메뉴 건너뛰기




Volumn 18, Issue 12, 2011, Pages 1134-1138

Current progress in the development of RNAi-based therapeutics for HIV-1

Author keywords

delivery; HIV 1; RNAi; siRNA

Indexed keywords

APTAMER; CD34 ANTIGEN; CHEMOKINE RECEPTOR CCR5; SHORT HAIRPIN RNA; SMALL INTERFERING RNA; VIRUS VECTOR;

EID: 83255187212     PISSN: 09697128     EISSN: 14765462     Source Type: Journal    
DOI: 10.1038/gt.2011.149     Document Type: Review
Times cited : (38)

References (46)
  • 1
    • 0032545933 scopus 로고    scopus 로고
    • Potent and specific genetic interference by double-stranded RNA in caenorhabditis elegans
    • DOI 10.1038/35888
    • Fire A, Xu S, Montgomery MK, Kostas SA, Driver SE, Mello CC. Potent and specific genetic interference by double-stranded RNA in Caenorhabditis elegans. Nature 1998; 391: 806-811. (Pubitemid 28099681)
    • (1998) Nature , vol.391 , Issue.6669 , pp. 806-811
    • Fire, A.1    Xu, S.2    Montgomery, M.K.3    Kostas, S.A.4    Driver, S.E.5    Mello, C.C.6
  • 2
    • 33845396979 scopus 로고    scopus 로고
    • RNA Interference: Big Applause for Silencing in Stockholm
    • DOI 10.1016/j.cell.2006.12.001, PII S009286740601542X
    • Zamore PD. RNA interference: big applause for silencing in Stockholm. Cell 2006; 127: 1083-1086. (Pubitemid 44894537)
    • (2006) Cell , vol.127 , Issue.6 , pp. 1083-1086
    • Zamore, P.D.1
  • 3
    • 58749104364 scopus 로고    scopus 로고
    • The promises and pitfalls of RNA-interference-based therapeutics
    • Castanotto D, Rossi JJ. The promises and pitfalls of RNA-interference- based therapeutics. Nature 2009; 457: 426-433.
    • (2009) Nature , vol.457 , pp. 426-433
    • Castanotto, D.1    Rossi, J.J.2
  • 4
    • 33847036990 scopus 로고    scopus 로고
    • Strategies for silencing human disease using RNA interference
    • Kim DH, Rossi JJ. Strategies for silencing human disease using RNA interference. Nat Rev Genet 2007; 8: 173-184.
    • (2007) Nat Rev Genet , vol.8 , pp. 173-184
    • Kim, D.H.1    Rossi, J.J.2
  • 6
    • 60149094505 scopus 로고    scopus 로고
    • RNA interference: From basic research to therapeutic applications
    • Kurreck J. RNA interference: from basic research to therapeutic applications. Angew Chem Int Ed Engl 2009; 48: 1378-1398.
    • (2009) Angew Chem Int Ed Engl , vol.48 , pp. 1378-1398
    • Kurreck, J.1
  • 7
    • 0034737298 scopus 로고    scopus 로고
    • RNAi: Double-stranded RNA directs the ATP-dependent cleavage of mRNA at 21 to 23 nucleotide intervals
    • Zamore PD, Tuschl T, Sharp PA, Bartel DP. RNAi: double-stranded RNA directs the ATP-dependent cleavage of mRNA at 21 to 23 nucleotide intervals. Cell 2000; 101: 25-33.
    • (2000) Cell , vol.101 , pp. 25-33
    • Zamore, P.D.1    Tuschl, T.2    Sharp, P.A.3    Bartel, D.P.4
  • 9
    • 34447094733 scopus 로고    scopus 로고
    • Progress and prospects: RNA-based therapies for treatment of HIV infection
    • DOI 10.1038/sj.gt.3302977, PII 3302977
    • Scherer L, Rossi JJ, Weinberg MS. Progress and prospects: RNA-based therapies for treatment of HIV infection. Gene Therapy 2007; 14: 1057-1064. (Pubitemid 47029489)
    • (2007) Gene Therapy , vol.14 , Issue.14 , pp. 1057-1064
    • Scherer, L.1    Rossi, J.J.2    Weinberg, M.S.3
  • 10
    • 70349302043 scopus 로고    scopus 로고
    • Progress towards therapeutic application of RNA interference for HIV infection
    • Singh SK, Gaur RK. Progress towards therapeutic application of RNA interference for HIV infection. BioDrugs 2009; 23: 269-276.
    • (2009) BioDrugs , vol.23 , pp. 269-276
    • Singh, S.K.1    Gaur, R.K.2
  • 11
    • 36849042601 scopus 로고    scopus 로고
    • RNA interference against viruses: Strike and counterstrike
    • DOI 10.1038/nbt1369, PII NBT1369
    • Haasnoot J, Westerhout EM, Berkhout B. RNA interference against viruses: strike and counterstrike. Nat Biotechnol 2007; 25: 1435-1443. (Pubitemid 350233142)
    • (2007) Nature Biotechnology , vol.25 , Issue.12 , pp. 1435-1443
    • Haasnoot, J.1    Westerhout, E.M.2    Berkhout, B.3
  • 12
    • 0142124143 scopus 로고    scopus 로고
    • Human Immunodeficiency Virus Type 1 Escape from RNA Interference
    • DOI 10.1128/JVI.77.21.11531-11535.2003
    • Boden D, Pusch O, Lee F, Tucker L, Ramratnam B. Human immunodeficiency virus type 1. escape from RNA interference. J Virol 2003; 77: 11531-11535. (Pubitemid 37271651)
    • (2003) Journal of Virology , vol.77 , Issue.21 , pp. 11531-11535
    • Boden, D.1    Pusch, O.2    Lee, F.3    Tucker, L.4    Ramratnam, B.5
  • 14
    • 0344668868 scopus 로고    scopus 로고
    • Nucleotide sequence homology requirements of HIV-1-specific short hairpin RNA
    • DOI 10.1093/nar/gkg876
    • Pusch O, Boden D, Silbermann R, Lee F, Tucker L, Ramratnam B. Nucleotide sequence homology requirements of HIV-1-specific short hairpin RNA. Nucleic Acids Res 2003; 31: 6444-6449. (Pubitemid 37508748)
    • (2003) Nucleic Acids Research , vol.31 , Issue.22 , pp. 6444-6449
    • Pusch, O.1    Boden, D.2    Silbermann, R.3    Lee, F.4    Tucker, L.5    Ramratnam, B.6
  • 15
    • 36849028631 scopus 로고    scopus 로고
    • Genetic therapies against HIV
    • DOI 10.1038/nbt1367, PII NBT1367
    • Rossi JJ, June CH, Kohn DB. Genetic therapies against HIV. Nat Biotechnol 2007; 25: 1444-1454. (Pubitemid 350233141)
    • (2007) Nature Biotechnology , vol.25 , Issue.12 , pp. 1444-1454
    • Rossi, J.J.1    June, C.H.2    Kohn, D.B.3
  • 17
    • 62249171613 scopus 로고    scopus 로고
    • Current developments in anti-HIV/AIDS gene therapy
    • Tsygankov AY. Current developments in anti-HIV/AIDS gene therapy. Curr Opin Investig Drugs 2009; 10: 137-149.
    • (2009) Curr Opin Investig Drugs , vol.10 , pp. 137-149
    • Tsygankov, A.Y.1
  • 19
    • 27744605569 scopus 로고    scopus 로고
    • Long-term inhibition of HIV-1 infection in primary hematopoietic cells by lentiviral vector delivery of a triple combination of anti-HIV shRNA, anti-CCR5 ribozyme, and a nucleolar-localizing TAR decoy
    • DOI 10.1016/j.ymthe.2005.07.524, PII S1525001605011123
    • Li MJ, Kim J, Li S, Zaia J, Yee JK, Anderson J et al. Long-term inhibition of HIV-1 infection in primary hematopoietic cells by lentiviral vector delivery of a triple combination of anti-HIV shRNA, anti-CCR5 ribozyme, and a nucleolar-localizing TAR decoy. Mol Ther 2005; 12: 900-909. (Pubitemid 41614486)
    • (2005) Molecular Therapy , vol.12 , Issue.5 , pp. 900-909
    • Li, M.-J.1    Kim, J.2    Li, S.3    Zaia, J.4    Yee, J.-K.5    Anderson, J.6    Akkina, R.7    Rossi, J.J.8
  • 20
    • 39349097864 scopus 로고    scopus 로고
    • Identification of host proteins required for HIV infection through a functional genomic screen
    • DOI 10.1126/science.1152725
    • Brass AL, Dykxhoorn DM, Benita Y, Yan N, Engelman A, Xavier RJ et al. Identification of host proteins required for HIV infection through a functional genomic screen. Science 2008; 319: 921-926. (Pubitemid 351263756)
    • (2008) Science , vol.319 , Issue.5865 , pp. 921-926
    • Brass, A.L.1    Dykxhoorn, D.M.2    Benita, Y.3    Yan, N.4    Engelman, A.5    Xavier, R.J.6    Lieberman, J.7    Elledge, S.J.8
  • 21
    • 52949130695 scopus 로고    scopus 로고
    • Global analysis of host-pathogen interactions that regulate early-stage HIV-1 replication
    • König R, Zhou Y, Elleder D, Diamond TL, Bonamy GM, Irelan JT et al. Global analysis of host-pathogen interactions that regulate early-stage HIV-1 replication. Cell 2008; 135: 49-60.
    • (2008) Cell , vol.135 , pp. 49-60
    • König, R.1    Zhou, Y.2    Elleder, D.3    Diamond, T.L.4    Bonamy, G.M.5    Irelan, J.T.6
  • 23
    • 54549091050 scopus 로고    scopus 로고
    • Knockdown screens to knockout HIV-1
    • Goff SP. Knockdown screens to knockout HIV-1. Cell 2008; 135: 417-420.
    • (2008) Cell , vol.135 , pp. 417-420
    • Goff, S.P.1
  • 24
    • 39849108343 scopus 로고    scopus 로고
    • Lentiviral vector design for multiple shRNA expression and durable HIV-1 inhibition
    • DOI 10.1038/sj.mt.6300382, PII 6300382
    • ter Brake O, t Hooft K, Liu YP, Centlivre M, von Eije KJ, Berkhout B. Lentiviral vector design for multiple shRNA expression and durable HIV-1 inhibition. Mol Ther 2008; 16: 557-564. (Pubitemid 351314996)
    • (2008) Molecular Therapy , vol.16 , Issue.3 , pp. 557-564
    • Ter Brake, O.1    Thooft, K.2    Liu, Y.P.3    Centlivre, M.4    Von Eije, K.J.5    Berkhout, B.6
  • 26
    • 66149132733 scopus 로고    scopus 로고
    • Towards a durable RNAi gene therapy for HIV-AIDS
    • Berkhout B, ter Brake O. Towards a durable RNAi gene therapy for HIV-AIDS. Expert Opin Biol Ther 2009; 9: 161-170.
    • (2009) Expert Opin Biol Ther , vol.9 , pp. 161-170
    • Berkhout, B.1    Ter Brake, O.2
  • 27
    • 49549117077 scopus 로고    scopus 로고
    • T cell-specific siRNA delivery suppresses HIV-1 infection in humanized mice
    • Kumar P, Ban HS, Kim SS, Wu H, Pearson T, Greiner DL et al. T cell-specific siRNA delivery suppresses HIV-1 infection in humanized mice. Cell 2008; 134: 577-586.
    • (2008) Cell , vol.134 , pp. 577-586
    • Kumar, P.1    Ban, H.S.2    Kim, S.S.3    Wu, H.4    Pearson, T.5    Greiner, D.L.6
  • 29
    • 0037093199 scopus 로고    scopus 로고
    • A recombinant CD7-specific single-chain immunotoxin is a potent inducer of apoptosis in acute leukemic T cells
    • Peipp M, Küpers H, Saul D, Schlierf B, Greil J, Zunino SJ et al. A recombinant CD7-specific single-chain immunotoxin is a potent inducer of apoptosis in acute leukemic T cells. Cancer Res 2002; 62: 2848-2855. (Pubitemid 34525770)
    • (2002) Cancer Research , vol.62 , Issue.10 , pp. 2848-2855
    • Peipp, M.1    Kupers, H.2    Saul, D.3    Schlierf, B.4    Greil, J.5    Zunino, S.J.6    Gramatzki, M.7    Fey, G.H.8
  • 30
    • 0032543307 scopus 로고    scopus 로고
    • Structure of an HIV gp 120 envelope glycoprotein in complex with the CD4 receptor and a neutralizing human antibody
    • DOI 10.1038/31405
    • Kwong PD, Wyatt R, Robinson J, Sweet RW, Sodroski J, Hendrickson WA. Structure of an HIV gp120 envelope glycoprotein in complex with the CD4 receptor and a neutralizing human antibody. Nature 1998; 393: 648-659. (Pubitemid 28289647)
    • (1998) Nature , vol.393 , Issue.6686 , pp. 648-659
    • Kwong, P.D.1    Wyatt, R.2    Robinson, J.3    Sweet, R.W.4    Sodroski, J.5    Hendrickson, W.A.6
  • 31
    • 0026001658 scopus 로고
    • An IgG human monoclonal antibody that reacts with HIV-1/GP120, inhibits virus binding to cells, and neutralizes infection
    • Posner MR, Hideshima T, Cannon T, Mukherjee M, Mayer KH, Byrn RA. An IgG human monoclonal antibody that reacts with HIV-1/GP120, inhibits virus binding to cells, and neutralizes infection. J Immunol 1991; 146: 4325-4332.
    • (1991) J Immunol , vol.146 , pp. 4325-4332
    • Posner, M.R.1    Hideshima, T.2    Cannon, T.3    Mukherjee, M.4    Mayer, K.H.5    Byrn, R.A.6
  • 32
    • 76349095131 scopus 로고    scopus 로고
    • RNAi-mediated CCR5 silencing by LFA-1-targeted nanoparticles prevents HIV infection in BLT mice
    • Kim SS, Peer D, Kumar P, Subramanya S, Wu H, Asthana D et al. RNAi-mediated CCR5 silencing by LFA-1-targeted nanoparticles prevents HIV infection in BLT mice. Mol Ther 2010; 18: 370-376.
    • (2010) Mol Ther , vol.18 , pp. 370-376
    • Kim, S.S.1    Peer, D.2    Kumar, P.3    Subramanya, S.4    Wu, H.5    Asthana, D.6
  • 33
    • 78751667739 scopus 로고    scopus 로고
    • An aptamer-siRNA chimera suppresses HIV-1 viral loads and protects from helper CD4(r) T cell decline in humanized mice
    • Neff CP, Zhou J, Remling L, Kuruvilla J, Zhang J, Li H et al. An aptamer-siRNA chimera suppresses HIV-1 viral loads and protects from helper CD4(r) T cell decline in humanized mice. Sci Transl Med 2011; 3: 66ra68.
    • (2011) Sci Transl Med , vol.3 , pp. 66-68
    • Neff, C.P.1    Zhou, J.2    Remling, L.3    Kuruvilla, J.4    Zhang, J.5    Li, H.6
  • 34
    • 66249129385 scopus 로고    scopus 로고
    • Selection, characterization and application of new RNA HIV gp 120 aptamers for facile delivery of Dicer substrate siRNAs into HIV infected cells
    • Zhou J, Swiderski P, Li H, Zhang J, Neff CP, Akkina R et al. Selection, characterization and application of new RNA HIV gp 120 aptamers for facile delivery of Dicer substrate siRNAs into HIV infected cells. Nucleic Acids Res 2009; 37: 3094-3109.
    • (2009) Nucleic Acids Res , vol.37 , pp. 3094-3109
    • Zhou, J.1    Swiderski, P.2    Li, H.3    Zhang, J.4    Neff, C.P.5    Akkina, R.6
  • 35
    • 48349105059 scopus 로고    scopus 로고
    • Novel dual inhibitory function aptamer-siRNA delivery system for HIV-1 therapy
    • Zhou J, Li H, Li S, Zaia J, Rossi JJ. Novel dual inhibitory function aptamer-siRNA delivery system for HIV-1 therapy. Mol Ther 2008; 16: 1481-1489.
    • (2008) Mol Ther , vol.16 , pp. 1481-1489
    • Zhou, J.1    Li, H.2    Li, S.3    Zaia, J.4    Rossi, J.J.5
  • 36
    • 79957905425 scopus 로고    scopus 로고
    • Inhibition of HIV transmission in human cervicovaginal explants and humanized mice using CD4 aptamer-siRNA chimeras
    • Wheeler LA, Trifonova R, Vrbanac V, Basar E, McKernan S, Xu Z et al. Inhibition of HIV transmission in human cervicovaginal explants and humanized mice using CD4 aptamer-siRNA chimeras. J Clin Invest 2011; 121: 2401-2412.
    • (2011) J Clin Invest , vol.121 , pp. 2401-2412
    • Wheeler, L.A.1    Trifonova, R.2    Vrbanac, V.3    Basar, E.4    McKernan, S.5    Xu, Z.6
  • 39
    • 0021751840 scopus 로고
    • The CD4 (T4) antigen is an essential component of the receptor for the AIDS retrovirus
    • DOI 10.1038/312763a0
    • Dalgleish AG, Beverley PC, Clapham PR, Crawford DH, Greaves MF, Weiss RA. The CD4 (T4) antigen is an essential component of the receptor for the AIDS retrovirus. Nature 1984; 312: 763-767. (Pubitemid 15195924)
    • (1984) Nature , vol.312 , Issue.5996 , pp. 763-767
    • Dalgleish, A.G.1    Beverley, P.C.L.2    Clapham, P.R.3
  • 40
    • 0032081316 scopus 로고    scopus 로고
    • + T lymphocyte function
    • Kraus E, James W, Barclay AN. Cutting edge: novel RNA ligands able to bind CD4 antigen and inhibit CD4f T lymphocyte function. J Immunol 1998; 160: 5209-5212. (Pubitemid 28267804)
    • (1998) Journal of Immunology , vol.160 , Issue.11 , pp. 5209-5212
    • Kraus, E.1    James, W.2    Barclay, A.N.3
  • 41
  • 42
    • 33646588689 scopus 로고    scopus 로고
    • Stable expression of shRNAs in human CD34f progenitor cells can avoid induction of interferon responses to siRNAs in vitro
    • Robbins MA, Li M, Leung I, Li H, Boyer DV, Song Y et al. Stable expression of shRNAs in human CD34f progenitor cells can avoid induction of interferon responses to siRNAs in vitro. Nat Biotechnol 2006; 24: 566-571.
    • (2006) Nat Biotechnol , vol.24 , pp. 566-571
    • Robbins, M.A.1    Li, M.2    Leung, I.3    Li, H.4    Boyer, D.V.5    Song, Y.6
  • 43
    • 77955608799 scopus 로고    scopus 로고
    • RNA-based gene therapy for HIV with lentiviral vector-modified CD34(r) cells in patients undergoing transplantation for AIDS-related lymphoma
    • DiGiusto DL, Krishnan A, Li L, Li H, Li S, Rao A et al. RNA-based gene therapy for HIV with lentiviral vector-modified CD34(r) cells in patients undergoing transplantation for AIDS-related lymphoma. Sci Transl Med 2010; 2: 36ra43.
    • (2010) Sci Transl Med , vol.2 , pp. 36-43
    • Digiusto, D.L.1    Krishnan, A.2    Li, L.3    Li, H.4    Li, S.5    Rao, A.6
  • 44
    • 70349444994 scopus 로고    scopus 로고
    • Toward a durable anti-HIV gene therapy based on RNA interference
    • Berkhout B. Toward a durable anti-HIV gene therapy based on RNA interference. Ann NY Acad Sci 2009; 1175: 3-14.
    • (2009) Ann NY Acad Sci , vol.1175 , pp. 3-14
    • Berkhout, B.1
  • 45
    • 80052830258 scopus 로고    scopus 로고
    • Molecular strategies to design an escape-proof antiviral therapy
    • Berkhout B, Sanders RW. Molecular strategies to design an escape-proof antiviral therapy. Antiviral Res 2011; 92: 7-14.
    • (2011) Antiviral Res , vol.92 , pp. 7-14
    • Berkhout, B.1    Sanders, R.W.2
  • 46
    • 74049153868 scopus 로고    scopus 로고
    • Lentiviral delivery of RNAi effectors against HIV-1
    • Liu YP, Berkhout B. Lentiviral delivery of RNAi effectors against HIV-1. Curr Top Med Chem 2009; 9: 1130-1143.
    • (2009) Curr Top Med Chem , vol.9 , pp. 1130-1143
    • Liu, Y.P.1    Berkhout, B.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.