Acetylcholine leads to signal transducer and activator of transcription 1 (STAT-1) mediated oxidative/nitrosative stress in human bronchial epithelial cell line

Biochimica et Biophysica Acta - Molecular Basis of Disease

Volumn 1832, Issue 12, 2013, Pages 1949-1958

  Profita, Mirella ^a   Albano, Giusy Daniela ^a,b   Montalbano, Angela Marina ^a   Di Sano, Caterina ^a   Anzalone, Giulia ^a   Gagliardo, Rosalia ^a   Riccobono, Loredana ^a   Bonanno, Anna ^a   Siena, Liboria ^a   Pieper, Michael Paul ^c   Gjomarkaj, Mark ^a  

^a CNR Consiglio Nazionale delle Ricerche   (Italy)

^b UNIVERSITY OF PALERMO   (Italy)

^c BOEHRINGER INGELHEIM PHARMA GMBH AND CO KG   (Germany)

Author keywords

Acetylcholine; Epithelial cell; Oxidative nitrosative stress; STAT 1

Indexed keywords

ACETYLCHOLINE; NITRIC OXIDE SYNTHASE; OLODATEROL; REACTIVE OXYGEN METABOLITE; STAT1 PROTEIN; TIOTROPIUM BROMIDE;

ADULT; AGED; ARTICLE; CHRONIC OBSTRUCTIVE LUNG DISEASE; CLINICAL ARTICLE; CONTROLLED STUDY; EPITHELIUM CELL; FEMALE; HUMAN; HUMAN CELL; LUNG FUNCTION TEST; MALE; NITROSATIVE STRESS; OXIDATIVE STRESS; PRIORITY JOURNAL; PROTEIN FUNCTION; PROTEIN PHOSPHORYLATION; WESTERN BLOTTING;

EID: 84882799328     PISSN: 09254439     EISSN: 1879260X     Source Type: Journal    
DOI: 10.1016/j.bbadis.2013.06.009     Document Type: Article

References (34)

1. Bast J.E.A., Lankhorst I. Oxidative stress in chronic obstructive pulmonary disease. Am. J. Respir. Crit. Care Med. 1997, 156:341-357.
2. Hanazawa T., Kharitonov S.A., Barnes P.J. Increased nitrotyrosine in exhaled breath condensate of patients with asthma. Am. J. Respir. Crit. Care Med. Oct 2000, 162(4 Pt 1):1273-1276.
3. Ricciardolo F.L., Caramori G., Ito K., Capelli A., Brun P., Abatangelo G., Papi A., Chung K.F., Adcock I., Barnes P.J., Donner C.F., Rossi A., Di Stefano A. Nitrosative stress in the bronchial mucosa of severe chronic obstructive pulmonary disease. J. Allergy Clin. Immunol. 2005, 116(5):1028-1035.
4. Ricciardolo F.L.M., Di Stefano A., Sabatini S., Folkerts G. Reactive nitrogen species in the respiratory tract. Eur. J. Pharmacol. 2006, 533:240-252.
5. Subramaniam S.V., Cooper R.S., Adunyah S.E. Evidence for the involvement of JAK/STAT pathway in the signaling mechanism of interleukin-17. Biochem. Biophys. Res. Commun. 1999, 262:14-19.
6. Ricciardolo F.L. cNOS-iNOS paradigm and arginase in asthma. Trends Pharmacol. Sci. Nov 2003, 24(11):560-561. (author reply 562-3).
7. Wen Z.Z.Z., Darnell J.E. Maximal activation of transcription by Stat1and Stat3 requires both tyrosine and serine phosphorylation. Cell 1995, 82:241-250.
8. Wessler I., Kirkpatrick C.J., Racke K. The cholinergic 'pitfall': acetylcholine, a universal cell molecule in biological systems, including humans. Clin. Exp. Pharmacol. Physiol. Mar 1999, 26:198-205.
9. Gosens R., Zaagsma J., Grootte Bromhaar M., Nelemans A., Meurs H. Acetylcholine: a novel regulator of airway smooth muscle remodelling?. Eur. J. Pharmacol. Oct 2004, 500:193-201.
10. Profita M., Di Giorgi R., Sala A., Bonanno A., Riccobono L., Mirabella F., Gjomarkaj M., Bonsignore G., Bousquet J., Vignola A.M. Muscarinic receptors, leukotriene B4 production and neutrophilic inflammation in COPD patients. Allergy Nov 2005, 60:1361-1369.
11. Profita M., Bonanno A., Siena L., Bruno A., Ferraro M., Montalbano A.M., Albano G.D., Riccobono L., Casarosa P., Pieper M.P., Gjomarkaj M. Smoke, choline acetyltransferase, muscarinic receptors, and fibroblast proliferation in chronic obstructive pulmonary disease. J. Pharmacol. Exp. Ther. May 2009, 329:753-763.
12. Profita M., Bonanno A., Montalbano A.M., Albano G.D., Riccobono L., Siena L., Ferraro M., Casarosa P., Pieper M.P., Gjomarkaj M. Beta(2) long-acting and anticholinergic drugs control TGF-beta1-mediated neutrophilic inflammation in COPD. Biochim. Biophys. Acta Jul 2012, 1822:1079-1089.
13. Oldenburg O., Critz S.D., Cohne M.V., Downey J.M. Acetylcholine-induced production of reactive oxygen species in adult rabbit ventricular myocytes is dependent on phosphatidylinositol and Src-kinase activation and mitochondrial K ATP channel opening. J. Mol. Cell. Cardiol. 2003, 35:653-660.
14. Johnson M. Combination therapy for asthma: complementary effects of long-acting beta2-agonists and corticosteroids. Curr. Allergy Clin. Immunol. 2002, 15:16-22.
15. Belmonte K.E. Cholinergic pathways in the lungs and anticholinergic therapy for chronic obstructive pulmonary disease. Proc. Am. Thorac. Soc. 2005, 2:297-304.
16. Profita M., Bonanno A., Siena L., Ferraro M., Montalbano A.M., Pompeo F., Riccobono L., Pieper M.P., Gjomarkaj M. Acetylcholine mediates the release of IL-8 in human bronchial epithelial cells by a NFkB/ERK-dependent mechanism. Eur. J. Pharmacol. 2008 Mar, 582:145-153.
17. Nadel M., Pfeifer K., Racke K.F., Rabe B.K., Rubin T., Welte I., Wessler I. Alternative mechanisms for Tiotropium. Pulm. Pharmacol. Ther. 2009, 533-542.
18. Gosens R., Rieks D., Meurs H., Ninaber D.K., Rabe K.F., Nanninga J., Kolahian S., Halayko A.J., Hiemstra P.S., Zuyderduyn S. Muscarinic M3 receptor stimulation increases cigarette smoke-induced IL-8 secretion by human airway smooth muscle cells. Eur. Respir. J. 2009, 34:1436-1443.
19. Profita M., Riccobono L., Montalbano A.M., Bonanno A., Ferraro M., Albano G.D., Gerbino S., Casarosa P., Pieper M.P., Gjomarkaj M. In vitro anticholinergic drugs affect CD8+ peripheral blood T-cells apoptosis in COPD. Immunobiology 2012 Mar, 217:345-353.
20. Santus P., Buccellati C., Centanni S., Fumagalli F., Busatto P., Blasi F., Sala A. Bronchodilators modulate inflammation in chronic obstructive pulmonary disease subjects. Pharmacol. Res. 2012, 66:343-348.
21. Pauwels R.A., Buist A.S., Calverley P.M., Jenkins C.R., Hurd S.S. Global strategy for the diagnosis, management, and prevention of chronic obstructive pulmonary disease. NHLBI/WHO Global Initiative for Chronic Obstructive Lung Disease (GOLD) Workshop summary. Am. J. Respir. Crit. Care Med. Apr 2001, 163:1256-1276.
22. Hargreave F.E., Popov T., Kidney J., Dolovich J. Sputum measurements to assess airway inflammation in asthma. Allergy 1993, 48:81-83.
23. Bruno A., Pace E., Chanez P., Gras D., Vachier I., Chiappara G., La Guardia M., Gerbino S., Profita M., Gjomarkaj M. Leptin and leptin receptor expression in asthma. J. Allergy Clin. Immunol. 2009 Aug, 124:230-237.
24. Profita M., Sala A., Bonanno A., Siena L., Ferraro M., Di Giorgi R., Montalbano A.M., Albano G.D., Gagliardo R., Gjomarkaj M. Cysteinyl leukotriene-1 receptor activation in a human bronchial epithelial cell line leads to signal transducer and activator of transcription 1-mediated eosinophil adhesion. J. Pharmacol. Exp. Ther. Jun 2008, 325:1024-1030.
25. Oldenburg O., Critz S.D., Cohen M.V., Downey J.M. Acetylcholine-induced production of reactive oxygen species in adult rabbit ventricular myocytes is dependent on phosphatidylinositol 3- and Src-kinase activation and mitochondrial K(ATP) channel opening. J. Mol. Cell. Cardiol. 2003 Jun, 35:653-660.
26. Barret E.G., Johnston C., Oberdorster G., Finkelstein J.N. Silica-induced chemokine expression in alveolar type II cells is mediated by TNF alfa induced oxidant stress. Am. J. Physiol. Lung Cell. Mol. Physiol. 1999, 276:L979-L988.
27. De Keulenaer G.W., Ushio-Fukai M., Yin Q., Chung A.B., Lyons P.R., Ishizaka N., Rengarajan K., Taylor W.R., Alexander R.W., Griendling K.K. Convergence of redox-sensitive and mitogen-activated protein kinase signaling pathways in tumor necrosis factor-alpha-mediated monocyte chemoattractant protein-1 induction in vascular smooth muscle cells. Arterioscler. Thromb. Vasc. Biol. 2000, 20:385-391.
28. Vacca G., Randerath W.J., Gillissen A. Inhibition of granulocyte migration by Tiotropium bromide. Respir. Res. 2011, 12:24.
29. Loven J., Svitacheva N., Jerre A., Miller-Larsson A., Korn S.H. Anti-inflammatory activity of beta2-agonists in primary lung epithelial cells is independent of glucocorticoid receptor. Eur. Respir. J. 2007 Nov, 30:848-856.
30. 2-adrenoceptors and muscarinic receptors mediate opposing effects on endothelin-1 expression in human lung fibroblasts. Eur. J. Pharmacol. 2012, 691:218-224.
31. MacNee W. Oxidative stress and lung inflammation in airways disease. Eur. J. Pharmacol. 2001, 429:195-207.
32. van der Vliet A., Eiserich J.P., Shigenaga M.K., Cross C.E. Reactive nitrogen species and tyrosine nitration in the respiratory tract: epiphenomena or a pathobiologic mechanism of disease?. Am. J. Respir. Crit. Care Med. 1999, 160:1-9.
33. Rahman I., Biswas S.K., Kode A. Oxidant and antioxidant balance in the airways and airway diseases. Eur. J. Pharmacol. 2006, 8:222-239.
34. Leonard W.J., O'Shea J.J. Jaks and STATs: biological implications. Annu. Rev. Immunol. 1998, 16:293-322.