Anticancer activity of new coumarin substituted hydrazide-hydrazone derivatives

European Journal of Medicinal Chemistry

Volumn 76, Issue , 2014, Pages 539-548

  Nasr, Tamer ^a   Bondock, Samir ^b,c   Youns, Mahmoud ^a  

^a Ein Helwan   (Egypt)

^b Mansoura University   (Egypt)

^c KING KHALID UNIVERSITY   (Saudi Arabia)

Author keywords

Antiproliferative; Apoptosis; Caspases 3 7; Coumarin; Hydrazide hydrazone; Microarray

Indexed keywords

2 OXO N' [(THIOPHEN 2 YL)METHYLENE] 2H CHROMENE 3 CARBOHYDRAZIDE; 6 BROMO 2 OXO N' (2 OXOINDOLIN 3 YLIDENE) 2H CHROMENE 3 CARBOHYDRAZINE; 6 BROMO 2 OXO N' [(THIOPHEN 2 YL)METHYLENE] 2H CHROMENE 3 CARBOHYDRAZIDE; 6 BROMO N' [(FURAN 2 YL)METHYLENE] 2 OXO 2H CHROMENE 3 CARBOHYDRAZIDE; 6 NITRO 2 OXO N' (2 OXOINDOLIN 3 YLIDENE) 2H CHROMENE 3 CARBOHYDRAZINE; 6 NITRO 2 OXO N' [(THIOPHEN 2 YL)METHYLENE] 2H CHROMENE 3 CARBOHYDRAZIDE; 7 HYDROXY 2 OXO N' [(THIOPHEN 2 YL)METHYLENE] 2H CHROMENE 3 CARBOHYDRAZIDE; ANTINEOPLASTIC AGENT; CELL CYCLE PROTEIN 20; COUMARIN DERIVATIVE; CYCLIN DEPENDENT KINASE 1; CYCLIN DEPENDENT KINASE 2; CYCLIN DEPENDENT KINASE INHIBITOR 1A; DNA DAMAGE INDUCIBLE TRANSCRIPT 4 PROTEIN; DOXORUBICIN; GROWTH DIFFERENTIATION FACTOR 15; HYDRAZIDE DERIVATIVE; HYDRAZONE DERIVATIVE; N' [(1H PYRROL 2 YL)METHYLENE] 2 OXO 2H CHROMENE 3 CARBOHYDRAZIDE; N' [(1H PYRROL 2 YL)METHYLENE] 6 BROMO 2 OXO 2H CHROMENE 3 CARBOHYDRAZIDE; N' [(1H PYRROL 2 YL)METHYLENE] 6 NITRO 2 OXO 2H CHROMENE 3 CARBOHYDRAZIDE; N' [(1H PYRROL 2 YL)METHYLENE] 7 HYDROXY 2 OXO 2H CHROMENE 3 CARBOHYDRAZIDE; N' [(FURAN 2 YL)METHYLENE] 2 OXO 2H CHROMENE 3 CARBOHYDRAZIDE; N' [(FURAN 2 YL)METHYLENE] 6 NITRO 2 OXO 2H CHROMENE 3 CARBOHYDRAZIDE; N' [(FURAN 2 YL)METHYLENE] 7 HYDROXY 2 OXO 2H CHROMENE 3 CARBOHYDRAZIDE; TRANSCRIPTION FACTOR; UNCLASSIFIED DRUG; CASPASE 3; CASPASE 7; COUMARIN;

ANTINEOPLASTIC ACTIVITY; ANTIPROLIFERATIVE ACTIVITY; APOPTOSIS; ARTICLE; CONTROLLED STUDY; DOWN REGULATION; DRUG CYTOTOXICITY; DRUG POTENCY; DRUG SCREENING; G2 PHASE CELL CYCLE CHECKPOINT; HUMAN; HUMAN CELL; IC 50; MICROARRAY ANALYSIS; PROTEIN EXPRESSION; STRUCTURE ACTIVITY RELATION; UPREGULATION; CHEMISTRY; MASS SPECTROMETRY; METABOLISM; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; TUMOR CELL LINE;

ANTINEOPLASTIC AGENTS; CASPASE 3; CASPASE 7; CELL LINE, TUMOR; COUMARINS; DRUG SCREENING ASSAYS, ANTITUMOR; HUMANS; HYDRAZONES; MAGNETIC RESONANCE SPECTROSCOPY; MASS SPECTROMETRY;

EID: 84897544142     PISSN: 02235234     EISSN: 17683254     Source Type: Journal    
DOI: 10.1016/j.ejmech.2014.02.026     Document Type: Article

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