Design, synthesis and vasorelaxant evaluation of novel coumarin-pyrimidine hybrids

Bioorganic and Medicinal Chemistry

Volumn 19, Issue 20, 2011, Pages 6087-6097

  Amin, Kamilia M ^a   Awadalla, Fadi M ^a   Eissa, Amal A M ^a   Abou Seri, Sahar M ^a   Hassan, Ghaneya S ^a  

^a CAIRO UNIVERSITY   (Egypt)

Author keywords

2D QSAR; Coumarin; Pyrimidine; Vasorelaxant efficacy

Indexed keywords

1 (2 OXO 2H CHROMEN 6 YL)GUANIDINE; 4 AMINO 2 (2 OXO 2H CHROMEN 6 YLAMINO) 6 PHENYLPYRIMIDINE 5 CARBONITRILE; 4 AMINO N HYDROXY 2 (2 OXO 2H CHROMEN 6 YLAMINO) 6 PHENYLPYRIMIDINE 5 CARBOXAMIDINE; 4 OXO 2 (2 OXO 2H CHROMEN 6 YLAMINO) 6 PHENYL 3,4 DIHYDROPYRIMIDINE 5 CARBONITRILE; 6 (3,4 DIHYDRO 6 METHYL 4 OXOPYRIMIDIN 2 YLAMINO) 2H CHROMEN 2 ONE; 6 (4 CHLORO 6 METHYLPYRIMIDIN 2 YLAMINO) 2H CHROMEN 2 ONE; 6 (4,6 DICHLOROPYRIMIDIN 2 YLAMINO) 2H CHROMEN 2 ONE; 6 (4,6 DIMETHYLPYRIMIDIN 2 YLAMINO) 2H CHROMEN 2 ONE; 6 (6 METHYL 4 PHENYLPYRIMIDIN 2 YLAMINO) 2H CHROMEN 2 ONE; 6 (SUBSTITUTED PYRIMIDIN 2 YL)AMINOCOUMARIN DERIVATIVE; 6 [4 (N,N DIETHYLAMINO) 6 METHYLPYRIMIDIN 2 YLAMINO] 2H CHROMEN 2 ONE; 6 [4 (N,N DIETHYLAMINO)PHENYL] 4 OXO 2 (2 OXO 2H CHROMEN 6 YLAMINO) 3,4 DIHYDROPYRIMIDINE 5 CARBONITRILE; 6 [4 CHLORO 5 (2 CHLOROETHYL) 6 METHYLPYRIMIDIN 2 YLAMINO] 2H CHROMEN 2 ONE; 6 AMINO 2H CHROMEN 2 ONE; 6 HYDROXY 2 (2 OXO 2H CHROMEN 6 YLAMINO)PYRIMIDIN 4(3H)ONE; 6 NITRO 2H CHROMEN 2 ONE; 7 METHOXY 8 (3 4 TOLYLACRYLOYL) 2H CHROMEN 2 ONE; 7 METHOXY 8 [3 (4 NITROPHENYL)ACRYLOYL] 2H CHROMEN 2 ONE; 7 METHOXY 8 [3 (5 METHYLFURAN 2 YL)ACRYLOYL] 2H CHROMEN 2 ONE; 7 METHOXY 8 [3 (THIOPHEN 2 YL)ACRYLOYL] 2H CHROMEN 2 ONE; 7 METHOXY 8 [3 [4 (METHYLTHIO)PHENYL]ACRYLOYL] 2H CHROMEN 2 ONE; 7 METHOXY 8 [3 [4 (TRIFLUOROMETHYL)PHENYL]ACRYLOYL] 2H CHROMEN 2 ONE; 7 METHOXY 8 [3 PHENYLACRYLOYL] 2H CHROMEN 2 ONE; 7 METHOXY 8 [ARYLACRYLOYL] 2H CHROMEN 2 ONE; 8 (6 ARYL 2 AMINOPYRIMIDIN 4 YL) 7 METHOXY COUMARIN DERIVATIVE; COUMARIN DERIVATIVE; N HYDROXY 4 OXO 2 (2 OXO 2H CHROMEN 6 YLAMINO) 6 PHENYL 3,4 DIHYDROPYRIMIDINE 5 CARBOXAMIDINE; PRAZOCIN; PYRIMIDINE DERIVATIVE; UNCLASSIFIED DRUG; UNINDEXED DRUG;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ANTIHYPERTENSIVE ACTIVITY; ARTICLE; CARDIOVASCULAR EFFECT; CHEMICAL PARAMETERS; CYCLIZATION; DRUG DESIGN; DRUG SCREENING; DRUG SOLUBILITY; DRUG STRUCTURE; DRUG SYNTHESIS; HYDROPHOBICITY; IC 50; IN VITRO STUDY; NONHUMAN; PHYSICAL CHEMISTRY; QUANTITATIVE STRUCTURE ACTIVITY RELATION; RAT; STANDARD; VASODILATATION;

ANIMALS; COUMARINS; MALE; MOLECULAR STRUCTURE; PYRIMIDINES; RATS; RATS, WISTAR; STRUCTURE-ACTIVITY RELATIONSHIP; VASODILATOR AGENTS;

RATTUS;

EID: 80053280961     PISSN: 09680896     EISSN: 14643391     Source Type: Journal    
DOI: 10.1016/j.bmc.2011.08.037     Document Type: Article

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