Inhibition of vascular endothelial growth factor-induced angiogenesis by scopoletin through interrupting the autophosphorylation of VEGF receptor 2 and its downstream signaling pathways

Vascular Pharmacology

Volumn 54, Issue 1-2, 2011, Pages 18-28

  Pan, Rong ^a   Dai, Yue ^a   Gao, Xing Hua ^a   Lu, Dan ^a   Xia, Yu Feng ^a  

^a CHINA PHARMACEUTICAL UNIVERSITY   (China)

Author keywords

Angiogenesis; HUVECs; Scopoletin; VEGF; VEGFR

Indexed keywords

ENDOTHELIAL NITRIC OXIDE SYNTHASE; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; MITOGEN ACTIVATED PROTEIN KINASE P38; NITRIC OXIDE; PROTEIN KINASE B; SCOPOLETIN; VASCULOTROPIN; VASCULOTROPIN RECEPTOR 1; VASCULOTROPIN RECEPTOR 2;

ANGIOGENESIS; ANIMAL MODEL; ANTIANGIOGENIC ACTIVITY; ARTICLE; CELL MIGRATION; CELL PROLIFERATION; CHORIOALLANTOIS; CONTROLLED STUDY; DOSE RESPONSE; DRUG EFFECT; DRUG MECHANISM; EMBRYO; ENZYME PHOSPHORYLATION; HUMAN; HUMAN CELL; IN VITRO STUDY; IN VIVO STUDY; NONHUMAN; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; RECEPTOR DOWN REGULATION; UMBILICAL VEIN ENDOTHELIAL CELL;

ANGIOGENESIS INHIBITORS; ANIMALS; CELL PROLIFERATION; CHICK EMBRYO; CHORIOALLANTOIC MEMBRANE; ENDOTHELIAL CELLS; HUMANS; NEOVASCULARIZATION, PATHOLOGIC; NITRIC OXIDE; PHOSPHORYLATION; SCOPOLETIN; SIGNAL TRANSDUCTION; UMBILICAL VEINS; VASCULAR ENDOTHELIAL GROWTH FACTOR A; VASCULAR ENDOTHELIAL GROWTH FACTOR RECEPTOR-2;

EID: 79952628489     PISSN: 15371891     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.vph.2010.11.001     Document Type: Article

References (31)

1. Bullard L.E., Qi X., Penn J.S. Role for extracellular signal-responsive kinase-1 and -2 in retinal angiogenesis. Invest. Ophthalmol. Vis. Sci. 2003, 44:1722-1731.
2. Cao Y., Cao R., Bråkenhielm E. Antiangiogenic mechanisms of diet-derived polyphenols. J. Nutr. Biochem. 2002, 13:380-390.
3. Ding Z., Dai Y., Wang Z. Hypouricemic action of scopoletin arising from xanthine oxidase inhibition and uricosuric activity. Planta Med. 2005, 71:183-185.
4. Ferrara N. Vascular endothelial growth factor. Eur. J. Cancer 1996, 32A(14):2413-2422.
5. Gerber H.P., McMurtrey A., Kowalski J., Yan M., Keyt B.A., Dixit V., Ferrara N. Vascular endothelial growth factor regulates endothelial cell survival through the phosphatidylinositol 3¢-kinase/Akt signal transduction pathway Requirement for Flk-1/KDRactivation. J. Biol. Chem. 1998, 273:30336-30343.
6. Hicklin D.J., Ellis L.M. Role of the vascular endothelial growth factor pathway in tumor growth and angiogenesis. J. Clin. Oncol. 2005, 23:1011-1027.
7. Jaffe E.A., Nachman R.L., Becker C.G., Minick C.R. Culture of human endothelial cells derived from umbilical veins. Identification by morphologic and immunologic criteria. J. Clin. Invest. 1973, 52:2745-2756.
8. Kok T.W., Yue Patrick Y.K., Mak N.K., Fan T.P., Liu L., Wong R.N. The anti-angiogenic effect of sinomenine. Angiogenesis 2005, 8:3-12.
9. Landry J., Huot J. Regulation of actin dynamics by stress-activated protein kinase 2 (SAPK2)-dependent phosphorylation of heat-shock protein of 27kDa (Hsp27). Biochem. Soc. Symp. 1999, 64:79-89.
10. Lee S., Sivakumar K., Shin W.S., Xie F., Wang Q. Synthesis and anti-angiogenesis activity of coumarin derivatives. Bioorg. Med. Chem. Lett. 2006, 16:4596-4599.
11. Liekens S., De Clercq E., Neyts J. Angiogenesis: regulators and clinical applications. Biochem. Pharmacol. 2001, 61:253-270.
12. López-Farre A., Sánchez-de-Miguel L., Caramelo C., GómezMacías J., García R., Mosquera J.R., de Frutos T., Millás I., Rivas F., Echezarreta G., Casado S. Role of nitric oxide in autocrine control of growth and apoptosis of endothelial cells. Am. J. Physiol. 1997, 272:H760-H768.
13. López-Farre A., Farre J., Sánchez de Miguel L., Romero J., González-Fernández F., Casado S. Endothelial dysfunction: a global response. Rev. Esp. Cardiol. 1998, 5118-5122.
14. Marinos R.S., Zhang W., Wu G.Y., Kelly K.A., Meininger C.J. Tetrahydrobiopterin levels regulate endothelial cell proliferation. Am. J. Physiol. Heart Circ. Physiol. 2001, 281:H482-H489.
15. Moon P.D., Lee B.H., Jeong H.J., An H.J., Park S.J., Kim H.R., Ko S.G., Um J.Y., Hong S.H., Kim H.M. Use of scopoletin to inhibit the production of inflammatory cytokines through inhibition of the I kappa B/NF-kappa B signal cascade in the human mast cell line HMC-1. Eur. J. Pharmacol. 2007, 555:218-225.
16. Morbidelli L., Chang C.H., Douglas J.G., Granger H.J., Ledda F., Ziche M. Nitric oxide mediates mitogenic effect of VEGF on coronary venular endothelium. Am. J. Physiol. 1996, 270:H411-H415.
17. Munoz-Chapuli R., Quesada A.R., Medina M.A. Angiogenesis and signal transduction in endothelial cells. Cell. Mol. Life Sci. 2004, 61:2224-2243.
18. Nam N.H., Kim Y., You Y.J., Hong D.H., Kim H.M., Ahn B.Z. Preliminary structure antiangiogenic activity relationships of 4-senecioyloxymethyl-6,7-dimethoxycoumarin. Bioorg. Med. Chem. Lett. 2002, 12:2345-2348.
19. Pan R., Gao X.H., Li Y., Xia Y.F., Dai Y. Anti-arthritic effect of scopoletin, a coumarin compound occurring in Erycibe obtusifolia Benth stems, is associated with decreased angiogenesis in synovium. Fundam. Clin. Pharmacol 2009, 10.1111/j.1472-8206.2009.00784.x.
20. Papapetropoulos A., Garcia-Cardena G., Madri J.A., Sessa W.C. Nitric oxide production contributes to the angiogenic properties of vascular endothelial growth factor in human endothelial cells. J. Clin. Invest. 1997, 100:3131-3139.
21. Papetti M., Herman I.M. Mechanisms of normal and tumor-derived angiogenesis. Am. J. Physiol. Cell Physiol. 2002, 282:C947-C970.
22. Parenti A., Morbidelli L., Cui X.L., Douglas J.G., Hood J.D., Granger H.J., Ledda F., Ziche M. Nitric oxide is an upstream signal of vascular endothelial growth factor-induced extracellular signal-regulated kinase1/2 activation in postcapillary endothelium. J. Biol. Chem. 1998, 273:4220-4226.
23. Ridnour L.A., Isenberg J.S., Espey M.G., Thomas D.D., Roberts D.D., Wink D.A. Nitric oxide regulates angiogenesis through a functional switch involving thrombospondin-1. Proc. Natl Acad. Sci. USA 2005, 102:13147-13152.
24. Rousseau S., Houle F., Landry J., Huot J. p38 MAP kinase activation by vascular endothelial growth factor mediates actin reorganization and cell migration in human endothelial cells. Oncogene 1997, 15:2169-2177.
25. Scotland R.S., Morales-Ruiz M., Chen Y., Yu J., Rudic R.D., Fulton D., Gratton J.P., Sessa W.C. Functional reconstitution of endothelial nitric oxide synthase reveals the importance of serine 1179 in endothelium-dependent vasomotion. Circ. Res. 2002, 90:904-910.
26. Shaw C.Y., Chen C.H., Hsu C.C., Chen C.C., Tsai Y.C. Antioxidant properties of scopoletin isolated from Sinomonium acutum. Phytother. Res. 2003, 17:823-825.
27. Shibuya M., Claesson-Welsh L. Signal transduction by VEGF receptors in regulation of angiogenesis and lymphangiogenesis. Exp. Cell Res. 2006, 312:549-560.
28. Shizukuda Y., Tang S.Q., Yokota R., Ware J.A. Vascular endothelial growth factor-induced endothelial cell migration and proliferation depend on a nitric oxide-mediated decrease in protein kinase C delta activity. Circ. Res. 1999, 85:247-256.
29. Singh A.K., Seth P., Anthony P., Husain M.M., Madhavan S., Mukhtar H., Maheshwari R.K. Green tea constituent epigallocatechin-3-gallate inhibits angiogenic differentiation of human endothelial cells. Arch. Biochem. Biophys. 2002, 401:29-37.
30. Thaloor D., Singh A.K., Sidhu G.S., Prasad P.V., Kleinman H.K., Maheshwari R.K. Inhibition of angiogenic differentiation of human umbilical vein endothelial cells by curcumin. Cell Growth Differ. 1998, 9:305-312.
31. Toi Masakazu, Bando Hiroko, Ramachandran Cheppail, Melnick S.J., Imai A., Fife R.S., Carr R.E., Oikawa T., Lansky E.P. Preliminary studies on the anti-angiogenic potential of pomegranate fractions in vitro and in vivo. Angiogenesis 2003, 6:121-128.