Thirteen novel VKORC1 mutations associated with oral anticoagulant resistance: Insights into improved patient diagnosis and treatment

Journal of Thrombosis and Haemostasis

Volumn 9, Issue 1, 2011, Pages 109-118

  Watzka, M ^a   Geisen, C ^b   Bevans, C G ^a,c   Sittinger, K ^b   Spohn, G ^b   Rost, S ^d   Seifried, E ^b   Muller C R ^d   Oldenburg, J ^a  

^a UNIVERSITY HOSPITAL BONN   (Germany)

^b University of Ulm   (Germany)

^c MAX PLANCK INSTITUTE OF BIOPHYSICS   (Germany)

^d UNIVERSITY OF WÜRZBURG   (Germany)

Author keywords

Acenocoumarol; Mutation; Phenprocoumon; Resistance; VKORC1; Warfarin

Indexed keywords

ACENOCOUMAROL; AMINO ACID; CYTOCHROME P450 2C9; FLUINDIONE; PHENPROCOUMON; UNCLASSIFIED DRUG; VITAMIN K 2,3 EPOXIDE REDUCTASE COMPLEX SUBUNIT 1; VITAMIN K GROUP; WARFARIN;

ADULT; AGED; AMINO ACID SEQUENCE; AMINO ACID SUBSTITUTION; ANTICOAGULANT THERAPY; ARTICLE; BIOINFORMATICS; CONTROLLED STUDY; DNA POLYMORPHISM; DRUG TARGETING; FEMALE; GENE MUTATION; GENETIC ASSOCIATION; HAPLOTYPE; HUMAN; INTERNATIONAL NORMALIZED RATIO; INTROSPECTION; MAJOR CLINICAL STUDY; MALE; MOLECULARLY TARGETED THERAPY; PHENOTYPE; PRESCRIPTION; PRIORITY JOURNAL; WILD TYPE;

ADMINISTRATION, ORAL; ADULT; AGED; AMINO ACID SEQUENCE; ANTICOAGULANTS; ARYL HYDROCARBON HYDROXYLASES; BLOOD COAGULATION; COMPUTATIONAL BIOLOGY; COUMARINS; DNA MUTATIONAL ANALYSIS; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG RESISTANCE; FEMALE; GENOTYPE; HAPLOTYPES; HETEROZYGOTE; HUMANS; INTERNATIONAL NORMALIZED RATIO; MALE; MIDDLE AGED; MIXED FUNCTION OXYGENASES; MOLECULAR SEQUENCE DATA; MUTATION, MISSENSE; PHENOTYPE; POLYMORPHISM, GENETIC; RETROSPECTIVE STUDIES;

EID: 78650962974     PISSN: 15387933     EISSN: 15387836     Source Type: Journal    
DOI: 10.1111/j.1538-7836.2010.04095.x     Document Type: Article

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