Selective activation of ATF6 and PERK endoplasmic reticulum stress signaling pathways prevent mutant rhodopsin accumulation

Investigative Ophthalmology and Visual Science

Volumn 53, Issue 11, 2012, Pages 7159-7166

  Chiang, Wei Chieh ^a   Hiramatsu, Nobuhiko ^a   Messah, Carissa ^a   Kroeger, Heike ^a   Lin, Jonathan H ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACTIVATING TRANSCRIPTION FACTOR 4; ACTIVATING TRANSCRIPTION FACTOR 6; GLUCOSE REGULATED PROTEIN 78; PROTEIN KINASE R; PROTEIN KINASE RNA LIKE ENDOPLASMIC RETICULUM KINASE; RHODOPSIN; UNCLASSIFIED DRUG; ATF6 PROTEIN, HUMAN; ERN2 PROTEIN, HUMAN; MEMBRANE PROTEIN; PERK KINASE; PROTEIN SERINE THREONINE KINASE; RIBONUCLEASE;

ARTICLE; BIOCHEMISTRY; BIOTINYLATION; CELL MEMBRANE; CONTROLLED STUDY; ENDOPLASMIC RETICULUM STRESS; HUMAN; HUMAN CELL; MOLECULAR BIOLOGY; POLYACRYLAMIDE GEL ELECTROPHORESIS; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN SYNTHESIS; REAL TIME POLYMERASE CHAIN REACTION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SIGNAL TRANDUCTION; WESTERN BLOTTING; CELL STRAIN HEK293; GENETICS; HOMEOSTASIS; METABOLISM; MUTAGENESIS; PATHOLOGY; PHYSIOLOGY; PROTEOSTASIS DEFICIENCY; RETINA; RETINITIS PIGMENTOSA; SIGNAL TRANSDUCTION; UNFOLDED PROTEIN RESPONSE;

ACTIVATING TRANSCRIPTION FACTOR 6; CELL MEMBRANE; EIF-2 KINASE; ENDOPLASMIC RETICULUM STRESS; ENDORIBONUCLEASES; HEK293 CELLS; HOMEOSTASIS; HUMANS; MEMBRANE PROTEINS; MUTAGENESIS; PROTEIN-SERINE-THREONINE KINASES; PROTEOSTASIS DEFICIENCIES; RETINA; RETINITIS PIGMENTOSA; RHODOPSIN; SIGNAL TRANSDUCTION; UNFOLDED PROTEIN RESPONSE;

EID: 84871870648     PISSN: 01460404     EISSN: 15525783     Source Type: Journal    
DOI: 10.1167/iovs.12-10222     Document Type: Article

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