메뉴 건너뛰기




Volumn 2011, Issue , 2011, Pages

Cyclin-dependent kinase 5/p35/p39: A novel and imminent therapeutic target for diabetes mellitus

Author keywords

[No Author keywords available]

Indexed keywords

1 [(1H IMIDAZOL 5 YL)METHYL] 7 FLUORO 9H PYRIDO[3,4 B]INDOLE; 2 [4 (BENZYLAMINO) 1 ISOPROPYL 1H BENZO[D]IMIDAZOL 6 YLOXY]BUTAN 1 OL; 2,2 DICHLORO N [4 METHYL (6 PHENYL [1,2,4]TRIAZOLO[3,4 B][1,3,4]THIADIAZOL 3 YL)THIOPHEN 2 YL]ACETAMIDE; 2,2 DICHLORO N [5 (6,7 DIPHENYL 5H [1,2,4]TRIAZOLO[3,4 B][1,3,4]THIADIAZIN 3 YL) 4 METHYLTHIOPEN 2 YL]ACETAMIDE; ADENOSINE TRIPHOSPHATE SENSITIVE POTASSIUM CHANNEL; CYCLIN DEPENDENT KINASE 5; CYCLIN DEPENDENT KINASE 5 INHIBITOR; CYCLIN DEPENDENT KINASE INHIBITOR; GLUCOSE TRANSPORTER; INSULIN; N [4 METHYL (6 PHENYL [1,2,4]TRIAZOLO[3,4 B][1,3,4]THIADIAZOL 3 YL)THIOPHEN 2 YL]ACETAMIDE; N [5 (6,7 DIPHENYL 5H [1,2,4]TRIAZOLO[3,4 B][1,3,4]THIADIAZIN 3 YL) 4 METHYLTHIOPEN 2 YL]ACETAMIDE; OLOMOUCINE; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA; PROTEIN P35; PROTEIN P39; ROSCOVITINE; TRANSCRIPTION FACTOR PDX 1; UNCLASSIFIED DRUG;

EID: 84855262907     PISSN: 16878337     EISSN: 16878345     Source Type: Journal    
DOI: 10.1155/2011/530274     Document Type: Review
Times cited : (20)

References (29)
  • 2
    • 0031466305 scopus 로고    scopus 로고
    • Cyclin-dependent kinases: Engines, clocks, and microprocessors
    • DOI 10.1146/annurev.cellbio.13.1.261
    • Morgan D. O., Cyclin-dependent kinases: engines, clocks, and microprocessors Annual Review of Cell and Developmental Biology 1997 13 261 291 (Pubitemid 28034527)
    • (1997) Annual Review of Cell and Developmental Biology , vol.13 , pp. 261-291
    • Morgan, D.O.1
  • 3
    • 0028122011 scopus 로고
    • A brain-specific activator of cyclin-dependent kinase 5
    • DOI 10.1038/371423a0
    • Lew J., Huang Q. Q., Qi Z., Winkfein R. J., Aebersold R., Hunt T., Wang J. H., A brain-specific activator of cyclin-dependent kinase 5 Nature 1994 371 6496 423 426 (Pubitemid 24302557)
    • (1994) Nature , vol.371 , Issue.6496 , pp. 423-426
    • Lew, J.1    Huang, Q.-Q.2    Qi, Z.3    Winkfein, R.J.4    Aebersold, R.5    Hunt, T.6    Wang, J.H.7
  • 4
    • 0027978170 scopus 로고
    • P35 is a neural-specific regulatory subunit of cyclin-dependent kinase 5
    • DOI 10.1038/371419a0
    • Tsai L. H., Delalle I., Caviness V. S., Chae T., Harlow E., p35 is a neural-specific regulatory subunit of cyclin-dependent kinase 5 Nature 1994 371 6496 419 423 (Pubitemid 24302556)
    • (1994) Nature , vol.371 , Issue.6496 , pp. 419-423
    • Teai, L.-H.1    Delalle, I.2    Cavness Jr., V.S.3    Chae, T.4    Harlow, E.5
  • 6
    • 0027425599 scopus 로고
    • Activity and expression pattern of cyclin-dependent kinase 5 in the embryonic mouse nervous system
    • Tsai L. H., Takahashi T., Caviness V. S., Harlow E., Activity and expression pattern of cyclin-dependent kinase 5 in the embryonic mouse nervous system Development 1993 119 4 1029 1040 (Pubitemid 23358574)
    • (1993) Development , vol.119 , Issue.4 , pp. 1029-1040
    • Tsai, L.-H.1    Takahashi, T.2    Caviness Jr., V.S.3    Harlow, E.4
  • 7
    • 2542461194 scopus 로고    scopus 로고
    • Glucose-induced expression of the cyclin-dependent protein kinase 5 activator p35 involved in Alzheimer's disease regulates insulin gene transcription in pancreatic β-cells
    • DOI 10.1210/en.2003-1522
    • Ubeda M., Kemp D. M., Habener J. F., Glucose-induced expression of the cyclin-dependent protein kinase 5 activator p35 involved in Alzheimer's disease regulates insulin gene transcription in pancreatic -cells Endocrinology 2004 145 6 3023 3031 (Pubitemid 38686252)
    • (2004) Endocrinology , vol.145 , Issue.6 , pp. 3023-3031
    • Ubeda, M.1    Kemp, D.M.2    Habener, J.F.3
  • 12
    • 0029767016 scopus 로고    scopus 로고
    • Structural basis of cyclin-dependent kinase activation by phosphorylation
    • DOI 10.1038/nsb0896-696
    • Russo A. A., Jeffrey P. D., Pavletich N. P., Structural basis of cyclin-dependent kinase activation by phosphorylation Nature Structural Biology 1996 3 8 696 700 (Pubitemid 26260060)
    • (1996) Nature Structural Biology , vol.3 , Issue.8 , pp. 696-700
    • Russo, A.A.1    Jeffrey, P.D.2    Pavletich, N.P.3
  • 14
    • 0029880475 scopus 로고    scopus 로고
    • Demonstration of cyclin-dependent kinase inhibitory serine/threonine kinase in bovine thymus
    • DOI 10.1074/jbc.271.10.5443
    • Matsuura I., Wang J. H., Demonstration of cyclin-dependent kinase inhibitory serine/threonine kinase in bovine thymus Journal of Biological Chemistry 1996 271 10 5443 5450 (Pubitemid 26083877)
    • (1996) Journal of Biological Chemistry , vol.271 , Issue.10 , pp. 5443-5450
    • Matsuura, I.1    Wang, J.H.2
  • 15
    • 0037219411 scopus 로고    scopus 로고
    • β-cell deficit and increased β-cell apoptosis in humans with type 2 diabetes
    • DOI 10.2337/diabetes.52.1.102
    • Butler A. E., Janson J., Bonner-Weir S., Ritzel R., Rizza R. A., Butler P. C., -cell deficit and increased -cell apoptosis in humans with type 2 diabetes Diabetes 2003 52 1 102 110 (Pubitemid 36042113)
    • (2003) Diabetes , vol.52 , Issue.1 , pp. 102-110
    • Butler, A.E.1    Janson, J.2    Bonner-Weir, S.3    Ritzel, R.4    Rizza, R.A.5    Butler, P.C.6
  • 16
    • 76149102617 scopus 로고    scopus 로고
    • Evidence for proteotoxicity in cells in type 2 diabetes: Toxic islet amyloid polypeptide oligomers form intracellularly in the secretory pathway
    • Gurlo T., Ryazantsev S., Huang C. J., Yeh M. W., Reber H. A., Hines O. J., O'Brien T. D., Glabe C. G., Butler P. C., Evidence for proteotoxicity in cells in type 2 diabetes: toxic islet amyloid polypeptide oligomers form intracellularly in the secretory pathway American Journal of Pathology 2010 176 2 861 869
    • (2010) American Journal of Pathology , vol.176 , Issue.2 , pp. 861-869
    • Gurlo, T.1    Ryazantsev, S.2    Huang, C.J.3    Yeh, M.W.4    Reber, H.A.5    Hines, O.J.6    O'Brien, T.D.7    Glabe, C.G.8    Butler, P.C.9
  • 17
    • 10644225416 scopus 로고    scopus 로고
    • Protein misfolding and aggregation: New examples in medicine and biology of the dark side of the protein world
    • DOI 10.1016/j.bbadis.2004.08.004, PII S092544390400136X, The Biology and Pathobiology of Tau
    • Stefani M., Protein misfolding and aggregation: new examples in medicine and biology of the dark side of the protein world Biochimica et Biophysica Acta 2004 1739 1 5 25 (Pubitemid 39647706)
    • (2004) Biochimica et Biophysica Acta - Molecular Basis of Disease , vol.1739 , Issue.1 , pp. 5-25
    • Stefani, M.1
  • 18
    • 0029086781 scopus 로고
    • The reduction of insulin gene transcription in HIT-T15 cells chronically exposed to high glucose concentration is associated with the loss of RIPE3b1 and STF-1 transcription factor expression
    • Sharma A., Olson L. K., Robertson R. P., Stein R., The reduction of insulin gene transcription in HIT-T15 cells chronically exposed to high glucose concentration is associated with the loss of RIPE3b1 and STF-1 transcription factor expression Molecular Endocrinology 1995 9 9 1127 1134
    • (1995) Molecular Endocrinology , vol.9 , Issue.9 , pp. 1127-1134
    • Sharma, A.1    Olson, L.K.2    Robertson, R.P.3    Stein, R.4
  • 20
    • 0022522943 scopus 로고
    • Chronic hyperglycemia is associated with impaired glucose influence on insulin secretion. A study in normal rats using chronic in vivo glucose infusions
    • Leahy J. L., Cooper H. E., Deal D. A., Weir G. C., Chronic hyperglycemia is associated with impaired glucose influence on insulin secretion. A study in normal rats using chronic in vivo glucose infusions Journal of Clinical Investigation 1986 77 3 908 915 (Pubitemid 16067964)
    • (1986) Journal of Clinical Investigation , vol.77 , Issue.3 , pp. 908-915
    • Leahy, J.L.1    Cooper, H.E.2    Deal, D.A.3    Weir, G.C.4
  • 22
    • 33749389928 scopus 로고    scopus 로고
    • Inhibition of cyclin-dependent kinase 5 activity protects pancreatic beta cells from glucotoxicity
    • DOI 10.1074/jbc.M604690200
    • Ubeda M., Rukstalis J. M., Habener J. F., Inhibition of cyclin-dependent kinase 5 activity protects pancreatic beta cells from glucotoxicity Journal of Biological Chemistry 2006 281 39 28858 28864 (Pubitemid 44507029)
    • (2006) Journal of Biological Chemistry , vol.281 , Issue.39 , pp. 28858-28864
    • Ubeda, M.1    Rukstalis, J.M.2    Habener, J.F.3
  • 23
    • 0028207389 scopus 로고
    • Identification of the 23 kDa subunit of tau protein kinase II as a putative activator of CDK5 in bovine brain
    • DOI 10.1016/0014-5793(94)80501-6
    • Ishiguro K., Kobayashi S., Omori A., Identification of the 23 kDa subunit of tau protein kinase II as a putative activator of CDK5 in bovine brain FEBS Letters 1994 342 2 203 208 (Pubitemid 24115197)
    • (1994) FEBS Letters , vol.342 , Issue.2 , pp. 203-208
    • Ishiguro, K.1
  • 26
    • 0035754080 scopus 로고    scopus 로고
    • To cycle or not to cycle: A critical decision in cancer
    • Malumbres M., Barbacid M., To cycle or not to cycle: a critical decision in cancer Nature Reviews Cancer 2001 1 3 222 231 (Pubitemid 33741897)
    • (2001) Nature Reviews Cancer , vol.1 , Issue.3 , pp. 222-231
    • Malumbres, M.1    Barbacid, M.2
  • 27
    • 74949134147 scopus 로고    scopus 로고
    • Cdk5, the multifunctional surveyor
    • Lalioti V., Pulido D., Sandoval I. V., Cdk5, the multifunctional surveyor Cell Cycle 2010 9 2 284 311
    • (2010) Cell Cycle , vol.9 , Issue.2 , pp. 284-311
    • Lalioti, V.1    Pulido, D.2    Sandoval, I.V.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.