Culture of highly differentiated human retinal pigment epithelium for analysis of the polarized uptake, processing, and secretion of retinoids

Methods in Molecular Biology

Volumn 652, Issue , 2010, Pages 55-73

  Hu, Jane ^a   Bok, Dean ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

11 cis retinal; age related macular degeneration; all trans retinal; inherited retinal disease; Leber congenital amaurosis; retinal pigment epithelium; Retinoid visual cycle; Stargardt macular dystrophy

Indexed keywords

PREALBUMIN; RECOMBINANT PROTEIN; RETINOID; RETINOL BINDING PROTEIN;

ANIMAL; ARTICLE; BIOSYNTHESIS; CATTLE; CELL DIFFERENTIATION; CULTURE MEDIUM; CYTOLOGY; ESCHERICHIA COLI; FEMALE; GENETICS; HUMAN; ISOLATION AND PURIFICATION; METABOLISM; METHODOLOGY; PIGMENT EPITHELIUM; PREGNANCY; SECRETION; TISSUE CULTURE TECHNIQUE; TRANSPORT AT THE CELLULAR LEVEL;

ANIMALS; BIOLOGICAL TRANSPORT; CATTLE; CELL DIFFERENTIATION; CULTURE MEDIA; ESCHERICHIA COLI; FEMALE; HUMANS; PREALBUMIN; PREGNANCY; RECOMBINANT PROTEINS; RETINAL PIGMENT EPITHELIUM; RETINOIDS; RETINOL-BINDING PROTEINS; TISSUE CULTURE TECHNIQUES;

EID: 77956402413     PISSN: 10643745     EISSN: None     Source Type: Book Series    
DOI: 10.1007/978-1-60327-325-1_2     Document Type: Article

References (35)

1. Allikmets, R., Singh, N., Sun, H., et al. (1997) A photoreceptor cell-specific ATPbinding transporter gene (ABCR) is mutated in recessive Stargardt macular dystrophy. Nat. Genet. 15, 236-246. (Pubitemid 27098715)
2. Weng, J., Mata, N.L., Azarian, S.M., Tzekov, R.T. Birch, D.G., Travis, G.H. (1999) Insights into the function of Rim protein in photoreceptors and etiology of Stargardt's disease from the phenotype in abcr knockout mice. Cell 98, 13-23. (Pubitemid 29331192)
3. Marlhens, F., Bareil, D., Griffoin, J-M, et al. (1997) Mutations in RPE65 cause Leber's congenital Amaurosis. Nat. Genet. 17, 139-141.
4. Redmond, T.M., Yu, S., Lee, E., et al. (1998) Rpe65 is necessary for production of 11-cisvitamin A in the retinal visual cycle. Nat. Genet. 20, 344-351. (Pubitemid 28541631)
5. Allikmets, R., Dean, M. (2008) Bringing age-related macular degeneration into focus. Nat. Genet. 40, 820-821. (Pubitemid 351913668)
6. Gehrs, K.M., Jackson, J.R., Brown, E.N., Allikmets, M.,Hageman, G. (2009) Complement, age-related macular degeneration and a vision of the future. Arch. Ophthalmol. 128, 349-358.
7. Travis, G.H., Golczak, M., Moise, A.R., Palczewski, K. (2007) Diseases caused by defects in the visual cycle: Retinoids as potential therapeutic agents. Annu. Rev. Pharmacol. Toxicol. 47, 469-512.
8. Bok, D., Heller, J. (1976) Transport of retinol from the blood to the retina: An autoradiographic study of the pigment epithelial cell surface receptor for plasma retinol-binding protein. Exp. Eye Res. 22, 395-402.
9. Kanai, M., Raz, A., Goodman, D.S. (1968) Retinol-binding protein: The transport protein for vitamin A in human plasma. J. Clin. Invest. 47, 2025-2044.
10. Bok, D., Heller, J. (1980). Autoradiographic localization of serum retinol-binding protein receptors on the pigment epithelium of dystrophic rat retinas. Invest. Ophthalmol. Vis. Sci. 19, 1405-1414. (Pubitemid 11081170)
11. Kawaguchi, R., Yu, J., Honda, J., et al. (2007) A membrane receptor for retinol binding protein mediates cellular uptake of Vitamin A. Science 315, 820-825.
12. Golzio, C., Martinovic-Bouriel, J., Thomas, S., et al. (2007) Matthew-Wood syndrome is caused by truncating mutations in the retinol-binding protein receptor gene STRA6. Am. M. Hum. Genet. 80, 1179-1187. (Pubitemid 47579353)
13. Pasutto, F., Sticht, H., Hammersen, G., et al. (2007) Mutations in STRA6 cause a broad spectrum of malformations including anophthalmia, congenital heart defects, diaphragmatic hernia, alveolar capillary dysplasia, lung hypoplasia and mental retardation. Am. J. Hum. Genet. 80, 550-560.
14. MacDonald, P.N., Ong, D.E. (1988) Evidence for a lecithin-retinol acyltransferase activity in the rat small intestine. J. Biol. Chem. 263, 12478-12482. (Pubitemid 19000429)
15. Saari, J., Bredberg, L. (1989) Lecithin: Retinolacyltransferase in retinal pigment epithelial microsomes. J. Biol. Chem. 264, 8636-8648.
16. Ruiz, A., Winston, A., Rando, R., Bok, D. (1999) Molecular and biochemical characterization of lecithin retinol acyltransferase. J. Biol. Chem. 274, 3834-3841. (Pubitemid 29077233)
17. Bernstein, P., Law, W., Rando, R. (1987) Biochemical characterization of the retinoid isomerase4 system of the eye. J. Biol. Chem. 262, 16848-16857.
18. Deigner, P., Law, W., Canada, F., Rando, R. (1989) Membranes as the energy source in the undergone transformation of vitamin A to 11-cis-retinol. Science 244, 968-971. (Pubitemid 19152285)
19. Jin, M., Moghrabi, W.N., Sun, H., Travis, G.H. (2005) Rpe65 is the retinoid isomerase in bovine retinal pigment epithelium. Cell 122, 449-459. (Pubitemid 41127145)
20. Moiseyev, G., Chen, Y., Takahashi, Y., Wu, B.X., Ma, J.X. (2005) RPE65 is the isomerhydrolase in the retinoid visual cycle. Proc. Nat. Acad. Sci. USA 102, 12413-12418. (Pubitemid 41266373)
21. Bok, D. (1994) The retinal pigment epithelium; a versatile partner in vision. J. Cell Sci. 17(Suppl), 189-195.
22. Redmond, R.M., Poliakov, E., Yu, S., Tsai, J.Y., Lu, Z., Gentlemen, S. (2005) Mutation of key residues of ROE65 abolishes its enzymatic role as isomerohydrolase in the visual cycle. Proc. Natl. Acad. Sci. USA 102, 13658-13663. (Pubitemid 41420904)
23. Molday, L.L., Rabin, A.R., Molday, R.S. (2000) ABCR expression in foveal cone photoreceptors and its role in Stargardt macular dystrophy. Nat. Genet. 25, 67-73.
24. Eldred, G.E., Lasky, M.R. (1993) Retinal age pigments generated by self-assembling lysosomotropic detergents. Nature 361, 724-726. (Pubitemid 23070479)
25. Maguire, A.M., Simonelli, F., Pierce, E.A. et al. (2008) Safety and efficacy of gene transfer for Leber's congenital Amaurosis. N. Engl. J. Med. 358, 2240-2248. (Pubitemid 351724453)
26. Bainbridge, J.W., Smith, A.J., Barker, S.S., et al. (2008) Effect of gene therapy on visual function in Leber's congenital Amaurosis. N. Engl. J. Med. 358, 2231-2239. (Pubitemid 351724452)
27. Hauswirth, W.W., Aleman, T.S., Causal, S., et al. (2008) Treatment of Leber congenital amaurosis due to RPE65 mutations by ocular subretinal injection of adenoassociated virus gene vector: Short-term results of a phase I trial. Hum. Gene Ther. 19, 979-990.
28. Zhou, J., Jang, P., Kim, S.R., Sparrow, J.R. (2006) Complement activation by photooxidation products of A2E, a lipofuscin constituent of the retinal pigment epithelium. Proc. Natl. Acad. Sci. USA 103, 16182-16187. (Pubitemid 44715171)
29. Hageman, G.S., Anderson, D.H. Johnson, L.V., et al. (2005) A common haplotype in the complement regulatory gene factor H (HF1/CFH) predisposes individuals to age-related macular degeneration. Proc.Natl. Acad. Sci. USA 102, 7227-7232. (Pubitemid 40696361)
30. Haines, J.L., Hauser, M.A., Schmidt, S., et al. (2005) Complement factor H variant increases the risk of age-related macular degeneration. Science 308, 419-421. (Pubitemid 40530081)
31. Klein, R.J., Zeiss, D., Chew, E.Y., et al. (2005) Complement factor H polymorphism in age-related macular degeneration. Science 308, 385-389. (Pubitemid 40530070)
32. Edwards, A.O., Ritter, R., 3rd, Abel, K.J., Manning, A., Panhuysen, C. Farrer, L.A. (2005) Complement factor H polymorphism and age-related macular degeneration. Science 308, 421-424. (Pubitemid 40530082)
33. Carlson, A., Bok, D. Promotion of the release of 11-cis-retinal from cultured retinal pigment epithelium by interphotoreceptor retinoid-binding protein. Biochemistry 31, 9056-9062.
34. Radu, R.A., Hu, J., Peng, J., Bok, D., Mata, N., Travis, G.H. (2008) Retinal pigment epithelium-retinal G protein receptor-opsin mediates light-dependent translocation of all-trans-retinyl esters for synthesis of visual chromophore in retinal pigment epithelial cells. J. Biol. Chem. 283, 19730-19738.
35. Maminishkis, A., Chen, S., Jalickee, S., et al. (2006) Confluent monolayers of cultured human fetal retinal pigment epithelium exhibit morphology and physiology of native tissue. Invest. Ophthalmol. Vis. Sci. 47, 3612-3624. (Pubitemid 351639731)