem, H.P.1    Wu, R.A.2    Sun, G.3    Von, L.D.4    Rossi, J.J.5    Trobridge, G.D.6
  • 118
    • 83255187212 scopus 로고    scopus 로고
    • Current progress in the development of RNAi-based therapeutics for HIV-1
    • [CrossRef] [PubMed]
    • Zhou, J.; Rossi, J.J. Current progress in the development of RNAi-based therapeutics for HIV-1. Gene Ther. 2011, 18, 1134–1138. [CrossRef] [PubMed]
    • (2011) Gene Ther , vol.18 , pp. 1134-1138
    • Zhou, J.1    Rossi, J.J.2
  • 121
    • 0037841763 scopus 로고    scopus 로고
    • Transcription start regions in the human genome are favored targets for MLV integration
    • [CrossRef] [PubMed]
    • Wu, X.; Li, Y.; Crise, B.; Burgess, S.M. Transcription start regions in the human genome are favored targets for MLV integration. Science 2003, 300, 1749–1751. [CrossRef] [PubMed]
    • (2003) Science , vol.300 , pp. 1749-1751
    • Wu, X.1    Li, Y.2    Crise, B.3    Burgess, S.M.4
  • 122
    • 84904115855 scopus 로고    scopus 로고
    • HIV latency. Specific HIV integration sites are linked to clonal expansion and persistence of infected cells
    • [CrossRef] [PubMed]
    • Maldarelli, F.; Wu, X.; Su, L.; Simonetti, F.R.; Shao, W.; Hill, S.; Spindler, J.; Ferris, A.L.; Mellors, J.W.; Kearney, M.F., et al. HIV latency. Specific HIV integration sites are linked to clonal expansion and persistence of infected cells. Science 2014, 345, 179–183. [CrossRef] [PubMed]
    • (2014) Science , vol.345 , pp. 179-183
    • Maldarelli, F.1    Wu, X.2    Su, L.3    Simonetti, F.R.4    Shao, W.5    Hill, S.6    Spindler, J.7    Ferris, A.L.8    Mellors, J.W.9    Kearney, M.F.10
  • 124
    • 0029872245 scopus 로고    scopus 로고
    • High-efficiency gene transfer into CD34+ cells with a human immunodeficiency virus type 1-based retroviral vector pseudotyped with vesicular stomatitis virus envelope glycoprotein, G
    • [PubMed]
    • Akkina, R.K.; Walton, R.M.; Chen, M.L.; Li, Q.X.; Planelles, V.; Chen, I.S. High-efficiency gene transfer into CD34+ cells with a human immunodeficiency virus type 1-based retroviral vector pseudotyped with vesicular stomatitis virus envelope glycoprotein, G. J. Virol. 1996, 70, 2581–2585. [PubMed]
    • (1996) J. Virol , vol.70 , pp. 2581-2585
    • Akkina, R.K.1    Walton, R.M.2    Chen, M.L.3    Li, Q.X.4    Planelles, V.5    Chen, I.S.6
  • 125
    • 0029150052 scopus 로고
    • HIV accessory proteins: Leading roles for the supporting cast
    • CrossRef
    • Trono, D. HIV accessory proteins: Leading roles for the supporting cast. Cell 1995, 82, 189–192. [CrossRef]
    • (1995) Cell , vol.82 , pp. 189-192
    • Trono, D.1
  • 126
    • 0031666744 scopus 로고    scopus 로고
    • Development of a self-inactivating lentivirus vector
    • [PubMed]
    • Miyoshi, H.; Blomer, U.; Takahashi, M.; Gage, F.H.; Verma, I.M. Development of a self-inactivating lentivirus vector. J. Virol. 1998, 72, 8150–8157. [PubMed]
    • (1998) J. Virol , vol.72 , pp. 8150-8157
    • Miyoshi, H.1    Blomer, U.2    Takahashi, M.3    Gage, F.H.4    Verma, I.M.5
  • 127
    • 0031743608 scopus 로고    scopus 로고
    • Trono, D. Self-inactivating lentivirus vector for safe and efficient in vivo gene delivery
    • [PubMed]
    • Zufferey, R.; Dull, T.; Mandel, R.J.; Bukovsky, A.; Quiroz, D.; Naldini, L.; Trono, D. Self-inactivating lentivirus vector for safe and efficient in vivo gene delivery. J. Virol. 1998, 72, 9873–9880. [PubMed]
    • (1998) J. Virol , vol.72 , pp. 9873-9880
    • Zufferey, R.1    Dull, T.2    Mandel, R.J.3    Bukovsky, A.4    Quiroz, D.5    Naldini, L.6
  • 128
    • 0032796643 scopus 로고    scopus 로고
    • Interaction of human immunodeficiency virus-derived vectors with wild-type virus in transduced cells
    • [PubMed]
    • Bukovsky, A.A.; Song, J.P.; Naldini, L. Interaction of human immunodeficiency virus-derived vectors with wild-type virus in transduced cells. J. Virol. 1999, 73, 7087–7092. [PubMed]
    • (1999) J. Virol , vol.73 , pp. 7087-7092
    • Bukovsky, A.A.1    Song, J.P.2    Naldini, L.3
  • 129
    • 74049153868 scopus 로고    scopus 로고
    • Lentiviral delivery of RNAi effectors against HIV-1
    • [CrossRef] [PubMed]
    • Liu, Y.P.; Berkhout, B. Lentiviral delivery of RNAi effectors against HIV-1. Curr. Top. Med. Chem. 2009, 9, 1130–1143. [CrossRef] [PubMed]
    • (2009) Curr. Top. Med. Chem , vol.9 , pp. 1130-1143
    • Liu, Y.P.1    Berkhout, B.2
  • 130
    • 77953642976 scopus 로고    scopus 로고
    • Titers of lentiviral vectors encoding shRNAs and miRNAs are reduced by different mechanisms that require distinct repair strategies
    • [CrossRef] [PubMed]
    • Liu, Y.P.; Vink, M.A.; Westerink, J.T.; Ramirez de, A.E.; Konstantinova, P.; Ter Brake, O.; Berkhout, B. Titers of lentiviral vectors encoding shRNAs and miRNAs are reduced by different mechanisms that require distinct repair strategies. RNA 2010, 16, 1328–1339. [CrossRef] [PubMed]
    • (2010) RNA , vol.16 , pp. 1328-1339
    • Liu, Y.P.1    Vink, M.A.2    Westerink, J.T.3    Ramirez De, A.E.4    Konstantinova, P.5    Ter Brake, O.6    Berkhout, B.7
  • 131
    • 34548574859 scopus 로고    scopus 로고
    • Lentiviral vectors that carry anti-HIV shRNAs: Problems and solutions
    • [CrossRef] [PubMed]
    • Ter Brake, O.; Berkhout, B. Lentiviral vectors that carry anti-HIV shRNAs: Problems and solutions. J. Gene Med. 2007, 9, 743–750. [CrossRef] [PubMed]
    • (2007) J. Gene Med , vol.9 , pp. 743-750
    • Ter Brake, O.1    Berkhout, B.2
  • 132
    • 65949090611 scopus 로고    scopus 로고
    • Probing the sequence space available for HIV-1 evolution
    • [CrossRef] [PubMed]
    • Ter Brake, O.; von Eije, K.J.; Berkhout, B. Probing the sequence space available for HIV-1 evolution. AIDS 2008, 22, 1875–1877. [CrossRef] [PubMed]
    • (2008) AIDS , vol.22 , pp. 1875-1877
    • Ter Brake, O.1    Von Eije, K.J.2    Berkhout, B.3
  • 133
    • 40149092147 scopus 로고    scopus 로고
    • Human immunodeficiency virus type 1 escape is restricted when conserved genome sequences are targeted by RNA interference
    • [CrossRef] [PubMed]
    • Von Eije, K.J.; Ter Brake, O.; Berkhout, B. Human immunodeficiency virus type 1 escape is restricted when conserved genome sequences are targeted by RNA interference. J. Virol. 2008, 82, 2895–2903. [CrossRef] [PubMed]
    • (2008) J. Virol , vol.82 , pp. 2895-2903
    • Von Eije, K.J.1    Ter Brake, O.2    Berkhout, B.3
  • 134
    • 84869090783 scopus 로고    scopus 로고
    • A competitive cell growth assay for the detection of subtle effects of gene transduction on cell proliferation
    • [CrossRef] [PubMed]
    • Eekels, J.J.; Pasternak, A.O.; Schut, A.M.; Geerts, D.; Jeeninga, R.E.; Berkhout, B. A competitive cell growth assay for the detection of subtle effects of gene transduction on cell proliferation. Gene Ther. 2012, 19, 1058–1064. [CrossRef] [PubMed]
    • (2012) Gene Ther , vol.19 , pp. 1058-1064
    • Eekels, J.J.1    Pasternak, A.O.2    Schut, A.M.3    Geerts, D.4    Jeeninga, R.E.5    Berkhout, B.6
  • 136
    • 78650735673 scopus 로고    scopus 로고
    • Zinc finger nuclease-mediated CCR5 knockout hematopoietic stem cell transplantation controls HIV-1 in vivo
    • [CrossRef] [PubMed]
    • Holt, N.; Wang, J.; Kim, K.; Friedman, G.; Wang, X.; Taupin, V.; Crooks, G.M.; Kohn, D.B.; Gregory, P.D.; Holmes, M.C., et al. Zinc finger nuclease-mediated CCR5 knockout hematopoietic stem cell transplantation controls HIV-1 in vivo. Nat. Biotechnol. 2010, 28, 839–847. [CrossRef] [PubMed]
    • (2010) Nat. Biotechnol , vol.28 , pp. 839-847
    • Holt, N.1    Wang, J.2    Kim, K.3    Friedman, G.4    Wang, X.5    Taupin, V.6    Crooks, G.M.7    Kohn, D.B.8    Gregory, P.D.9    Holmes, M.C.10
  • 137
    • 84895501470 scopus 로고    scopus 로고
    • The impact of unprotected T cells in RNAi-based gene therapy for HIV-AIDS
    • [CrossRef] [PubMed]
    • Herrera-Carrillo, E.; Liu, Y.P.; Berkhout, B. The impact of unprotected T cells in RNAi-based gene therapy for HIV-AIDS. Mol. Ther. 2014, 22, 596–606. [CrossRef] [PubMed]
    • (2014) Mol. Ther , vol.22 , pp. 596-606
    • Herrera-Carrillo, E.1    Liu, Y.P.2    Berkhout, B.3
  • 138
    • 84930483081 scopus 로고    scopus 로고
    • The impact of HIV-1 genetic diversity on the efficacy of a combinatorial RNAi-based gene therapy
    • [CrossRef] [PubMed]
    • Herrera-Carrillo, E.; Berkhout, B. The impact of HIV-1 genetic diversity on the efficacy of a combinatorial RNAi-based gene therapy. Gene Ther. 2015. [CrossRef] [PubMed]
    • (2015) Gene Ther
    • Herrera-Carrillo, E.1    Berkhout, B.2
  • 139
    • 84876475656 scopus 로고    scopus 로고
    • Antiviral effects of autologous CD4 T cells genetically modified with a conditionally replicating lentiviral vector expressing long antisense to HIV
    • [CrossRef] [PubMed]
    • Tebas, P.; Stein, D.; Binder-Scholl, G.; Mukherjee, R.; Brady, T.; Rebello, T.; Humeau, L.; Kalos, M.; Papasavvas, E.; Montaner, L.J., et al. Antiviral effects of autologous CD4 T cells genetically modified with a conditionally replicating lentiviral vector expressing long antisense to HIV. Blood 2013, 121, 1524–1533. [CrossRef] [PubMed]
    • (2013) Blood , vol.121 , pp. 1524-1533
    • Tebas, P.1    Stein, D.2    Binder-Scholl, G.3    Mukherjee, R.4    Brady, T.5    Rebello, T.6    Humeau, L.7    Kalos, M.8    Papasavvas, E.9    Montaner, L.J.10
  • 140
    • 78651304712 scopus 로고    scopus 로고
    • Management of relapsed and refractory classical Hodgkin lymphoma in children and adolescents
    • [CrossRef] [PubMed]
    • Daw, S.; Wynn, R.; Wallace, H. Management of relapsed and refractory classical Hodgkin lymphoma in children and adolescents. Br. J. Haematol. 2011, 152, 249–260. [CrossRef] [PubMed]
    • (2011) Br. J. Haematol , vol.152 , pp. 249-260
    • Daw, S.1    Wynn, R.2    Wallace, H.3
  • 141
    • 0033650534 scopus 로고    scopus 로고
    • Autologous hematopoietic cell transplantation in Hodgkin’s disease
    • [CrossRef]
    • Johnston, L.J.; Horning, S.J. Autologous hematopoietic cell transplantation in Hodgkin’s disease. Biol. Blood Marrow Transpl. 2000, 6, 289–300. [CrossRef]
    • (2000) Biol. Blood Marrow Transpl , vol.6 , pp. 289-300
    • Johnston, L.J.1    Horning, S.J.2
  • 143
    • 84863457438 scopus 로고    scopus 로고
    • T-lymphocyte perturbation following large-scale apheresis and hematopoietic stem cell transplantation in HIV-infected individuals
    • [CrossRef] [PubMed]
    • Savkovic, B.; MacPherson, J.L.; Zaunders, J.; Kelleher, A.D.; Knop, A.E.; Pond, S.; Evans, L.; Symonds, G.; Murray, J.M. T-lymphocyte perturbation following large-scale apheresis and hematopoietic stem cell transplantation in HIV-infected individuals. Clin. Immunol. 2012, 144, 159–171. [CrossRef] [PubMed]
    • (2012) Clin. Immunol , vol.144 , pp. 159-171
    • Savkovic, B.1    Macpherson, J.L.2    Zaunders, J.3    Kelleher, A.D.4    Knop, A.E.5    Pond, S.6    Evans, L.7    Symonds, G.8    Murray, J.M.9


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.