Lack of long-term effect of vitamin C supplementation on blood pressure

Hypertension

Volumn 40, Issue 6, 2002, Pages 797-803

  Kim, Mi Kyung ^a   Sasaki, Satoshi ^a   Sasazuki, Shizuka ^a   Okubo, Shunji ^b   Hayashi, Masato ^b   Tsugane, Shoichiro ^a  

^a NATIONAL CANCER CENTER RESEARCH INSTITUTE   (Japan)

^b Hiraka General Hospital   (Japan)

Author keywords

Antihypertensive agents; Blood pressure; Clinical trials; Vitamins

Indexed keywords

ASCORBIC ACID; BETA CAROTENE;

ADULT; AGED; ALCOHOL CONSUMPTION; ARTICLE; ATROPHIC GASTRITIS; BLOOD PRESSURE; BODY MASS; CLINICAL TRIAL; CONFIDENCE INTERVAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DIASTOLIC BLOOD PRESSURE; DIET SUPPLEMENTATION; DRUG BLOOD LEVEL; DRUG EFFECT; DRUG MEGADOSE; FEMALE; GENDER; HUMAN; LOW DRUG DOSE; MAJOR CLINICAL STUDY; MALE; PRIORITY JOURNAL; SERUM; STATISTICAL SIGNIFICANCE; STRATIFICATION; SYSTOLIC BLOOD PRESSURE;

ADULT; AGED; ANTIOXIDANTS; ASCORBIC ACID; BETA CAROTENE; BLOOD PRESSURE; DIASTOLE; DIETARY SUPPLEMENTS; DOSE-RESPONSE RELATIONSHIP, DRUG; DOUBLE-BLIND METHOD; FEMALE; FOLLOW-UP STUDIES; GASTRITIS, ATROPHIC; HUMANS; HYPERTENSION; JAPAN; MALE; MIDDLE AGED; STOMACH NEOPLASMS; SYSTOLE; TIME; TREATMENT OUTCOME;

EID: 0036900193     PISSN: 0194911X     EISSN: None     Source Type: Journal    
DOI: 10.1161/01.HYP.0000038339.67450.60     Document Type: Article

References (36)

1. Greenberg ER, Sporn MB. Antioxidant vitamins, cancer, and cardiovascular disease. N Engl J Med. 1996;334:1189-1190.
2. Miller ER 3rd, Appel LJ, Levander OA, Levine DM. The effect of antioxidant vitamin supplementation on traditional cardiovascular risk factors. J Cardiovasc Risk. 1997;4:19-24.
3. Ness AR, Khaw KT, Bingham S, Day NE. Vitamin C status and blood pressure. J Hypertens. 1996;14:503-508.
4. Yokoyama T, Date C, Kokubo Y, Yoshiike N, Matsumura Y, Tanaka H. Serum vitamin C concentration was inversely associated with subsequent 20-year incidence of stroke in a Japanese rural community: The Shibata study. Stroke. 2000;31:2287-2294.
5. Bulpitt CJ. Vitamin C and blood pressure. J Hypertens. 1990;8: 1071-1075.
6. Jialal I, Devaraj S. Vitamin E supplementation and cardiovascular events in high-risk patients. N Engl J Med. 2000;342:1917-1918.
7. Collaborative Group of the Primary Prevention Project (PPP). Low-dose aspirin and vitamin E in people at cardiovascular risk: A randomized trial in general practice. Lancet. 2001;357:89-95.
8. Mezzetti A, Zuliani G, Romano F, Costantini F, Pierdomenico SD, Cuccurullo F, Fellin R, for the Associazione Medica Sabin. Vitamin E and lipid peroxide plasma levels predict the risk of cardiovascular events in a group of healthy very old people. J Am Geriatr Soc. 2001;49: 533-537.
9. Appel LJ, Moore TJ, Obarzanek E, Vollmer WM, Svetkey LP, Sacks FM, Bray GA, Vogt TM, Cutler JA, Windhauser MM, Lin P-H, Karanja N. A clinical trial of the effects of dietary patterns on blood pressure. N Engl J Med. 1997;336:1117-1124.
10. Block G, Mangels AR, Norkus EP, Patterson BH, Levander OA, Taylor PR. Ascorbic acid status and subsequent diastolic and systolic blood pressure. Hypertension. 2001;37:261-267.
11. Sakai N, Yokoyama T, Date C, Yoshiike N, Matsumura Y. An inverse relationship between serum vitamin C and blood pressure in a Japanese community. J Nutr Sci Vitaminol. 1998;44:853-867.
12. Gale CR, Martyn CN, Winter PD, Cooper C. Vitamin C and risk of death from stroke and coronary heart disease in cohort of elderly people. BMJ. 1995;310:1563-1566.
13. Riemersma RA, Carruthers KF, Elton RA, Fox KAA. Vitamin C and the risk of acute myocardial infarction. Am J Clin Nutr. 2000;71:1181-1186.
14. Nyyssönen K, Parviainen MT, Salonen R, Tuomilehto J, Salonen JT. Vitamin C deficiency and risk of myocardial infarction: Prospective population study of men from eastern Finland, BMJ. 1997;314:634-638.
15. Osilesi O, Trout DL, Ogunwole JO, Glover EE. Blood pressure and plasma lipids during ascorbic acid supplementation in borderline hypertensive and normotensive adults. Nutr Res. 1991;11:405-412.
16. Koh ET. Effects of vitamin C on blood parameters of hypertensive subjects. J Oklahoma Med Assoc. 1984;77:177-182.
17. Lovat LB. Lu Y. Palmer AJ, Edwards R, Fletcher AE, Bulpitt CJ. Double-blind trial of vitamin C in elderly hypertensives. J Hum Hypertens. 1993;7:403-405.
18. Tsugane S, Gey F, Ichinowatari Y, Miyajima Y, Ishibashi T, Matsushita S, Hirota Y. Inami T, Yamaguchi M, Karita K, Kabuto M, Takashima Y. Todoriki H, Tsuda M, Akabane M, Furuichi Y, Hamada G, Watanabe S. Cross-sectional epidemiologic study for assessing cancer risks at the population level. I. Study design and participation rate. J Epidemiol 1992;2:75-81.
19. Tsubono Y, Okubo S, Hayashi M, Kakizoe T, Tsugane S. A randomized controlled trial for chemoprevention of gastric cancer in high-risk Japanese population: Study design, feasibility and protocol modification. Jpn J Cancer Res. 1997;88:344-349.
20. Inoue M, Kobayashi S, Matsuura A, Hamajima N, Tajima K, Tominaga S. Agreement of endoscopic findings and serum pepsinogen levels as an indicator of atrophic gastritis. Cancer Epidemiol Biomarkers Prev. 1998; 7:261-263.
21. Samloff IM, Varis K, Ihamaki T, Siurala M, Rotter JI. Relationships among serum pepsinogen I, serum pepsinogen II, and gastric mucosal histology: A study in relatives of patients with pernicious anemia. Gastroenterology. 1982;83:204-209.
22. Smigel K. Beta-Carotene and Vitamin A Halted in Lung Cancer Prevention Trial. National Cancer Institute Press Release. Bethesda, Md: National Institutes of Health, US Department of Health and Human Services; January 18, 1996.
23. Tsubono Y, Takamori S, Kobayashi M, Takahashi T, Iwase Y, Iitoi Y, Akabane M, Yamaguchi M, Tsugane S. A data-based approach for designing a semiquantitative food frequency questionnaire for a population-based prospective study in Japan. J Epidemiol. 1995;6:45-53.
24. Zannoni V. Lynch M. Goldstein S, Sato P. A rapid micromethod for the determination of ascorbic acid in plasma and tissues. Biochem Med. 1974;11:41-48.
25. Moran JP, Cohen L, Greene JM, Xu G, Feldman EB, Hames CG, Felman DS. Plasma ascorbic acid concentrations relate inversely to blood pressure in human subjects. Am J Clin Nutr. 1993;57:213-217.
26. Salonen JT, Salonen R, Ihanainen M, Parviainen M, Seppanen R, Kantola M, Seppanen K, Rauramaa R. Blood pressure, dietary fats, and antioxidants. Am Clin Nutr. 1988;48:1226-1232.
27. Yoshioka M, Matsushita T, Chuman Y. Inverse association of serum ascorbic acid level and blood pressure or rate of hypertension in male adults aged 30-39 years. Int J Vit Nutr Res. 1984:54:343-347.
28. Drewnowski A, Rock CL, Henderson SA, Shore AB, Fischeler C, Galan P, Preziosi P, Hercberg S. Serum β-carotene and vitamin C as biomarkers of vegetable and fruit intakes in a community-based sample of French adults. Am J Clin Nutr. 1997;65:1796-1802.
29. Polsinelli ML, Rock CL, Henderson SA, Drewnowski A. Plasma carotenoids as biomarkers of fruit and vegetable servings in women. J Am Diet Assoc. 1997;98:194-196.
30. Tsugane S, Fahey MT, Kobayashi M, Sasaki S, Tsubono Y, Akabane M, Gey F. Four frequency categories of fruit intake as a predictor of plasma ascorbic acid level in middle-aged Japanese men. Ann Epidemiol. 1998; 8:378-383.
31. Stamler J, Caggiula AW, Grandits GA. Relation of body mass and alcohol, nutrient, fiber, and caffeine intakes to blood pressure in the special intervention and usual care groups in the Multiple Risk Factor Intervention Trial. Am J Clin Nutr. 1997;65:338s-365s.
32. Feldman EB, Gold S, Greene J, Moran G, Xu G, Shulz GG, Hames CG, Feldman DS. Ascorbic supplements and blood pressure: A four-week pilot study. Ann NY Acad Sci. 1992;669:342-344.
33. Sacks FM, Rosner B, and Kass EH. Blood pressure in vegetarians. Am J Epidemiol. 1974;100:390-398.
34. Kabuto M. Imai H, Tsugane S, Watanabe S. Correlation between atrophic gastritis prevalence and gastric cancer mortality among middle-aged men in 5 areas in Japan. J Epidemiol. 1993;3:35-39.
35. Waring AJ, Drake IM, Schorah CJ, White KL. Lynch DA, Axon AT, Dixon MF. Ascorbic acid and total vitamin C concentrations in plasma. gastric juice, and gastrointestinal mucosa: Effects of gastritis and oral supplementation. Gut. 1996;38:171-176.
36. Sobue T, Yamamoto S, Watanabe S, for the JPHC Study Group. Smoking and drinking habits among the JPHC Study participants at baseline survey. J Epidemiol. 2001;11(suppl):S44-S56.