Oxidative stress in hypertension: Mechanisms and therapeutic opportunities

Experimental and Clinical Endocrinology and Diabetes

Volumn 123, Issue 6, 2015, Pages 325-335

  Brito, R ^a   Castillo, G ^a   Gonzalez J ^a   Valls, N ^a   Rodrigo, R ^a  

^a UNIVERSITY OF CHILE   (Chile)

Author keywords

cardiovascular risk management; hypertension; oxidative stress

Indexed keywords

ACETYLCHOLINE; ACETYLCYSTEINE; ALLOPURINOL; ALPHA TOCOPHEROL; ASCORBIC ACID; ENDOTHELIAL NITRIC OXIDE SYNTHASE; ENDOTHELIN 1; HOMOCYSTEINE; NITRIC OXIDE; NORADRENALIN; POLYPHENOL; PROSTAGLANDIN; REACTIVE OXYGEN METABOLITE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE OXIDASE; SELENIUM; UROTENSIN II; XANTHINE OXIDASE; NOS3 PROTEIN, HUMAN; SUPEROXIDE;

ANTIHYPERTENSIVE THERAPY; BLOOD VESSEL WALL; CENTRAL NERVOUS SYSTEM; CLINICAL TRIAL (TOPIC); DIET; DISORDERS OF MITOCHONDRIAL FUNCTIONS; ENDOTHELIAL DYSFUNCTION; HUMAN; HYPERTENSION; KIDNEY; NONHUMAN; OXIDATIVE STRESS; PRIORITY JOURNAL; RENIN ANGIOTENSIN ALDOSTERONE SYSTEM; REVIEW; ANIMAL; ENZYME ACTIVATION; METABOLISM; MITOCHONDRION; PATHOLOGY;

ANIMALS; ENZYME ACTIVATION; HUMANS; HYPERTENSION; MITOCHONDRIA; NADPH OXIDASE; NITRIC OXIDE SYNTHASE TYPE III; OXIDATIVE STRESS; SUPEROXIDES; XANTHINE OXIDASE;

EID: 84930753441     PISSN: 09477349     EISSN: 14393646     Source Type: Journal    
DOI: 10.1055/s-0035-1548765     Document Type: Review

References (151)

1. Alonso A., de la Fuente C., Martín-Arnau A. M. et al. Fruit and vegetable consumption is inversely associated with blood pressure in a Mediterranean population with a high vegetable-fat intake: the Seguimiento Universidad de Navarra (SUN) Study. Br J Nutr: 2004; 92 311 319
2. Appel L. J., Moore T. J., Obarzanek E. et al. A clinical trial of the effects of dietary patterns on blood pressure. DASH Collaborative Research Group. N Engl J Med: 1997; 336 1117 1124
3. Atarashi K., Ishiyama A., Takagi M. et al. Vitamin E ameliorates the renal injury of Dahl Salt-sensitive rats. Am J Hypertens: 1997; 10 116 119
4. Azadbakht L., Fard N. R., Karimi M. et al. Effects of the Dietary Approaches to Stop Hypertension (DASH) eating plan on cardiovascular risks among type 2 diabetic patients: A Randomized Cross-Over Clinical Trial. Diabetes Care: 2011; 34 55 57
5. Barrios V., Calderón A., Navarro-Cid J. et al. N-acetylcysteine potentiates the antihypertensive effect of ACE inhibitors in hypertensive patients. Blood Press: 2002; 11 235 239
6. Bengtsson S. H., Gulluyan L. M., Dusting G. J. et al. Novel isoforms of NADPH oxidase in vascular physiology and pathophysiology. Clin Exp Pharmacol Physiol: 2003; 30 849 854
7. Bilodeau J. F., Hubel C. A. Current concepts in the use of antioxidants for the treatment of preeclampsia. J Obstet Gynaecol Can: 2003; 25 742 750
8. Bitar M. S., Wahid S., Mustafa S. et al. Nitric oxide dynamics and endothelial dysfunction in type II model of genetic diabetes. Eur J Pharmacol: 2005; 511 53 64
9. Block G., Mangels A. R., Norkus E. P. et al. Ascorbic acid status and subsequent diastolic and systolic blood pressure. Hypertension: 2001; 37 261 267
10. Blumenthal J. A., Babyak M. A., Hinderliter A. et al. Effects of the DASH diet alone and in combination with exercise and weight loss on blood pressure and cardiovascular biomarkers in men and women with high blood pressure: the ENCORE study. Arch Intern Med: 2010; 170 126 135
11. Brigelius-Flohé R., Banning A., Schnurr K. Selenium-dependent enzymes in endothelial cell function. Antioxid Redox Signal: 2003; 5 205 215
12. Briones A. M., Touyz R. M. Oxidative stress and hypertension: current concepts. Curr Hypertens Rep: 2010; 12 135 142
13. Campbell L., Howie F., Arthur J. R. et al. Selenium and sulforaphane modify the expression of selenoenzymes in the human endothelial cell line EAhy926 and protect cells from oxidative damage. Nutrition: 2007; 23 138 144
14. Campos R. R., Oliveira-Sales E. B., Nish E. M. et al. The role of oxidative stress in renovascular hypertension Special Series: Stress and Hypertension. Clin Exp Pharmacol Physiol: 2011; 38 144 152
15. Chen S. T., Maruthur N. M., Appel L. J. The effect of dietary patterns on estimated coronary heart disease risk: results from the Dietary Approaches to Stop Hypertension (DASH) trial. Circ Cardiovasc Qual Outcomes: 2010; 3 484 489
16. Chen X., Touyz R. M., Park J. B. et al. Antioxidant effects of vitamins C and E are associated with altered activation of vascular NADPH oxidase and superoxide dismutase in stroke-prone SHR. Hypertension: 2001; 38 606 611
17. Chung S., Park C. W., Shin S. J. et al. Tempol or candesartan prevents high-fat diet-induced hypertension and renal damage in spontaneously hypertensive rats. Nephrol Dial Transplant: 2010; 25 389 399
18. Costa-Hong V., Bortolotto L. A., Jorgetti V. et al. Oxidative stress and endothelial dysfunction in chronic kidney disease. Arq Bras Cardiol: 2009; 92 381 386
19. De la Fuente M., Victor V. M. Ascorbic acid and N-acetylcysteine improve in vitro the function of lymphocytes from mice with endotoxin-induced oxidative stress. Free Radic Res: 2001; 35 73 84
20. DeLano F. A., Parks D. A., Ruedi J. M. et al. Microvascular display of xanthine oxidase and NADPH oxidase in the spontaneously hypertensive rat. Microcirculation: 2006; 13 551 566
21. Djordjevic T., BelAiba R. S., Bonello S. et al. Human urotensin II is a novel activator of NADPH oxidase in human pulmonary artery smooth muscle cells. Arterioscler Thromb Vasc Biol: 2005; 25 519 525
22. Duarte J., Andriambeloson E., Diebolt M. et al. Wine polyphenols stimulate superoxide anion production to promote calcium signaling and endothelial-dependent vasodilatation. Physiol Res: 2004; 53 595 602
23. Duffy S. J., Gokce N., Holbrook M. et al. Treatment of hypertension with ascorbic acid. Lancet: 1999; 354 2048 2049
24. Duffy S. J., Gokce N., Holbrook M. et al. Effect of ascorbic acid treatment on conduit vessel endothelial dysfunction in patients with hypertension. Am J Physiol Heart Circ Physiol: 2001; 280 528 534
25. Ettarh R. R., Odigie I. P., Adigun S. A. Vitamin C lowers blood pressure and alters vascular responsiveness in salt-induced hypertension. Can J Physiol Pharmacol: 2002; 80 1199 1202
26. Eto Y., Kang D., Hasegawa E. et al. Succinate-dependent lipid peroxidation and its prevention by reduced ubiquinone in beef heart submitochondrial particles. Arch Biochem Biophys: 1992; 295 101 106
27. Faure P. Protective effects of antioxidant micronutrients (vitamin E, zinc and selenium) in type 2 diabetes mellitus. Clin Chem Lab Med: 2003; 41 995 998
28. Faure P., Ramon O., Favier A. et al. Selenium supplementation decreases nuclear factor-kappa B activity in peripheral blood mononuclear cells from type 2 diabetic patients. Eur J Clin Invest: 2004; 34 475 481
29. Feairheller D. L., Brown M. D., Park J. Y. et al. Exercise training, NADPH oxidase p22phox gene polymorphisms, and hypertension. Med Sci Sports Exerc: 2009; 41 1421 1428
30. Feig D. I., Soletsky B., Johnson R. J. Effect of allopurinol on blood pressure of adolescents with newly diagnosed essential hypertension: a randomized trial. JAMA: 2008; 300 924 932
31. Feldman E. B., Gold S., Greene J. et al. Ascorbic acid supplements and blood pressure:a four-week pilot study. Ann N Y Acad Sci: 1992; 669 342 344
32. Fotherby M. D., Williams J. C., Forster L. A. et al. Effect of vitamin C on ambulatory blood pressure and plasma lipids in older persons. J Hypertens: 2000; 18 411 415
33. Galley H. F., Thornton J., Howdle P. D. et al. Combination oral antioxidant supplementation reduces blood pressure. Clin Sci (Lond): 1997; 92 361 365
34. Gavazzi G., Banfi B., Deffert C. et al. Decreased blood pressure in NOX1-deficient mice. FEBS Lett: 2006; 580 497 504
35. George J., Struthers A. The role of urate and xanthine oxidase in vascular oxidative stress: future directions. Ther Clin Risk Manag: 2009; 5 799 803
36. Ghiadoni L., Magagna A., Versari D. et al. Different effect of antihypertensive drugs on conduit artery endothelial function. Hypertension: 2003; 41 1281 1286
37. Ghosh S. K., Ekpo E. B., Shah I. U. et al. A double-blind, placebo-controlled parallel trial of vitamin C treatment in elderly patients with hypertension. Gerontology: 1994; 40 268 272
38. Goicoechea M., Vinuesa S. G., Verdalles U. et al. Effect of Allopurinol in Chronic Kidney Disease Progression and Cardiovascular Risk. Clin J Am Soc Nephrol: 2010; 5 1388 1393
39. Gomez-Alamillo C., Juncos L. A., Cases A. et al. Interactions between vasoconstrictors and vasodilators in regulating hemodynamics of distinct vascular beds. Hypertension: 2003; 42 831 836
40. Grande M. T., Pérez-Barriocanal F., López-Novoa J. M. Role of inflammation in túbulo-interstitial damage associated to obstructive nephropathy. J Inflamm (Lond): 2010; 7 19 32
41. Grassi G. Assessment of sympathetic cardiovascular drive in human hypertension: Achievements and perspectives. Hypertension: 2009; 54 690 697
42. Guarnieri G., Zanetti M., Vinci P. et al. Metabolic syndrome and chronic kidney disease. J Ren Nutr: 2010; 20 19 23
43. Guyenet P. G. The sympathetic control of blood pressure. Nat Rev Neurosci: 2006; 7 335 346
44. Hajjar I. M., George V., Sasse E. A. et al. A randomized, double-blind, controlled trial of vitamin C in the management of hypertension and lipids. Am J Ther: 2002; 9 289 293
45. Han D., Antunes F., Canali R. et al. Voltage-dependent anion channels control the release of the superoxide anion from mitochondria to cytosol. J Biol Chem: 2003; 278 5557 5563
46. Harrison D. G., Gongora M. C. Oxidative stress and hypertension. Med Clin North Am: 2009; 93 621 635
47. Heller R., Werner-Felmayer G., Werner E. R. Alpha-tocopherol and endothelial nitric oxide synthesis. Ann N Y Acad Sci: 2004; 1031 74 85
48. Heller R., Werner-Felmayer G., Werner E. R. Antioxidants and endothelial nitric oxide synthesis. Eur J Clin Pharmacol: 2006; 62 21 28
49. Hirooka Y., Sagara Y., Kishi T. et al. Oxidative stress and central cardiovascular regulation. Pathogenesis of hypertension and therapeutic aspects. Circ J: 2010; 74 827 835
50. Hitomi H., Kiyomoto H., Nishiyama A. Angiotensin II and oxidative stress. Curr Opin Cardiol: 2007; 22 311 315
51. AWJH Hoitink. Research on the influence of vitamin C administration on the human organism, in particular in connection with the working capacity. Verh Nederlands Inst Praevent: 1946; 4 62 63
52. Hool L. C., Corry B. Redox control of calcium channels: from mechanisms to therapeutic opportunities. Antioxid Redox Signal: 2007; 9 409 435
53. Houston M. C. Nutraceuticals, vitamins, antioxidants, and minerals in the prevention and treatment of hypertension. Prog Cardiovasc Dis: 2005; 47 396 449
54. Ito Y., Fujita T. Trace elements and blood pressure regulation. Nippon Rinsho: 1996; 54 106 110
55. Jackson T. S., Xu A., Vita J. A. et al. Ascorbate prevents the interaction of superoxide and nitric oxide only at very high physiological concentrations. Circ Res: 1998; 83 916 922
56. Jegou S., Cartier D., Dubessy C. et al. Localization of the urotensin II receptor in the rat central nervous system. J Comp Neurol: 2006; 495 21 36
57. Juraschek S. P., Guallar E., Appel L. J. et al. Effects of vitamin C supplementation on blood pressure: a meta-analysis of randomized controlled trials. Am J Clin Nutr: 2012; 95 1079 1088
58. Kim M. K., Sasaki S., Sasazuki S. et al. Lack of long-term effect of vitamin C supplementation on blood pressure. Hypertension: 2002; 40 797 803
59. Kim I. Y., Stadtman T. C. Inhibition of NF-kappaB DNA binding and nitric oxide induction in human T cells and lung adenocarcinoma cells by selenite treatment. Proc Natl Acad Sci: 1997; 94 12904 12907
60. Kimura S., Zhang G. X., Nishiyama A. et al. Mitochondria-derived reactive oxygen species and vascular MAP kinases: comparison of angiotensin II and diazoxide. Hypertension: 2005; 45 438 444
61. Kishi T., Hirooka Y., Kimura Y. et al. Increased reactive oxygen species in rostral ventrolateral medulla contribute to neural mechanisms of hypertension in stroke-prone spontaneously hypertensive rats. Circulation: 2004; 109 2357 2362
62. Klahr S. Urinary tract obstruction. Semin Nephrol: 2001; 21 133 145
63. Koh E. T. Effect of vitamin C on blood parameters of hypertensive subjects. J Okla State Med Assoc: 1984; 77 177 182
64. Kuzkaya N., Weissmann N., Harrison D. G. et al. Interactions of peroxynitrite, tetrahydrobiopterin, ascorbic acid, and thiols: implications for uncoupling endothelial nitric-oxide synthase. J Biol Chem: 2003; 278 22546 22554
65. Laakso J. T., Teräväinen T. L., Martelin E. et al. Renal xanthine oxidoreductase activity during development of hypertension in spontaneously hypertensive rats. J Hypertens: 2004; 22 1333 1340
66. Lacy F., Kailasam M. T., O'Connor D. T. et al. Plasma hydrogen peroxide production in human essential hypertension: role of heredity, gender, and ethnicity. Hypertension: 2000; 36 878 884
67. Landmesser U., Cai H., Dikalov S. et al. Role of p47(phox) in vascular oxidative stress and hypertension caused by angiotensin II. Hypertension: 2002; 40 511 515
68. Landmesser U., Dikalov S., Price S. R. et al. Oxidation of tetrahydrobiopterin leads to uncoupling of endothelial cell nitric oxide synthase in hypertension. J Clin Invest: 2003; 111 1201 1209
69. Lassègue B., Clempus R. E. Vascular NAD(P)H oxidases: specific features, expression, and regulation. Am J Physiol Regul Integr Comp Physiol: 2003; 285 277 297
70. Lassègue B., Griendling K. Reactive Oxygen Species in Hypertension, An Update. Am J Hypertens: 2004; 17 852 860
71. Laursen J. B., Somers M., Kurz S. et al. Endothelial regulation of vasomotion in apoE-deficient mice: implications for interactions between peroxynitrite and tetrahydrobiopterin. Circulation: 2001; 103 1282 1288
72. Lee I. M., Cook N. R., Gaziano J. M. et al. Vitamin E in the primary prevention of cardiovascular disease and cancer: the Women's Health Study: a randomized controlled trial. JAMA: 2005; 294 56 65
73. Levitan E. B., Wolk A., Mittleman M. A. Relation of consistency with the dietary approaches to stop hypertension diet and incidence of heart failure in men aged 45 to 79 years. Am J Cardiol: 2009; 104 1416 1420
74. Lonn E., Bosch J., Yusuf S. et al. HOPE and HOPE-TOO Trial Investigators. Effects of long-term vitamin E supplementation on cardiovascular events and cancer: a randomized controlled trial. JAMA: 2005; 293 1338 1347
75. Lymbury R. S., Marino M. J., Perkins A. V. Effect of dietary selenium on the progression of heart failure in the ageing spontaneously hypertensive rat. Mol Nutr Food Res: 2010; 54 1436 1444
76. Malyszko J. Mechanism of endothelial dysfunction in chronic kidney disease. Clin Chim Acta: 2010; 411 1412 1420
77. Matsushita M., Shichiri M., Imai T. et al. Co-expression of urotensin II and its receptor (GPR14) in human cardiovascular and renal tissues. J Hypertens: 2001; 19 2185 2190
78. Mazzali M., Hughes J., Kim Y. et al. Elevated Uric Acid Increases Blood Pressure in the Rat by a Novel Crystal-Independent Mechanism. Hypertension: 2001; 38 1101 1106
79. Michel J. B., Feron O., Sase K. et al. Caveolin versus calmodulin. Counterbalancing allosteric modulators of endothelial nitric oxide synthase. J Biol Chem: 1997; 272 25907 25912
80. Miller S., Walker S. W., Arthur J. R. et al. Selenite protects human endothelial cells from oxidative damage and induces thioredoxin reductase. Clin Sci (Lond): 2001; 100 543 550
81. Mistry H. D., Wilson V., Ramsay M. M. et al. Reduced selenium concentrations and glutathione peroxidase activity in preeclamptic pregnancies. Hypertension: 2008; 52 881 888
82. Moran J. P., Cohen L., Greene J. M. et al. Plasma ascorbic acid concentrations relate inversely to blood pressure in human subjects. Am J Clin Nutr: 1993; 57 213 217
83. Mullan B. A., Young I. S., Fee H. et al. Ascorbic acid reduces blood pressure and arterial stiffness in type 2 diabetes. Hypertension: 2002; 40 804 809
84. Münzel T., Keaney J. F. Jr. Are ACE inhibitors a magic bullet against oxidative stress? Circulation: 2001; 104 1571 1574
85. Nanayakkara P. W., Teerlink T., Stehouwer C. D. et al. Plasma asymmetric dimethylarginine (ADMA) concentration is independently associated with carotid intima-media thickness and plasma soluble vascular cell adhesión molecule-1 (sVCAM-1) concentration in patients with mild-to-moderate renal failure. Kidney Int: 2005; 68 2230 2236
86. Nawrot T. S., Staessen J. A., Roels H. A. et al. Blood pressure and blood selenium: a cross-sectional and longitudinal population study. Eur Heart J: 2007; 28 628 633
87. Nishikawa Y., Tatsumi K., Matsuura T. et al. Effects of vitamin C on high blood pressure induced by salt in spontaneously hypertensive rats. J Nutr Sci Vitaminol (Tokyo): 2003; 49 301 309
88. Nowson C. A., Wattanapenpaiboon N., Pachett A. Low-sodium Dietary Approaches to Stop Hypertension-type diet including lean red meat lowers blood pressure in postmenopausal women. Nutr Res: 2009; 29 8 18
89. Oliveira-Sales E. B., Nishi E. E., Carillo B. A. et al. Oxidative stress in the sympathetic promotor neurons contributes to sympathetic activation in renovascular hypertension. Am J Hypertens: 2009; 22 484 492
90. On Y. K., Kim C. H., Sohn D. W. et al. Improvement of endothelial function by amlodipine and vitamin C in essential hypertension. Korean J Intern Med: 2002; 17 131 137
91. Padayatty S. J., Katz A., Wang Y. et al. Vitamin C as an antioxidant: evaluation of its role in disease prevention. J Am Coll Nutr: 2003; 22 18 35
92. Palumbo G., Avanzini F., Alli C. et al. Effects of vitamin E on clinic and ambulatory blood pressure in treated hypertensive patients. Collaborative Group of the Primary Prevention Project (PPP) - Hypertension study. Am J Hypertens: 2000; 13 564 567
93. Paravicini T. M., Touyz R. M. Redox signalling in hypertension. Cardiovasc Res: 2006; 71 247 258
94. Pechánová O., Zicha J., Kojsová S. et al. Effect of chronic N-acetylcysteine treatment on the development of spontaneous hypertension. Clin Sci (Lond): 2006; 110 235 242
95. Pechánová O., Rezzani R., Babál P. et al. Beneficial effects of Provinols: cardiovascular system and kidney. Physiol Res: 2006; 55 17 30
96. Pechánová O. Contribution of captopril thiol group to the prevention of spontaneous hypertension. Physiol Res: 2007; 56 41 48
97. Penugonda S., Mare S., Goldstein G. et al. Effects of N-acetylcysteine amide (NACA), a novel thiol antioxidant against glutamate-induced cytotoxicity in neuronal cell line PC12. Brain Res: 2005; 1056 132 138
98. Plantinga Y., Ghiadoni L., Magagna A. et al. Suplementation with vitamins C and E improves arterial stiffness and endothelial function in essential hypertensive patients. Am J Hypertens: 2007; 20 392 397
99. Piccoli C., Quarato G., D'Aprile A. et al. Native LDL-induced oxidative stress in human proximal 1 tubular cells: multiple players involved. J Cell Mol Med: 2011; 15 375 395
100. Pietta P., Simonetti P., Gardana C. et al. Relationship between rate and extent of catechin absorption and plasma antioxidant status. Biochem Mol Biol Int: 1998; 46 895 903
101. Rapola J. M., Virtamo J., Ripatti S. et al. Randomised trial of a-tocopherol and b-carotene supplements on incidence of major coronary events in men with previous myocardial infarction. Lancet: 1997; 349 1715 1720
102. Reckelhoff J. F., Kanji V., Racusen L. C. et al. Vitamin E ameliorates enhanced renal lipid peroxidation and accumulation of F2-isoprostanes in aging kidneys. Am J Physiol: 1998; 274 767 774
103. Redon J., Oliva M. R., Tormos C. et al. Antioxidant activities and oxidative stress byproducts in human hypertension. Hypertension: 2003; 41 1096 1101
104. Rodrigo R., Rivera G. Renal damage mediated by oxidative stress: a hypothesis of protective effects of red wine. Free Radic Biol Med: 2002; 33 409 422
105. Rodrigo R., Passalacqua W., Araya J. et al. Implications of oxidative stress and homocysteine in the pathophysiology of essential hypertension. J Cardiovasc Pharmacol: 2003; 42 453 461
106. Rodrigo R., Passalacqua W., Araya J. et al. Homocysteine and essential hypertension. J Clin Pharmacol: 2003; 43 1299 1306
107. Rodrigo R., Bosco C. Oxidative stress and protective effects of polyphenols: comparative studies in human and rodent kidney. A review. Comp Biochem Physiol C Toxicol Pharmacol: 2006; 142 317 327
108. Rodrigo R., Prat H., Passalacqua W. et al. Relationship between oxidative stress and essential hypertension. Hypertens Res: 2007; 30 1159 1167
109. Rodrigo R., Guichard C., Charles R. Clinical pharmacology and therapeutic use of antioxidant vitamins. Fundam Clin Pharmacol: 2007; 21 111 127
110. Rodrigo R., Prat H., Passalacqua W. et al. Decrease in oxidative stress through supplementation of vitamins C and E is associated with a reduction in blood pressure in patients with essential hypertension. Clin Sci (Lond): 2008; 114 625 634
111. Rodrigo R., Gil D., Miranda-Merchak A. et al. Antihypertensive role of polyphenols. Adv Clin Chem: 2012; 58 225 254
112. Sachse A., Wolf G. Angiotensin II-induced reactive oxygen species and the kidney. J Am Soc Nephrol: 2007; 18 2439 2446
113. Sato K., Dohi Y., Kojima M. et al. Effects of ascorbic acid on ambulatory blood pressure in elderly patients with refractory hypertension. Arzneimittelforschung: 2006; 56 535 540
114. Savica V., Bellinghieri G., Kopple J. D. The effect of nutrition on blood pressure. Annu Rev Nutr: 2010; 30 365 401
115. Schneider M. P., Delles C., Schmidt B. M. et al. Superoxide scavenging effects of N-acetylcysteine and vitamin C in subjects with essential hypertension. Am J Hypertens: 2005; 18 1111 1117
116. Simko F., Luptak I., Matuskova J. et al. L-arginine fails to protect against myocardial remodelling in L-NAME-induced hypertension. Eur J Clin Invest: 2005; 35 362 368
117. Sládková M., Kojsová S., Jendeková L. et al. Chronic and acute effects of different antihypertensive drugs on femoral artery relaxation of L-NAME hypertensive rats. Physiol Res: 2007; 56 85 91
118. Smith P. J., Blumenthal J. A., Babyak M. A. et al. Effects of the dietary approaches to stop hypertension diet, exercise, and caloric restriction on neurocognition in overweight adults with high blood pressure. Hypertension: 2010; 55 1331 1338
119. Steinbrenner H., Sies H. Protection against reactive oxygen species by selenoproteins. Biochim Biophys Acta: 2009; 1790 1478 1485
120. Stirrat A., Gallagher M., Douglas S. A. et al. Potent vasodilator responses to human urotensin-II in human pulmonary and abdominal resistance arteries. Am J Physiol Heart Circ Physiol: 2001; 280 925 928
121. Stojiljkovic M. P., Lopes H. F., Zhang D. et al. Increasing plasma fatty acids elevates F2-isoprostanes in humans: implications for the cardiovascular risk factor cluster. J Hypertens: 2002; 20 1215 1221
122. Suzuki H., DeLano F. A., Parks D. A. et al. Xanthine oxidase activity associated with arterial blood pressure in spontaneously hypertensive rats. Proc Natl Acad Sci USA: 1998; 95 4754 4759
123. Sved A. F., Ito S., Sved J. C. Brainstem mechanisms of hypertension: Role of the rostral ventrolateral medulla. Curr Hypertens Rep: 2003; 5 262 268
124. Taddei S., Virdis A., Ghiadoni L. et al. Vitamin C improves endothelium-dependent vasodilation by restoring nitric oxide activity in essential hypertension. Circulation: 1998; 97 2222 2229
125. Takizawa M., Komori K., Tampo Y. et al. Paraquat-induced oxidative stress and dysfunction of cellular redox systems including antioxidative defense enzymes glutathione peroxidase and thioredoxin reductase. Toxicol In Vitro: 2007; 21 355 363
126. Tanito M., Nakamura H., Kwon Y. W. et al. Enhanced oxidative stress and impaired thioredoxin expression in spontaneously hypertensive rats. Antioxid Redox Signal: 2004; 6 89 97
127. Taniyama Y., Griendling K. Reactive Oxygen Species in the Vasculature: Molecular and Cellular Mechanisms. Hypertension: 2003; 42 1075 1081
128. Tian N., Rose R. A., Jordan S. et al. N-Acetylcysteine improves renal dysfunction, ameliorates kidney damage and decreases blood pressure in salt-sensitive hypertension. J Hypertens: 2006; 24 2263 2270
129. Touyz R. M., Schiffrin E. L. Increased generation of superoxide by angiotensin II in smooth muscle cells from resistance arteries of hypertensive patients: role of phospholipase D-dependent NAD(P)H oxidase-sensitive pathways. J Hypertens: 2001; 19 1245 1254
130. Touyz R. M. Reactive oxygen species, vascular oxidative stress, and redox signaling in hypertension: what is the clinical significance? Hypertension: 2004; 44 248 252
131. Ulker S., McKeown P. P., Bayraktutan U. Vitamins reverse endothelial dysfunction through regulation of eNOS and NAD(P)H oxidase activities. Hypertension: 2003; 41 534 539
132. Viel E. C., Benkirane K., Javeshghani D. et al. Xanthine oxidase and mitochondria contribute to vascular superoxide anion generation in DOCA-salt hypertensive rats. Am J Physiol Heart Circ Physiol: 2008; 295 281 288
133. Vita J. A., Frei B., Holbrook M. et al. L-2-Oxothiazolidine-4-carboxylic acid reverses endothelial dysfunction in patients with coronary artery disease. J Clin Invest: 1998; 101 1408 1414
134. Ward N. C., Hodgson J. M., Croft K. D. et al. The combination of vitamin C and grape-seed polyphenols increases blood pressure: a randomized, double-blind, placebo-controlled trial. J Hypertens: 2005; 23 427 434
135. Ward N. C., Wu J. H., Clarke M. W. et al. The effect of vitamin E on blood pressure in individuals with type 2 diabetes: a randomized, double-blind, placebo-controlled trial. J Hypertens: 2007; 25 227 234
136. Wen H., Gwathmey J. K., Xie L. H. Oxidative stress-mediated effects of angiotensin II in the cardiovascular system. World J Hypertens: 2012; 2 34 44
137. Yoshida J., Yamamoto K., Mano T. et al. AT1 receptor blocker added to ACE inhibitor provides benefits at advanced stage of hypertensive diastolic heart failure. Hypertension: 2004; 43 686 691
138. Yoshioka M., Aoyama K., Matsushita T. Effects of ascorbic acid on blood pressure and ascorbic acid metabolism in spontaneously hypertensive rats (SH rats). Int J Vitam Nutr Res: 1985; 55 301 307
139. Yoshioka J., Schreiter E. R., Lee R. T. Role of thioredoxin in cell growth through interactions with signaling molecules. Antioxid Redox Signal: 2006; 8 2143 2145
140. Young J. M., Florkowski C. M., Molyneux S. L. et al. A randomized, double-blind, placebo-controlled crossover study of coenzyme Q10 therapy in hypertensive patients with the metabolic syndrome. Am J Hypertens: 2012; 25 261 270
141. Yusuf S., Hawken S., Ounpuu S. et al. Effect of potentially modifiable risk factors associated with myocardial infarction in 52 countries (the INTERHEART Study): case control study. Lancet: 2004; 364 937 952
142. Zaslavskaia R. M., Shcherban' E. A., Lilitsa G. V. et al. Melatonin in the combined treatment of cardiovascular diseases. Klin Med (Mosk): 2010; 88 26 30
143. Zembowicz A., Hatchett R. J., Radziszewski W. et al. Inhibition of endothelial nitric oxide synthase by ebselen. Prevention by thiols suggests the inactivation by ebselen of a critical thiol essential for the catalytic activity of nitric oxide synthase. J Pharmacol Exp Ther: 1993; 267 1112 1118
144. Zenebe W., Pechánová O., Andriantsitohaina R. Red wine polyphenols induce vasorelaxation by increased nitric oxide bioactivity. Physiol Res: 2003; 52 425 432
145. Zhang Y., Hogg N. S-Nitrosothiols: cellular formation and transport. Free Radic Biol Med: 2005; 38 831 838
146. Zhang C., Hu J. J., Xia M. et al. Redox signaling via lipid raft clustering in homocysteine-induced injury of podocytes. Biochim Biophys Acta: 2010; 1803 482 491
147. Zhou L., Xiang W., Potts J. et al. Reduction in extracellular superoxide dismutase activity in African-American patients with hypertension. Free Radic Biol Med: 2006; 41 1384 1391
148. Zhou X., Ji W. J., Zhu Y. et al. Enhancement of endogenous defenses against ROS by supra-nutritional level of selenium is more safe and effective than antioxidant supplementation in reducing hypertensive target organ damage. Med Hypotheses: 2007; 68 952 956
149. Zimmerman M. C., Lazartigues E., Sharma R. V. et al. Hypertension caused by angiotensin II infusion involves increased superoxide production in the central nervous system. Circ Res: 2004; 95 210 216
150. Zoccali C., Bode-Böger S., Mallamaci F. et al. Plasma concentration of asymmetrical dimethylarginine and mortality in patients with end-stage renal disease: aprospective study. Lancet: 2001; 358 2113 2117
151. Zou M. H., Cohen R. A., Ullrich V. Peroxynitrite and vascular endothelial dysfunction in diabetes mellitus. Endothelium: 2004; 11 89 97