Neurodegeneration and unfolded-protein response in mice expressing a membrane-tethered flexible tail of PrP

PLoS ONE

Volumn 10, Issue 2, 2015, Pages

  Dametto, Paolo ^a   Lakkaraju, Asvin K K ^a   Bridel, Claire ^a,d   Villiger, Lukas ^a   O'Connor, Tracy ^a   Herrmann, Uli S ^a   Pelczar, Pawel ^b   Rülicke, Thomas ^c   McHugh, Donal ^a,b   Adili, Arlind ^a   Aguzzi, Adriano ^a  

^a UNIVERSITY HOSPITAL ZURICH   (Switzerland)

^b UNIVERSITY OF ZURICH   (Switzerland)

^c UNIVERSITY OF VETERINARY MEDICINE   (Austria)

^d GENEVA UNIVERSITY HOSPITALS   (Switzerland)

Author keywords

[No Author keywords available]

Indexed keywords

BAFILOMYCIN; BENZYLOXYCARBONYLLEUCYLLEUCYLLEUCINAL; GLYCOSYLPHOSPHATIDYLINOSITOL ANCHORED PROTEIN; GROWTH ARREST AND DNA DAMAGE INDUCIBLE PROTEIN 153; INITIATION FACTOR 2ALPHA; MEMBRANE PROTEIN; PLACEBO; PRION PROTEIN; PROTEIN PERK; UNCLASSIFIED DRUG; PRION;

ALLOSTERISM; AMINO TERMINAL SEQUENCE; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BINDING SITE; CELLULAR DISTRIBUTION; CEREBELLUM DEGENERATION; CONTROLLED STUDY; DISEASE COURSE; ENDOPLASMIC RETICULUM; ENDOPLASMIC RETICULUM STRESS; GENE INTERACTION; IN VITRO STUDY; IN VIVO STUDY; LETHALITY; MOUSE; NERVE DEGENERATION; NEUROPATHOLOGY; NEUROTOXICITY; NONHUMAN; PHENOTYPIC PLASTICITY; PRION DISEASE; PROTEIN BINDING; PROTEIN DEGRADATION; PROTEIN DOMAIN; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN PHOSPHORYLATION; PROTEIN PROTEIN INTERACTION; TRANSGENIC MOUSE; UNFOLDED PROTEIN RESPONSE; UPREGULATION; ANIMAL; CEREBELLUM; METABOLISM; PATHOLOGY; PRION;

MUS; MUS MUSCULUS;

ANIMALS; CEREBELLUM; ENDOPLASMIC RETICULUM STRESS; MICE; MICE, TRANSGENIC; PRION DISEASES; PRIONS; PRPC PROTEINS; UNFOLDED PROTEIN RESPONSE;

EID: 84922575735     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0117412     Document Type: Article

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