-
1
-
-
69749123786
-
Fine-tuning of the unfolded protein response: assembling the IRE1alpha interactome
-
C. Hetz, and L.H. Glimcher Fine-tuning of the unfolded protein response: assembling the IRE1alpha interactome Mol Cell 35 2009 551 561
-
(2009)
Mol Cell
, vol.35
, pp. 551-561
-
-
Hetz, C.1
Glimcher, L.H.2
-
2
-
-
0027324844
-
Transcriptional induction of genes encoding endoplasmic reticulum resident proteins requires a transmembrane protein kinase
-
J.S. Cox, C.E. Shamu, and P. Walter Transcriptional induction of genes encoding endoplasmic reticulum resident proteins requires a transmembrane protein kinase Cell 73 1993 1197 1206
-
(1993)
Cell
, vol.73
, pp. 1197-1206
-
-
Cox, J.S.1
Shamu, C.E.2
Walter, P.3
-
3
-
-
0029903049
-
Oligomerization and phosphorylation of the Ire1p kinase during intracellular signaling from the endoplasmic reticulum to the nucleus
-
C.E. Shamu, and P. Walter Oligomerization and phosphorylation of the Ire1p kinase during intracellular signaling from the endoplasmic reticulum to the nucleus EMBO J 15 1996 3028 3039
-
(1996)
EMBO J
, vol.15
, pp. 3028-3039
-
-
Shamu, C.E.1
Walter, P.2
-
4
-
-
0037011917
-
IRE1 couples endoplasmic reticulum load to secretory capacity by processing the XBP-1 mRNA
-
M. Calfon, H. Zeng, F. Urano, J.H. Till, S.R. Hubbard, H.P. Harding, S.G. Clark, and D. Ron IRE1 couples endoplasmic reticulum load to secretory capacity by processing the XBP-1 mRNA Nature 415 2002 92 96
-
(2002)
Nature
, vol.415
, pp. 92-96
-
-
Calfon, M.1
Zeng, H.2
Urano, F.3
Till, J.H.4
Hubbard, S.R.5
Harding, H.P.6
Clark, S.G.7
Ron, D.8
-
5
-
-
0035966269
-
XBP1 mRNA is induced by ATF6 and spliced by IRE1 in response to ER stress to produce a highly active transcription factor
-
H. Yoshida, T. Matsui, A. Yamamoto, T. Okada, and K. Mori XBP1 mRNA is induced by ATF6 and spliced by IRE1 in response to ER stress to produce a highly active transcription factor Cell 107 2001 881 891
-
(2001)
Cell
, vol.107
, pp. 881-891
-
-
Yoshida, H.1
Matsui, T.2
Yamamoto, A.3
Okada, T.4
Mori, K.5
-
6
-
-
84926106643
-
A synthetic biology approach identifies the mammalian UPR RNA ligase RtcB
-
Y. Lu, F.X. Liang, and X. Wang A synthetic biology approach identifies the mammalian UPR RNA ligase RtcB Mol Cell 55 2014 758 770
-
(2014)
Mol Cell
, vol.55
, pp. 758-770
-
-
Lu, Y.1
Liang, F.X.2
Wang, X.3
-
7
-
-
84918823958
-
The mammalian tRNA ligase complex mediates splicing of XBP1 mRNA and controls antibody secretion in plasma cells
-
J. Jurkin, T. Henkel, A.F. Nielsen, M. Minnich, J. Popow, T. Kaufmann, K. Heindl, T. Hoffmann, M. Busslinger, and J. Martinez The mammalian tRNA ligase complex mediates splicing of XBP1 mRNA and controls antibody secretion in plasma cells EMBO J 33 2014 2922 2936
-
(2014)
EMBO J
, vol.33
, pp. 2922-2936
-
-
Jurkin, J.1
Henkel, T.2
Nielsen, A.F.3
Minnich, M.4
Popow, J.5
Kaufmann, T.6
Heindl, K.7
Hoffmann, T.8
Busslinger, M.9
Martinez, J.10
-
8
-
-
84915814883
-
The RtcB RNA ligase is an essential component of the metazoan unfolded protein response
-
S.G. Kosmaczewski, T.J. Edwards, S.M. Han, M.J. Eckwahl, B.I. Meyer, S. Peach, J.R. Hesselberth, S.L. Wolin, and M. Hammarlund The RtcB RNA ligase is an essential component of the metazoan unfolded protein response EMBO Rep 15 2014 1278 1285
-
(2014)
EMBO Rep
, vol.15
, pp. 1278-1285
-
-
Kosmaczewski, S.G.1
Edwards, T.J.2
Han, S.M.3
Eckwahl, M.J.4
Meyer, B.I.5
Peach, S.6
Hesselberth, J.R.7
Wolin, S.L.8
Hammarlund, M.9
-
9
-
-
0142059951
-
XBP-1 regulates a subset of endoplasmic reticulum resident chaperone genes in the unfolded protein response
-
A.H. Lee, N.N. Iwakoshi, and L.H. Glimcher XBP-1 regulates a subset of endoplasmic reticulum resident chaperone genes in the unfolded protein response Mol Cell Biol 23 2003 7448 7459
-
(2003)
Mol Cell Biol
, vol.23
, pp. 7448-7459
-
-
Lee, A.H.1
Iwakoshi, N.N.2
Glimcher, L.H.3
-
10
-
-
84876991539
-
Stress-independent activation of XBP1s and/or ATF6 reveals three functionally diverse ER proteostasis environments
-
M.D. Shoulders, L.M. Ryno, J.C. Genereux, J.J. Moresco, P.G. Tu, C. Wu, J.R. Yates 3rd, A.I. Su, J.W. Kelly, and R.L. Wiseman Stress-independent activation of XBP1s and/or ATF6 reveals three functionally diverse ER proteostasis environments Cell Rep 3 2013 1279 1292
-
(2013)
Cell Rep
, vol.3
, pp. 1279-1292
-
-
Shoulders, M.D.1
Ryno, L.M.2
Genereux, J.C.3
Moresco, J.J.4
Tu, P.G.5
Wu, C.6
Yates, J.R.7
Su, A.I.8
Kelly, J.W.9
Wiseman, R.L.10
-
11
-
-
9144228073
-
Differential contributions of ATF6 and XBP1 to the activation of endoplasmic reticulum stress-responsive cis-acting elements ERSE, UPRE and ERSE-II
-
K. Yamamoto, H. Yoshida, K. Kokame, R.J. Kaufman, and K. Mori Differential contributions of ATF6 and XBP1 to the activation of endoplasmic reticulum stress-responsive cis-acting elements ERSE, UPRE and ERSE-II J Biochem 136 2004 343 350
-
(2004)
J Biochem
, vol.136
, pp. 343-350
-
-
Yamamoto, K.1
Yoshida, H.2
Kokame, K.3
Kaufman, R.J.4
Mori, K.5
-
12
-
-
34548172495
-
Transcriptional induction of mammalian ER quality control proteins is mediated by single or combined action of ATF6alpha and XBP1
-
K. Yamamoto, T. Sato, T. Matsui, M. Sato, T. Okada, H. Yoshida, A. Harada, and K. Mori Transcriptional induction of mammalian ER quality control proteins is mediated by single or combined action of ATF6alpha and XBP1 Dev Cell 13 2007 365 376
-
(2007)
Dev Cell
, vol.13
, pp. 365-376
-
-
Yamamoto, K.1
Sato, T.2
Matsui, T.3
Sato, M.4
Okada, T.5
Yoshida, H.6
Harada, A.7
Mori, K.8
-
13
-
-
3142658576
-
XBP1, downstream of Blimp-1, expands the secretory apparatus and other organelles, and increases protein synthesis in plasma cell differentiation
-
A.L. Shaffer, M. Shapiro-Shelef, N.N. Iwakoshi, A.H. Lee, S.B. Qian, H. Zhao, X. Yu, L. Yang, B.K. Tan, A. Rosenwald, E.M. Hurt, E. Petroulakis, N. Sonenberg, J.W. Yewdell, K. Calame, L.H. Glimcher, and L.M. Staudt XBP1, downstream of Blimp-1, expands the secretory apparatus and other organelles, and increases protein synthesis in plasma cell differentiation Immunity 21 2004 81 93
-
(2004)
Immunity
, vol.21
, pp. 81-93
-
-
Shaffer, A.L.1
Shapiro-Shelef, M.2
Iwakoshi, N.N.3
Lee, A.H.4
Qian, S.B.5
Zhao, H.6
Yu, X.7
Yang, L.8
Tan, B.K.9
Rosenwald, A.10
Hurt, E.M.11
Petroulakis, E.12
Sonenberg, N.13
Yewdell, J.W.14
Calame, K.15
Glimcher, L.H.16
Staudt, L.M.17
-
14
-
-
84896382541
-
Spliced X-box binding protein 1 couples the unfolded protein response to hexosamine biosynthetic pathway
-
Z.V. Wang, Y. Deng, N. Gao, Z. Pedrozo, D.L. Li, C.R. Morales, A. Criollo, X. Luo, W. Tan, N. Jiang, M.A. Lehrman, B.A. Rothermel, A.H. Lee, S. Lavandero, P.P. Mammen, A. Ferdous, T.G. Gillette, P.E. Scherer, and J.A. Hill Spliced X-box binding protein 1 couples the unfolded protein response to hexosamine biosynthetic pathway Cell 156 2014 1179 1192
-
(2014)
Cell
, vol.156
, pp. 1179-1192
-
-
Wang, Z.V.1
Deng, Y.2
Gao, N.3
Pedrozo, Z.4
Li, D.L.5
Morales, C.R.6
Criollo, A.7
Luo, X.8
Tan, W.9
Jiang, N.10
Lehrman, M.A.11
Rothermel, B.A.12
Lee, A.H.13
Lavandero, S.14
Mammen, P.P.15
Ferdous, A.16
Gillette, T.G.17
Scherer, P.E.18
Hill, J.A.19
-
15
-
-
0033590451
-
Protein translation and folding are coupled by an endoplasmic-reticulum-resident kinase
-
H.P. Harding, Y. Zhang, and D. Ron Protein translation and folding are coupled by an endoplasmic-reticulum-resident kinase Nature 397 1999 271 274
-
(1999)
Nature
, vol.397
, pp. 271-274
-
-
Harding, H.P.1
Zhang, Y.2
Ron, D.3
-
16
-
-
0036437307
-
Transcriptional and translational control in the Mammalian unfolded protein response
-
H.P. Harding, M. Calfon, F. Urano, I. Novoa, and D. Ron Transcriptional and translational control in the Mammalian unfolded protein response Annu Rev Cell Dev Biol 18 2002 575 599
-
(2002)
Annu Rev Cell Dev Biol
, vol.18
, pp. 575-599
-
-
Harding, H.P.1
Calfon, M.2
Urano, F.3
Novoa, I.4
Ron, D.5
-
17
-
-
84870732594
-
Protein-folding homeostasis in the endoplasmic reticulum and nutritional regulation
-
pii: a013177
-
D. Ron, and H.P. Harding Protein-folding homeostasis in the endoplasmic reticulum and nutritional regulation Cold Spring Harb Perspect Biol 2012 4 pii: a013177
-
(2012)
Cold Spring Harb Perspect Biol
, pp. 4
-
-
Ron, D.1
Harding, H.P.2
-
18
-
-
0032693671
-
Mammalian transcription factor ATF6 is synthesized as a transmembrane protein and activated by proteolysis in response to endoplasmic reticulum stress
-
K. Haze, H. Yoshida, H. Yanagi, T. Yura, and K. Mori Mammalian transcription factor ATF6 is synthesized as a transmembrane protein and activated by proteolysis in response to endoplasmic reticulum stress Mol Biol Cell 10 1999 3787 3799
-
(1999)
Mol Biol Cell
, vol.10
, pp. 3787-3799
-
-
Haze, K.1
Yoshida, H.2
Yanagi, H.3
Yura, T.4
Mori, K.5
-
19
-
-
0034515724
-
ER stress induces cleavage of membrane-bound ATF6 by the same proteases that process SREBPs
-
J. Ye, R.B. Rawson, R. Komuro, X. Chen, U.P. Dave, R. Prywes, M.S. Brown, and J.L. Goldstein ER stress induces cleavage of membrane-bound ATF6 by the same proteases that process SREBPs Mol Cell 6 2000 1355 1364
-
(2000)
Mol Cell
, vol.6
, pp. 1355-1364
-
-
Ye, J.1
Rawson, R.B.2
Komuro, R.3
Chen, X.4
Dave, U.P.5
Prywes, R.6
Brown, M.S.7
Goldstein, J.L.8
-
20
-
-
34548189283
-
ATF6alpha optimizes long-term endoplasmic reticulum function to protect cells from chronic stress
-
J. Wu, D.T. Rutkowski, M. Dubois, J. Swathirajan, T. Saunders, J. Wang, B. Song, G.D. Yau, and R.J. Kaufman ATF6alpha optimizes long-term endoplasmic reticulum function to protect cells from chronic stress Dev Cell 13 2007 351 364
-
(2007)
Dev Cell
, vol.13
, pp. 351-364
-
-
Wu, J.1
Rutkowski, D.T.2
Dubois, M.3
Swathirajan, J.4
Saunders, T.5
Wang, J.6
Song, B.7
Yau, G.D.8
Kaufman, R.J.9
-
21
-
-
0037320265
-
A time-dependent phase shift in the mammalian unfolded protein response
-
H. Yoshida, T. Matsui, N. Hosokawa, R.J. Kaufman, K. Nagata, and K. Mori A time-dependent phase shift in the mammalian unfolded protein response Dev Cell 4 2003 265 271
-
(2003)
Dev Cell
, vol.4
, pp. 265-271
-
-
Yoshida, H.1
Matsui, T.2
Hosokawa, N.3
Kaufman, R.J.4
Nagata, K.5
Mori, K.6
-
22
-
-
59649092854
-
Messenger RNA targeting to endoplasmic reticulum stress signalling sites
-
T. Aragon, E. van Anken, D. Pincus, I.M. Serafimova, A.V. Korennykh, C.A. Rubio, and P. Walter Messenger RNA targeting to endoplasmic reticulum stress signalling sites Nature 457 2009 736 740
-
(2009)
Nature
, vol.457
, pp. 736-740
-
-
Aragon, T.1
Van Anken, E.2
Pincus, D.3
Serafimova, I.M.4
Korennykh, A.V.5
Rubio, C.A.6
Walter, P.7
-
23
-
-
77958016968
-
Mammalian endoplasmic reticulum stress sensor IRE1 signals by dynamic clustering
-
H. Li, A.V. Korennykh, S.L. Behrman, and P. Walter Mammalian endoplasmic reticulum stress sensor IRE1 signals by dynamic clustering Proc Natl Acad Sci U S A 107 2010 16113 16118
-
(2010)
Proc Natl Acad Sci U S A
, vol.107
, pp. 16113-16118
-
-
Li, H.1
Korennykh, A.V.2
Behrman, S.L.3
Walter, P.4
-
24
-
-
36049049392
-
IRE1 signaling affects cell fate during the unfolded protein response
-
J.H. Lin, H. Li, D. Yasumura, H.R. Cohen, C. Zhang, B. Panning, K.M. Shokat, M.M. Lavail, and P. Walter IRE1 signaling affects cell fate during the unfolded protein response Science 318 2007 944 949
-
(2007)
Science
, vol.318
, pp. 944-949
-
-
Lin, J.H.1
Li, H.2
Yasumura, D.3
Cohen, H.R.4
Zhang, C.5
Panning, B.6
Shokat, K.M.7
Lavail, M.M.8
Walter, P.9
-
25
-
-
84919708686
-
Ire1 has distinct catalytic mechanisms for XBP1/HAC1 splicing and RIDD
-
A.B. Tam, A.C. Koong, and M. Niwa Ire1 has distinct catalytic mechanisms for XBP1/HAC1 splicing and RIDD Cell Rep 9 2014 850 858
-
(2014)
Cell Rep
, vol.9
, pp. 850-858
-
-
Tam, A.B.1
Koong, A.C.2
Niwa, M.3
-
26
-
-
33745893809
-
Decay of endoplasmic reticulum-localized mRNAs during the unfolded protein response
-
J. Hollien, and J.S. Weissman Decay of endoplasmic reticulum-localized mRNAs during the unfolded protein response Science 313 2006 104 107
-
(2006)
Science
, vol.313
, pp. 104-107
-
-
Hollien, J.1
Weissman, J.S.2
-
27
-
-
68549092781
-
Regulated Ire1-dependent decay of messenger RNAs in mammalian cells
-
J. Hollien, J.H. Lin, H. Li, N. Stevens, P. Walter, and J.S. Weissman Regulated Ire1-dependent decay of messenger RNAs in mammalian cells J Cell Biol 186 2009 323 331
-
(2009)
J Cell Biol
, vol.186
, pp. 323-331
-
-
Hollien, J.1
Lin, J.H.2
Li, H.3
Stevens, N.4
Walter, P.5
Weissman, J.S.6
-
28
-
-
0035958913
-
Oxidative stress-induced phospholipase C-gamma 1 activation enhances cell survival
-
X.T. Wang, K.D. McCullough, X.J. Wang, G. Carpenter, and N.J. Holbrook Oxidative stress-induced phospholipase C-gamma 1 activation enhances cell survival J Biol Chem 276 2001 28364 28371
-
(2001)
J Biol Chem
, vol.276
, pp. 28364-28371
-
-
Wang, X.T.1
McCullough, K.D.2
Wang, X.J.3
Carpenter, G.4
Holbrook, N.J.5
-
29
-
-
84903749341
-
Cell death: opposing unfolded-protein-response signals converge on death receptor 5 to control apoptosis
-
M. Lu, D.A. Lawrence, S. Marsters, D. Acosta-Alvear, P. Kimmig, A.S. Mendez, A.W. Paton, J.C. Paton, P. Walter, and A. Ashkenazi Cell death: opposing unfolded-protein-response signals converge on death receptor 5 to control apoptosis Science 345 2014 98 101
-
(2014)
Science
, vol.345
, pp. 98-101
-
-
Lu, M.1
Lawrence, D.A.2
Marsters, S.3
Acosta-Alvear, D.4
Kimmig, P.5
Mendez, A.S.6
Paton, A.W.7
Paton, J.C.8
Walter, P.9
Ashkenazi, A.10
-
30
-
-
84856856011
-
IRE1alpha activation protects mice against acetaminophen-induced hepatotoxicity
-
K.Y. Hur, J.S. So, V. Ruda, M. Frank-Kamenetsky, K. Fitzgerald, V. Koteliansky, T. Iwawaki, L.H. Glimcher, and A.H. Lee IRE1alpha activation protects mice against acetaminophen-induced hepatotoxicity J Exp Med 209 2012 307 318
-
(2012)
J Exp Med
, vol.209
, pp. 307-318
-
-
Hur, K.Y.1
So, J.S.2
Ruda, V.3
Frank-Kamenetsky, M.4
Fitzgerald, K.5
Koteliansky, V.6
Iwawaki, T.7
Glimcher, L.H.8
Lee, A.H.9
-
31
-
-
84877870687
-
The unfolded protein response element IRE1alpha senses bacterial proteins invading the ER to activate RIG-I and innate immune signaling
-
J.A. Cho, A.H. Lee, B. Platzer, B.C. Cross, B.M. Gardner, H. De Luca, P. Luong, H.P. Harding, L.H. Glimcher, P. Walter, E. Fiebiger, D. Ron, J.C. Kagan, and W.I. Lencer The unfolded protein response element IRE1alpha senses bacterial proteins invading the ER to activate RIG-I and innate immune signaling Cell Host Microbe 13 2013 558 569
-
(2013)
Cell Host Microbe
, vol.13
, pp. 558-569
-
-
Cho, J.A.1
Lee, A.H.2
Platzer, B.3
Cross, B.C.4
Gardner, B.M.5
De Luca, H.6
Luong, P.7
Harding, H.P.8
Glimcher, L.H.9
Walter, P.10
Fiebiger, E.11
Ron, D.12
Kagan, J.C.13
Lencer, W.I.14
-
32
-
-
84867038186
-
Silencing of lipid metabolism genes through IRE1alpha-mediated mRNA decay lowers plasma lipids in mice
-
J.S. So, K.Y. Hur, M. Tarrio, V. Ruda, M. Frank-Kamenetsky, K. Fitzgerald, V. Koteliansky, A.H. Lichtman, T. Iwawaki, L.H. Glimcher, and A.H. Lee Silencing of lipid metabolism genes through IRE1alpha-mediated mRNA decay lowers plasma lipids in mice Cell Metab 16 2012 487 499
-
(2012)
Cell Metab
, vol.16
, pp. 487-499
-
-
So, J.S.1
Hur, K.Y.2
Tarrio, M.3
Ruda, V.4
Frank-Kamenetsky, M.5
Fitzgerald, K.6
Koteliansky, V.7
Lichtman, A.H.8
Iwawaki, T.9
Glimcher, L.H.10
Lee, A.H.11
-
33
-
-
0034312290
-
The endoribonuclease activity of mammalian IRE1 autoregulates its mRNA and is required for the unfolded protein response
-
W. Tirasophon, K. Lee, B. Callaghan, A. Welihinda, and R.J. Kaufman The endoribonuclease activity of mammalian IRE1 autoregulates its mRNA and is required for the unfolded protein response Genes Dev 14 2000 2725 2736
-
(2000)
Genes Dev
, vol.14
, pp. 2725-2736
-
-
Tirasophon, W.1
Lee, K.2
Callaghan, B.3
Welihinda, A.4
Kaufman, R.J.5
-
34
-
-
84868525253
-
IRE1α cleaves select microRNAs during ER stress to derepress translation of proapoptotic Caspase-2
-
J.P. Upton, L. Wang, D. Han, E.S. Wang, N.E. Huskey, L. Lim, M. Truitt, M.T. McManus, D. Ruggero, A. Goga, F.R. Papa, and S.A. Oakes IRE1α cleaves select microRNAs during ER stress to derepress translation of proapoptotic Caspase-2 Science 338 2012 818 822
-
(2012)
Science
, vol.338
, pp. 818-822
-
-
Upton, J.P.1
Wang, L.2
Han, D.3
Wang, E.S.4
Huskey, N.E.5
Lim, L.6
Truitt, M.7
McManus, M.T.8
Ruggero, D.9
Goga, A.10
Papa, F.R.11
Oakes, S.A.12
-
35
-
-
84875857579
-
The unfolded protein response in fission yeast modulates stability of select mRNAs to maintain protein homeostasis
-
P. Kimmig, M. Diaz, J. Zheng, C.C. Williams, A. Lang, T. Aragon, H. Li, and P. Walter The unfolded protein response in fission yeast modulates stability of select mRNAs to maintain protein homeostasis Elife 1 2012 e00048
-
(2012)
Elife
, vol.1
-
-
Kimmig, P.1
Diaz, M.2
Zheng, J.3
Williams, C.C.4
Lang, A.5
Aragon, T.6
Li, H.7
Walter, P.8
-
36
-
-
0034723235
-
Coupling of stress in the ER to activation of JNK protein kinases by transmembrane protein kinase IRE1
-
F. Urano, X. Wang, A. Bertolotti, Y. Zhang, P. Chung, H.P. Harding, and D. Ron Coupling of stress in the ER to activation of JNK protein kinases by transmembrane protein kinase IRE1 Science 287 2000 664 666
-
(2000)
Science
, vol.287
, pp. 664-666
-
-
Urano, F.1
Wang, X.2
Bertolotti, A.3
Zhang, Y.4
Chung, P.5
Harding, H.P.6
Ron, D.7
-
37
-
-
0036606540
-
ASK1 is essential for endoplasmic reticulum stress-induced neuronal cell death triggered by expanded polyglutamine repeats
-
H. Nishitoh, A. Matsuzawa, K. Tobiume, K. Saegusa, K. Takeda, K. Inoue, S. Hori, A. Kakizuka, and H. Ichijo ASK1 is essential for endoplasmic reticulum stress-induced neuronal cell death triggered by expanded polyglutamine repeats Genes Dev 16 2002 1345 1355
-
(2002)
Genes Dev
, vol.16
, pp. 1345-1355
-
-
Nishitoh, H.1
Matsuzawa, A.2
Tobiume, K.3
Saegusa, K.4
Takeda, K.5
Inoue, K.6
Hori, S.7
Kakizuka, A.8
Ichijo, H.9
-
38
-
-
77951645463
-
A crucial role for RACK1 in the regulation of glucose-stimulated IRE1alpha activation in pancreatic beta cells
-
Y. Qiu, T. Mao, Y. Zhang, M. Shao, J. You, Q. Ding, Y. Chen, D. Wu, D. Xie, X. Lin, X. Gao, R.J. Kaufman, W. Li, and Y. Liu A crucial role for RACK1 in the regulation of glucose-stimulated IRE1alpha activation in pancreatic beta cells Sci Signal 3 2010 ra7
-
(2010)
Sci Signal
, vol.3
, pp. ra7
-
-
Qiu, Y.1
Mao, T.2
Zhang, Y.3
Shao, M.4
You, J.5
Ding, Q.6
Chen, Y.7
Wu, D.8
Xie, D.9
Lin, X.10
Gao, X.11
Kaufman, R.J.12
Li, W.13
Liu, Y.14
-
39
-
-
33646237823
-
Proapoptotic BAX and BAK modulate the unfolded protein response by a direct interaction with IRE1alpha
-
C. Hetz, P. Bernasconi, J. Fisher, A.H. Lee, M.C. Bassik, B. Antonsson, G.S. Brandt, N.N. Iwakoshi, A. Schinzel, L.H. Glimcher, and S.J. Korsmeyer Proapoptotic BAX and BAK modulate the unfolded protein response by a direct interaction with IRE1alpha Science 312 2006 572 576
-
(2006)
Science
, vol.312
, pp. 572-576
-
-
Hetz, C.1
Bernasconi, P.2
Fisher, J.3
Lee, A.H.4
Bassik, M.C.5
Antonsson, B.6
Brandt, G.S.7
Iwakoshi, N.N.8
Schinzel, A.9
Glimcher, L.H.10
Korsmeyer, S.J.11
-
40
-
-
62549129467
-
BAX inhibitor-1 is a negative regulator of the ER stress sensor IRE1alpha
-
F. Lisbona, D. Rojas-Rivera, P. Thielen, S. Zamorano, D. Todd, F. Martinon, A. Glavic, C. Kress, J.H. Lin, P. Walter, J.C. Reed, L.H. Glimcher, and C. Hetz BAX inhibitor-1 is a negative regulator of the ER stress sensor IRE1alpha Mol Cell 33 2009 679 691
-
(2009)
Mol Cell
, vol.33
, pp. 679-691
-
-
Lisbona, F.1
Rojas-Rivera, D.2
Thielen, P.3
Zamorano, S.4
Todd, D.5
Martinon, F.6
Glavic, A.7
Kress, C.8
Lin, J.H.9
Walter, P.10
Reed, J.C.11
Glimcher, L.H.12
Hetz, C.13
-
41
-
-
84870808965
-
Nonmuscle myosin IIB links cytoskeleton to IRE1alpha signaling during ER stress
-
Y. He, A. Beatty, X. Han, Y. Ji, X. Ma, R.S. Adelstein, J.R. Yates 3rd, K. Kemphues, and L. Qi Nonmuscle myosin IIB links cytoskeleton to IRE1alpha signaling during ER stress Dev Cell 23 2012 1141 1152
-
(2012)
Dev Cell
, vol.23
, pp. 1141-1152
-
-
He, Y.1
Beatty, A.2
Han, X.3
Ji, Y.4
Ma, X.5
Adelstein, R.S.6
Yates, J.R.7
Kemphues, K.8
Qi, L.9
-
42
-
-
41449095062
-
Phosphorylation of eIF2 directs ATF5 translational control in response to diverse stress conditions
-
D. Zhou, L.R. Palam, L. Jiang, J. Narasimhan, K.A. Staschke, and R.C. Wek Phosphorylation of eIF2 directs ATF5 translational control in response to diverse stress conditions J Biol Chem 283 2008 7064 7073
-
(2008)
J Biol Chem
, vol.283
, pp. 7064-7073
-
-
Zhou, D.1
Palam, L.R.2
Jiang, L.3
Narasimhan, J.4
Staschke, K.A.5
Wek, R.C.6
-
43
-
-
0033634654
-
Regulated translation initiation controls stress-induced gene expression in mammalian cells
-
H.P. Harding, I. Novoa, Y. Zhang, H. Zeng, R. Wek, M. Schapira, and D. Ron Regulated translation initiation controls stress-induced gene expression in mammalian cells Mol Cell 6 2000 1099 1108
-
(2000)
Mol Cell
, vol.6
, pp. 1099-1108
-
-
Harding, H.P.1
Novoa, I.2
Zhang, Y.3
Zeng, H.4
Wek, R.5
Schapira, M.6
Ron, D.7
-
44
-
-
79953224498
-
Phosphorylation of eIF2 facilitates ribosomal bypass of an inhibitory upstream ORF to enhance CHOP translation
-
L.R. Palam, T.D. Baird, and R.C. Wek Phosphorylation of eIF2 facilitates ribosomal bypass of an inhibitory upstream ORF to enhance CHOP translation J Biol Chem 286 2011 10939 10949
-
(2011)
J Biol Chem
, vol.286
, pp. 10939-10949
-
-
Palam, L.R.1
Baird, T.D.2
Wek, R.C.3
-
45
-
-
84877578475
-
ER-stress-induced transcriptional regulation increases protein synthesis leading to cell death
-
J. Han, S.H. Back, J. Hur, Y.H. Lin, R. Gildersleeve, J. Shan, C.L. Yuan, D. Krokowski, S. Wang, M. Hatzoglou, M.S. Kilberg, M.A. Sartor, and R.J. Kaufman ER-stress-induced transcriptional regulation increases protein synthesis leading to cell death Nat Cell Biol 15 2013 481 490
-
(2013)
Nat Cell Biol
, vol.15
, pp. 481-490
-
-
Han, J.1
Back, S.H.2
Hur, J.3
Lin, Y.H.4
Gildersleeve, R.5
Shan, J.6
Yuan, C.L.7
Krokowski, D.8
Wang, S.9
Hatzoglou, M.10
Kilberg, M.S.11
Sartor, M.A.12
Kaufman, R.J.13
-
46
-
-
0037353039
-
An integrated stress response regulates amino acid metabolism and resistance to oxidative stress
-
H.P. Harding, Y. Zhang, H. Zeng, I. Novoa, P.D. Lu, M. Calfon, N. Sadri, C. Yun, B. Popko, R. Paules, D.F. Stojdl, J.C. Bell, T. Hettmann, J.M. Leiden, and D. Ron An integrated stress response regulates amino acid metabolism and resistance to oxidative stress Mol Cell 11 2003 619 633
-
(2003)
Mol Cell
, vol.11
, pp. 619-633
-
-
Harding, H.P.1
Zhang, Y.2
Zeng, H.3
Novoa, I.4
Lu, P.D.5
Calfon, M.6
Sadri, N.7
Yun, C.8
Popko, B.9
Paules, R.10
Stojdl, D.F.11
Bell, J.C.12
Hettmann, T.13
Leiden, J.M.14
Ron, D.15
-
47
-
-
43549125786
-
ATF4 is an oxidative stress-inducible, prodeath transcription factor in neurons in vitro and in vivo
-
P.S. Lange, J.C. Chavez, J.T. Pinto, G. Coppola, C.W. Sun, T.M. Townes, D.H. Geschwind, and R.R. Ratan ATF4 is an oxidative stress-inducible, prodeath transcription factor in neurons in vitro and in vivo J Exp Med 205 2008 1227 1242
-
(2008)
J Exp Med
, vol.205
, pp. 1227-1242
-
-
Lange, P.S.1
Chavez, J.C.2
Pinto, J.T.3
Coppola, G.4
Sun, C.W.5
Townes, T.M.6
Geschwind, D.H.7
Ratan, R.R.8
-
48
-
-
0035947778
-
Feedback inhibition of the unfolded protein response by GADD34-mediated dephosphorylation of eIF2alpha
-
I. Novoa, H. Zeng, H.P. Harding, and D. Ron Feedback inhibition of the unfolded protein response by GADD34-mediated dephosphorylation of eIF2alpha J Cell Biol 153 2001 1011 1022
-
(2001)
J Cell Biol
, vol.153
, pp. 1011-1022
-
-
Novoa, I.1
Zeng, H.2
Harding, H.P.3
Ron, D.4
-
49
-
-
79251589342
-
Identification of an Ire1alpha endonuclease specific inhibitor with cytotoxic activity against human multiple myeloma
-
I. Papandreou, N.C. Denko, M. Olson, H. Van Melckebeke, S. Lust, A. Tam, D.E. Solow-Cordero, D.M. Bouley, F. Offner, M. Niwa, and A.C. Koong Identification of an Ire1alpha endonuclease specific inhibitor with cytotoxic activity against human multiple myeloma Blood 117 2011 1311 1314
-
(2011)
Blood
, vol.117
, pp. 1311-1314
-
-
Papandreou, I.1
Denko, N.C.2
Olson, M.3
Van Melckebeke, H.4
Lust, S.5
Tam, A.6
Solow-Cordero, D.E.7
Bouley, D.M.8
Offner, F.9
Niwa, M.10
Koong, A.C.11
-
50
-
-
79953288480
-
Selective inhibition of a regulatory subunit of protein phosphatase 1 restores proteostasis
-
P. Tsaytler, H.P. Harding, D. Ron, and A. Bertolotti Selective inhibition of a regulatory subunit of protein phosphatase 1 restores proteostasis Science 332 2011 91 94
-
(2011)
Science
, vol.332
, pp. 91-94
-
-
Tsaytler, P.1
Harding, H.P.2
Ron, D.3
Bertolotti, A.4
-
51
-
-
13644256191
-
A selective inhibitor of eIF2alpha dephosphorylation protects cells from ER stress
-
M. Boyce, K.F. Bryant, C. Jousse, K. Long, H.P. Harding, D. Scheuner, R.J. Kaufman, D. Ma, D.M. Coen, D. Ron, and J. Yuan A selective inhibitor of eIF2alpha dephosphorylation protects cells from ER stress Science 307 2005 935 939
-
(2005)
Science
, vol.307
, pp. 935-939
-
-
Boyce, M.1
Bryant, K.F.2
Jousse, C.3
Long, K.4
Harding, H.P.5
Scheuner, D.6
Kaufman, R.J.7
Ma, D.8
Coen, D.M.9
Ron, D.10
Yuan, J.11
-
52
-
-
80455124076
-
Transgenic zebrafish model to study translational control mediated by upstream open reading frame of human chop gene
-
H.C. Lee, Y.J. Chen, Y.W. Liu, K.Y. Lin, S.W. Chen, C.Y. Lin, Y.C. Lu, P.C. Hsu, S.C. Lee, and H.J. Tsai Transgenic zebrafish model to study translational control mediated by upstream open reading frame of human chop gene Nucleic Acids Res 39 2011 e139
-
(2011)
Nucleic Acids Res
, vol.39
, pp. e139
-
-
Lee, H.C.1
Chen, Y.J.2
Liu, Y.W.3
Lin, K.Y.4
Chen, S.W.5
Lin, C.Y.6
Lu, Y.C.7
Hsu, P.C.8
Lee, S.C.9
Tsai, H.J.10
-
53
-
-
0032054744
-
CHOP is implicated in programmed cell death in response to impaired function of the endoplasmic reticulum
-
H. Zinszner, M. Kuroda, X. Wang, N. Batchvarova, R.T. Lightfoot, H. Remotti, J.L. Stevens, and D. Ron CHOP is implicated in programmed cell death in response to impaired function of the endoplasmic reticulum Genes Dev 12 1998 982 995
-
(1998)
Genes Dev
, vol.12
, pp. 982-995
-
-
Zinszner, H.1
Kuroda, M.2
Wang, X.3
Batchvarova, N.4
Lightfoot, R.T.5
Remotti, H.6
Stevens, J.L.7
Ron, D.8
-
54
-
-
34250758642
-
ER stress triggers apoptosis by activating BH3-only protein Bim
-
H. Puthalakath, L.A. O'Reilly, P. Gunn, L. Lee, P.N. Kelly, N.D. Huntington, P.D. Hughes, E.M. Michalak, J. McKimm-Breschkin, N. Motoyama, T. Gotoh, S. Akira, P. Bouillet, and A. Strasser ER stress triggers apoptosis by activating BH3-only protein Bim Cell 129 2007 1337 1349
-
(2007)
Cell
, vol.129
, pp. 1337-1349
-
-
Puthalakath, H.1
O'Reilly, L.A.2
Gunn, P.3
Lee, L.4
Kelly, P.N.5
Huntington, N.D.6
Hughes, P.D.7
Michalak, E.M.8
McKimm-Breschkin, J.9
Motoyama, N.10
Gotoh, T.11
Akira, S.12
Bouillet, P.13
Strasser, A.14
-
55
-
-
77954370584
-
CHOP and AP-1 cooperatively mediate PUMA expression during lipoapoptosis
-
S.C. Cazanave, N.A. Elmi, Y. Akazawa, S.F. Bronk, J.L. Mott, and G.J. Gores CHOP and AP-1 cooperatively mediate PUMA expression during lipoapoptosis Am J Physiol Gastrointest Liver Physiol 299 2010 G236 G243
-
(2010)
Am J Physiol Gastrointest Liver Physiol
, vol.299
, pp. G236-G243
-
-
Cazanave, S.C.1
Elmi, N.A.2
Akazawa, Y.3
Bronk, S.F.4
Mott, J.L.5
Gores, G.J.6
-
56
-
-
17144417669
-
TRB3, a novel ER stress-inducible gene, is induced via ATF4-CHOP pathway and is involved in cell death
-
N. Ohoka, S. Yoshii, T. Hattori, K. Onozaki, and H. Hayashi TRB3, a novel ER stress-inducible gene, is induced via ATF4-CHOP pathway and is involved in cell death EMBO J 24 2005 1243 1255
-
(2005)
EMBO J
, vol.24
, pp. 1243-1255
-
-
Ohoka, N.1
Yoshii, S.2
Hattori, T.3
Onozaki, K.4
Hayashi, H.5
-
57
-
-
8544283103
-
CHOP is involved in endoplasmic reticulum stress-induced apoptosis by enhancing DR5 expression in human carcinoma cells
-
H. Yamaguchi, and H.G. Wang CHOP is involved in endoplasmic reticulum stress-induced apoptosis by enhancing DR5 expression in human carcinoma cells J Biol Chem 279 2004 45495 45502
-
(2004)
J Biol Chem
, vol.279
, pp. 45495-45502
-
-
Yamaguchi, H.1
Wang, H.G.2
-
58
-
-
84899672694
-
Translational and post-translational regulation of XIAP by eIF2α and ATF4 promotes ER stress-induced cell death during the unfolded protein response
-
N. Hiramatsu, C. Messah, J. Han, M.M. LaVail, R.J. Kaufman, and J.H. Lin Translational and post-translational regulation of XIAP by eIF2α and ATF4 promotes ER stress-induced cell death during the unfolded protein response Mol Biol Cell 25 2014 1411 1420
-
(2014)
Mol Biol Cell
, vol.25
, pp. 1411-1420
-
-
Hiramatsu, N.1
Messah, C.2
Han, J.3
Lavail, M.M.4
Kaufman, R.J.5
Lin, J.H.6
-
59
-
-
0036088471
-
IAP proteins: blocking the road to death's door
-
G.S. Salvesen, and C.S. Duckett IAP proteins: blocking the road to death's door Nat Rev Mol Cell Biol 3 2002 401 410
-
(2002)
Nat Rev Mol Cell Biol
, vol.3
, pp. 401-410
-
-
Salvesen, G.S.1
Duckett, C.S.2
-
60
-
-
84871870648
-
Selective activation of ATF6 and PERK endoplasmic reticulum stress signaling pathways prevent mutant rhodopsin accumulation
-
W.C. Chiang, N. Hiramatsu, C. Messah, H. Kroeger, and J.H. Lin Selective activation of ATF6 and PERK endoplasmic reticulum stress signaling pathways prevent mutant rhodopsin accumulation Invest Ophthalmol Vis Sci 53 2012 7159 7166
-
(2012)
Invest Ophthalmol Vis Sci
, vol.53
, pp. 7159-7166
-
-
Chiang, W.C.1
Hiramatsu, N.2
Messah, C.3
Kroeger, H.4
Lin, J.H.5
-
61
-
-
79951648063
-
Monitoring and manipulating mammalian unfolded protein response
-
N. Hiramatsu, V.T. Joseph, and J.H. Lin Monitoring and manipulating mammalian unfolded protein response Methods Enzymol 491 2011 183 198
-
(2011)
Methods Enzymol
, vol.491
, pp. 183-198
-
-
Hiramatsu, N.1
Joseph, V.T.2
Lin, J.H.3
-
62
-
-
34447558382
-
Melatonin attenuates arsenite-induced apoptosis in rat brain: involvement of mitochondrial and endoplasmic reticulum pathways and aggregation of alpha-synuclein
-
A.M. Lin, S.F. Fang, P.L. Chao, and C.H. Yang Melatonin attenuates arsenite-induced apoptosis in rat brain: involvement of mitochondrial and endoplasmic reticulum pathways and aggregation of alpha-synuclein J Pineal Res 43 2007 163 171
-
(2007)
J Pineal Res
, vol.43
, pp. 163-171
-
-
Lin, A.M.1
Fang, S.F.2
Chao, P.L.3
Yang, C.H.4
-
63
-
-
58449084895
-
Divergent effects of PERK and IRE1 signaling on cell viability
-
J.H. Lin, H. Li, Y. Zhang, D. Ron, and P. Walter Divergent effects of PERK and IRE1 signaling on cell viability PLoS One 4 2009 e4170
-
(2009)
PLoS One
, vol.4
-
-
Lin, J.H.1
Li, H.2
Zhang, Y.3
Ron, D.4
Walter, P.5
-
64
-
-
33645535034
-
G protein-coupled receptor rhodopsin
-
K. Palczewski G protein-coupled receptor rhodopsin Annu Rev Biochem 75 2006 743 767
-
(2006)
Annu Rev Biochem
, vol.75
, pp. 743-767
-
-
Palczewski, K.1
-
65
-
-
0033582173
-
Morphological, physiological, and biochemical changes in rhodopsin knockout mice
-
J. Lem, N.V. Krasnoperova, P.D. Calvert, B. Kosaras, D.A. Cameron, M. Nicolo, C.L. Makino, and R.L. Sidman Morphological, physiological, and biochemical changes in rhodopsin knockout mice Proc Natl Acad Sci U S A 96 1999 736 741
-
(1999)
Proc Natl Acad Sci U S A
, vol.96
, pp. 736-741
-
-
Lem, J.1
Krasnoperova, N.V.2
Calvert, P.D.3
Kosaras, B.4
Cameron, D.A.5
Nicolo, M.6
Makino, C.L.7
Sidman, R.L.8
-
66
-
-
0031045876
-
Retinopathy induced in mice by targeted disruption of the rhodopsin gene
-
M.M. Humphries, D. Rancourt, G.J. Farrar, P. Kenna, M. Hazel, R.A. Bush, P.A. Sieving, D.M. Sheils, N. McNally, P. Creighton, A. Erven, A. Boros, K. Gulya, M.R. Capecchi, and P. Humphries Retinopathy induced in mice by targeted disruption of the rhodopsin gene Nat Genet 15 1997 216 219
-
(1997)
Nat Genet
, vol.15
, pp. 216-219
-
-
Humphries, M.M.1
Rancourt, D.2
Farrar, G.J.3
Kenna, P.4
Hazel, M.5
Bush, R.A.6
Sieving, P.A.7
Sheils, D.M.8
McNally, N.9
Creighton, P.10
Erven, A.11
Boros, A.12
Gulya, K.13
Capecchi, M.R.14
Humphries, P.15
-
67
-
-
0033399668
-
Molecular genetics of human retinal disease
-
A. Rattner, H. Sun, and J. Nathans Molecular genetics of human retinal disease Annu Rev Genet 33 1999 89 131
-
(1999)
Annu Rev Genet
, vol.33
, pp. 89-131
-
-
Rattner, A.1
Sun, H.2
Nathans, J.3
-
68
-
-
0037072934
-
A rhodopsin mutant linked to autosomal dominant retinitis pigmentosa is prone to aggregate and interacts with the ubiquitin proteasome system
-
M.E. Illing, R.S. Rajan, N.F. Bence, and R.R. Kopito A rhodopsin mutant linked to autosomal dominant retinitis pigmentosa is prone to aggregate and interacts with the ubiquitin proteasome system J Biol Chem 277 2002 34150 34160
-
(2002)
J Biol Chem
, vol.277
, pp. 34150-34160
-
-
Illing, M.E.1
Rajan, R.S.2
Bence, N.F.3
Kopito, R.R.4
-
69
-
-
0026058548
-
Functional heterogeneity of mutant rhodopsins responsible for autosomal dominant retinitis pigmentosa
-
C.H. Sung, B.G. Schneider, N. Agarwal, D.S. Papermaster, and J. Nathans Functional heterogeneity of mutant rhodopsins responsible for autosomal dominant retinitis pigmentosa Proc Natl Acad Sci U S A 88 1991 8840 8844
-
(1991)
Proc Natl Acad Sci U S A
, vol.88
, pp. 8840-8844
-
-
Sung, C.H.1
Schneider, B.G.2
Agarwal, N.3
Papermaster, D.S.4
Nathans, J.5
-
70
-
-
0028287273
-
Structure and function in rhodopsin, 7: point mutations associated with autosomal dominant retinitis pigmentosa
-
S. Kaushal, and H.G. Khorana Structure and function in rhodopsin, 7: point mutations associated with autosomal dominant retinitis pigmentosa Biochemistry 33 1994 6121 6128
-
(1994)
Biochemistry
, vol.33
, pp. 6121-6128
-
-
Kaushal, S.1
Khorana, H.G.2
-
71
-
-
84863250283
-
IRE1 directs proteasomal and lysosomal degradation of misfolded rhodopsin
-
W.C. Chiang, C. Messah, and J.H. Lin IRE1 directs proteasomal and lysosomal degradation of misfolded rhodopsin Mol Biol Cell 23 2012 758 770
-
(2012)
Mol Biol Cell
, vol.23
, pp. 758-770
-
-
Chiang, W.C.1
Messah, C.2
Lin, J.H.3
-
72
-
-
79953181251
-
Probing mechanisms of photoreceptor degeneration in a new mouse model of the common form of autosomal dominant retinitis pigmentosa due to P23H opsin mutations
-
S. Sakami, T. Maeda, G. Bereta, K. Okano, M. Golczak, A. Sumaroka, A.J. Roman, A.V. Cideciyan, S.G. Jacobson, and K. Palczewski Probing mechanisms of photoreceptor degeneration in a new mouse model of the common form of autosomal dominant retinitis pigmentosa due to P23H opsin mutations J Biol Chem 286 2011 10551 10567
-
(2011)
J Biol Chem
, vol.286
, pp. 10551-10567
-
-
Sakami, S.1
Maeda, T.2
Bereta, G.3
Okano, K.4
Golczak, M.5
Sumaroka, A.6
Roman, A.J.7
Cideciyan, A.V.8
Jacobson, S.G.9
Palczewski, K.10
-
73
-
-
84937971488
-
Robust endoplasmic reticulum-associated degradation of rhodopsin precedes retinal degeneration
-
Epub ahead of print
-
W.C. Chiang, H. Kroeger, S. Sakami, C. Messah, D. Yasumura, M.T. Matthes, J.A. Coppinger, K. Palczewski, M.M. LaVail, and J.H. Lin Robust endoplasmic reticulum-associated degradation of rhodopsin precedes retinal degeneration Mol Neurobiol 2014 [Epub ahead of print]
-
(2014)
Mol Neurobiol
-
-
Chiang, W.C.1
Kroeger, H.2
Sakami, S.3
Messah, C.4
Yasumura, D.5
Matthes, M.T.6
Coppinger, J.A.7
Palczewski, K.8
Lavail, M.M.9
Lin, J.H.10
-
74
-
-
84877003413
-
Ablation of C/EBP homologous protein does not protect T17M RHO mice from retinal degeneration
-
S. Nashine, Y. Bhootada, A.S. Lewin, and M. Gorbatyuk Ablation of C/EBP homologous protein does not protect T17M RHO mice from retinal degeneration PLoS One 8 2013 e63205
-
(2013)
PLoS One
, vol.8
-
-
Nashine, S.1
Bhootada, Y.2
Lewin, A.S.3
Gorbatyuk, M.4
-
75
-
-
84895823108
-
Ablation of the proapoptotic genes chop or ask1 does not prevent or delay loss of visual function in a P23H transgenic mouse model of retinitis pigmentosa
-
A. Adekeye, M. Haeri, E. Solessio, and B.E. Knox Ablation of the proapoptotic genes chop or ask1 does not prevent or delay loss of visual function in a P23H transgenic mouse model of retinitis pigmentosa PLoS One 9 2014 e83871
-
(2014)
PLoS One
, vol.9
-
-
Adekeye, A.1
Haeri, M.2
Solessio, E.3
Knox, B.E.4
-
76
-
-
77649091387
-
Axonal prion protein is required for peripheral myelin maintenance
-
J. Bremer, F. Baumann, C. Tiberi, C. Wessig, H. Fischer, P. Schwarz, A.D. Steele, K.V. Toyka, K.A. Nave, J. Weis, and A. Aguzzi Axonal prion protein is required for peripheral myelin maintenance Nat Neurosci 13 2010 310 318
-
(2010)
Nat Neurosci
, vol.13
, pp. 310-318
-
-
Bremer, J.1
Baumann, F.2
Tiberi, C.3
Wessig, C.4
Fischer, H.5
Schwarz, P.6
Steele, A.D.7
Toyka, K.V.8
Nave, K.A.9
Weis, J.10
Aguzzi, A.11
-
77
-
-
0027997387
-
Prion protein is necessary for normal synaptic function
-
J. Collinge, M.A. Whittington, K.C. Sidle, C.J. Smith, M.S. Palmer, A.R. Clarke, and J.G. Jefferys Prion protein is necessary for normal synaptic function Nature 370 1994 295 297
-
(1994)
Nature
, vol.370
, pp. 295-297
-
-
Collinge, J.1
Whittington, M.A.2
Sidle, K.C.3
Smith, C.J.4
Palmer, M.S.5
Clarke, A.R.6
Jefferys, J.G.7
-
78
-
-
43149121009
-
The prion protein knockout mouse: a phenotype under challenge
-
A.D. Steele, S. Lindquist, and A. Aguzzi The prion protein knockout mouse: a phenotype under challenge Prion 1 2007 83 93
-
(2007)
Prion
, vol.1
, pp. 83-93
-
-
Steele, A.D.1
Lindquist, S.2
Aguzzi, A.3
-
79
-
-
42049099020
-
Physiology of the prion protein
-
R. Linden, V.R. Martins, M.A. Prado, M. Cammarota, I. Izquierdo, and R.R. Brentani Physiology of the prion protein Physiol Rev 88 2008 673 728
-
(2008)
Physiol Rev
, vol.88
, pp. 673-728
-
-
Linden, R.1
Martins, V.R.2
Prado, M.A.3
Cammarota, M.4
Izquierdo, I.5
Brentani, R.R.6
-
80
-
-
34250351315
-
Perturbation of endoplasmic reticulum homeostasis facilitates prion replication
-
C. Hetz, J. Castilla, and C. Soto Perturbation of endoplasmic reticulum homeostasis facilitates prion replication J Biol Chem 282 2007 12725 12733
-
(2007)
J Biol Chem
, vol.282
, pp. 12725-12733
-
-
Hetz, C.1
Castilla, J.2
Soto, C.3
-
81
-
-
33750087269
-
Conditions of endoplasmic reticulum stress favor the accumulation of cytosolic prion protein
-
A. Orsi, L. Fioriti, R. Chiesa, and R. Sitia Conditions of endoplasmic reticulum stress favor the accumulation of cytosolic prion protein J Biol Chem 281 2006 30431 30438
-
(2006)
J Biol Chem
, vol.281
, pp. 30431-30438
-
-
Orsi, A.1
Fioriti, L.2
Chiesa, R.3
Sitia, R.4
-
82
-
-
80053212141
-
Proteasomal dysfunction and endoplasmic reticulum stress enhance trafficking of prion protein aggregates through the secretory pathway and increase accumulation of pathologic prion protein
-
M. Nunziante, K. Ackermann, K. Dietrich, H. Wolf, L. Gädtke, S. Gilch, I. Vorberg, M. Groschup, and H.M. Schätzl Proteasomal dysfunction and endoplasmic reticulum stress enhance trafficking of prion protein aggregates through the secretory pathway and increase accumulation of pathologic prion protein J Biol Chem 286 2011 33942 33953
-
(2011)
J Biol Chem
, vol.286
, pp. 33942-33953
-
-
Nunziante, M.1
Ackermann, K.2
Dietrich, K.3
Wolf, H.4
Gädtke, L.5
Gilch, S.6
Vorberg, I.7
Groschup, M.8
Schätzl, H.M.9
-
83
-
-
84861450392
-
Sustained translational repression by eIF2[alpha]-P mediates prion neurodegeneration
-
J.A. Moreno Sustained translational repression by eIF2[alpha]-P mediates prion neurodegeneration Nature 485 2012 507 511
-
(2012)
Nature
, vol.485
, pp. 507-511
-
-
Moreno, J.A.1
-
84
-
-
84885463900
-
Oral treatment targeting the unfolded protein response prevents neurodegeneration and clinical disease in prion-infected mice
-
J.A. Moreno Oral treatment targeting the unfolded protein response prevents neurodegeneration and clinical disease in prion-infected mice Sci Transl Med 5 2013 206ra138
-
(2013)
Sci Transl Med
, vol.5
, pp. 206ra138
-
-
Moreno, J.A.1
-
85
-
-
38649108109
-
Unfolded protein response transcription factor XBP-1 does not influence prion replication or pathogenesis
-
C. Hetz Unfolded protein response transcription factor XBP-1 does not influence prion replication or pathogenesis Proc Natl Acad Sci U S A 105 2008 757 762
-
(2008)
Proc Natl Acad Sci U S A
, vol.105
, pp. 757-762
-
-
Hetz, C.1
-
86
-
-
84922575735
-
Neurodegeneration and unfolded-protein response in mice expressing a membrane-tethered flexible tail of PrP
-
P. Dametto, A.K. Lakkaraju, C. Bridel, L. Villiger, T. O'Connor, U.S. Herrmann, P. Pelczar, T. Rülicke, D. McHugh, A. Adili, and A. Aguzzi Neurodegeneration and unfolded-protein response in mice expressing a membrane-tethered flexible tail of PrP PLoS One 10 2015 e0117412
-
(2015)
PLoS One
, vol.10
-
-
Dametto, P.1
Lakkaraju, A.K.2
Bridel, C.3
Villiger, L.4
O'Connor, T.5
Herrmann, U.S.6
Pelczar, P.7
Rülicke, T.8
McHugh, D.9
Adili, A.10
Aguzzi, A.11
|