Adipocyte-specific transgenic and knockout models

Methods in Enzymology

Volumn 537, Issue , 2014, Pages 1-16

  Kang, Sona ^a   Kong, Xingxing ^a   Rosen, Evan D ^a,b  

^a BETH ISRAEL DEACONESS MEDICAL CENTER   (United States)

^b HARVARD MEDICAL SCHOOL   (United States)

Author keywords

Adipocyte; Adipose tissue; BAC transgenic; Brown adipose tissue; Cre recombinase; Knockout mouse; Transgenic mouse; White adipose tissue

Indexed keywords

ADIPOCYTE; ADIPOSE TISSUE; BROWN ADIPOSE TISSUE; CELL FUNCTION; CELL HETEROGENEITY; CELL MATURATION; DEVELOPMENTAL STAGE; GAIN OF FUNCTION MUTATION; GENE OVEREXPRESSION; GENETIC MODEL; IN VIVO STUDY; KNOCKOUT GENE; LIPID STORAGE; LOSS OF FUNCTION MUTATION; NONHUMAN; PRIORITY JOURNAL; REVIEW; TISSUE SPECIFICITY; TRANSGENICS; WHITE ADIPOSE TISSUE;

ADIPOCYTE; ADIPOSE TISSUE; BAC TRANSGENIC; BROWN ADIPOSE TISSUE; CRE RECOMBINASE; KNOCKOUT MOUSE; TRANSGENIC MOUSE; WHITE ADIPOSE TISSUE;

ADIPOCYTES; ADIPOSE TISSUE, BROWN; ADIPOSE TISSUE, WHITE; ANIMALS; CELL DIFFERENTIATION; HUMANS; INTEGRASES; MICE; MICE, KNOCKOUT; MICE, TRANSGENIC; OBESITY;

EID: 84893194016     PISSN: 00766879     EISSN: 15577988     Source Type: Book Series    
DOI: 10.1016/B978-0-12-411619-1.00001-X     Document Type: Chapter

References (55)

1. E.D. Abel, O. Peroni, J.K. Kim, Y.B. Kim, O. Boss, and E. Hadro et al. Adipose-selective targeting of the GLUT4 gene impairs insulin action in muscle and liver Nature 409 6821 2001 729 733
2. E.U. Alt, C. Senst, S.N. Murthy, D.P. Slakey, C.L. Dupin, and A.E. Chaffin et al. Aging alters tissue resident mesenchymal stem cell properties Stem Cell Research 8 2 2012 215 225
3. P. Arner, and K.L. Spalding Fat cell turnover in humans Biochemical and Biophysical Research Communications 396 1 2010 101 104
4. C. Barlow, M. Schroeder, J. Lekstrom-Himes, H. Kylefjord, C.X. Deng, and A. Wynshaw-Boris et al. Targeted expression of Cre recombinase to adipose tissue of transgenic mice directs adipose-specific excision of loxP-flanked gene segments Nucleic Acids Research 25 12 1997 2543 2545
5. C. Beard, K. Hochedlinger, K. Plath, A. Wutz, and R. Jaenisch Efficient method to generate single-copy transgenic mice by site-specific integration in embryonic stem cells Genesis 44 1 2006 23 28
6. M. Bluher, M.D. Michael, O.D. Peroni, K. Ueki, N. Carter, and B.B. Kahn et al. Adipose tissue selective insulin receptor knockout protects against obesity and obesity-related glucose intolerance Developmental Cell 3 1 2002 25 38
7. C. Carlsson, D. Tornehave, K. Lindberg, P. Galante, N. Billestrup, and B. Michelsen et al. Growth hormone and prolactin stimulate the expression of rat preadipocyte factor-1/delta-like protein in pancreatic islets: Molecular cloning and expression pattern during development and growth of the endocrine pancreas Endocrinology 138 9 1997 3940 3948
8. A. Chawla, K.D. Nguyen, and Y.P. Goh Macrophage-mediated inflammation in metabolic disease Nature Reviews. Immunology 11 11 2011 738 749
9. S.H. Chiang, M. Bazuine, C.N. Lumeng, L.M. Geletka, J. Mowers, and N.M. White et al. The protein kinase IKKepsilon regulates energy balance in obese mice Cell 138 5 2009 961 975
10. P.S. Danielian, D. Muccino, D.H. Rowitch, S.K. Michael, and A.P. McMahon Modification of gene activity in mouse embryos in utero by a tamoxifen-inducible form of Cre recombinase Current Biology 8 24 1998 1323 1326
11. N.C. Dubois, D. Hofmann, K. Kaloulis, J.M. Bishop, and A. Trumpp Nestin-Cre transgenic mouse line Nes-Cre1 mediates highly efficient Cre/loxP mediated recombination in the nervous system, kidney, and somite-derived tissues Genesis 44 8 2006 355 360
12. J. Eguchi, X. Wang, S. Yu, E.E. Kershaw, P.C. Chiu, and J. Dushay et al. Transcriptional control of adipose lipid handling by IRF4 Cell Metabolism 13 3 2011 249 259
13. M.T. Elghetany, and J. Patel Assessment of CD24 expression on bone marrow neutrophilic granulocytes: CD24 is a marker for the myelocytic stage of development American Journal of Hematology 71 4 2002 348 349
14. S. Feil, N. Valtcheva, and R. Feil Inducible Cre mice Methods in Molecular Biology 530 2009 343 363
15. R.E. Ferrell, M.A. Kimak, E.C. Lawrence, and D.N. Finegold Candidate gene analysis in primary lymphedema Lymphatic Research and Biology 6 2 2008 69 76
16. F.M. Fisher, S. Kleiner, N. Douris, E.C. Fox, R.J. Mepani, and F. Verdeguer et al. FGF21 regulates PGC-1alpha and browning of white adipose tissues in adaptive thermogenesis Genes & Development 26 3 2012 271 281
17. G. Friedrich, and P. Soriano Promoter traps in embryonic stem cells: A genetic screen to identify and mutate developmental genes in mice Genes & Development 5 9 1991 1513 1523
18. Y. Fu, N. Luo, M.F. Lopes-Virella, and W.T. Garvey The adipocyte lipid binding protein (ALBP/aP2) gene facilitates foam cell formation in human THP-1 macrophages Atherosclerosis 165 2 2002 259 269
19. R.A. Graves, P. Tontonoz, K.A. Platt, S.R. Ross, and B.M. Spiegelman Identification of a fat cell enhancer: Analysis of requirements for adipose tissue-specific gene expression Journal of Cellular Biochemistry 49 3 1992 219 224
20. R.A. Graves, P. Tontonoz, and B.M. Spiegelman Analysis of a tissue-specific enhancer: ARF6 regulates adipogenic gene expression Molecular and Cellular Biology 12 7 1992 3313
21. C. Guerra, P. Navarro, A.M. Valverde, M. Arribas, J. Bruning, and L.P. Kozak et al. Brown adipose tissue-specific insulin receptor knockout shows diabetic phenotype without insulin resistance The Journal of Clinical Investigation 108 8 2001 1205 1213
22. W. He, Y. Barak, A. Hevener, P. Olson, D. Liao, and J. Le et al. Adipose-specific peroxisome proliferator-activated receptor gamma knockout causes insulin resistance in fat and liver but not in muscle Proceedings of the National Academy of Sciences of the United States of America 100 26 2003 15712 15717
23. T. Imai, M. Jiang, P. Chambon, and D. Metzger Impaired adipogenesis and lipolysis in the mouse upon selective ablation of the retinoid X receptor alpha mediated by a tamoxifen-inducible chimeric Cre recombinase (Cre-ERT2) in adipocytes Proceedings of the National Academy of Sciences of the United States of America 98 1 2001 224 228
24. T. Imai, R. Takakuwa, S. Marchand, E. Dentz, J.M. Bornert, and N. Messaddeq et al. Peroxisome proliferator-activated receptor gamma is required in mature white and brown adipocytes for their survival in the mouse Proceedings of the National Academy of Sciences of the United States of America 101 13 2004 4543 4547
25. N. Inoue, N. Yahagi, T. Yamamoto, M. Ishikawa, K. Watanabe, and T. Matsuzaka et al. Cyclin-dependent kinase inhibitor, p21WAF1/CIP1, is involved in adipocyte differentiation and hypertrophy, linking to obesity, and insulin resistance The Journal of Biological Chemistry 283 30 2008 21220 21229
26. P. Jarver, T. Coursindel, S.E. Andaloussi, C. Godfrey, M.J. Wood, and M.J. Gait Peptide-mediated cell and in vivo delivery of antisense oligonucleotides and siRNA Molecular Therapy - Nucleic Acids 1 2012 e27
27. S. Kang, P. Akerblad, R. Kiviranta, R.K. Gupta, S. Kajimura, and M.J. Griffin et al. Regulation of early adipose commitment by Zfp521 PLoS Biology 10 11 2012 e1001433
28. G. Karsenty, and M. Ferron The contribution of bone to whole-organism physiology Nature 481 7381 2012 314 320
29. Y.H. Lee, A.P. Petkova, E.P. Mottillo, and J.G. Granneman In vivo identification of bipotential adipocyte progenitors recruited by beta3-adrenoceptor activation and high-fat feeding Cell Metabolism 15 4 2012 480 491
30. K.Y. Lee, S.J. Russell, S. Ussar, J. Boucher, C. Vernochet, and M.A. Mori et al. Lessons on conditional gene targeting in mouse adipose tissue Diabetes 62 3 2013 864 874
31. M.J. Lee, Y. Wu, and S.K. Fried Adipose tissue heterogeneity: Implication of depot differences in adipose tissue for obesity complications Molecular Aspects of Medicine 34 1 2013 1 11
32. J.A. Levine, M.D. Jensen, N.L. Eberhardt, and T. O'Brien Adipocyte macrophage colony-stimulating factor is a mediator of adipose tissue growth The Journal of Clinical Investigation 101 8 1998 1557 1564
33. L. Makowski, J.B. Boord, K. Maeda, V.R. Babaev, K.T. Uysal, and M.A. Morgan et al. Lack of macrophage fatty-acid-binding protein aP2 protects mice deficient in apolipoprotein E against atherosclerosis Nature Medicine 7 6 2001 699 705
34. S. Mandrup, T.M. Loftus, O.A. MacDougald, F.P. Kuhajda, and M.D. Lane Obese gene expression at in vivo levels by fat pads derived from s.c. implanted 3T3-F442A preadipocytes Proceedings of the National Academy of Sciences of the United States of America 94 9 1997 4300 4305
35. S.E. Mullican, T. Tomaru, C.A. Gaddis, L.C. Peed, A. Sundaram, and M.A. Lazar A novel adipose-specific gene deletion model demonstrates potential pitfalls of existing methods Molecular Endocrinology 27 1 2013 127 134
36. W. Oh, L. Abu-Elheiga, P. Kordari, Z. Gu, T. Shaikenov, and S.S. Chirala et al. Glucose and fat metabolism in adipose tissue of acetyl-CoA carboxylase 2 knockout mice Proceedings of the National Academy of Sciences of the United States of America 102 5 2005 1384 1389
37. O. Osborn, and J.M. Olefsky The cellular and signaling networks linking the immune system and metabolism in disease Nature Medicine 18 3 2012 363 374
38. C.M. Rondinone, J.M. Trevillyan, J. Clampit, R.J. Gum, C. Berg, and P. Kroeger et al. Protein tyrosine phosphatase 1B reduction regulates adiposity and expression of genes involved in lipogenesis Diabetes 51 8 2002 2405 2411
39. E.D. Rosen, and B.M. Spiegelman Adipocytes as regulators of energy balance and glucose homeostasis Nature 444 7121 2006 847 853
40. M. Rosenwald, A. Perdikari, T. Rulicke, and C. Wolfrum Bidirectional interconversion of brite and white adipocytes Nature Cell Biology 15 2013 659 667 advance online publication
41. S.R. Ross, R.A. Graves, A. Greenstein, K.A. Platt, H.L. Shyu, and B. Mellovitz et al. A fat-specific enhancer is the primary determinant of gene expression for adipocyte P2 in vivo Proceedings of the National Academy of Sciences of the United States of America 87 24 1990 9590 9594
42. V.T. Samuel, C.S. Choi, T.G. Phillips, A.J. Romanelli, J.G. Geisler, and S. Bhanot et al. Targeting foxo1 in mice using antisense oligonucleotide improves hepatic and peripheral insulin action Diabetes 55 7 2006 2042 2050
43. P. Seale, S. Kajimura, and B.M. Spiegelman Transcriptional control of brown adipocyte development and physiological function of mice and men Genes & Development 23 7 2009 788 797
44. R. Serrano, M. Villar, C. Martinez, J.M. Carrascosa, N. Gallardo, and A. Andres Differential gene expression of insulin receptor isoforms A and B and insulin receptor substrates 1, 2 and 3 in rat tissues: Modulation by aging and differentiation in rat adipose tissue Journal of Molecular Endocrinology 34 1 2005 153 161
45. S. Shaughnessy, E.R. Smith, S. Kodukula, J. Storch, and S.K. Fried Adipocyte metabolism in adipocyte fatty acid binding protein knockout mice (aP2-/-) after short-term high-fat feeding: Functional compensation by the keratinocyte [correction of keritinocyte] fatty acid binding protein Diabetes 49 6 2000 904 911
46. P. Soriano Generalized lacZ expression with the ROSA26 Cre reporter strain Nature Genetics 21 1 1999 70 71
47. K.L. Spalding, E. Arner, P.O. Westermark, S. Bernard, B.A. Buchholz, and O. Bergmann et al. Dynamics of fat cell turnover in humans Nature 453 7196 2008 783 787
48. C.M. Steppan, S.T. Bailey, S. Bhat, E.J. Brown, R.R. Banerjee, and C.M. Wright et al. The hormone resistin links obesity to diabetes Nature 409 6818 2001 307 312
49. A.L. Szymczak, C.J. Workman, Y. Wang, K.M. Vignali, S. Dilioglou, and E.F. Vanin et al. Correction of multi-gene deficiency in vivo using a single 'self-cleaving' 2A peptide-based retroviral vector Nature Biotechnology 22 5 2004 589 594
50. Y.D. Tchoukalova, M. Fitch, P.M. Rogers, J.D. Covington, T.M. Henagan, and J. Ye et al. In vivo adipogenesis in rats measured by cell kinetics in adipocytes and plastic-adherent stroma-vascular cells in response to high-fat diet and thiazolidinedione Diabetes 61 1 2012 137 144
51. S. Urs, A. Harrington, L. Liaw, and D. Small Selective expression of an aP2/fatty acid binding protein 4-Cre transgene in non-adipogenic tissues during embryonic development Transgenic Research 15 5 2006 647 653
52. Z.V. Wang, Y. Deng, Q.A. Wang, K. Sun, and P.E. Scherer Identification and characterization of a promoter cassette conferring adipocyte-specific gene expression Endocrinology 151 6 2010 2933 2939
53. J. Wu, P. Bostrom, L.M. Sparks, L. Ye, J.H. Choi, and A.H. Giang et al. Beige adipocytes are a distinct type of thermogenic fat cell in mouse and human Cell 150 2 2012 366 376
54. J. Wu, P. Cohen, and B.M. Spiegelman Adaptive thermogenesis in adipocytes: Is beige the new brown? Genes & Development 27 3 2013 234 250
55. X.X. Yu, S.F. Murray, L. Watts, S.L. Booten, J. Tokorcheck, and B.P. Monia et al. Reduction of JNK1 expression with antisense oligonucleotide improves adiposity in obese mice American Journal of Physiology, Endocrinology and Metabolism 295 2 2008 E436 E445