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Volumn 20, Issue 18, 2012, Pages 5537-5549

Structure-anti-leukemic activity relationship study of ortho- dihydroxycoumarins in U-937 cells: Key role of the δ-lactone ring in determining differentiation-inducing potency and selective pro-apoptotic action

(13) Vázquez, Ramiro a,b Riveiro, María E a Vermeulen, Mónica c Alonso, Eliana b Mondillo, Carolina a Facorro, Graciela b Piehl, Lidia b Gómez, Natalia b Moglioni, Albertina b Fernández, Natalia b Baldi, Alberto a Shayo, Carina a Davio, Carlos b

a INST DE BIOL Y MED EXPERIMENTAL (Argentina)

b UNIVERSIDAD DE BUENOS AIRES (Argentina)

c INST DE INVEST HEMATOLOGICAS (Argentina)

Author keywords

Apoptosis; Catechol; Coumarins; Differentiating activity; Leukemia; Selective cytotoxicity

Indexed keywords

1,2 PYRONE; 2 DIHYDROXYCOUMARIN; 3 PHENYLBUTYRIC ACID; 3,4 DIMETHOXY HYDROCINNAMIC ACID; 3,4 DIMETHOXYCINNAMIC ACID; 4 HYDROXY 6 METHYL 1,2 PYRONE; 4 METHOXY 6 METHYL 1,2 PYRONE; 4 METHYLESCULETIN; 4,6 DIMETHYL 1,2 PYRONE; 5,7 DIHYDROXY 4 METHYLCOUMARIN; 6 CHLORO 7 HYDROXY 4 METHYLCOUMARIN; 6 HYDROXY 4 METHYLCOUMARIN; 6 METHOXY 7,8 DIHYDROXY 4 METHYLCOUMARIN; 7 AMINE 4 METHYLCOUMARIN; 7 HYDROXY 4 METHYLQUINOLONE; 7 HYDROXY 8 ACETYL 4 METHYLCOUMARIN; 7,8 DIHYDROXY 4 METHYLCOUMARIN; CAFFEIC ACID; CASPASE 3; COUMARIN DERIVATIVE; DIHYDROCAFFEIC ACID; ESCULETIN; ISOSCOPOLETIN; PARA COUMARIC ACID; SCOPARONE; UNCLASSIFIED DRUG;

ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; CELL CYCLE ARREST; CELL DIFFERENTIATION; CELL PROLIFERATION; CELL VIABILITY; CLONOGENIC ASSAY; CONTROLLED STUDY; DRUG CYTOTOXICITY; DRUG DESIGN; DRUG POTENCY; DRUG STRUCTURE; ENZYME ACTIVATION; HUMAN; HUMAN CELL; IC 50; LEUKEMIA CELL LINE; STRUCTURE ACTIVITY RELATION;

4-HYDROXYCOUMARINS; APOPTOSIS; CELL CYCLE; CELL DIFFERENTIATION; CELL PROLIFERATION; CELLS, CULTURED; CINNAMATES; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG EVALUATION, PRECLINICAL; HUMANS; JURKAT CELLS; LACTONES; LEUKOCYTES, MONONUCLEAR; PYRONES; STRUCTURE-ACTIVITY RELATIONSHIP; U937 CELLS;

EID: 84866242432 PISSN: 09680896 EISSN: 14643391 Source Type: Journal
DOI: 10.1016/j.bmc.2012.07.043 Document Type: Article

Times cited : (31)

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