New series of 6-substituted coumarin derivatives as effective factor Xa inhibitors: Synthesis, in vivo antithrombotic evaluation and molecular docking

Bioorganic Chemistry

Volumn 52, Issue , 2014, Pages 31-43

  Amin, Kamelia M ^a   Abdel Gawad, Nagwa M ^a   Abdel Rahman, Doaa E ^a   El Ashry, Mohamed K M ^a  

^a CAIRO UNIVERSITY   (Egypt)

Author keywords

Anticoagulant; Coumarin; Factor Xa; Prothrombin time

Indexed keywords

3 (4 BROMOPHENYL) 5 (4 CHLOROPHENYL) N (2 OXO 2H CHROMEN 6 YL) 4,5 DIHYDROPYRAZOLE 1 CARBOXAMIDE; 3 (4 BROMOPHENYL) 5 (4 METHOXYPHENYL) N (2 OXO 2H CHROMEN 6 YL) 4,5 DIHYDROPYRAZOLE 1 CARBOXAMIDE; 4 (2 OXO 2H CHROMEN 6 YL)SEMICARBAZIDE; 4 (2 OXO 2H CHROMEN 6 YLAMINO) 1H IMIDAZOL 2(5H) ONE; 4 CYANO N (2 OXO 2H CHROMEN 6 YL)BENZAMIDE; 4 [5 (CHLOROMETHYL) 1,2,4 OXADIAZOL 3 YL] N (2 OXO 2H CHROMEN 6 YL)BENZAMIDE; 4 [5 [(BENZO[D]THIAZOL 2 YLAMINO)METHYL] 1,2,4 OXADIAZOL 3 YL] N (2 OXO 2H CHROMEN 6 YL)BENZAMIDE; 4 [AMINO (ETHYLIMINO) METHYL] N (2 OXO 2H CHROMEN 6 YL)BENZAMIDE; 4 [AMINO (HYDROXYIMINO) METHYL] N (2 OXO 2H CHROMEN 6 YL)BENZAMIDE; 4 [AMINO (IMINO) METHYL] N (2 OXO 2H CHROMEN 6 YL)BENZAMIDE; 4 [AMINO (ISOPROPYLIMINO) METHYL] N (2 OXO 2 CHROMEN 6 YL)BENZAMIDE; 4 [AMINO (METHYLIMINO) METHYL] N 2 (2 OXO 2H CHROMEN 6 YL)BENZAMIDE; 4 [AMINO (TERT BUTYLIMINO) METHYL] N (2 OXO 2H CHROMEN 6 YL)BENZAMIDE; 5 (4 CHLOROPHENYL) 3 (4 METHOXYPHENYL) N (2 OXO 2H CHROMEN 6 YL) 4,5 DIHYDROPYRAZOLE 1 CARBOXAMIDE; 5 (4 DIMETHYLAMINOPHENYL) N (2 OXO 2H CHROMEN 6YL) 3 (4 METHYLPHENYL) 4,5 DIHYDROPYRAZOLE 1 CARBOXAMIDE; 6 (2 IMINO 2,5 DIHYDRO 1H IMIDAZOL 4 YLAMINO) 2H CHROMEN 2 ONE; 6 (2 THIOXO 2,5 DIHYDRO 1H IMIDAZOL 4 YLAMINO) 2H CHROMEN 2 ONE; 6 AMINOCOUMARIN; 6 NITROCOUMARIN; AMIDINE; ANTICOAGULANT AGENT; BIS COUMARINYL OXADIAZOLE; BLOOD CLOTTING FACTOR 10A INHIBITOR; COUMARIN DERIVATIVE; COUMARINYL PYRAZOLE; N (2 OXO 2H CHROMEN 6 YL)CARBAMATE; RAZAXABAN; UNCLASSIFIED DRUG; UNINDEXED DRUG; WARFARIN; XIMELAGATRAN;

ACYLATION; ALKYLATION; ANIMAL EXPERIMENT; ANTICOAGULANT THERAPY; ANTICOAGULATION; ARTICLE; BLOOD CLOTTING TIME; CONTROLLED STUDY; CYCLIZATION; DIAZOTIZATION; DRUG BINDING SITE; DRUG SCREENING; DRUG STRUCTURE; DRUG SYNTHESIS; IN VIVO STUDY; MALE; MOLECULAR DOCKING; NONHUMAN; PRIORITY JOURNAL; PROTHROMBIN TIME; RAT;

ANTICOAGULANT; COUMARIN; FACTOR XA; PROTHROMBIN TIME;

ANIMALS; ANTICOAGULANTS; BINDING SITES; COUMARINS; FACTOR XA; FIBRINOLYTIC AGENTS; MALE; MICE; MOLECULAR DOCKING SIMULATION; MOLECULAR STRUCTURE; PROTHROMBIN TIME; STRUCTURE-ACTIVITY RELATIONSHIP; WARFARIN;

EID: 84888994543     PISSN: 00452068     EISSN: 10902120     Source Type: Journal    
DOI: 10.1016/j.bioorg.2013.11.002     Document Type: Article

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