Adipocyte SIRT1 knockout promotes PPARγ activity, adipogenesis and insulin sensitivity in chronic-HFD and obesity

Molecular Metabolism

Volumn 4, Issue 5, 2015, Pages 378-391

  Mayoral, Rafael ^a,b   Osborn, Olivia ^a   McNelis, Joanne ^a   Johnson, Andrew M ^a   Oh, Da Young ^a   Izquierdo, Cristina Llorente ^a   Chung, Heekyung ^a   Li, Pingping ^a   Traves, Paqui G ^c   Bandyopadhyay, Gautam ^a   Pessentheiner, Ariane R ^d   Ofrecio, Jachelle M ^a   Cook, Joshua R ^e   Qiang, Li ^e   Accili, Domenico ^e   Olefsky, Jerrold M ^a  

^a UNIVERSITY OF CALIFORNIA SAN DIEGO   (United States)

^b INSTITUTO DE SALUD CARLOS III   (Spain)

^c SALK INSTITUTE FOR BIOLOGICAL STUDIES   (United States)

^d UNIVERSITY OF GRAZ   (Austria)

^e NewYork Presbyterian Hospital   (United States)

Author keywords

Glucose homeostasis; Insulin resistance; Obesity; Phosphorylation; PPAR03B3; SIRT1

Indexed keywords

PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA; SERINE; SIRTUIN 1;

ADIPOCYTE; ADIPOGENESIS; ADIPOSE TISSUE; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CELL DIFFERENTIATION; CELL HYPERPLASIA; CHRONIC INFLAMMATION; CONTROLLED STUDY; DOWN REGULATION; ENZYME ACTIVITY; GENE DELETION; GENE EXPRESSION REGULATION; GLUCOSE INTOLERANCE; HYPERINSULINEMIA; INSULIN RESISTANCE; INSULIN SENSITIVITY; LIPID DIET; MOUSE; NONHUMAN; OBESITY; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN ACETYLATION; PROTEIN DEPHOSPHORYLATION; PROTEIN FUNCTION; PROTEIN PHOSPHORYLATION; PROTEIN PROTEIN INTERACTION; PROTEIN TARGETING; SIRT1 GENE; UPREGULATION;

MUS;

EID: 84933678205     PISSN: 22128778     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.molmet.2015.02.007     Document Type: Article

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