Relationship between RPE and choriocapillaris in age-related macular degeneration

Investigative Ophthalmology and Visual Science

Volumn 50, Issue 10, 2009, Pages 4982-4991

  Mcleod, D Scott ^a   Grebe, Rhonda ^a   Bhutto, Imran ^a   Merges, Carol ^a   Baba, Takayuki ^a   Lutty, Gerard A ^a  

^a JOHNS HOPKINS UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AGED; AGING; ARTICLE; AUTOPSY; BLOOD VESSEL DIAMETER; BRUCH MEMBRANE; CHOROID CAPILLARY LAYER; CONTROLLED STUDY; DISEASE ASSOCIATION; ENZYME ACTIVITY; FEMALE; HISTOPATHOLOGY; HUMAN; HUMAN TISSUE; MALE; PIGMENT EPITHELIUM; PRIORITY JOURNAL; QUANTITATIVE ANALYSIS; RETINA DEGENERATION; RETINA MACULA AGE RELATED DEGENERATION; SUBRETINAL NEOVASCULARIZATION; TISSUE STRUCTURE; ATROPHY; CAPILLARY; CHOROID; ENZYME IMMUNOASSAY; ENZYMOLOGY; METABOLISM; PATHOLOGY; RETINA MACULA DEGENERATION; VASCULARIZATION;

ALKALINE PHOSPHATASE;

AGED; AGED, 80 AND OVER; ALKALINE PHOSPHATASE; ATROPHY; BRUCH MEMBRANE; CAPILLARIES; CHOROID; CHOROIDAL NEOVASCULARIZATION; FEMALE; HUMANS; IMMUNOENZYME TECHNIQUES; MACULAR DEGENERATION; MALE; RETINAL PIGMENT EPITHELIUM;

EID: 70349572812     PISSN: 01460404     EISSN: 15525783     Source Type: Journal    
DOI: 10.1167/iovs.09-3639     Document Type: Article

References (56)

1. Hayashi A, Majji AB, Fujioka S, Kim HC, Fukushima I, de Juan E Jr. Surgically induced degeneration and regeneration of the choriocapillaris in rabbit. Graefes Arch Clin Exp Ophthalmol. 1999;237: 668-677.
2. Henkind P, Gartner S. The relationship between retinal pigment epithelium and the choriocapillaris. Trans Ophthalmol Soc U K. 1983;103:444-447.
3. Heriot WJ, Machemer R. Pigment epithelial repair. Graefes Arch Clin Exp Ophthalmol. 1992;230:91-100.
4. Korte GE, Repucci V, Henkind P. RPE destruction causes choriocapillary atrophy. Invest Ophthalmol Vis Sci. 1984;25:1135-1145.
5. Leonard DS, Sugino IK, Zhang XG, et al. Ultrastructural analysis of hydraulic and abrasive retinal pigment epithelial cell debridements. Exp Eye Res. 2003;76:473-491.
6. Leonard DS, Zhang XG, Panozzo G, Sugino IK, Zarbin MA. Clinicopathologic correlation of localized retinal pigment epithelium debridement. Invest Ophthalmol Vis Sci. 1997;38:1094-1109.
7. Ivert L, Kong J, Gouras P. Changes in the choroidal circulation of rabbit following RPE removal. Graefes Arch Clin Exp Ophthalmol. 2003;241:656-666.
8. Del Priore LV, Kaplan HJ, Hornbeck R, Jones Z, Swinn M. Retinal pigment epithelial debridement as a model for the pathogenesis and treatment of macular degeneration. Am J Ophthalmol. 1996; 122:629-643.
9. Alon T, Hemo I, Itin A, Pe'er J, Stone J, Keshet E. Vascular endothelial growth factor acts as a survival factor for newly formed retinal vessels and has implications for retinopathy of prematurity. Nat Med. 1995;1:1024-1028.
10. Karsan A, Yee E, Poirier GG, Zhou P, Craig R, Harlan JM. Fibroblast growth factor-2 inhibits endothelial cell apoptosis by Bcl-2-dependent and independent mechanisms. Am J Pathol. 1997;151:1775-1784.
11. Liu X, Ye X, Yanoff M, Li W. Extracellular matrix of retinal pigment epithelium regulates choriocapillaris endothelial survival in vitro. Exp Eye Res. 1997;65:117-126.
12. Roberts W, Palade G. Increased microvascular permeability and endothelial fenestration induced by vascular endothelial growth factor. J Cell Sci. 1995;108:2369-2379.
13. Shichiri M, Kato H, Marumo F, Hirata Y. Endothelin-1 as an autocrine/ paracrine apoptosis survival factor for endothelial cells. Hypertension. 1997;30:1198-1203.
14. Watanabe Y, Dvorak HF. Vascular permeability factor/vascular endothelial growth factor inhibits anchorage-disruption-induced apoptosis in microvessel endothelial cells by inducing scaffold formation. Exp Cell Res. 1997;233:340-349.
15. Friedman E, Krupsky S, Lane AM, et al. Ocular blood flow velocity in age-related macular degeneration. Ophthalmology. 1995;102: 640-646.
16. Grunwald J, Hariprasad S, DuPont J, et al. Foveolar choroidal blood flow in age-related macular degeneration. Invest Ophthalmol Vis Sci. 1998;39:385-390.
17. Kornzweig A. Changes in the choriocapillaris associated with senile macular degeneration. Ann Ophthalmol. 1977;9:753-764.
18. Duan Y, Mo J, Klein R, et al. Age-related macular degeneration is associated with incident myocardial infarction among elderly Americans. Ophthalmology. 2007;114:732-737.
19. Wong TY, Klein R, Sun C, et al. Age-related macular degeneration and risk for stroke. Ann Intern Med. 2006;145:98-106.
20. Beatty S, Koh H, Phil M, Henson D, Boulton M. The role of oxidative stress in the pathogenesis of age-related macular degeneration. Surv Ophthalmol. 2000;45:115-134.
21. Hogg RE, Woodside JV, Gilchrist SE, et al. Cardiovascular disease and hypertension are strong risk factors for choroidal neovascularization. Ophthalmology. 2008;115:1046-1052 e1042.
22. Lutty GA, McLeod DS. A new technique for visualization of the human retinal vasculature. Arch Ophthalmol. 1992;110:267-276.
23. McLeod DS, Lutty GA. High resolution histologic analysis of the human choroidal vasculature. Invest Ophthalmol Vis Sci. 1994;35: 3799-3811.
24. McLeod DS, Taomoto M, Otsuji T, Green WR, Sunness JS, Lutty GA. Quantifying changes in RPE and choriocapillaris in eyes with age-related macular degeneration. Invest Ophthalmol Vis Sci. 2002;43:1986-1993.
25. Adamis AP, Shima DT, Yeo KT, et al. Synthesis and secretion of vascular permeability factor/vascular endothelial growth factor by human retinal pigment epithelial cells. Biochem Biophys Res Commun. 1993;193:631-638.
26. Esser S, Wolburg K, Wolburg H, Breier G, Kurzchalia T, Risau W. Vascular endothelial growth factor induces endothelial fenestrations in vitro. J Cell Biol. 1998;140:947-959.
27. Tolentino MJ, McLeod DS, Taomoto M, Otsuji T, Adamis AP, Lutty GA. Pathological features of vascular endothelial growth factorinduced retinopathy in non-human primates. Am J Ophthalmol. 2002;133:373-385.
28. Benjamin LE, Keshet E. Conditional switching of vascular endothelial growth factor (VEGF) expression in tumors: induction of endothelial cell shedding and regression of hemangioblastoma-like vessels by VEGF withdrawal. Proc Natl Acad Sci U S A. 1997;94: 8761-8766.
29. Blaauwgeers HG, Holtkamp GM, Rutten H, et al. Polarized vascular endothelial growth factor secretion by human retinal pigment epithelium and localization of vascular endothelial growth factor receptors on the inner choriocapillaris. Am J Pathol. 1999;155: 421-428.
30. Cai J, Nelson KC, Wu M, Sternberg P Jr, Jones DP. Oxidative damage and protection of the RPE. Prog Retin Eye Res. 2000;19: 205-221.
31. Spaide RF, Armstrong D, Browne R. Continuing medical education review: choroidal neovascularization in age-related macular degeneration-what is the cause? Retina. 2003;23:595-614.
32. Margrain TH, Boulton M, Marshall J, Sliney DH. Do blue light filters confer protection against age-related macular degeneration? Prog Retin Eye Res. 2004;23:523-531.
33. Espinosa-Heidmann DG, Suner IJ, Catanuto P, Hernandez EP, Marin-Castano ME, Cousins SW. Cigarette smoke-related oxidants and the development of sub-RPE deposits in an experimental animal model of dry AMD. Invest Ophthalmol Vis Sci. 2006;47: 729-737.
34. Dunaief JL. Iron induced oxidative damage as a potential factor in age-related macular degeneration: the Cogan Lecture. Invest Ophthalmol Vis Sci. 2006;47:4660-4664.
35. Tian J, Ishibashi K, Ishibashi K, et al. Advanced glycation end product-induced aging of the retinal pigment epithelium and choroid: a comprehensive transcriptional response. Proc Natl Acad Sci U S A. 2005;102:11846-11851.
36. Yamada Y, Ishibashi K, Ishibashi K, et al. The expression of advanced glycation end product receptors in RPE cells associated with basal deposits in human maculas. Exp Eye Res. 2006;82:840-848.
37. Age-Related Eye Disease Study Research Group. A randomized, placebo-controlled, clinical trial of high-dose supplementation with vitamins C and E, beta carotene, and zinc for age-related macular degeneration and vision loss: AREDS report no. 8. Arch Ophthalmol. 2001;119:1417-1436.
38. Duke-Elder S. System of Ophthalmology: Diseases of the Uveal Tract. St. Louis: CV Mosby; 1966;608.
39. Friedman E. A hemodynamic model of the pathogenesis of agerelated macular degeneration. Am J Ophthalmol. 1997;124:677-682.
40. Friedman E. Age-related macular degeneration: update of the vascular model of AMD. Br J Ophthalmol. 2004;88:161-163.
41. Friedman E. The pathogenesis of age-related macular degeneration. Am J Ophthalmol. 2008;146:348-349.
42. Hyman L, Schachat AP, He Q, Leske MC. Hypertension, cardiovascular disease, and age-related macular degeneration: Age-Related Macular Degeneration Risk Factors Study Group. Arch Ophthalmol. 2000;118:351-358.
43. Snow KK, Seddon JM. Do age-related macular degeneration and cardiovascular disease share common antecedents? Ophthalmic Epidemiol. 1999;6:125-143.
44. van Leeuwen R, Ikram MK, Vingerling JR, Witteman JC, Hofman A, de Jong PT. Blood pressure, atherosclerosis, and the incidence of age-related maculopathy: the Rotterdam Study. Invest Ophthalmol Vis Sci. 2003;44:3771-3777.
45. Vingerling JR, Dielemans I, Bots ML, Hofman A, Grobbee DE, de Jong PT. Age-related macular degeneration is associated with atherosclerosis: the Rotterdam Study. Am J Epidemiol. 1995;142: 404-409.
46. Harris A, Chung HS, Ciulla TA, Kagemann L. Progress in measurement of ocular blood flow and relevance to our understanding of glaucoma and age-related macular degeneration. Prog Retin Eye Res. 1999;18:669-687.
47. Chen J, Fitzke F, Bird A. Functional loss in age-related Bruch's membrane change with choroidal perfusion defect. Invest Ophthalmol Vis Sci. 1992;33:334-340.
48. Feigl B. Age-related maculopathy-linking aetiology and pathophysiological changes to the ischaemia hypothesis. Prog Retin Eye Res. 2009;28:63-86.
49. Grunwald J, Hariprasad S, DuPont J. Effect of aging on foveolar choroidal circulation. Arch Ophthalmol. 1998;116:150-154.
50. Grunwald JE, Metelitsina TI, Dupont JC, Ying GS, Maguire MG. Reduced foveolar choroidal blood flow in eyes with increasing AMD severity. Invest Ophthalmol Vis Sci. 2005;46:1033-1038.
51. Pauleikhoff D, Chen J, Chisholm I, Bird A. Choroidal perfusion abnormality with age-related Bruch's membrane change. Am J Ophthalmol. 1990;109:211-217.
52. Ramrattan RS, van der Schaft TL, Mooy CM, de Bruijn WC, Mulder PG, de Jong PT. Morphometric analysis of Bruch's membrane, the choriocapillaris, and the choroid in aging. Invest Ophthalmol Vis Sci. 1994;35:2857-2864.
53. Sarks JP, Sarks SH, Killingsworth MC. Evolution of geographic atrophy of the retinal pigment epithelium. Eye. 1988;2:552-577.
54. Gass JD. Stereoscopic Atlas of Macular Diseases: Diagnosis and Treatment. St. Louis: CV Mosby;1997:80.
55. Melrose MA, Magargal LE, Goldberg RE, Annesley WH Jr. Subretinal neovascular membranes associated with choroidal nonperfusion and retinal ischemia. Ann Ophthalmol. 1987;19:396-399.
56. Hayashi K, de Laey JJ. Indocyanine green angiography of choroidal neovascular membranes. Ophthalmologica. 1985;190:30-39.