Transcriptional profiling and targeted proteomics reveals common molecular changes associated with cigarette smoke-induced lung emphysema development in five susceptible mouse strains

Inflammation Research

Volumn 64, Issue 7, 2015, Pages 471-486

  Cabanski, Maciej ^a,c   Fields, Brett ^b   Boue, Stephanie ^a   Boukharov, Natalia ^b   DeLeon, Hector ^a   Dror, Natalie ^b   Geertz, Marcel ^a,d   Guedj, Emmanuel ^a   Iskandar, Anita ^a   Kogel, Ulrike ^a   Merg, Celine ^a   Peck, Michael J ^a   Poussin, Carine ^a   Schlage, Walter K ^a   Talikka, Marja ^a   Ivanov, Nikolai V ^a   Hoeng, Julia ^a   Peitsch, Manuel C ^a  

^a PHILIP MORRIS PRODUCTS S A   (Switzerland)

^b Selventa   (United States)

^c NOVARTIS PHARMA AG   (Switzerland)

^d BAYER AG   (Germany)

Author keywords

Cigarette smoke; Emphysema; Gene expression; Molecular mechanisms; Mouse models; Systems biology

Indexed keywords

APOLIPOPROTEIN E; BETA6 INTEGRIN; CCAAT ENHANCER BINDING PROTEIN; CCAAT ENHANCER BINDING PROTEIN ALPHA; CCAAT ENHANCER BINDING PROTEIN BETA; CD1 ANTIGEN; CIGARETTE SMOKE; COLONY STIMULATING FACTOR; COLONY STIMULATING FACTOR 2; CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR; CYTOKINE; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; NUCLEAR RECEPTOR COREPRESSOR; STAT1 PROTEIN; TOLL LIKE RECEPTOR 4; TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR FOXM1; TRANSCRIPTION FACTOR NRF2; TRANSCRIPTION FACTOR PU 1; TRANSCRIPTION FACTOR YY1; TRANSCRIPTOME; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG; SMOKE;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CAUSAL MODELING; CONTROLLED STUDY; FEMALE; HISTOPATHOLOGY; LUNG; LUNG EMPHYSEMA; MOLECULAR BIOLOGY; MOUSE; MOUSE STRAIN; NONHUMAN; PATHOPHYSIOLOGY; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEOMICS; REVERSE CAUSAL REASONING; SIGNAL TRANSDUCTION; SYSTEMS BIOLOGY; TRANSCRIPTION INITIATION; TRANSCRIPTOMICS; ANIMAL; BRONCHOALVEOLAR LAVAGE FLUID; C57BL MOUSE; CAUSALITY; CHEMICALLY INDUCED; CHEMISTRY; COMPARATIVE STUDY; CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR MOUSE; CYTOLOGY; EXPOSURE; GENE EXPRESSION PROFILING; GENETICS; KNOCKOUT MOUSE; PATHOLOGY; POLYMERASE CHAIN REACTION; SMOKE; SMOKING; SPECIES DIFFERENCE; TOBACCO;

ANIMALS; APOLIPOPROTEINS E; BRONCHOALVEOLAR LAVAGE FLUID; CAUSALITY; GENE EXPRESSION PROFILING; INHALATION EXPOSURE; LUNG; MICE; MICE, INBRED C57BL; MICE, INBRED CFTR; MICE, KNOCKOUT; POLYMERASE CHAIN REACTION; PROTEOMICS; PULMONARY EMPHYSEMA; SMOKE; SMOKING; SPECIES SPECIFICITY; TOBACCO;

EID: 84930822711     PISSN: 10233830     EISSN: 1420908X     Source Type: Journal    
DOI: 10.1007/s00011-015-0820-2     Document Type: Article

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