Essential role of protein-tyrosine phosphatase 1B in the modulation of insulin signaling by acetaminophen in hepatocytes

Journal of Biological Chemistry

Volumn 289, Issue 42, 2014, Pages 29406-29419

  Mobasher, Maysa Ahmed ^a,b   De Toro Martín, Juan ^b,c   González Rodríguez, Águeda ^a,b   Ramos, Sonia ^d   Letzig, Lynda G ^e   James, Laura P ^e   Muntané, Jordi ^f   Álvarez, Carmen ^a,b   Valverde, Ángela M ^a,b  

^a INSTITUTO DE INVESTIGACIONES BIOMÉDICAS ALBERTO SOLS   (Spain)

^b INSTITUTO DE SALUD CARLOS III   (Spain)

^c UNIVERSIDAD COMPLUTENSE DE MADRID   (Spain)

^d INSTITUTE OF FOOD SCIENCE   (Spain)

^e UNIVERSITY OF ARKANSAS FOR MEDICAL SCIENCES   (United States)

^f HOSPITAL UNIVERSITARIO VIRGEN DEL ROCÍO   (Spain)

Author keywords

[No Author keywords available]

Indexed keywords

AMINO ACIDS; SIGNALING;

HEPATOCYTES; INSULIN RECEPTORS; INSULIN RESISTANCE; INSULIN SIGNALING; PROTEIN-TYROSINE PHOSPHATASE 1B;

INSULIN;

GLUCOSE; INSULIN; PARACETAMOL; PROTEIN TYROSINE PHOSPHATASE 1B; ROSIGLITAZONE; STRESS ACTIVATED PROTEIN KINASE; SURAMIN; 2,4 THIAZOLIDINEDIONE DERIVATIVE; GLUTATHIONE TRANSFERASE; PTPN1 PROTEIN, HUMAN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL DEATH; CELL PROTECTION; CONCENTRATION RESPONSE; CONTROLLED STUDY; ENERGY EXPENDITURE; ENZYME ACTIVITY; ENZYME DEFICIENCY; ENZYME PHOSPHORYLATION; GENE SILENCING; GLUCOSE HOMEOSTASIS; HEPATOCELLULAR CARCINOMA CELL LINE; HISTOPATHOLOGY; HUH7 CELL LINE; HUMAN; HUMAN CELL; INSULIN METABOLISM; INSULIN RESISTANCE; LIVER CELL; LIVER TOXICITY; LOCOMOTION; MALE; MOLECULAR INTERACTION; MOUSE; NONHUMAN; PANCREAS ISLET ALPHA CELL; PANCREAS ISLET BETA CELL; PROTEIN ANALYSIS; PROTEIN EXPRESSION; SIGNAL TRANSDUCTION; WILD TYPE; ANIMAL; C57BL MOUSE; CELL LINE; CELL SURVIVAL; CHEMISTRY; CYTOLOGY; DRUG EFFECTS; GLUCOSE TOLERANCE TEST; HOMEOSTASIS; METABOLISM; PANCREAS ISLET; PHOSPHORYLATION;

ACETAMINOPHEN; ANIMALS; CELL LINE; CELL SURVIVAL; GENE SILENCING; GLUCOSE; GLUCOSE TOLERANCE TEST; GLUTATHIONE TRANSFERASE; HEPATOCYTES; HOMEOSTASIS; HUMANS; INSULIN; ISLETS OF LANGERHANS; MALE; MICE; MICE, INBRED C57BL; PHOSPHORYLATION; PROTEIN TYROSINE PHOSPHATASE, NON-RECEPTOR TYPE 1; SIGNAL TRANSDUCTION; SURAMIN; THIAZOLIDINEDIONES;

EID: 84908140283     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M113.539189     Document Type: Article

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