Coumarins as anticancer agents: A review on synthetic strategies, mechanism of action and SAR studies

European Journal of Medicinal Chemistry

Volumn 101, Issue , 2015, Pages 476-495

  Thakur, Anuradha ^a   Singla, Ramit ^a   Jaitak, Vikas ^a  

^a CENTRAL UNIVERSITY OF PUNJAB   (India)

Author keywords

Anticancer; Coumarins; IC50; SAR; Synthesis; Targets

Indexed keywords

AMINOCOUMARIN DERIVATIVE; ANGIOGENESIS INHIBITOR; ANTIMITOTIC AGENT; ANTINEOPLASTIC AGENT; AROMATASE INHIBITOR; BENZOTHIAZOLE DERIVATIVE; CELL CYCLE PROTEIN 20; CHALCONE DERIVATIVE; COUMARIN DERIVATIVE; CYCLIN DEPENDENT KINASE 2; CYCLIN DEPENDENT KINASE INHIBITOR 1A; EPIDERMAL GROWTH FACTOR RECEPTOR 2; ETHANOLAMINE; ETOPOSIDE; HEAT SHOCK PROTEIN 90 INHIBITOR; HYDRAZIDE; HYDRAZONE DERIVATIVE; IMIDAZOLE DERIVATIVE; IROSUSTAT; METHOTREXATE; PHOSPHOTRANSFERASE INHIBITOR; QUATERNARY AMMONIUM DERIVATIVE; RESVERATROL; STAUROSPORINE; SULFONAMIDE; TELOMERASE INHIBITOR; PROTEIN KINASE; PROTEIN KINASE INHIBITOR;

ANTINEOPLASTIC ACTIVITY; ANTIPROLIFERATIVE ACTIVITY; APOPTOSIS; ARTICLE; CYTOSTASIS; CYTOTOXICITY; DRUG MECHANISM; DRUG SYNTHESIS; ENZYME ACTIVITY; G1 PHASE CELL CYCLE CHECKPOINT; HUMAN; HYDROGEN BOND; MITOSIS; MOLECULAR DOCKING; MOLECULARLY TARGETED THERAPY; NONHUMAN; PHARMACOPHORE; S PHASE CELL CYCLE CHECKPOINT; STRUCTURE ACTIVITY RELATION; CELL PROLIFERATION; CHEMICAL STRUCTURE; CHEMISTRY; DOSE RESPONSE; DRUG EFFECTS; DRUG SCREENING; METABOLISM; NEOPLASMS; PATHOLOGY; SYNTHESIS;

ANTINEOPLASTIC AGENTS; CELL PROLIFERATION; COUMARINS; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG SCREENING ASSAYS, ANTITUMOR; HUMANS; MOLECULAR STRUCTURE; NEOPLASMS; PROTEIN KINASE INHIBITORS; PROTEIN KINASES; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 84937217512     PISSN: 02235234     EISSN: 17683254     Source Type: Journal    
DOI: 10.1016/j.ejmech.2015.07.010     Document Type: Review

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