Discovery of emphysema relevant molecular networks from an A/J mouse inhalation study using reverse engineering and forward simulation (REFS™)

Gene Regulation and Systems Biology

Volumn 2014, Issue 8, 2014, Pages 45-61

  Xiang, Yang ^a   Kogel, Ulrike ^a   Gebel, Stephan ^b   Peck, Michael J ^a   Peitsch, Manuel C ^a   Akmaev, Viatcheslav R ^c   Hoeng, Julia ^a  

^a Philip Morris Research and Development   (Switzerland)

^b Philip Morris Research Laboratories GmbH   (Germany)

^c Berg Biosystems   (United States)

Author keywords

Bayesian network; Chronic obstructive pulmonary disease (COPD); Reverse engineering and forward simulation (REFS )

Indexed keywords

CIGARETTE SMOKE; GELATINASE B; INTERSTITIAL COLLAGENASE; TISSUE INHIBITOR OF METALLOPROTEINASE 1;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CAUSAL MODELING; CHRONIC OBSTRUCTIVE LUNG DISEASE; COMPUTER MODEL; COMPUTER PROGRAM; COMPUTER SIMULATION; CONTROLLED STUDY; ENZYME ACTIVITY; FEMALE; GENE EXPRESSION PROFILING; GENE SILENCING; LUNG EMPHYSEMA; LUNG WEIGHT; MMP 9 GENE; MOLECULAR INTERACTION; MOUSE; NONHUMAN; PROTEIN EXPRESSION; REVERSE ENGINEERING AND FORWARD SIMULATION; TIMP 1 GENE;

EID: 84894519783     PISSN: None     EISSN: 11776250     Source Type: Journal    
DOI: 10.4137/GRSB.S13140     Document Type: Article

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