Anti-tumour activity of a novel coumarin-chalcone hybrid is mediated through intrinsic apoptotic pathway by inducing PUMA and altering Bax/Bcl-2 ratio

Apoptosis

Volumn 19, Issue 6, 2014, Pages 1017-1028

  Singh, Neetu ^a,b   Sarkar, Jayanta ^a   Sashidhara, Koneni V ^a,b   Ali, Shakir ^c   Sinha, Sudhir ^a,b  

^a CENTRAL DRUG RESEARCH INSTITUTE   (India)

^b ACADEMY OF SCIENTIFIC AND INNOVATIVE RESEARCH ACSIR   (India)

^c HAMDARD UNIVERSITY   (India)

Author keywords

Apoptosis; Chalcone; Coumarin; Intrinsic pathway

Indexed keywords

ANTINEOPLASTIC AGENT; CHALCONE; COUMARIN; DOXORUBICIN; PROTEIN BAX; PROTEIN BCL 2; PUMA PROTEIN; S 009 131; S009 131; UNCLASSIFIED DRUG; APOPTOSIS REGULATORY PROTEIN; BBC3 PROTEIN, HUMAN; CHALCONE DERIVATIVE; COUMARIN DERIVATIVE; CYTOCHROME C; ETHYL 8-SEC-BUTYL-2-OXO-6-(3-OXO-3-P-TOLYLPROP-1-ENYL)-2H-CHROMENE-3-CARBOXYLATE; ONCOPROTEIN; REACTIVE OXYGEN METABOLITE;

ANTINEOPLASTIC ACTIVITY; ANTIPROLIFERATIVE ACTIVITY; APOPTOSIS; ARTICLE; CANCER CELL; CANCER SURVIVAL; CELL DEATH; CELL GROWTH; CELL POPULATION; CELL PROLIFERATION; COLONY FORMATION; CONTROLLED STUDY; DRUG EFFICACY; DRUG SYNTHESIS; FEMALE; FLOW CYTOMETRY; FLUORESCENCE MICROSCOPY; G2 PHASE CELL CYCLE CHECKPOINT; HELA CELL LINE; HUMAN; HUMAN CELL; IN VIVO STUDY; MITOCHONDRIAL MEMBRANE POTENTIAL; MOUSE; NONHUMAN; PRIORITY JOURNAL; SURVIVAL RATE; UTERINE CERVIX CARCINOMA; ANALOGS AND DERIVATIVES; ANIMAL; DRUG EFFECTS; GENETICS; M PHASE CELL CYCLE CHECKPOINT; METABOLISM; PATHOLOGY; SCID MOUSE; SIGNAL TRANSDUCTION; TUMOR CELL LINE; UTERINE CERVICAL NEOPLASMS; XENOGRAFT;

MUS;

ANIMALS; ANTINEOPLASTIC AGENTS; APOPTOSIS; APOPTOSIS REGULATORY PROTEINS; BCL-2-ASSOCIATED X PROTEIN; CELL LINE, TUMOR; CELL PROLIFERATION; CHALCONE; CHALCONES; COUMARINS; CYTOCHROMES C; FEMALE; G2 PHASE CELL CYCLE CHECKPOINTS; HETEROGRAFTS; HUMANS; M PHASE CELL CYCLE CHECKPOINTS; MEMBRANE POTENTIAL, MITOCHONDRIAL; MICE; MICE, SCID; PROTO-ONCOGENE PROTEINS; PROTO-ONCOGENE PROTEINS C-BCL-2; REACTIVE OXYGEN SPECIES; SIGNAL TRANSDUCTION; UTERINE CERVICAL NEOPLASMS;

EID: 84902383131     PISSN: 13608185     EISSN: 1573675X     Source Type: Journal    
DOI: 10.1007/s10495-014-0975-2     Document Type: Article

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