Toddaculin, a natural coumarin from Toddalia asiatica, induces differentiation and apoptosis in U-937 leukemic cells

Phytomedicine

Volumn 19, Issue 8-9, 2012, Pages 737-746

  Vázquez, Ramiro ^a,b   Riveiro, María E ^a   Vermeulen, Mónica ^c   Mondillo, Carolina ^a   Coombes, Philip H ^d   Crouch, Neil R ^d,e   Ismail, Fathima ^d   Mulholland, Dulcie A ^d,f   Baldi, Alberto ^a   Shayo, Carina ^a   Davio, Carlos ^b  

^a Facultad de Ciencias Naturales e Instituto M Lillo   (Argentina)

^b UNIVERSIDAD DE BUENOS AIRES   (Argentina)

^c INST DE INVEST HEMATOLOGICAS   (Argentina)

^d UNIVERSITY OF KWAZULU NATAL   (South Africa)

^e SOUTH AFRICAN NATIONAL BIODIVERSITY INSTITUTE   (South Africa)

^f UNIVERSITY OF SURREY   (United Kingdom)

Author keywords

Apoptosis; Differentiating activity; Leukemia; Toddaculin; Toddalia asiatica

Indexed keywords

ANTILEUKEMIC AGENT; HERBACEOUS AGENT; MITOGEN ACTIVATED PROTEIN KINASE; PROTEIN KINASE B; TODDACULIN; UNCLASSIFIED DRUG;

ANTINEOPLASTIC ACTIVITY; ANTIPROLIFERATIVE ACTIVITY; APOPTOSIS; ARTICLE; BARK; CELL DIFFERENTIATION; CONTROLLED STUDY; HUMAN; HUMAN CELL; IN VITRO STUDY; LEUKEMIA CELL; MEDICINAL PLANT; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; TODDALIA ASIATICA;

ANTINEOPLASTIC AGENTS, PHYTOGENIC; APOPTOSIS; CELL DIFFERENTIATION; CELL LINE, TUMOR; CELL PROLIFERATION; COUMARINS; DOWN-REGULATION; DRUG SCREENING ASSAYS, ANTITUMOR; EXTRACELLULAR SIGNAL-REGULATED MAP KINASES; HUMANS; LEUKEMIA; MAP KINASE KINASE 4; P38 MITOGEN-ACTIVATED PROTEIN KINASES; PROTO-ONCOGENE PROTEINS C-AKT; RUTACEAE;

RUTACEAE; TODDALIA ASIATICA;

EID: 84861821328     PISSN: 09447113     EISSN: 1618095X     Source Type: Journal    
DOI: 10.1016/j.phymed.2012.03.008     Document Type: Article

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