메뉴 건너뛰기




Volumn 7, Issue 1, 2015, Pages

Restoration of mesenchymal retinal pigmented epithelial cells by TGFβ pathway inhibitors: Implications for age-related macular degeneration

Author keywords

[No Author keywords available]

Indexed keywords

TRANSFORMING GROWTH FACTOR BETA; TRANSFORMING GROWTH FACTOR BETA1; TRANSFORMING GROWTH FACTOR BETA2;

EID: 84935432115     PISSN: None     EISSN: 1756994X     Source Type: Journal    
DOI: 10.1186/s13073-015-0183-x     Document Type: Article
Times cited : (92)

References (148)
  • 1
    • 80054019114 scopus 로고    scopus 로고
    • Wound repair: toward understanding and integration of single-cell and multicellular wound responses
    • Sonnemann KJ, Bement WM. Wound repair: toward understanding and integration of single-cell and multicellular wound responses. Annu Rev Cell Dev Biol. 2011;27:237-63.
    • (2011) Annu Rev Cell Dev Biol , vol.27 , pp. 237-263
    • Sonnemann, K.J.1    Bement, W.M.2
  • 2
    • 33847020833 scopus 로고    scopus 로고
    • Inflammation in wound repair: molecular and cellular mechanisms
    • Eming SA, Krieg T, Davidson JM. Inflammation in wound repair: molecular and cellular mechanisms. J Invest Dermatol. 2007;127:514-25.
    • (2007) J Invest Dermatol , vol.127 , pp. 514-525
    • Eming, S.A.1    Krieg, T.2    Davidson, J.M.3
  • 3
    • 79960381007 scopus 로고    scopus 로고
    • Integrating mechanisms of pulmonary fibrosis
    • Wynn TA. Integrating mechanisms of pulmonary fibrosis. J Exp Med. 2011;208:1339-50.
    • (2011) J Exp Med , vol.208 , pp. 1339-1350
    • Wynn, T.A.1
  • 5
    • 33847404037 scopus 로고    scopus 로고
    • Fibrosis and diseases of the eye
    • Friedlander M. Fibrosis and diseases of the eye. J Clin Invest. 2007;117:576-86.
    • (2007) J Clin Invest , vol.117 , pp. 576-586
    • Friedlander, M.1
  • 8
    • 0028934221 scopus 로고
    • An international classification and grading system for age-related maculopathy and age-related macular degeneration. The International ARM Epidemiological Study Group
    • Bird AC, Bressler NM, Bressler SB, Chisholm IH, Coscas G, Davis MD, et al. An international classification and grading system for age-related maculopathy and age-related macular degeneration. The International ARM Epidemiological Study Group. Surv Ophthalmol. 1995;39:367-74.
    • (1995) Surv Ophthalmol , vol.39 , pp. 367-374
    • Bird, A.C.1    Bressler, N.M.2    Bressler, S.B.3    Chisholm, I.H.4    Coscas, G.5    Davis, M.D.6
  • 9
    • 0034759691 scopus 로고    scopus 로고
    • The Age-Related Eye Disease Study system for classifying age-related macular degeneration from stereoscopic color fundus photographs: the Age-Related Eye Disease Study Report Number 6
    • Age-Related Eye Disease Study Research G. The Age-Related Eye Disease Study system for classifying age-related macular degeneration from stereoscopic color fundus photographs: the Age-Related Eye Disease Study Report Number 6. Am J Ophthalmol. 2001;132:668-81.
    • (2001) Am J Ophthalmol , vol.132 , pp. 668-681
  • 11
    • 0034012166 scopus 로고    scopus 로고
    • Drusen associated with aging and age-related macular degeneration contain proteins common to extracellular deposits associated with atherosclerosis, elastosis, amyloidosis, and dense deposit disease
    • Mullins RF, Russell SR, Anderson DH, Hageman GS. Drusen associated with aging and age-related macular degeneration contain proteins common to extracellular deposits associated with atherosclerosis, elastosis, amyloidosis, and dense deposit disease. FASEB J. 2000;14:835-46.
    • (2000) FASEB J , vol.14 , pp. 835-846
    • Mullins, R.F.1    Russell, S.R.2    Anderson, D.H.3    Hageman, G.S.4
  • 14
    • 85027939027 scopus 로고    scopus 로고
    • Systems-level analysis of age-related macular degeneration reveals global biomarkers and phenotype-specific functional networks
    • Newman AM, Gallo NB, Hancox LS, Miller NJ, Radeke CM, Maloney MA, et al. Systems-level analysis of age-related macular degeneration reveals global biomarkers and phenotype-specific functional networks. Genome Med. 2012;4:16.
    • (2012) Genome Med , vol.4 , pp. 16
    • Newman, A.M.1    Gallo, N.B.2    Hancox, L.S.3    Miller, N.J.4    Radeke, C.M.5    Maloney, M.A.6
  • 15
    • 0035789510 scopus 로고    scopus 로고
    • A cell culture medium that supports the differentiation of human retinal pigment epithelium into functionally polarized monolayers
    • Hu J, Bok D. A cell culture medium that supports the differentiation of human retinal pigment epithelium into functionally polarized monolayers. Mol Vis. 2001;7:14-9.
    • (2001) Mol Vis , vol.7 , pp. 14-19
    • Hu, J.1    Bok, D.2
  • 16
    • 77956402413 scopus 로고    scopus 로고
    • Culture of highly differentiated human retinal pigment epithelium for analysis of the polarized uptake, processing, and secretion of retinoids
    • Hu J, Bok D. Culture of highly differentiated human retinal pigment epithelium for analysis of the polarized uptake, processing, and secretion of retinoids. Methods Mol Biol. 2010;652:55-73.
    • (2010) Methods Mol Biol , vol.652 , pp. 55-73
    • Hu, J.1    Bok, D.2
  • 17
    • 33748100271 scopus 로고    scopus 로고
    • Confluent monolayers of cultured human fetal retinal pigment epithelium exhibit morphology and physiology of native tissue
    • Maminishkis A, Chen S, Jalickee S, Banzon T, Shi G, Wang FE, et al. Confluent monolayers of cultured human fetal retinal pigment epithelium exhibit morphology and physiology of native tissue. Invest Ophthalmol Vis Sci. 2006;47:3612-24.
    • (2006) Invest Ophthalmol Vis Sci , vol.47 , pp. 3612-3624
    • Maminishkis, A.1    Chen, S.2    Jalickee, S.3    Banzon, T.4    Shi, G.5    Wang, F.E.6
  • 18
    • 84876996918 scopus 로고    scopus 로고
    • TopHat2: accurate alignment of transcriptomes in the presence of insertions, deletions and gene fusions
    • Kim D, Pertea G, Trapnell C, Pimentel H, Kelley R, Salzberg SL. TopHat2: accurate alignment of transcriptomes in the presence of insertions, deletions and gene fusions. Genome Biol. 2013;14:R36.
    • (2013) Genome Biol , vol.14 , pp. R36
    • Kim, D.1    Pertea, G.2    Trapnell, C.3    Pimentel, H.4    Kelley, R.5    Salzberg, S.L.6
  • 19
    • 77953176036 scopus 로고    scopus 로고
    • A scaling normalization method for differential expression analysis of RNA-seq data
    • Robinson MD, Oshlack A. A scaling normalization method for differential expression analysis of RNA-seq data. Genome Biol. 2010;11:R25.
    • (2010) Genome Biol , vol.11 , pp. R25
    • Robinson, M.D.1    Oshlack, A.2
  • 20
    • 84858041341 scopus 로고    scopus 로고
    • Differential expression analysis of multifactor RNA-Seq experiments with respect to biological variation
    • McCarthy DJ, Chen Y, Smyth GK. Differential expression analysis of multifactor RNA-Seq experiments with respect to biological variation. Nucleic Acids Res. 2012;40:4288-97.
    • (2012) Nucleic Acids Res , vol.40 , pp. 4288-4297
    • McCarthy, D.J.1    Chen, Y.2    Smyth, G.K.3
  • 21
    • 75249087100 scopus 로고    scopus 로고
    • edgeR: a Bioconductor package for differential expression analysis of digital gene expression data
    • Robinson MD, McCarthy DJ, Smyth GK. edgeR: a Bioconductor package for differential expression analysis of digital gene expression data. Bioinformatics. 2010;26:139-40.
    • (2010) Bioinformatics , vol.26 , pp. 139-140
    • Robinson, M.D.1    McCarthy, D.J.2    Smyth, G.K.3
  • 22
    • 77952311570 scopus 로고    scopus 로고
    • AutoSOME: a clustering method for identifying gene expression modules without prior knowledge of cluster number
    • Newman AM, Cooper JB. AutoSOME: a clustering method for identifying gene expression modules without prior knowledge of cluster number. BMC Bioinformatics. 2010;11:117.
    • (2010) BMC Bioinformatics , vol.11 , pp. 117
    • Newman, A.M.1    Cooper, J.B.2
  • 23
    • 58549112996 scopus 로고    scopus 로고
    • Bioinformatics enrichment tools: paths toward the comprehensive functional analysis of large gene lists
    • da Huang W, Sherman BT, Lempicki RA. Bioinformatics enrichment tools: paths toward the comprehensive functional analysis of large gene lists. Nucleic Acids Res. 2009;37:1-13.
    • (2009) Nucleic Acids Res , vol.37 , pp. 1-13
    • Huang, W.1    Sherman, B.T.2    Lempicki, R.A.3
  • 24
    • 61449172037 scopus 로고    scopus 로고
    • Systematic and integrative analysis of large gene lists using DAVID bioinformatics resources
    • da Huang W, Sherman BT, Lempicki RA. Systematic and integrative analysis of large gene lists using DAVID bioinformatics resources. Nat Protoc. 2009;4:44-57.
    • (2009) Nat Protoc , vol.4 , pp. 44-57
    • Huang, W.1    Sherman, B.T.2    Lempicki, R.A.3
  • 25
  • 28
    • 0242490780 scopus 로고    scopus 로고
    • Cytoscape: a software environment for integrated models of biomolecular interaction networks
    • Shannon P, Markiel A, Ozier O, Baliga NS, Wang JT, Ramage D, et al. Cytoscape: a software environment for integrated models of biomolecular interaction networks. Genome Res. 2003;13:2498-504.
    • (2003) Genome Res , vol.13 , pp. 2498-2504
    • Shannon, P.1    Markiel, A.2    Ozier, O.3    Baliga, N.S.4    Wang, J.T.5    Ramage, D.6
  • 29
    • 0037129827 scopus 로고    scopus 로고
    • Accurate normalization of real-time quantitative RT-PCR data by geometric averaging of multiple internal control genes
    • RESEARCH0034
    • Vandesompele J, De Preter K, Pattyn F, Poppe B, Van Roy N, De Paepe A, et al. Accurate normalization of real-time quantitative RT-PCR data by geometric averaging of multiple internal control genes. Genome Biol. 2002;3:RESEARCH0034.
    • (2002) Genome Biol , vol.3
    • Vandesompele, J.1    Preter, K.2    Pattyn, F.3    Poppe, B.4    Roy, N.5    Paepe, A.6
  • 30
    • 0028813531 scopus 로고
    • Transdifferentiation of retinal pigment epithelial cells from epithelial to mesenchymal phenotype
    • Grisanti S, Guidry C. Transdifferentiation of retinal pigment epithelial cells from epithelial to mesenchymal phenotype. Invest Ophthalmol Vis Sci. 1995;36:391-405.
    • (1995) Invest Ophthalmol Vis Sci , vol.36 , pp. 391-405
    • Grisanti, S.1    Guidry, C.2
  • 32
    • 29644443725 scopus 로고    scopus 로고
    • The ALK-5 inhibitor A-83-01 inhibits Smad signaling and epithelial-to-mesenchymal transition by transforming growth factor-beta
    • Tojo M, Hamashima Y, Hanyu A, Kajimoto T, Saitoh M, Miyazono K, et al. The ALK-5 inhibitor A-83-01 inhibits Smad signaling and epithelial-to-mesenchymal transition by transforming growth factor-beta. Cancer Sci. 2005;96:791-800.
    • (2005) Cancer Sci , vol.96 , pp. 791-800
    • Tojo, M.1    Hamashima, Y.2    Hanyu, A.3    Kajimoto, T.4    Saitoh, M.5    Miyazono, K.6
  • 33
    • 25444529969 scopus 로고    scopus 로고
    • Identification of receptors and signaling pathways for orphan bone morphogenetic protein/growth differentiation factor ligands based on genomic analyses
    • Mazerbourg S, Sangkuhl K, Luo CW, Sudo S, Klein C, Hsueh AJ. Identification of receptors and signaling pathways for orphan bone morphogenetic protein/growth differentiation factor ligands based on genomic analyses. J Biol Chem. 2005;280:32122-32.
    • (2005) J Biol Chem , vol.280 , pp. 32122-32132
    • Mazerbourg, S.1    Sangkuhl, K.2    Luo, C.W.3    Sudo, S.4    Klein, C.5    Hsueh, A.J.6
  • 35
    • 0029789678 scopus 로고    scopus 로고
    • The p160 RhoA-binding kinase ROK alpha is a member of a kinase family and is involved in the reorganization of the cytoskeleton
    • Leung T, Chen XQ, Manser E, Lim L. The p160 RhoA-binding kinase ROK alpha is a member of a kinase family and is involved in the reorganization of the cytoskeleton. Mol Cell Biol. 1996;16:5313-27.
    • (1996) Mol Cell Biol , vol.16 , pp. 5313-5327
    • Leung, T.1    Chen, X.Q.2    Manser, E.3    Lim, L.4
  • 36
    • 47949090917 scopus 로고    scopus 로고
    • Structure-activity relationship study of bone morphogenetic protein (BMP) signaling inhibitors
    • Cuny GD, Yu PB, Laha JK, Xing X, Liu JF, Lai CS, et al. Structure-activity relationship study of bone morphogenetic protein (BMP) signaling inhibitors. Bioorg Med Chem Lett. 2008;18:4388-92.
    • (2008) Bioorg Med Chem Lett , vol.18 , pp. 4388-4392
    • Cuny, G.D.1    Yu, P.B.2    Laha, J.K.3    Xing, X.4    Liu, J.F.5    Lai, C.S.6
  • 37
    • 80051471864 scopus 로고    scopus 로고
    • The specificities of small molecule inhibitors of the TGFbeta and BMP pathways
    • Vogt J, Traynor R, Sapkota GP. The specificities of small molecule inhibitors of the TGFbeta and BMP pathways. Cell Signal. 2011;23:1831-42.
    • (2011) Cell Signal , vol.23 , pp. 1831-1842
    • Vogt, J.1    Traynor, R.2    Sapkota, G.P.3
  • 39
    • 0025350021 scopus 로고
    • Propagation of fetal human RPE cells: preservation of original culture morphology after serial passage
    • Song MK, Lui GM. Propagation of fetal human RPE cells: preservation of original culture morphology after serial passage. J Cell Physiol. 1990;143:196-203.
    • (1990) J Cell Physiol , vol.143 , pp. 196-203
    • Song, M.K.1    Lui, G.M.2
  • 40
    • 0031572347 scopus 로고    scopus 로고
    • Basic, not acidic fibroblast growth factor stimulates proliferation of cultured human retinal pigment epithelial cells
    • Schwegler JS, Knorz MC, Akkoyun I, Liesenhoff H. Basic, not acidic fibroblast growth factor stimulates proliferation of cultured human retinal pigment epithelial cells. Mol Vis. 1997;3:10.
    • (1997) Mol Vis , vol.3 , pp. 10
    • Schwegler, J.S.1    Knorz, M.C.2    Akkoyun, I.3    Liesenhoff, H.4
  • 41
    • 4143066817 scopus 로고    scopus 로고
    • Identification of 1,5-naphthyridine derivatives as a novel series of potent and selective TGF-beta type I receptor inhibitors
    • Gellibert F, Woolven J, Fouchet MH, Mathews N, Goodland H, Lovegrove V, et al. Identification of 1,5-naphthyridine derivatives as a novel series of potent and selective TGF-beta type I receptor inhibitors. J Med Chem. 2004;47:4494-506.
    • (2004) J Med Chem , vol.47 , pp. 4494-4506
    • Gellibert, F.1    Woolven, J.2    Fouchet, M.H.3    Mathews, N.4    Goodland, H.5    Lovegrove, V.6
  • 42
    • 84880330190 scopus 로고    scopus 로고
    • Sequential introduction of reprogramming factors reveals a time-sensitive requirement for individual factors and a sequential EMT-MET mechanism for optimal reprogramming
    • Liu X, Sun H, Qi J, Wang L, He S, Liu J, et al. Sequential introduction of reprogramming factors reveals a time-sensitive requirement for individual factors and a sequential EMT-MET mechanism for optimal reprogramming. Nat Cell Biol. 2013;15:829-38.
    • (2013) Nat Cell Biol , vol.15 , pp. 829-838
    • Liu, X.1    Sun, H.2    Qi, J.3    Wang, L.4    He, S.5    Liu, J.6
  • 43
    • 70350536767 scopus 로고    scopus 로고
    • A small-molecule inhibitor of Tgf-Beta signaling replaces Sox2 in reprogramming by inducing nanog
    • Ichida JK, Blanchard J, Lam K, Son EY, Chung JE, Egli D, et al. A small-molecule inhibitor of Tgf-Beta signaling replaces Sox2 in reprogramming by inducing nanog. Cell Stem Cell. 2009;5:491-503.
    • (2009) Cell Stem Cell , vol.5 , pp. 491-503
    • Ichida, J.K.1    Blanchard, J.2    Lam, K.3    Son, E.Y.4    Chung, J.E.5    Egli, D.6
  • 44
    • 0036082554 scopus 로고    scopus 로고
    • Inhibition of transforming growth factor (TGF)-beta1-induced extracellular matrix with a novel inhibitor of the TGF-beta type I receptor kinase activity: SB-431542
    • Laping NJ, Grygielko E, Mathur A, Butter S, Bomberger J, Tweed C, et al. Inhibition of transforming growth factor (TGF)-beta1-induced extracellular matrix with a novel inhibitor of the TGF-beta type I receptor kinase activity: SB-431542. Mol Pharmacol. 2002;62:58-64.
    • (2002) Mol Pharmacol , vol.62 , pp. 58-64
    • Laping, N.J.1    Grygielko, E.2    Mathur, A.3    Butter, S.4    Bomberger, J.5    Tweed, C.6
  • 45
    • 0036085920 scopus 로고    scopus 로고
    • SB-431542 is a potent and specific inhibitor of transforming growth factor-beta superfamily type I activin receptor-like kinase (ALK) receptors ALK4, ALK5, and ALK7
    • Inman GJ, Nicolas FJ, Callahan JF, Harling JD, Gaster LM, Reith AD, et al. SB-431542 is a potent and specific inhibitor of transforming growth factor-beta superfamily type I activin receptor-like kinase (ALK) receptors ALK4, ALK5, and ALK7. Mol Pharmacol. 2002;62:65-74.
    • (2002) Mol Pharmacol , vol.62 , pp. 65-74
    • Inman, G.J.1    Nicolas, F.J.2    Callahan, J.F.3    Harling, J.D.4    Gaster, L.M.5    Reith, A.D.6
  • 46
    • 0027305971 scopus 로고
    • Thrombospondin causes activation of latent transforming growth factor-beta secreted by endothelial cells by a novel mechanism
    • Schultz-Cherry S, Murphy-Ullrich JE. Thrombospondin causes activation of latent transforming growth factor-beta secreted by endothelial cells by a novel mechanism. J Cell Biol. 1993;122:923-32.
    • (1993) J Cell Biol , vol.122 , pp. 923-932
    • Schultz-Cherry, S.1    Murphy-Ullrich, J.E.2
  • 47
    • 0027967771 scopus 로고
    • Thrombospondin binds and activates the small and large forms of latent transforming growth factor-beta in a chemically defined system
    • Schultz-Cherry S, Ribeiro S, Gentry L, Murphy-Ullrich JE. Thrombospondin binds and activates the small and large forms of latent transforming growth factor-beta in a chemically defined system. J Biol Chem. 1994;269:26775-82.
    • (1994) J Biol Chem , vol.269 , pp. 26775-26782
    • Schultz-Cherry, S.1    Ribeiro, S.2    Gentry, L.3    Murphy-Ullrich, J.E.4
  • 48
    • 84857788858 scopus 로고    scopus 로고
    • Thrombospondin1 in tissue repair and fibrosis: TGF-beta-dependent and independent mechanisms
    • Sweetwyne MT, Murphy-Ullrich JE. Thrombospondin1 in tissue repair and fibrosis: TGF-beta-dependent and independent mechanisms. Matrix Biol. 2012;31:178-86.
    • (2012) Matrix Biol , vol.31 , pp. 178-186
    • Sweetwyne, M.T.1    Murphy-Ullrich, J.E.2
  • 49
    • 0032794692 scopus 로고    scopus 로고
    • Role and interaction of connective tissue growth factor with transforming growth factor-beta in persistent fibrosis: a mouse fibrosis model
    • Mori T, Kawara S, Shinozaki M, Hayashi N, Kakinuma T, Igarashi A, et al. Role and interaction of connective tissue growth factor with transforming growth factor-beta in persistent fibrosis: a mouse fibrosis model. J Cell Physiol. 1999;181:153-9.
    • (1999) J Cell Physiol , vol.181 , pp. 153-159
    • Mori, T.1    Kawara, S.2    Shinozaki, M.3    Hayashi, N.4    Kakinuma, T.5    Igarashi, A.6
  • 50
    • 59649107705 scopus 로고    scopus 로고
    • Functions and mechanisms of action of CCN matricellular proteins
    • Chen CC, Lau LF. Functions and mechanisms of action of CCN matricellular proteins. Int J Biochem Cell Biol. 2009;41:771-83.
    • (2009) Int J Biochem Cell Biol , vol.41 , pp. 771-783
    • Chen, C.C.1    Lau, L.F.2
  • 51
    • 84864796944 scopus 로고    scopus 로고
    • Decorin-TGFbeta axis in hepatic fibrosis and cirrhosis
    • Baghy K, Iozzo RV, Kovalszky I. Decorin-TGFbeta axis in hepatic fibrosis and cirrhosis. J Histochem Cytochem. 2012;60:262-8.
    • (2012) J Histochem Cytochem , vol.60 , pp. 262-268
    • Baghy, K.1    Iozzo, R.V.2    Kovalszky, I.3
  • 52
    • 0025353729 scopus 로고
    • Negative regulation of transforming growth factor-beta by the proteoglycan decorin
    • Yamaguchi Y, Mann DM, Ruoslahti E. Negative regulation of transforming growth factor-beta by the proteoglycan decorin. Nature. 1990;346:281-4.
    • (1990) Nature , vol.346 , pp. 281-284
    • Yamaguchi, Y.1    Mann, D.M.2    Ruoslahti, E.3
  • 53
    • 0028600614 scopus 로고
    • Bone matrix decorin binds transforming growth factor-beta and enhances its bioactivity
    • Takeuchi Y, Kodama Y, Matsumoto T. Bone matrix decorin binds transforming growth factor-beta and enhances its bioactivity. J Biol Chem. 1994;269:32634-8.
    • (1994) J Biol Chem , vol.269 , pp. 32634-32638
    • Takeuchi, Y.1    Kodama, Y.2    Matsumoto, T.3
  • 54
    • 0035793550 scopus 로고    scopus 로고
    • Antisense inhibition of decorin expression in myoblasts decreases cell responsiveness to transforming growth factor beta and accelerates skeletal muscle differentiation
    • Riquelme C, Larrain J, Schonherr E, Henriquez JP, Kresse H, Brandan E. Antisense inhibition of decorin expression in myoblasts decreases cell responsiveness to transforming growth factor beta and accelerates skeletal muscle differentiation. J Biol Chem. 2001;276:3589-96.
    • (2001) J Biol Chem , vol.276 , pp. 3589-3596
    • Riquelme, C.1    Larrain, J.2    Schonherr, E.3    Henriquez, J.P.4    Kresse, H.5    Brandan, E.6
  • 55
    • 34547131835 scopus 로고    scopus 로고
    • A novel modulatory mechanism of transforming growth factor-beta signaling through decorin and LRP-1
    • Cabello-Verrugio C, Brandan E. A novel modulatory mechanism of transforming growth factor-beta signaling through decorin and LRP-1. J Biol Chem. 2007;282:18842-50.
    • (2007) J Biol Chem , vol.282 , pp. 18842-18850
    • Cabello-Verrugio, C.1    Brandan, E.2
  • 56
    • 84887838450 scopus 로고    scopus 로고
    • Altered gene expression in dry age-related macular degeneration suggests early loss of choroidal endothelial cells
    • Whitmore SS, Braun TA, Skeie JM, Haas CM, Sohn EH, Stone EM, et al. Altered gene expression in dry age-related macular degeneration suggests early loss of choroidal endothelial cells. Mol Vis. 2013;19:2274-97.
    • (2013) Mol Vis , vol.19 , pp. 2274-2297
    • Whitmore, S.S.1    Braun, T.A.2    Skeie, J.M.3    Haas, C.M.4    Sohn, E.H.5    Stone, E.M.6
  • 58
    • 84862939642 scopus 로고    scopus 로고
    • High temperature requirement factor A1 (HTRA1) gene regulates angiogenesis through transforming growth factor-beta family member growth differentiation factor 6
    • Zhang L, Lim SL, Du H, Zhang M, Kozak I, Hannum G, et al. High temperature requirement factor A1 (HTRA1) gene regulates angiogenesis through transforming growth factor-beta family member growth differentiation factor 6. J Biol Chem. 2012;287:1520-6.
    • (2012) J Biol Chem , vol.287 , pp. 1520-1526
    • Zhang, L.1    Lim, S.L.2    Du, H.3    Zhang, M.4    Kozak, I.5    Hannum, G.6
  • 60
    • 80053385445 scopus 로고    scopus 로고
    • Genome-wide association study identifies two susceptibility loci for exudative age-related macular degeneration in the Japanese population
    • Arakawa S, Takahashi A, Ashikawa K, Hosono N, Aoi T, Yasuda M, et al. Genome-wide association study identifies two susceptibility loci for exudative age-related macular degeneration in the Japanese population. Nat Genet. 2011;43:1001-4.
    • (2011) Nat Genet , vol.43 , pp. 1001-1004
    • Arakawa, S.1    Takahashi, A.2    Ashikawa, K.3    Hosono, N.4    Aoi, T.5    Yasuda, M.6
  • 62
    • 84894419138 scopus 로고    scopus 로고
    • TNFRSF10A-LOC389641 rs13278062 but not REST-C4orf14-POLR2B-IGFBP7 rs1713985 was found associated with age-related macular degeneration in a Chinese population
    • Sun Y, Li S, Li H, Yang F, Bai Y, Zhao M, et al. TNFRSF10A-LOC389641 rs13278062 but not REST-C4orf14-POLR2B-IGFBP7 rs1713985 was found associated with age-related macular degeneration in a Chinese population. Invest Ophthalmol Vis Sci. 2013;54:8199-203.
    • (2013) Invest Ophthalmol Vis Sci , vol.54 , pp. 8199-8203
    • Sun, Y.1    Li, S.2    Li, H.3    Yang, F.4    Bai, Y.5    Zhao, M.6
  • 64
    • 27744462212 scopus 로고    scopus 로고
    • Hypothetical LOC387715 is a second major susceptibility gene for age-related macular degeneration, contributing independently of complement factor H to disease risk
    • Rivera A, Fisher SA, Fritsche LG, Keilhauer CN, Lichtner P, Meitinger T, et al. Hypothetical LOC387715 is a second major susceptibility gene for age-related macular degeneration, contributing independently of complement factor H to disease risk. Hum Mol Genet. 2005;14:3227-36.
    • (2005) Hum Mol Genet , vol.14 , pp. 3227-3236
    • Rivera, A.1    Fisher, S.A.2    Fritsche, L.G.3    Keilhauer, C.N.4    Lichtner, P.5    Meitinger, T.6
  • 65
    • 33751011889 scopus 로고    scopus 로고
    • HTRA1 promoter polymorphism in wet age-related macular degeneration
    • Dewan A, Liu M, Hartman S, Zhang SS, Liu DT, Zhao C, et al. HTRA1 promoter polymorphism in wet age-related macular degeneration. Science. 2006;314:989-92.
    • (2006) Science , vol.314 , pp. 989-992
    • Dewan, A.1    Liu, M.2    Hartman, S.3    Zhang, S.S.4    Liu, D.T.5    Zhao, C.6
  • 66
  • 67
    • 20244388812 scopus 로고    scopus 로고
    • Complement factor H variant increases the risk of age-related macular degeneration
    • Haines JL, Hauser MA, Schmidt S, Scott WK, Olson LM, Gallins P, et al. Complement factor H variant increases the risk of age-related macular degeneration. Science. 2005;308:419-21.
    • (2005) Science , vol.308 , pp. 419-421
    • Haines, J.L.1    Hauser, M.A.2    Schmidt, S.3    Scott, W.K.4    Olson, L.M.5    Gallins, P.6
  • 69
    • 21044453724 scopus 로고    scopus 로고
    • A common haplotype in the complement regulatory gene factor H (HF1/CFH) predisposes individuals to age-related macular degeneration
    • Hageman GS, Anderson DH, Johnson LV, Hancox LS, Taiber AJ, Hardisty LI, et al. A common haplotype in the complement regulatory gene factor H (HF1/CFH) predisposes individuals to age-related macular degeneration. Proc Natl Acad Sci U S A. 2005;102:7227-32.
    • (2005) Proc Natl Acad Sci U S A , vol.102 , pp. 7227-7232
    • Hageman, G.S.1    Anderson, D.H.2    Johnson, L.V.3    Hancox, L.S.4    Taiber, A.J.5    Hardisty, L.I6
  • 70
    • 77952120581 scopus 로고    scopus 로고
    • Genome-wide association study of advanced age-related macular degeneration identifies a role of the hepatic lipase gene (LIPC)
    • Neale BM, Fagerness J, Reynolds R, Sobrin L, Parker M, Raychaudhuri S, et al. Genome-wide association study of advanced age-related macular degeneration identifies a role of the hepatic lipase gene (LIPC). Proc Natl Acad Sci U S A. 2010;107:7395-400.
    • (2010) Proc Natl Acad Sci U S A , vol.107 , pp. 7395-7400
    • Neale, B.M.1    Fagerness, J.2    Reynolds, R.3    Sobrin, L.4    Parker, M.5    Raychaudhuri, S.6
  • 71
    • 80052196120 scopus 로고    scopus 로고
    • Common variants near FRK/COL10A1 and VEGFA are associated with advanced age-related macular degeneration
    • Yu Y, Bhangale TR, Fagerness J, Ripke S, Thorleifsson G, Tan PL, et al. Common variants near FRK/COL10A1 and VEGFA are associated with advanced age-related macular degeneration. Hum Mol Genet. 2011;20:3699-709.
    • (2011) Hum Mol Genet , vol.20 , pp. 3699-3709
    • Yu, Y.1    Bhangale, T.R.2    Fagerness, J.3    Ripke, S.4    Thorleifsson, G.5    Tan, P.L.6
  • 72
    • 33644843900 scopus 로고    scopus 로고
    • Functional candidate genes in age-related macular degeneration: significant association with VEGF, VLDLR, and LRP6
    • Haines JL, Schnetz-Boutaud N, Schmidt S, Scott WK, Agarwal A, Postel EA, et al. Functional candidate genes in age-related macular degeneration: significant association with VEGF, VLDLR, and LRP6. Invest Ophthalmol Vis Sci. 2006;47:329-35.
    • (2006) Invest Ophthalmol Vis Sci , vol.47 , pp. 329-335
    • Haines, J.L.1    Schnetz-Boutaud, N.2    Schmidt, S.3    Scott, W.K.4    Agarwal, A.5    Postel, E.6
  • 73
    • 33645538395 scopus 로고    scopus 로고
    • Glutathione S-transferase M1, T1, and P1 gene polymorphism in exudative age-related macular degeneration: a preliminary report
    • Oz O, Aras Ates N, Tamer L, Yildirim O, Adiguzel U. Glutathione S-transferase M1, T1, and P1 gene polymorphism in exudative age-related macular degeneration: a preliminary report. Eur J Ophthalmol. 2006;16:105-10.
    • (2006) Eur J Ophthalmol , vol.16 , pp. 105-110
    • Oz, O.1    Aras Ates, N.2    Tamer, L.3    Yildirim, O.4    Adiguzel, U.5
  • 74
    • 78650868796 scopus 로고    scopus 로고
    • Glutathione S-transferase M1, GSTT1 and GSTP1 genetic polymorphisms and the risk of age-related macular degeneration
    • Guven M, Gorgun E, Unal M, Yenerel M, Batar B, Kucumen B, et al. Glutathione S-transferase M1, GSTT1 and GSTP1 genetic polymorphisms and the risk of age-related macular degeneration. Ophthalmic Res. 2011;46:31-7.
    • (2011) Ophthalmic Res , vol.46 , pp. 31-37
    • Guven, M.1    Gorgun, E.2    Unal, M.3    Yenerel, M.4    Batar, B.5    Kucumen, B.6
  • 75
    • 84866930501 scopus 로고    scopus 로고
    • Association of glutathione S-transferase pi isoform single-nucleotide polymorphisms with exudative age-related macular degeneration in a Chinese population
    • Gu H, Sun E, Cui L, Yang X, Lim A, Xu J, et al. Association of glutathione S-transferase pi isoform single-nucleotide polymorphisms with exudative age-related macular degeneration in a Chinese population. Retina. 2012;32:1967-72.
    • (2012) Retina , vol.32 , pp. 1967-1972
    • Gu, H.1    Sun, E.2    Cui, L.3    Yang, X.4    Lim, A.5    Xu, J.6
  • 76
    • 84893184902 scopus 로고    scopus 로고
    • Genetic evidence for role of carotenoids in age-related macular degeneration in the Carotenoids in Age-Related Eye Disease Study (CAREDS)
    • Meyers KJ, Mares JA, Igo Jr RP, Truitt B, Liu Z, Millen AE, et al. Genetic evidence for role of carotenoids in age-related macular degeneration in the Carotenoids in Age-Related Eye Disease Study (CAREDS). Invest Ophthalmol Vis Sci. 2014;55:587-99.
    • (2014) Invest Ophthalmol Vis Sci , vol.55 , pp. 587-599
    • Meyers, K.J.1    Mares, J.A.2    Igo, R.P.3    Truitt, B.4    Liu, Z.5    Millen, A.E.6
  • 77
    • 80053323728 scopus 로고    scopus 로고
    • Evaluation of serum lipid concentrations and genetic variants at high-density lipoprotein metabolism loci and TIMP3 in age-related macular degeneration
    • Fauser S, Smailhodzic D, Caramoy A, van de Ven JP, Kirchhof B, Hoyng CB, et al. Evaluation of serum lipid concentrations and genetic variants at high-density lipoprotein metabolism loci and TIMP3 in age-related macular degeneration. Invest Ophthalmol Vis Sci. 2011;52:5525-8.
    • (2011) Invest Ophthalmol Vis Sci , vol.52 , pp. 5525-5528
    • Fauser, S.1    Smailhodzic, D.2    Caramoy, A.3    Ven, J.P.4    Kirchhof, B.5    Hoyng, C.6
  • 80
    • 79551560263 scopus 로고    scopus 로고
    • Genetic association study of age-related macular degeneration in the Spanish population
    • Brion M, Sanchez-Salorio M, Corton M, de la Fuente M, Pazos B, Othman M, et al. Genetic association study of age-related macular degeneration in the Spanish population. Acta Ophthalmol. 2011;89:e12-22.
    • (2011) Acta Ophthalmol , vol.89 , pp. e12-e22
    • Brion, M.1    Sanchez-Salorio, M.2    Corton, M.3    Fuente, M.4    Pazos, B.5    Othman, M.6
  • 81
    • 33645419787 scopus 로고    scopus 로고
    • Variation in factor B (BF) and complement component 2 (C2) genes is associated with age-related macular degeneration
    • Gold B, Merriam JE, Zernant J, Hancox LS, Taiber AJ, Gehrs K, et al. Variation in factor B (BF) and complement component 2 (C2) genes is associated with age-related macular degeneration. Nat Genet. 2006;38:458-62.
    • (2006) Nat Genet , vol.38 , pp. 458-462
    • Gold, B.1    Merriam, J.E.2    Zernant, J.3    Hancox, L.S.4    Taiber, A.J.5    Gehrs, K.6
  • 82
    • 33748309136 scopus 로고    scopus 로고
    • Common variation in three genes, including a noncoding variant in CFH, strongly influences risk of age-related macular degeneration
    • Maller J, George S, Purcell S, Fagerness J, Altshuler D, Daly MJ, et al. Common variation in three genes, including a noncoding variant in CFH, strongly influences risk of age-related macular degeneration. Nat Genet. 2006;38:1055-9.
    • (2006) Nat Genet , vol.38 , pp. 1055-1059
    • Maller, J.1    George, S.2    Purcell, S.3    Fagerness, J.4    Altshuler, D.5    Daly, M.J.6
  • 83
    • 84865751901 scopus 로고    scopus 로고
    • Genome-wide association study of age-related macular degeneration identifies associated variants in the TNXB-FKBPL-NOTCH4 region of chromosome 6p21.3
    • Cipriani V, Leung HT, Plagnol V, Bunce C, Khan JC, Shahid H, et al. Genome-wide association study of age-related macular degeneration identifies associated variants in the TNXB-FKBPL-NOTCH4 region of chromosome 6p21.3. Hum Mol Genet. 2012;21:4138-50.
    • (2012) Hum Mol Genet , vol.21 , pp. 4138-4150
    • Cipriani, V.1    Leung, H.2    Plagnol, V.3    Bunce, C.4    Khan, J.C.5    Shahid, H.6
  • 84
    • 70350034035 scopus 로고    scopus 로고
    • rs5888 variant of SCARB1 gene is a possible susceptibility factor for age-related macular degeneration
    • Zerbib J, Seddon JM, Richard F, Reynolds R, Leveziel N, Benlian P, et al. rs5888 variant of SCARB1 gene is a possible susceptibility factor for age-related macular degeneration. PLoS One. 2009;4:e7341.
    • (2009) PLoS One , vol.4 , pp. e7341
    • Zerbib, J.1    Seddon, J.M.2    Richard, F.3    Reynolds, R.4    Leveziel, N.5    Benlian, P.6
  • 85
    • 0032014838 scopus 로고    scopus 로고
    • The epsilon4 allele of the apolipoprotein E gene as a potential protective factor for exudative age-related macular degeneration
    • Souied EH, Benlian P, Amouyel P, Feingold J, Lagarde JP, Munnich A, et al. The epsilon4 allele of the apolipoprotein E gene as a potential protective factor for exudative age-related macular degeneration. Am J Ophthalmol. 1998;125:353-9.
    • (1998) Am J Ophthalmol , vol.125 , pp. 353-359
    • Souied, E.H.1    Benlian, P.2    Amouyel, P.3    Feingold, J.4    Lagarde, J.P.5    Munnich, A.6
  • 87
    • 2442649319 scopus 로고    scopus 로고
    • The epsilon2 and epsilon4 alleles of the apolipoprotein gene are associated with age-related macular degeneration
    • Baird PN, Guida E, Chu DT, Vu HT, Guymer RH. The epsilon2 and epsilon4 alleles of the apolipoprotein gene are associated with age-related macular degeneration. Invest Ophthalmol Vis Sci. 2004;45:1311-5.
    • (2004) Invest Ophthalmol Vis Sci , vol.45 , pp. 1311-1315
    • Baird, P.N.1    Guida, E.2    Chu, D.T.3    Vu, H.T.4    Guymer, R.H.5
  • 88
    • 2442711751 scopus 로고    scopus 로고
    • Association of apolipoprotein E alleles with susceptibility to age-related macular degeneration in a large cohort from a single center
    • Zareparsi S, Reddick AC, Branham KE, Moore KB, Jessup L, Thoms S, et al. Association of apolipoprotein E alleles with susceptibility to age-related macular degeneration in a large cohort from a single center. Invest Ophthalmol Vis Sci. 2004;45:1306-10.
    • (2004) Invest Ophthalmol Vis Sci , vol.45 , pp. 1306-1310
    • Zareparsi, S.1    Reddick, A.C.2    Branham, K.E.3    Moore, K.B.4    Jessup, L.5    Thoms, S.6
  • 89
    • 67649670138 scopus 로고    scopus 로고
    • Age-related macular degeneration and functional promoter and coding variants of the apolipoprotein E gene
    • Fritsche LG, Freitag-Wolf S, Bettecken T, Meitinger T, Keilhauer CN, Krawczak M, et al. Age-related macular degeneration and functional promoter and coding variants of the apolipoprotein E gene. Hum Mutat. 2009;30:1048-53.
    • (2009) Hum Mutat , vol.30 , pp. 1048-1053
    • Fritsche, L.G.1    Freitag-Wolf, S.2    Bettecken, T.3    Meitinger, T.4    Keilhauer, C.N.5    Krawczak, M.6
  • 92
    • 84887080613 scopus 로고    scopus 로고
    • Rare variants in CFI, C3 and C9 are associated with high risk of advanced age-related macular degeneration
    • Seddon JM, Yu Y, Miller EC, Reynolds R, Tan PL, Gowrisankar S, et al. Rare variants in CFI, C3 and C9 are associated with high risk of advanced age-related macular degeneration. Nat Genet. 2013;45:1366-70.
    • (2013) Nat Genet , vol.45 , pp. 1366-1370
    • Seddon, J.M.1    Yu, Y.2    Miller, E.C.3    Reynolds, R.4    Tan, P.L.5    Gowrisankar, S.6
  • 94
  • 95
    • 78649691414 scopus 로고    scopus 로고
    • Genome-wide association identifies SKIV2L and MYRIP as protective factors for age-related macular degeneration
    • Kopplin LJ, Igo Jr RP, Wang Y, Sivakumaran TA, Hagstrom SA, Peachey NS, et al. Genome-wide association identifies SKIV2L and MYRIP as protective factors for age-related macular degeneration. Genes Immun. 2010;11:609-21.
    • (2010) Genes Immun , vol.11 , pp. 609-621
    • Kopplin, L.J.1    Igo, R.P.2    Wang, Y.3    Sivakumaran, T.A.4    Hagstrom, S.A.5    Peachey, N.S.6
  • 96
    • 77952147434 scopus 로고    scopus 로고
    • Genetic variants near TIMP3 and high-density lipoprotein-associated loci influence susceptibility to age-related macular degeneration
    • Chen W, Stambolian D, Edwards AO, Branham KE, Othman M, Jakobsdottir J, et al. Genetic variants near TIMP3 and high-density lipoprotein-associated loci influence susceptibility to age-related macular degeneration. Proc Natl Acad Sci U S A. 2010;107:7401-6.
    • (2010) Proc Natl Acad Sci U S A , vol.107 , pp. 7401-7406
    • Chen, W.1    Stambolian, D.2    Edwards, A.O.3    Branham, K.E.4    Othman, M.5    Jakobsdottir, J.6
  • 97
    • 84892396509 scopus 로고    scopus 로고
    • Association of HDL-related loci with age-related macular degeneration and plasma lutein and zeaxanthin: the Alienor study
    • Merle BM, Maubaret C, Korobelnik JF, Delyfer MN, Rougier MB, Lambert JC, et al. Association of HDL-related loci with age-related macular degeneration and plasma lutein and zeaxanthin: the Alienor study. PLoS One. 2013;8, e79848.
    • (2013) PLoS One , vol.8 , pp. e79848
    • Merle, B.M.1    Maubaret, C.2    Korobelnik, J.F.3    Delyfer, M.N.4    Rougier, M.B.5    Lambert, J.C.6
  • 98
    • 80052302059 scopus 로고    scopus 로고
    • Increased expression of multifunctional serine protease, HTRA1, in retinal pigment epithelium induces polypoidal choroidal vasculopathy in mice
    • Jones A, Kumar S, Zhang N, Tong Z, Yang JH, Watt C, et al. Increased expression of multifunctional serine protease, HTRA1, in retinal pigment epithelium induces polypoidal choroidal vasculopathy in mice. Proc Natl Acad Sci U S A. 2011;108:14578-83.
    • (2011) Proc Natl Acad Sci U S A , vol.108 , pp. 14578-14583
    • Jones, A.1    Kumar, S.2    Zhang, N.3    Tong, Z.4    Yang, J.H.5    Watt, C.6
  • 99
    • 79960983554 scopus 로고    scopus 로고
    • Overexpression of HTRA1 leads to ultrastructural changes in the elastic layer of Bruch's membrane via cleavage of extracellular matrix components
    • Vierkotten S, Muether PS, Fauser S. Overexpression of HTRA1 leads to ultrastructural changes in the elastic layer of Bruch's membrane via cleavage of extracellular matrix components. PLoS One. 2011;6, e22959.
    • (2011) PLoS One , vol.6 , pp. e22959
    • Vierkotten, S.1    Muether, P.S.2    Fauser, S.3
  • 100
  • 101
    • 49949115930 scopus 로고    scopus 로고
    • HtrA1-dependent proteolysis of TGF-beta controls both neuronal maturation and developmental survival
    • Launay S, Maubert E, Lebeurrier N, Tennstaedt A, Campioni M, Docagne F, et al. HtrA1-dependent proteolysis of TGF-beta controls both neuronal maturation and developmental survival. Cell Death Differ. 2008;15:1408-16.
    • (2008) Cell Death Differ , vol.15 , pp. 1408-1416
    • Launay, S.1    Maubert, E.2    Lebeurrier, N.3    Tennstaedt, A.4    Campioni, M.5    Docagne, F.6
  • 102
    • 79954509056 scopus 로고    scopus 로고
    • Cerebral small-vessel disease protein HTRA1 controls the amount of TGF-beta1 via cleavage of proTGF-beta1
    • Shiga A, Nozaki H, Yokoseki A, Nihonmatsu M, Kawata H, Kato T, et al. Cerebral small-vessel disease protein HTRA1 controls the amount of TGF-beta1 via cleavage of proTGF-beta1. Hum Mol Genet. 2011;20:1800-10.
    • (2011) Hum Mol Genet , vol.20 , pp. 1800-1810
    • Shiga, A.1    Nozaki, H.2    Yokoseki, A.3    Nihonmatsu, M.4    Kawata, H.5    Kato, T.6
  • 103
    • 84897494657 scopus 로고    scopus 로고
    • Serine protease HTRA1 antagonizes transforming growth factor-beta signaling by cleaving its receptors and loss of HTRA1 in vivo enhances bone formation
    • Graham JR, Chamberland A, Lin Q, Li XJ, Dai D, Zeng W, et al. Serine protease HTRA1 antagonizes transforming growth factor-beta signaling by cleaving its receptors and loss of HTRA1 in vivo enhances bone formation. PLoS One. 2013;8, e74094.
    • (2013) PLoS One , vol.8 , pp. e74094
    • Graham, J.R.1    Chamberland, A.2    Lin, Q.3    Li, X.J.4    Dai, D.5    Zeng, W.6
  • 104
    • 82255179304 scopus 로고    scopus 로고
    • Eye development genes and known syndromes
    • Slavotinek AM. Eye development genes and known syndromes. Mol Genet Metab. 2011;104:448-56.
    • (2011) Mol Genet Metab , vol.104 , pp. 448-456
    • Slavotinek, A.M.1
  • 105
    • 0033709572 scopus 로고    scopus 로고
    • Extraocular mesenchyme patterns the optic vesicle during early eye development in the embryonic chick
    • Fuhrmann S, Levine EM, Reh TA. Extraocular mesenchyme patterns the optic vesicle during early eye development in the embryonic chick. Development. 2000;127:4599-609.
    • (2000) Development , vol.127 , pp. 4599-4609
    • Fuhrmann, S.1    Levine, E.M.2    Reh, T.A.3
  • 106
    • 70349327681 scopus 로고    scopus 로고
    • Directed differentiation of human embryonic stem cells into functional retinal pigment epithelium cells
    • Idelson M, Alper R, Obolensky A, Ben-Shushan E, Hemo I, Yachimovich-Cohen N, et al. Directed differentiation of human embryonic stem cells into functional retinal pigment epithelium cells. Cell Stem Cell. 2009;5:396-408.
    • (2009) Cell Stem Cell , vol.5 , pp. 396-408
    • Idelson, M.1    Alper, R.2    Obolensky, A.3    Ben-Shushan, E.4    Hemo, I.5    Yachimovich-Cohen, N.6
  • 107
    • 4644356541 scopus 로고    scopus 로고
    • Activin: an important regulator of wound repair, fibrosis, and neuroprotection
    • Sulyok S, Wankell M, Alzheimer C, Werner S. Activin: an important regulator of wound repair, fibrosis, and neuroprotection. Mol Cell Endocrinol. 2004;225:127-32.
    • (2004) Mol Cell Endocrinol , vol.225 , pp. 127-132
    • Sulyok, S.1    Wankell, M.2    Alzheimer, C.3    Werner, S.4
  • 109
    • 0028168242 scopus 로고
    • p15INK4B is a potential effector of TGF-beta-induced cell cycle arrest
    • Hannon GJ, Beach D. p15INK4B is a potential effector of TGF-beta-induced cell cycle arrest. Nature. 1994;371:257-61.
    • (1994) Nature , vol.371 , pp. 257-261
    • Hannon, G.J.1    Beach, D.2
  • 110
    • 0029153609 scopus 로고
    • Kip/Cip and Ink4 Cdk inhibitors cooperate to induce cell cycle arrest in response to TGF-beta
    • Reynisdottir I, Polyak K, Iavarone A, Massague J. Kip/Cip and Ink4 Cdk inhibitors cooperate to induce cell cycle arrest in response to TGF-beta. Genes Dev. 1995;9:1831-45.
    • (1995) Genes Dev , vol.9 , pp. 1831-1845
    • Reynisdottir, I.1    Polyak, K.2    Iavarone, A.3    Massague, J.4
  • 111
    • 0033083517 scopus 로고    scopus 로고
    • Regulation by transforming growth factor-beta 1 of G1 cyclin-dependent kinases in human retinal epithelial cells
    • Pillaire MJ, Casagrande F, Malecaze F, Manenti S, Darbon JM. Regulation by transforming growth factor-beta 1 of G1 cyclin-dependent kinases in human retinal epithelial cells. Exp Eye Res. 1999;68:193-9.
    • (1999) Exp Eye Res , vol.68 , pp. 193-199
    • Pillaire, M.J.1    Casagrande, F.2    Malecaze, F.3    Manenti, S.4    Darbon, J.M.5
  • 112
    • 84880904769 scopus 로고    scopus 로고
    • Rho-associated coiled-coil kinase (ROCK) signaling and disease
    • Schofield AV, Bernard O. Rho-associated coiled-coil kinase (ROCK) signaling and disease. Crit Rev Biochem Mol Biol. 2013;48:301-16.
    • (2013) Crit Rev Biochem Mol Biol , vol.48 , pp. 301-316
    • Schofield, A.V.1    Bernard, O.2
  • 113
    • 84888437392 scopus 로고    scopus 로고
    • Physiological roles of Rho and Rho effectors in mammals
    • Thumkeo D, Watanabe S, Narumiya S. Physiological roles of Rho and Rho effectors in mammals. Eur J Cell Biol. 2013;92:303-15.
    • (2013) Eur J Cell Biol , vol.92 , pp. 303-315
    • Thumkeo, D.1    Watanabe, S.2    Narumiya, S.3
  • 114
    • 84922235747 scopus 로고    scopus 로고
    • Rho-associated coiled-coil containing kinases (ROCK): Structure, regulation, and functions
    • Julian L, Olson MF. Rho-associated coiled-coil containing kinases (ROCK): Structure, regulation, and functions. Small GTPases. 2014;5, e29846.
    • (2014) Small GTPases , vol.5 , pp. e29846
    • Julian, L.1    Olson, M.F.2
  • 115
    • 84880687429 scopus 로고    scopus 로고
    • Rho kinase pathway is likely responsible for the profibrotic actions of aldosterone in renal epithelial cells via inducing epithelial-mesenchymal transition and extracellular matrix excretion
    • Wei J, Li Z, Ma C, Zhan F, Wu W, Han H, et al. Rho kinase pathway is likely responsible for the profibrotic actions of aldosterone in renal epithelial cells via inducing epithelial-mesenchymal transition and extracellular matrix excretion. Cell Biol Int. 2013;37:725-30.
    • (2013) Cell Biol Int , vol.37 , pp. 725-730
    • Wei, J.1    Li, Z.2    Ma, C.3    Zhan, F.4    Wu, W.5    Han, H.6
  • 116
    • 84879339562 scopus 로고    scopus 로고
    • TGF-beta1 induces the dissolution of tight junctions in human renal proximal tubular cells: role of the RhoA/ROCK signaling pathway
    • Zhang K, Zhang H, Xiang H, Liu J, Liu Y, Zhang X, et al. TGF-beta1 induces the dissolution of tight junctions in human renal proximal tubular cells: role of the RhoA/ROCK signaling pathway. Int J Mol Med. 2013;32:464-8.
    • (2013) Int J Mol Med , vol.32 , pp. 464-468
    • Zhang, K.1    Zhang, H.2    Xiang, H.3    Liu, J.4    Liu, Y.5    Zhang, X.6
  • 117
    • 26244460316 scopus 로고    scopus 로고
    • RhoGTPase activation is a key step in renal epithelial mesenchymal transdifferentiation
    • Patel S, Takagi KI, Suzuki J, Imaizumi A, Kimura T, Mason RM, et al. RhoGTPase activation is a key step in renal epithelial mesenchymal transdifferentiation. J Am Soc Nephrol. 2005;16:1977-84.
    • (2005) J Am Soc Nephrol , vol.16 , pp. 1977-1984
    • Patel, S.1    Takagi, K.I.2    Suzuki, J.3    Imaizumi, A.4    Kimura, T.5    Mason, R.M.6
  • 118
    • 84857995001 scopus 로고    scopus 로고
    • Inhibition of actin dynamics during epithelial-to-mesenchymal transition
    • Schneider D, Janshoff A. Inhibition of actin dynamics during epithelial-to-mesenchymal transition. Biochem Biophys Res Commun. 2012;419:221-5.
    • (2012) Biochem Biophys Res Commun , vol.419 , pp. 221-225
    • Schneider, D.1    Janshoff, A.2
  • 119
    • 0942298142 scopus 로고    scopus 로고
    • Involvement of rho-kinase pathway in contractile activity of rabbit RPE cells in vivo and in vitro
    • Zheng Y, Bando H, Ikuno Y, Oshima Y, Sawa M, Ohji M, et al. Involvement of rho-kinase pathway in contractile activity of rabbit RPE cells in vivo and in vitro. Invest Ophthalmol Vis Sci. 2004;45:668-74.
    • (2004) Invest Ophthalmol Vis Sci , vol.45 , pp. 668-674
    • Zheng, Y.1    Bando, H.2    Ikuno, Y.3    Oshima, Y.4    Sawa, M.5    Ohji, M.6
  • 120
    • 66749109829 scopus 로고    scopus 로고
    • Molecular mechanisms regulating dissociation of cell-cell junction of epithelial cells by oxidative stress
    • Inumaru J, Nagano O, Takahashi E, Ishimoto T, Nakamura S, Suzuki Y, et al. Molecular mechanisms regulating dissociation of cell-cell junction of epithelial cells by oxidative stress. Genes Cells. 2009;14:703-16.
    • (2009) Genes Cells , vol.14 , pp. 703-716
    • Inumaru, J.1    Nagano, O.2    Takahashi, E.3    Ishimoto, T.4    Nakamura, S.5    Suzuki, Y.6
  • 121
    • 78649680349 scopus 로고    scopus 로고
    • Thrombin promotes actin stress fiber formation in RPE through Rho/ROCK-mediated MLC phosphorylation
    • Ruiz-Loredo AY, Lopez E, Lopez-Colome AM. Thrombin promotes actin stress fiber formation in RPE through Rho/ROCK-mediated MLC phosphorylation. J Cell Physiol. 2011;226:414-23.
    • (2011) J Cell Physiol , vol.226 , pp. 414-423
    • Ruiz-Loredo, A.Y.1    Lopez, E.2    Lopez-Colome, A.M.3
  • 122
    • 84906862141 scopus 로고    scopus 로고
    • ROCK inhibition extends passage of pluripotent stem cell-derived retinal pigmented epithelium
    • Croze RH, Buchholz DE, Radeke MJ, Thi WJ, Hu Q, Coffey PJ, et al. ROCK inhibition extends passage of pluripotent stem cell-derived retinal pigmented epithelium. Stem Cells Transl Med. 2014;3:1066-78.
    • (2014) Stem Cells Transl Med , vol.3 , pp. 1066-1078
    • Croze, R.H.1    Buchholz, D.E.2    Radeke, M.J.3    Thi, W.J.4    Hu, Q.5    Coffey, P.J.6
  • 123
    • 0034574298 scopus 로고    scopus 로고
    • How cells read TGF-beta signals
    • Massague J. How cells read TGF-beta signals. Nat Rev Mol Cell Biol. 2000;1:169-78.
    • (2000) Nat Rev Mol Cell Biol , vol.1 , pp. 169-178
    • Massague, J.1
  • 124
    • 0027415806 scopus 로고
    • Identification of transforming growth factor-beta expressed in cultured human retinal pigment epithelial cells
    • Tanihara H, Yoshida M, Matsumoto M, Yoshimura N. Identification of transforming growth factor-beta expressed in cultured human retinal pigment epithelial cells. Invest Ophthalmol Vis Sci. 1993;34:413-9.
    • (1993) Invest Ophthalmol Vis Sci , vol.34 , pp. 413-419
    • Tanihara, H.1    Yoshida, M.2    Matsumoto, M.3    Yoshimura, N.4
  • 125
    • 0028564923 scopus 로고
    • Expression and secretion of transforming growth factor-beta in transformed and nontransformed retinal pigment epithelial cells
    • Kvanta A. Expression and secretion of transforming growth factor-beta in transformed and nontransformed retinal pigment epithelial cells. Ophthalmic Res. 1994;26:361-7.
    • (1994) Ophthalmic Res , vol.26 , pp. 361-367
    • Kvanta, A.1
  • 126
    • 0027942734 scopus 로고
    • Increased production of transforming growth factor-beta 2 from cultured human retinal pigment epithelial cells by photocoagulation
    • Matsumoto M, Yoshimura N, Honda Y. Increased production of transforming growth factor-beta 2 from cultured human retinal pigment epithelial cells by photocoagulation. Invest Ophthalmol Vis Sci. 1994;35:4245-52.
    • (1994) Invest Ophthalmol Vis Sci , vol.35 , pp. 4245-4252
    • Matsumoto, M.1    Yoshimura, N.2    Honda, Y.3
  • 127
    • 0033139771 scopus 로고    scopus 로고
    • Synthesized TGF-betas in RPE regulates cellular proliferation
    • Lee SC, Seong GJ, Kim SH, Kwon OW. Synthesized TGF-betas in RPE regulates cellular proliferation. Korean J Ophthalmol. 1999;13:16-24.
    • (1999) Korean J Ophthalmol , vol.13 , pp. 16-24
    • Lee, S.C.1    Seong, G.J.2    Kim, S.H.3    Kwon, O.W.4
  • 129
    • 0035375802 scopus 로고    scopus 로고
    • TGF-betas synthesized by RPE cells have autocrine activity on mesenchymal transformation and cell proliferation
    • Lee SC, Kim SH, Koh HJ, Kwon OW. TGF-betas synthesized by RPE cells have autocrine activity on mesenchymal transformation and cell proliferation. Yonsei Med J. 2001;42:271-7.
    • (2001) Yonsei Med J , vol.42 , pp. 271-277
    • Lee, S.C.1    Kim, S.H.2    Koh, H.J.3    Kwon, O.W.4
  • 131
    • 79960357508 scopus 로고    scopus 로고
    • Divergent activities of osteogenic BMP2, and tenogenic BMP12 and BMP13 independent of receptor binding affinities
    • Berasi SP, Varadarajan U, Archambault J, Cain M, Souza TA, Abouzeid A, et al. Divergent activities of osteogenic BMP2, and tenogenic BMP12 and BMP13 independent of receptor binding affinities. Growth Factors. 2011;29:128-39.
    • (2011) Growth Factors , vol.29 , pp. 128-139
    • Berasi, S.P.1    Varadarajan, U.2    Archambault, J.3    Cain, M.4    Souza, T.A.5    Abouzeid, A.6
  • 132
    • 84899141905 scopus 로고    scopus 로고
    • Growth differentiation factor 6 and transforming growth factor-beta differentially mediate mesenchymal stem cell differentiation, composition and micromechanical properties of nucleus pulposus constructs
    • Clarke LE, McConnell JC, Sherratt MJ, Derby B, Richardson SM, Hoyland JA. Growth differentiation factor 6 and transforming growth factor-beta differentially mediate mesenchymal stem cell differentiation, composition and micromechanical properties of nucleus pulposus constructs. Arthritis Res Ther. 2014;16:R67.
    • (2014) Arthritis Res Ther , vol.16 , pp. R67
    • Clarke, L.E.1    McConnell, J.C.2    Sherratt, M.J.3    Derby, B.4    Richardson, S.M.5    Hoyland, J.A.6
  • 133
    • 84878257423 scopus 로고    scopus 로고
    • Gdf6 induces commitment of pluripotent mesenchymal C3H10T1/2 cells to the adipocyte lineage
    • Wang SS, Huang HY, Chen SZ, Li X, Zhang WT, Tang QQ. Gdf6 induces commitment of pluripotent mesenchymal C3H10T1/2 cells to the adipocyte lineage. FEBS J. 2013;280:2644-51.
    • (2013) FEBS J , vol.280 , pp. 2644-2651
    • Wang, S.S.1    Huang, H.Y.2    Chen, S.Z.3    Li, X.4    Zhang, W.T.5    Tang, Q.6
  • 134
  • 136
    • 0028582165 scopus 로고
    • Identification and characterization of LTBP-2, a novel latent transforming growth factor-beta-binding protein
    • Moren A, Olofsson A, Stenman G, Sahlin P, Kanzaki T, Claesson-Welsh L, et al. Identification and characterization of LTBP-2, a novel latent transforming growth factor-beta-binding protein. J Biol Chem. 1994;269:32469-78.
    • (1994) J Biol Chem , vol.269 , pp. 32469-32478
    • Moren, A.1    Olofsson, A.2    Stenman, G.3    Sahlin, P.4    Kanzaki, T.5    Claesson-Welsh, L.6
  • 137
    • 0025364777 scopus 로고
    • TGF-beta 1 binding protein: a component of the large latent complex of TGF-beta 1 with multiple repeat sequences
    • Kanzaki T, Olofsson A, Moren A, Wernstedt C, Hellman U, Miyazono K, et al. TGF-beta 1 binding protein: a component of the large latent complex of TGF-beta 1 with multiple repeat sequences. Cell. 1990;61:1051-61.
    • (1990) Cell , vol.61 , pp. 1051-1061
    • Kanzaki, T.1    Olofsson, A.2    Moren, A.3    Wernstedt, C.4    Hellman, U.5    Miyazono, K.6
  • 138
    • 39749191827 scopus 로고    scopus 로고
    • Activation of TGF-beta1 through up-regulation of TSP-1 by retinoic acid in retinal pigment epithelial cells
    • Uchida H, Kuroki M, Shitama T, Hayashi H, Kuroki M. Activation of TGF-beta1 through up-regulation of TSP-1 by retinoic acid in retinal pigment epithelial cells. Curr Eye Res. 2008;33:199-203.
    • (2008) Curr Eye Res , vol.33 , pp. 199-203
    • Uchida, H.1    Kuroki, M.2    Shitama, T.3    Hayashi, H.4    Kuroki, M.5
  • 139
    • 70449507402 scopus 로고    scopus 로고
    • Modulation of migration and Ca2+ signaling in retinal pigment epithelium cells by recombinant human CTGF
    • Guo CM, Wang YS, Hu D, Han QH, Wang JB, Hou X, et al. Modulation of migration and Ca2+ signaling in retinal pigment epithelium cells by recombinant human CTGF. Curr Eye Res. 2009;34:852-62.
    • (2009) Curr Eye Res , vol.34 , pp. 852-862
    • Guo, C.M.1    Wang, Y.S.2    Hu, D.3    Han, Q.H.4    Wang, J.B.5    Hou, X.6
  • 140
    • 80052538877 scopus 로고    scopus 로고
    • Regulation of fibronectin-EDA through CTGF domain-specific interactions with TGFbeta2 and its receptor TGFbetaRII
    • Khankan R, Oliver N, He S, Ryan SJ, Hinton DR. Regulation of fibronectin-EDA through CTGF domain-specific interactions with TGFbeta2 and its receptor TGFbetaRII. Invest Ophthalmol Vis Sci. 2011;52:5068-78.
    • (2011) Invest Ophthalmol Vis Sci , vol.52 , pp. 5068-5078
    • Khankan, R.1    Oliver, N.2    He, S.3    Ryan, S.J.4    Hinton, D.R.5
  • 141
    • 84857308088 scopus 로고    scopus 로고
    • Decorin antagonizes the angiogenic network: concurrent inhibition of Met, hypoxia inducible factor 1alpha, vascular endothelial growth factor A, and induction of thrombospondin-1 and TIMP3
    • Neill T, Painter H, Buraschi S, Owens RT, Lisanti MP, Schaefer L, et al. Decorin antagonizes the angiogenic network: concurrent inhibition of Met, hypoxia inducible factor 1alpha, vascular endothelial growth factor A, and induction of thrombospondin-1 and TIMP3. J Biol Chem. 2012;287:5492-506.
    • (2012) J Biol Chem , vol.287 , pp. 5492-5506
    • Neill, T.1    Painter, H.2    Buraschi, S.3    Owens, R.T.4    Lisanti, M.P.5    Schaefer, L.6
  • 142
    • 84877701575 scopus 로고    scopus 로고
    • Decorin induces rapid secretion of thrombospondin-1 in basal breast carcinoma cells via inhibition of Ras homolog gene family, member A/Rho-associated coiled-coil containing protein kinase 1
    • Neill T, Jones HR, Crane-Smith Z, Owens RT, Schaefer L, Iozzo RV. Decorin induces rapid secretion of thrombospondin-1 in basal breast carcinoma cells via inhibition of Ras homolog gene family, member A/Rho-associated coiled-coil containing protein kinase 1. FEBS J. 2013;280:2353-68.
    • (2013) FEBS J , vol.280 , pp. 2353-2368
    • Neill, T.1    Jones, H.R.2    Crane-Smith, Z.3    Owens, R.T.4    Schaefer, L.5    Iozzo, R.V.6
  • 143
  • 144
    • 0024358954 scopus 로고
    • Multiple forms of SppI (secreted phosphoprotein, osteopontin) synthesized by normal and transformed rat bone cell populations: regulation by TGF-beta
    • Kubota T, Zhang Q, Wrana JL, Ber R, Aubin JE, Butler WT, et al. Multiple forms of SppI (secreted phosphoprotein, osteopontin) synthesized by normal and transformed rat bone cell populations: regulation by TGF-beta. Biochem Biophys Res Commun. 1989;162:1453-9.
    • (1989) Biochem Biophys Res Commun , vol.162 , pp. 1453-1459
    • Kubota, T.1    Zhang, Q.2    Wrana, J.L.3    Ber, R.4    Aubin, J.E.5    Butler, W.T.6
  • 145
    • 0023732819 scopus 로고
    • Transcriptional regulation of osteopontin production in rat osteosarcoma cells by type beta transforming growth factor
    • Noda M, Yoon K, Prince CW, Butler WT, Rodan GA. Transcriptional regulation of osteopontin production in rat osteosarcoma cells by type beta transforming growth factor. J Biol Chem. 1988;263:13916-21.
    • (1988) J Biol Chem , vol.263 , pp. 13916-13921
    • Noda, M.1    Yoon, K.2    Prince, C.W.3    Butler, W.T.4    Rodan, G.A.5
  • 146
    • 0028037723 scopus 로고
    • Growth factor localization in choroidal neovascular membranes of age-related macular degeneration
    • Amin R, Puklin JE, Frank RN. Growth factor localization in choroidal neovascular membranes of age-related macular degeneration. Invest Ophthalmol Vis Sci. 1994;35:3178-88.
    • (1994) Invest Ophthalmol Vis Sci , vol.35 , pp. 3178-3188
    • Amin, R.1    Puklin, J.E.2    Frank, R.N.3
  • 147
  • 148
    • 84879223893 scopus 로고    scopus 로고
    • Subfoveal fibrosis in eyes with neovascular age-related macular degeneration treated with intravitreal ranibizumab
    • Bloch SB, Lund-Andersen H, Sander B, Larsen M. Subfoveal fibrosis in eyes with neovascular age-related macular degeneration treated with intravitreal ranibizumab. Am J Ophthalmol. 2013;156:116-24.
    • (2013) Am J Ophthalmol , vol.156 , pp. 116-124
    • Bloch, S.B.1    Lund-Andersen, H.2    Sander, B.3    Larsen, M.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.