Induction of ROS-independent JNK-activation-mediated apoptosis by a novel coumarin-derivative, DMAC, in human colon cancer cells

Chemico-Biological Interactions

Volumn 218, Issue , 2014, Pages 42-49

  Lin, Mei Hsiang ^a   Cheng, Chia Hsiung ^b,c   Chen, Ku Chung ^b,c   Lee, Wai Theng ^c   Wang, Yen Fang ^c   Xiao, Cai Qin ^c   Lin, Cheng Wei ^b,c  

^a TAIPEI MEDICAL UNIVERSITY   (Taiwan)

^b TAIPEI MEDICAL UNIVERSITY   (Taiwan)

^c TAIPEI MEDICAL UNIVERSITY   (Taiwan)

Author keywords

Apoptosis; Coumarin; MAPK; Reactive oxygen species

Indexed keywords

5,7 DIHYDROXY 4 METHYL 6 (3 METHYLBUTANOYL)COUMARIN; ACETYLCYSTEINE; ANTHRA[1,9 CD]PYRAZOL 6(2H) ONE; ANTINEOPLASTIC AGENT; CASPASE 3; COUMARIN DERIVATIVE; DIPHENYLIODONIUM SALT; FLUOROURACIL; IRINOTECAN; LIPOCORTIN 5; MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE P38; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE; OCHROCARPIN B; PROTEIN BAK; PROTEIN BCL XL; PROTEIN MCL 1; REACTIVE OXYGEN METABOLITE; STRESS ACTIVATED PROTEIN KINASE; UNCLASSIFIED DRUG;

ALKYLATION; ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; CANCER CHEMOTHERAPY; CARCINOMA CELL; CHROMATIN CONDENSATION; COLORECTAL CARCINOMA; CONTROLLED STUDY; DRUG EFFICACY; DRUG MECHANISM; DRUG POTENTIATION; DRUG STRUCTURE; ENZYME ACTIVATION; ENZYME PHOSPHORYLATION; HUMAN; HUMAN CELL; PROTEIN CLEAVAGE; PROTEIN DEGRADATION; PROTEIN EXPRESSION; STRUCTURE ACTIVITY RELATION;

APOPTOSIS; COUMARIN; MAPK; REACTIVE OXYGEN SPECIES;

ANTINEOPLASTIC AGENTS; APOPTOSIS; ARSENICALS; BLOTTING, WESTERN; CELL LINE, TUMOR; COLONIC NEOPLASMS; COUMARINS; CYSTEINE; ENZYME ACTIVATION; HUMANS; JNK MITOGEN-ACTIVATED PROTEIN KINASES; MOLECULAR STRUCTURE; REACTIVE OXYGEN SPECIES;

EID: 84901258269     PISSN: 00092797     EISSN: 18727786     Source Type: Journal    
DOI: 10.1016/j.cbi.2014.04.015     Document Type: Article

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