Ascorbic acid and N-acetylcysteine improve in vitro the function of lymphocytes from mice with endotoxin-induced oxidative stress

Free Radical Research

Volumn 35, Issue 1, 2001, Pages 73-84

  De La Fuente, M ^a   Victor, V M ^a  

^a UNIVERSIDAD COMPLUTENSE DE MADRID   (Spain)

Author keywords

Antioxidants; Endotoxic shock; Lipopolysaccharide; Lymphocytes; Oxidative stress

Indexed keywords

ACETYLCYSTEINE; ANTIOXIDANT; ASCORBIC ACID; CYTOKINE; ENDOTOXIN; ESCHERICHIA COLI LIPOPOLYSACCHARIDE; REACTIVE OXYGEN METABOLITE; SCAVENGER; TUMOR NECROSIS FACTOR ALPHA;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; AXILLARY LYMPH NODE; CHEMOTAXIS; CONTROLLED STUDY; DRUG MECHANISM; FEMALE; HOMEOSTASIS; IMMUNE RESPONSE; IMMUNOCOMPETENT CELL; IMMUNOMODULATION; IN VITRO STUDY; LYMPHOCYTE FUNCTION; MACROPHAGE; MOUSE; NONHUMAN; OXIDATIVE STRESS; PERITONEUM; SEPTIC SHOCK; SPLEEN; THYMUS;

EID: 0034898299     PISSN: 10715762     EISSN: None     Source Type: Journal    
DOI: 10.1080/10715760100300611     Document Type: Article

References (36)

1. Endotoxemia in human septic shock
2. Does N-acetyl-L-cysteine influence cytokine response during early human septic shock?
3. Effects of endotoxic shock in several functions of murine peritoneal macrophages
4. T-cell activation signals up-regulate p38 mitogen-activated protein kinase activity induce TNF-α production in a manner distinct from LPS activation of monocytes
5. Modulation of murine macrophage function by N-acetylcysteine in a model of endotoxic shock
6. Regulation of macrophage inflammatory protein-1α mRNA by oxidative stress
7. Lethality of endotoxin in mice genetically deficient in the respiratory burst oxidase, inducible nitric oxide synthase, or both
8. The effects of intravenous antioxidants in patients with septic shock
9. Reactive oxygen intermediates as regulators of TNFα production in rat lung inflammation induced by silica
10. Oxidants as stimulators of signal transduction
11. Redox-sensitive protein phosphatase activity regulates the phosphorylation state of p38 protein kinase in primary astrocyte culture
12. Antioxidant therapy in the prevention of organ dysfunction syndrome and infectious complications after trauma: Early results of a prospective randomized study
13. The effects of N-acetylcysteine treatment and nitric oxide synthase inhibition on oxidative stress induced by E. coli endotoxin
14. Antioxidants inhibit stimulation of HIV long terminal repeat-directed transcription
15. Low-dose N-acetylcysteine protects rats against endotoxin-mediated oxidative stress, but high dose increases mortality
16. The antioxidant action of N-acetylcysteine: Its relation with hydrogen peroxide, hydroxyl radical, superoxide, and hypochorous acid
17. The physiological functions of glutathione
18. Ascorbic acid modulates in vitro the function of macrophages from mice with endotoxic shock
19. Antioxidants as modulators of immune function
20. Differential effects of IL-1β and ibuprofen after endotoxic challenge in mice
21. Changes in the macrophage function with aging
22. Vasoactive intestinal peptide modulation of adherence and mobility in rat peritoneal lymphocytes and macrophages
23. The basis for the immunoregulatory role of macrophages and other accessory cells
24. Improvement by several antioxidants of macrophage function in vitro
25. Role of lymphocytes in the ovine response to endotoxin
26. Study of gene regulation by NF-kB and AP-1 in response to reactive oxygen intermediates
27. Peptidoglycan and lipopolysaccharide bind to the same binding site on lymphocytes
28. Toxic shock syndrome: Role of the environment, the host and the microorganism
29. Identification and characterization of a novel Ets-2-related nuclear complex implicated in the activation of the human interleukin-12 p40 gene promoter
30. The cytokine network in the critically ill
31. Monocyte adherence induced by lipopolysaccharide involves CD14, LFA-1 and cytohesin-1. Regulation by rho and phosphatidylinositol 3-kinase
32. Redox regulation of the mitogen-activated protein kinase pathway during lymphocyte activation
33. Brown fat thermogenesis and exercise: Two examples of physiological oxidative stress?
34. Macrophage migration inhibitory factor (MIF): A glucocorticoid counter-regulator within the immune system