Serine protease HTRA1 antagonizes transforming growth factor-β signaling by cleaving its receptors and loss of HTRA1 in vivo enhances bone formation.

PloS one

Volumn 8, Issue 9, 2013, Pages

  Graham, Julie R ^a   Chamberland, Angela ^b   Lin, Qingcong ^b   Li, X Jian ^b   Dai, David ^b   Zeng, Weilan ^b   Ryan, Mark S ^b   Rivera Bermúdez, Moisés A ^b   Flannery, Carl R ^b   Yang, Zhiyong ^b  

^a PFIZER INC   (United States)

^b NONE

Author keywords

[No Author keywords available]

Indexed keywords

PRSS11 PROTEIN, MOUSE; SERINE PROTEINASE; TRANSFORMING GROWTH FACTOR BETA; TRANSFORMING GROWTH FACTOR BETA RECEPTOR;

ANIMAL; ARTICLE; BONE DEVELOPMENT; CELL LINE; FIBROBLAST; GENE ORDER; GENE SILENCING; GENETIC TRANSCRIPTION; GENETICS; HUMAN; KNOCKOUT MOUSE; MALE; METABOLISM; MOUSE; PHYSIOLOGY; PROTEIN BINDING; PROTEIN DEGRADATION; SIGNAL TRANSDUCTION;

ANIMALS; CELL LINE; FIBROBLASTS; GENE ORDER; GENE SILENCING; HUMANS; MALE; MICE; MICE, KNOCKOUT; OSTEOGENESIS; PROTEIN BINDING; PROTEOLYSIS; RECEPTORS, TRANSFORMING GROWTH FACTOR BETA; SERINE ENDOPEPTIDASES; SIGNAL TRANSDUCTION; TRANSCRIPTION, GENETIC; TRANSFORMING GROWTH FACTOR BETA;

EID: 84897494657     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0074094     Document Type: Article

References (0)