Effects of intratracheal administration of nuclear factor-kappaB decoy oligodeoxynucleotides on long-term cigarette smoke-induced lung inflammation and pathology in mice

Respiratory Research

Volumn 10, Issue , 2009, Pages

  Li, Yu Tao ^a   He, Bei ^a   Wang, Yu Zhu ^a   Wang, Jing ^a  

^a PEKING UNIVERSITY THIRD HOSPITAL   (China)

Author keywords

[No Author keywords available]

Indexed keywords

CIGARETTE SMOKE; GELATINASE B; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; MACROPHAGE INFLAMMATORY PROTEIN 1ALPHA; MONOCYTE CHEMOTACTIC PROTEIN 1; NUCLEAR FACTOR KAPPA B DECOY OLIGODEOXYNUCLEOTIDE DERIVATIVE; OLIGODEOXYNUCLEOTIDE DERIVATIVE; TRANSCRIPTION FACTOR AP 1; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG; OLIGODEOXYRIBONUCLEOTIDE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; CYTOPATHOLOGY; HISTOPATHOLOGY; LUNG ALVEOLUS MACROPHAGE; LUNG HOMOGENATE; LUNG LAVAGE; MALE; MOUSE; NONHUMAN; PEAK EXPIRATORY FLOW; PNEUMONIA; RESPIRATORY FAILURE; ANIMAL; C57BL MOUSE; GENETIC TRANSFECTION; GENETICS; LUNG; METABOLISM; METHODOLOGY; SMOKE; TOBACCO; TRACHEA;

ANIMALS; LUNG; MALE; MICE; MICE, INBRED C57BL; NF-KAPPA B; OLIGODEOXYRIBONUCLEOTIDES; PNEUMONIA; SMOKE; TOBACCO; TRACHEA; TRANSFECTION;

EID: 77950829373     PISSN: 14659921     EISSN: 1465993X     Source Type: Journal    
DOI: 10.1186/1465-9921-10-79     Document Type: Article

References (66)

1. Chung KF. Cytokines in chronic obstructive pulmonary disease. Eur Respir J Suppl 2001, 34:50s-59s. 10.1183/09031936.01.00229701, 12392035.
2. Caramori G, Adcock I. Pharmacology of airway inflammation in asthma and COPD. Pulm Pharmacol Ther 2003, 16:247-277. 10.1016/S1094-5539(03)00070-1, 12877818.
3. De Boer WI. Cytokines and therapy in COPD: a promising combination?. Chest 2002, 121(5 suppl):209S-218S. 10.1378/chest.121.5_suppl.209S, 12010854.
4. Barnes PJ. Chronic Obstructive Pulmonary Disease: Cellular and Molecular Mechanisms (Series: Lung Biology in Health and Disease; v 198) 2005, 368-369. Boca Raton, Taylor & Francis Group.
5. Blackwell TS, Christman JW. The role of nuclear factor κB in cytokine gene regulation. Am J Respir Cell Mol Biol 1997, 17:3-9.
6. Ho TY, Bagnell CA. Relaxin induces matrix metalloproteinase-9 through activation of nuclear factor kappa B in human THP-1 Cells. Ann N Y Acad Sci 2005, 1041:314-316. 10.1196/annals.1282.049, 15956726.
7. Chen F, Castranova V, Shi X, Demers LM. New insights into the role of nuclear factor-κB, a ubiquitous transcription factor in the initiation of diseases. Clin Chem 1999, 45:7-17.
8. Baldwin AS. The NF-κB and I-κB proteins: new discoveries and insights. Annu Rev Immunol 1996, 14:649-683. 10.1146/annurev.immunol.14.1.649, 8717528.
9. Ghosh S, May MJ, Kopp EB. NF-κB and Rel proteins: evolutionarily conserved mediators of immune responses. Annu Rev Immunol 1998, 16:225-260. 10.1146/annurev.immunol.16.1.225, 9597130.
10. Baldwin AS. The transcription factor NF-κB and human disease. J Clin Invest 2001, 107:3-6. 10.1172/JCI11891, 198555, 11134170.
11. Rahman I, MacNee W. Lung glutathione and oxidative stress: implications in cigarette smoke-induced airways disease. Am J Physiol Lung Cell Mol Physiol 1999, 227:1067-1088.
12. Church DF, Pryor WA. Free radical chemistry of cigarette smoke and its toxicological implications. Environ Health Perspect 1985, 64:111-126. 10.2307/3430003, 1568603, 3007083.
13. Rahman I. Oxidative stress, chromatin remodelling and gene transcription in inflammation and chronic lung disease. J Biochem Mol Biol 2003, 36:95-109.
14. Schreck R, Rieber P, Baeuerle PA. Reactive oxygen intermediates as apparently widely used messengers in the activation of the NF-κB transcription factor and HIV-1. EMBO J 1991, 10:2247-2258. 452914, 2065663.
15. Di Stefano A, Caramori G, Oates T, Capelli A, Lusuardi M, Gnemmi I, Ioli F, Chung KF, Donner CF, Barnes PJ, Adcock IM. Increased expression of nuclear factor-kappaB in bronchial biopsies from smokers and patients with COPD. Eur Respir J 2002, 20:556-563. 10.1183/09031936.02.00272002, 12358328.
16. Nishikawa M, Kakemizu N, Ito T, Kudo M, Kaneko T, Suzuki M, Udaka N, Ikeda H, Okubo T. Superoxide mediates cigarette smoke-induced infiltration of neutrophils into the airway through nuclear factor-κB activation and IL-8 mRNA expression in guinea pigs in vivo. Am J Respir Cell Mol Biol 1999, 20:189-198.
17. He B, Zhao MW, Qi GY. Activation of transcription factors and induction of cytokines from macrophages in chronic obstructive pulmonary disease. National Medical Journal of China 2001, 22:1360-1364.
18. Conron M, Andreakos E, Pantelidis P, Smith C, Beynon HL, Dubois RM, Foxwell BM. Nuclear factor-kappaB activation in alveolar macrophages requires IkappaB kinase-beta, but not nuclear factor-kappaB inducing kinase. Am J Respir Crit Care Med 2002, 165:996-1004.
19. Lora JM, Zhang DM, Liao SM, Burwell T, King AM, Barker PA, Singh L, Keaveney M, Morgenstern J, Gutiérrez-Ramos JC, Coyle AJ, Fraser CC. Tumor necrosis factor-alpha triggers mucus production in airway epithelium through an IkappaB kinase beta-dependent mechanism. J Biol Chem 2005, 280:36510-36517. 10.1074/jbc.M507977200, 16123045.
20. Laza-Stanca V, Stanciu LA, Message SD, Edwards MR, Gern JE, Johnston SL. Rhinovirus replication in human macrophages induces NF-kappaB dependent tumor necrosis factor alpha production. J Virol 2006, 80:8248-8258. 10.1128/JVI.00162-06, 1563804, 16873280.
21. Mann MJ, Dzau VJ. Therapeutic applications of transcription factor decoy oligonucleotides. J Clin Invest 2000, 106:1071-1075. 10.1172/JCI11459, 301425, 11067859.
22. Bielinska A, Shivdasani RA, Zhang LQ, Nabel GJ. Regulation of gene expression with double-stranded phosphorothioate oligonucleotides. Science 1990, 250:997-1000. 10.1126/science.2237444, 2237444.
23. Niewoehner DE, Klienerman J, Rice D. Pathologic changes in the peripheral airways of young cigarette smokers. N Engl J Med 1974, 291:755-758.
24. Fujioka S, Niu J, Schmidt C, Sclabas GM, Peng B, Uwagawa T, Li Z, Evans DB, Abbruzzese JL, Chiao PJ. NF-κB and AP-1 connection: Mechanism of NF-κB-dependent regulation of AP-1 activity. Mol Cell Biol 2004, 24:7806-7819. 10.1128/MCB.24.17.7806-7819.2004, 507000, 15314185.
25. Desmet C, Gosset P, Pajak B, Cataldo D, Bentires-Alj M, Lekeux P, Bureau F. Selective Blockade of NF-κB Activity in Airway Immune Cells Inhibits the Effector Phase of Experimental Asthma. J Immunol 2004, 173:5766-5775.
26. Shen F, Zhao MW, He B, Pei F, Yao WZ. Observations on lung function and pathological changes of airway lung tissues in rats with different passive-smoking durations. J GuiYang Med Coll 2006, 3:247-251. [in Chinese].
27. Li YT, He B, Wang YZ. Exposure to cigarette smoke upregulates AP-1 activity and induces TNF-alpha overexpression in mouse lungs. Inhalation Toxicology 2009, 21:641-647. 10.1080/08958370802524381, 19235541.
28. Matthew E, Warden G, Dedman J. A murine model of smoke inhalation. Am J Physiol Lung Cell Mol Physiol 2001, 280:L716-L723.
29. Manoury B, Nenan S, Leclerc O, Guenon I, Boichot E, Planquois JM, Bertrand CP, Lagente V. The absence of reactive oxygen species production protects mice against bleomycin-induced pulmonary fibrosis. Respiratory Research 2005, 6:11-23. 10.1186/1465-9921-6-11, 548519, 15663794.
30. Fremond CM, Yeremeev V, Nicolle DM, Jacobs M, Quesniaux VF, Ryffel B. Fatal Mycobacterium tuberculosis infection despite adaptive immune response in the absence of MyD88. J Clin Invest 2004, 114:1790-1799. 535064, 15599404.
31. Vernooy JH, Dentener MA, van Suylen RJ, Buurman WA, Wouters EF. Long-term intratracheal lipopolysaccharide exposure in mice results in chronic lung inflammation and persistent pathology. Am J Respir Cell Mol Biol 2002, 26(1):152-159. 11751215.
32. Saetta M, Shiner RJ, Angus GE, Kim WD, Wang NS, King M, Ghezzo H, Cosio MG. Destructive index: a measurement of lung parenchymal destruction in smokers. Am Rev Respir Dis 1985, 131:764-769.
33. Saito K, Cagle P, Berend N, Thurlbeck WM. The "destructive index" in nonemphysematous and emphysematous lungs. Morphologic observations and correlation with function. Am Rev Respir Dis 1989, 139:308-312.
34. Robbesom AA, Versteeg EM, Veerkamp JH, van Krieken JH, Bulten HJ, Smits HT, Willems LN, van Herwaarden CL, Dekhuijzen PN, van Kuppevelt TH. Morphological quantification of emphysema in small human lung specimens: comparison of methods and relation with clinical data. Mod Pathol 2003, 16:1-7. 10.1097/01.MP.0000043519.29370.C2, 12527706.
35. Thurlbeck WM. Measurement of pulmonary emphysema. Am Rev Respir Dis 1967, 95:752-764.
36. Bartalesi B, Cavarra E, Fineschi S, Lucattelli M, Lunghi B, Martorana PA, Lungarella G. Different lung responses to cigarette smoke in two strains of mice sensitive to oxidants. Eur Respir J 2005, 25:15-22. 10.1183/09031936.04.00067204, 15640318.
37. Cosio M, Ghezzo H, Hogg JC, Corbin R, Loveland M, Dosman J, Macklem PT. The relations between structural changes in small airways and pulmonary-function tests. N Engl J Med 1978, 298:1277-1281.
38. Matsuda N, Hattori Y, Jesmin S, Gando S. Nuclear factor-κB decoy oligodeoxynucleotides prevent acute lung injury in mice with cecal ligation and puncture-induced sepsis. Mol Pharmacol 2005, 67:1018-1025. 10.1124/mol.104.005926, 15576632.
39. Geary RS, Leeds JM, Fitchett J, Burckin T, Truong L, Spainhour C, Creek M, Levin AA. Pharmacokinetics and metabolism in mice of a phosphorothioate oligonucleotide antisense inhibitor of C-raf-1 kinase expression. Drug Metab Dispos 1997, 25:1272-1281. 9351904.
40. Valenca SS, Castro P, Pimenta WA, Lanzetti M, Silva SV, Barja-Fidalgo C, Koatz VL, Porto LC. Light cigarette smoke-induced emphysema and NFκB activation in mouse lung. Int J Exp Pathol 2006, 87(5):373-381. 10.1111/j.1365-2613.2006.00492.x, 16965565.
41. Babusyte A, Stravinskaite K, Jeroch J, Lötvall J, Sakalauskas R, Sitkauskiene B. Patterns of airway inflammation and MMP-12 expression in smokers and ex-smokers with COPD. Respiratory Research 2007, 8:81-90. 10.1186/1465-9921-8-81, 2200652, 18001475.
42. Tetley TD. Macrophages and the pathogenesis of COPD. Chest 2002, 121:156S-159S. 10.1378/chest.121.5_suppl.156S, 12010845.
43. Lem VM, Lipscomb MF, Weissler JC, Nunez G, Ball EJ, Stastny P, Toews GB. Bronchoalveolar cells from sarcoid patients demonstrate enhanced antigen presentation. J Immunol 1985, 135:1766-71.
44. Barnes PJ, Shapiro SD, Pauwels RA. Chronic obstructive pulmonary disease: molecular and cellular mechanisms. Eur Respir J 2003, 22:672-88. 10.1183/09031936.03.00040703, 14582923.
45. Ohnishi K, Takagi M, Kurokawa Y, Satomi S, Konttinen YT. Matrix metalloproteinase-mediated extracellular matrix protein degradation in human pulmonary emphysema. Lab Invest 1998, 78:1077-1087.
46. Caramori G, Romagnoli M, Casolari P, Bellettato C, Casoni G, Boschetto P, Chung KF, Barnes PJ, Adcock IM, Ciaccia A, Fabbri LM, Papi A. Nuclear localisation of p65 in sputum macrophages but not in sputum neutrophils during COPD exacerbations. Thorax 2003, 58:348-351. 10.1136/thorax.58.4.348, 1746629, 12668802.
47. Kirkham PA, Spooner G, Ffoulkes-Jones C, Calvez R. Cigarette smoke triggers macrophage adhesion and activation: role of lipid peroxidation products and scavenger receptor. Free Radic Biol Med 2003, 35:697-710. 10.1016/S0891-5849(03)00390-3, 14583334.
48. Geissmann F, Jung S, Littman DR. Blood monocytes consist of two principal subsets with distinct migratory properties. Immunity 2003, 19:71-82. 10.1016/S1074-7613(03)00174-2, 12871640.
49. Di Stefana A, Capelli A, Lusuardi M, Balbo P, Vecchio C, Maestrelli P, Mapp CE, Fabbri LM, Donner CF, Saetta M. Severity of airflow limitation is associated with severity of airway inflammation in smokers. Am J Respir Crit Care Med 1998, 158:1277-1285.
50. Newton R, Holden NS, Catley MC, Oyelusi W, Leigh R, Proud D, Barnes PJ. Repression of inflammatory gene expression in human pulmonary epithelial cells by small-molecule IkappaB kinase inhibitors. J Pharmacol Exp Ther 2007, 321:734-742. 10.1124/jpet.106.118125, 17322026.
51. Birrell MA, Hardaker E, Wong S, McCluskie K, Catley M, De Alba J, Newton R, Haj-Yahia S, Pun KT, Watts CJ, Shaw RJ, Savage TJ, Belvisi MG. Ikappa-B kinase-2 inhibitor blocks inflammation in human airway smooth muscle and a rat model of asthma. Am J Respir Crit Care Med 2005, 172:962-971. 10.1164/rccm.200412-1647OC, 16002568.
52. Koth LL, Rodriguez MW, Bernstein XL, Chan S, Huang X, Charo IF, Rollins BJ, Erle DJ. Aspergillus antigen induces robust Th2 cytokine production, inflammation, airway hyperreactivity and fibrosis in the absence of MCP-1 or CCR2. Respiratory Research 2004, 5:12. 10.1186/1465-9921-5-12, 520828, 15377395.
53. Thompson WL, Karpus WJ, Van Eldik LJ. MCP-1-deficient mice show reduced neuroinflammatory responses and increased peripheral inflammatory responses to peripheral endotoxin insult. J Neuroinflammation 2008, 5:35. 2527558, 18706086, 10.1186/1742-2094-5-35.
54. Tian B, Nowak DE, Brasier AR. A TNF-induced gene expression program under oscillatory NF-κB control. BMC Genomics 2005, 6:137. 10.1186/1471-2164-6-137, 1262712, 16191192.
55. Capelli A, Di Stefano A, Gnemmi I, Balbo P, Cerutti CG, Balbi B, Lusuardi M, Donner CF. Increased MCP-1 and MIP-1β in bronchoalveolar lavage fluid of chronic bronchitis. Eur Respir J 1999, 14:160-165. 10.1034/j.1399-3003.1999.14a27.x, 10489845.
56. Foronjy R, Nkyimbeng T, Wallace A, Thankachen J, Okada Y, Lemaitre V, D'Armiento J. Transgenic expression of matrix metalloproteinase-9 causes adult-onset emphysema in mice associated with the loss of alveolar elastin. Am J Physiol Lung Cell Mol Physiol 2008, 294(6):L1149-L1157. 10.1152/ajplung.00481.2007, 18408070.
57. Hogg JC, Senior RM. Chronic obstructive pulmonary disease - part 2: pathology and biochemistry of emphysema. Thorax 2002, 57:830-834. 10.1136/thorax.57.9.830, 1746435, 12200530.
58. Atkinson JJ, Senior RM. Matrix metalloproteinase-9 in lung remodeling. Am J Respir Cell Mol Biol 2003, 28:12-24. 10.1165/rcmb.2002-0166TR, 12495928.
59. Welgus HG, Campbell EJ, Cury JD, Eisen AZ, Senior RM, Wilhelm SM, Goldberg GI. Neutral metalloproteinases produced by human mononuclear phagocytes. Enzyme profile, regulation, and expression during cellular development. J Clin Invest 1990, 86(5):1496-1502. 10.1172/JCI114867, 2173721, 296895.
60. Ma Z, Shah RC, Chang MJ, Benveniste EN. Coordination of cell signaling, chromatin remodeling, histone modifications, and regulator recruitment in human matrix metalloproteinase 9 gene transcription. Mol Cell Biol 2004, 24:5496-5509. 10.1128/MCB.24.12.5496-5509.2004, 419859, 15169910.
61. Barnes PJ, Adcock IM. Transcription factors and asthma. Eur Respir J 1998, 12:221-234. 10.1183/09031936.98.12010221, 9701442.
62. Morales V, Giamarchi C, Chailleux C, Moro F, Marsaud A, Le Ricousse S, Richard-Foy H. Chromatin structure and dynamics: functional implications. Biochimie 2001, 83:1029-1039. 10.1016/S0300-9084(01)01347-5, 11879731.
63. Zhang Y, McCluskey K, Fujii K, Wahl LM. Differential regulation of monocyte matrix metalloproteinase and TIMP-1 production by TNF-α, granulocyte-macrophage CSF, and IL-1β through prostaglandin-dependent and -independent mechanisms. J Immunol 1998, 161:3071-3076.
64. Gearing AJ, Beckett P, Christodoulou M, Churchill M, Clements J, Davidson AH, Drummond AH, Galloway WA, Gilbert R, Gordon JL. Processing of tumor necrosis factor-alpha precursor by metalloproteinases. Nature 1994, 370:555-557. 10.1038/370555a0, 8052310.
65. Fujita M, Shannon JM, Irvin CG, Fagan KA, Cool C, Augustin A, Mason RJ. Overexpression of tumor necrosis factor-α produces an increase in lung volumes and pulmonary hypertension. Am J Physiol Lung Cell Mol Physiol 2001, 280:L39-L49.
66. Ogawa K, Chen F, Kuang C, Chen Y. Suppression of matrix metalloproteinase-9 transcription by transforming growth factor-β is mediated by a nuclear factor-κB site. Biochem J 2004, 381(Pt 2):413-422. 1133847, 15086314.