Ascorbic acid reduces blood pressure and arterial stiffness in type 2 diabetes

Hypertension

Volumn 40, Issue 6, 2002, Pages 804-809

  Mullan, Brian A ^a   Young, Ian S ^b   Fee, Howard ^b   McCance, David R ^a  

^a ROYAL VICTORIA HOSPITAL   (United Kingdom)

^b QUEEN'S UNIVERSITY BELFAST   (United Kingdom)

Author keywords

Antioxidants; Arteries; Blood pressure; Diabetes mellitus; Vitamins

Indexed keywords

ASCORBIC ACID; PLACEBO;

ADULT; AGED; AORTA; ARTERIAL STIFFNESS; ARTERY DISEASE; ARTICLE; BLOOD PRESSURE; BLOOD PRESSURE REGULATION; BRACHIAL ARTERY; CLINICAL ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DATA ANALYSIS; DIABETES MELLITUS; DIASTOLIC BLOOD PRESSURE; DIET SUPPLEMENTATION; DOUBLE BLIND PROCEDURE; DRUG EFFECT; FEMALE; HEMODYNAMICS; HUMAN; MALE; NON INSULIN DEPENDENT DIABETES MELLITUS; PRIORITY JOURNAL; PULSE WAVE; RADIAL ARTERY; RANDOMIZED CONTROLLED TRIAL; RISK FACTOR; STIMULATION; SYSTOLIC BLOOD PRESSURE; TREATMENT OUTCOME;

ADMINISTRATION, ORAL; ADULT; AGED; ANTIOXIDANTS; AORTA; ARTERIES; ASCORBIC ACID; BLOOD PRESSURE; DIABETES MELLITUS, TYPE 2; DIETARY SUPPLEMENTS; DOUBLE-BLIND METHOD; ELASTICITY; FEMALE; HEMODYNAMIC PROCESSES; HUMANS; MALE; MIDDLE AGED; PULSE; RADIAL ARTERY; TIME FACTORS; TREATMENT OUTCOME;

EID: 0036900442     PISSN: 0194911X     EISSN: None     Source Type: Journal    
DOI: 10.1161/01.HYP.0000039961.13718.00     Document Type: Article

References (52)

1. Nathan DM. Treating type 2 diabetes with respect. Ann Intern Med. 1999;130:440-441.
2. Pieper GM. Review of alterations in endothelial nitric oxide production in diabetes: Protective role of arginine on endothelial dysfunction. Hypertension. 1998;31:1047-1060.
3. Ross R, Atherosclerosis: An inflammatory disease. N Engl J Med. 1999; 340:115-126.
4. Cockcroft JR, Webb DJ, Wilkinson IB. Arterial stiffness, hypertension and diabetes mellitus. J Hum Hypertens. 2000;14:377-380.
5. Arnett DK, Evans GW, Riley WA. Arterial stiffness: A new cardiovascular risk factor? Am J Epidemiol. 1994;140:669-682.
6. Nichols WW, O'Rourke MF. McDonald's Blood Flow in Arteries: Theoretical, Experimental and Clinical Principles. 4th Ed. London, UK: Arnold; 1998.
7. May JM. How does ascorbic acid prevent endothelial dysfunction? Free Radic Biol Med. 2000;28:1421-1429.
8. Price KD, Price CS, Reynolds RD. Hyperglycemia-induced ascorbic acid deficiency promotes endothelial dysfunction and the development of atherosclerosis. Atherosclerosis. 2001;158:1-12.
9. Sinclair AJ, Taylor PB, Lunec J, Girling AJ, Barnett AH. Low plasma ascorbate levels in patients with type 2 diabetes mellitus consuming adequate dietary vitamin C. Diabet Med. 1994;11:893-898.
10. Bode AM, Yavarow CR, Fry DA, Vargas T. Enzymatic basis for altered ascorbic acid and dehydroascorbic acid levels in diabetes. Biochem Biophys Res Commun. 1993;191:1347-1353.
11. Carr AC, Frei B. Toward a new recommended dietary allowance for vitamin C based on antioxidant and health effects in humans. Am J Clin Nutr. 1999;69:1086-1107.
12. Timimi FK, Ting HH, Haley EA, Roddy MA, Ganz P, Creager MA. Vitamin C improves endothelium-dependent vasodilation in patients with insulin-dependent diabetes mellitus. J Am Coll Cardiol. 1998;31: 552-557.
13. Ting HH, Timimi FK, Boles KS, Creager SJ, Ganz P, Creager MA. Vitamin C improves endothelium-dependent vasodilation in patients with non-insulin-dependent diabetes mellitus. J Clin Invest. 1996;97:22-28.
14. Ceriello A, Giugliano D, Quatraro A, Lefebvre PJ. Anti-oxidants show an anti-hypertensive effect in diabetic and hypertensive subjects. Clin Sci. 1991;81:739-742.
15. Mullan BA, Young IS, Harper R, McCance DR. Ascorbic acid can reduce insulin resistance and augmentation of central systolic pressure in patients with type 2 diabetes. Diabet Med. 2001;18(suppl 2):P168. Abstract.
16. O'Brien E, Mee F, Atkins N, Thomas M. Evaluation of three devices for self-measurement of blood pressure according to the revised British Hypertension Society Protocol: The Omron HEM-705CP, Philips HP5332, and Nissei DS-175. Blood Press Monit. 1996;1:55-61.
17. Wilkinson IB, Fuchs SA, Jansen IM, Spratt JC, Murray GD, Cockcroft JR, Webb DJ. Reproducibility of pulse wave velocity and augmentation index measured by pulse wave analysis. J Hypertens. 1998;16: 2079-2084.
18. Brooks B, Molyneaux L, Yue DK. Augmentation of central arterial pressure in type 1 diabetes. Diabetes Care. 1999;22:1722-1727.
19. Filipovsky J, Svobodova V, Pecen L. Reproducibility of radial pulse wave analysis in healthy subjects. J Hypertens. 2000;18:1033-1040.
20. Wilkinson IB, MacCallum H, Rooijmans DF, Murray GD, Cockcroft JR, McKnight JA, Webb DJ. Increased augmentation index and systolic stress in type 1 diabetes mellitus. QJM. 2000;93:441-448.
21. Wilkinson IB, MacCallum H, Flint L, Cockcroft JR, Newby DE, Webb DJ. The influence of heart rate on augmentation index and central arterial pressure in humans. J Physiol. 2000;525:263-270.
22. Wilkinson IB, MacCallum H, Hupperetz PC, van Thoor CJ, Cockcroft JR, Webb DJ. Changes in the derived central pressure waveform and pulse pressure in response to angiotensin II and noradrenaline in man. J Physiol. 2001;530:541-550.
23. Wilkinson IB, Cockcroft JR, Webb DJ. Pulse wave analysis and arterial stiffness. J Cardiovasc Pharmacol. 1998;32(suppl 3):S33-S37.
24. Marchais SJ, Guerin AP, Pannier BM, Levy BI, Safar ME, London GM. Wave reflections and cardiac hypertrophy in chronic uremia: Influence of body size. Hypertension. 1993;22:876-883.
25. Buckberg GD, Towers B, Paglia DE, Mulder DG, Maloney JV. Subendocardial ischemia after cardiopulmonary bypass. J Thorac Cardiovasc Surg. 1972;64:669-684.
26. Vuillemier JP, Keck E. Fluorometric assay of vitamin C in biological materials using a centrifugal analyser with fluorescence attachment. J Micronutrient Anal. 1989;5:25-34.
27. Cockcroft JR, Wilkinson IB, Webb DJ. The Trevor Howell Lecture: Age, arterial stiffness and the endothelium. Age Ageing. 1997;26:53-60.
28. West IC. Radicals and oxidative stress in diabetes. Diabet Med. 2000;17: 171-180.
29. Jackson TS, Xu A, Vita JA, Keaney JFJ. Ascorbate prevents the interaction of superoxide and nitric oxide only at very high physiological concentrations. Circ Res. 1998;83:916-922.
30. Grundy SM. Small LDL, atherogenic dyslipidemia, and the metabolic syndrome. Circulation. 1997;95:1-4.
31. Baker TA, Milstien S, Katusic ZS. Effect of vitamin C on the availability of tetrahydrobiopterin in human endothelial cells. J Cardiovasc Pharmacol. 2001;37:333-338.
32. Murphy ME. Ascorbate and dehydroascorbate modulate nitric oxide-induced vasodilations of rat coronary arteries. J Cardiovasc Pharmacol. 1999;34:295-303.
33. Paolisso G, Balbi V, Volpe C, Varricchio G, Gambardella A, Saccomanno F, Ammendola S, Varricchio M, D'Onofrio F. Metabolic benefits deriving from chronic vitamin C supplementation in aged non-insulin dependent diabetics. J Am Coll Nutr. 1995;14:387-392.
34. Hirashima O, Kawano H, Motoyama T, Hirai N, Ohgushi M, Kugiyama K, Ogawa H, Yasue H. Improvement of endothelial function and insulin sensitivity with vitamin C in patients with coronary spastic angina: Possible role of reactive oxygen species. J Am Coll Cardiol. 2000;35: 1860-1866.
35. Steinberg HO, Brechtel G, Johnson A, Fineberg N, Baron AD. Insulin-mediated skeletal muscle vasodilation is nitric oxide dependent: A novel action of insulin to increase nitric oxide release. J Clin Invest. 1994;94: 1172-1179.
36. Rolla G, Brussino L, Carra R, Garbella E, Bucca C. Hypertension and ascorbic acid. Lancet. 2000;355:1271-1272.
37. Duffy SJ, Gokce N, Holbrook M, Hunter LM, Biegelsen ES, Huang A, Keaney JF Jr, Vita JA. Effect of ascorbic acid treatment on conduit vessel endothelial dysfunction in patients with hypertension. Am J Physiol Heart Circ Physiol. 2001;280:H528-H534.
38. Duffy SJ, Gokce N, Holbrook M, Huang A, Frei B, Keaney JF Jr, Vita JA. Treatment of hypertension with ascorbic acid. Lancet. 1999;354: 2048-2049.
39. Khaw KT, Bingham S, Welch A, Luben R, Wareham N, Oakes S, Day N. Relation between plasma ascorbic acid and mortality in men and women in EPIC-Norfolk prospective study: a prospective population study: European Prospective Investigation into Cancer and Nutrition. Lancet. 2001;357:657-663.
40. Block G, Mangels AR, Norkus EP, Patterson BH, Levander OA, Taylor PR. Ascorbic acid status and subsequent diastolic and systolic blood pressure. Hypertension. 2001;37:261-267.
41. Valagussa F, Franzosi MG, Geraci E, Mininni N, Nicolosi GL, Santini M, Tavazzi L, Vecchio C, Marchioli R. Dietry supplementation with N-3 polyunsaturated fatty acids and vitamin E after myocardial infarction: Results of the GISSI-Pervenzione trial. Lancet. 1999;354:447-455.
42. Yusuf S, Dagenais G, Pogue J, Bosch J, Sleight P. Vitamin E supplementation and cardiovascular events in high-risk patients: The Heart Outcomes Prevention Evaluation Study Investigators. N Engl J Med. 2000;342:154-160.
43. Brown BG, Zhao X-Q, Chait A, Fisher LD, Cheung MC, Morse JS, Dowdy AA, Marino EK, Bolson EL, Alaupovic P, Frohlich J, Albers JJ. Simvastatin and niacin, antioxidant vitamins, or the combination for the prevention of coronary disease. N Engl J Med. 2001;345:1583-1592.
44. Ness AR, Chee D, Elliott P. Vitamin C and blood pressure: An overview. J Hum Hypertens. 1997;11:343-350.
45. Lovat LB, Lu Y, Palmer AJ, Edwards R, Fletcher AE, Bulpitt CJ. Double-blind trial of vitamin C in elderly hypertensives. J Hum Hypertens. 1993;7:403-405.
46. Ghosh SK, Ekpo EB, Shah IU, Girling AJ, Jenkins C, Sinclair AJ. A double-blind placebo-controlled parallel trial of vitamin C treatment in elderly patients with hypertension. Gerontology. 1994;40:268-272.
47. Carr A, Frei B. The role of natural antioxidants in preserving the biological activity of endothelium-derived nitric oxide. Free Radic Biol Med. 2000;28:1806-1814.
48. Boreham C, Twisk J, Van Mechelen W, Savage M, Strain J, Cran G. Relationships between the development of biological risk factors for coronary heart disease and lifestyle parameters during adolescence: The Northern Ireland Young Hearts Project. Public Health. 1999;113:7-12.
49. Sowers JR, Epstein M. Diabetes mellitus and associated hypertension, vascular disease, and nephropathy: An update. Hypertension. 1995;26: 869-879.
50. Fotherby MD, Williams JC, Forster LA, Craner P, Ferns GA. Effect of vitamin C on ambulatory blood pressure and plasma lipids in older persons. J Hypertens. 2000;18:411-415.
51. Wilkinson IB, Megson IL, MacCallum H, Sogo N, Cockcroft JR, Webb DJ. Oral vitamin C reduces arterial stiffness and platelet aggregation in humans. J Cardiovasc Pharmacol. 1999;34:690-693.
52. UK Prospective Diabetes Study Group. Tight blood pressure control and risk of macrovascular and microvascular complications in type 2 diabetes: UKPDS 38. BMJ. 1998;317:703-713.