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Volumn 15, Issue 2, 2011, Pages 375-395

Native LDL-induced oxidative stress in human proximal tubular cells: Multiple players involved

Author keywords

Chronic kidney disease; Cytoplasmic phospholipase A2; Kidney proximal tubular cells; Lipid signalling; Low density lipoproteins; Mitochondria; NADPH oxidase; Reactive oxygen species; Redox signalling; ROS induced ROS release

Indexed keywords

CALCIUM; CYTOCHROME C; LOW DENSITY LIPOPROTEIN; PHOSPHOLIPASE A2; REACTIVE OXYGEN METABOLITE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE OXIDASE;

EID: 79951909095     PISSN: 15821838     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1582-4934.2009.00946.x     Document Type: Article
Times cited : (10)

References (57)
  • 1
    • 0019744728 scopus 로고
    • Role of lipid and lipoprotein fractions in atherogenesis: the Framingham Study
    • Kannel WB, Gordon T, Castelli WP. Role of lipid and lipoprotein fractions in atherogenesis: the Framingham Study. Prog Lipid Res. 1981; 20: 339-48.
    • (1981) Prog Lipid Res. , vol.20 , pp. 339-48
    • Kannel, W.B.1    Gordon, T.2    Castelli, W.P.3
  • 2
    • 0024603895 scopus 로고
    • Beyond cholesterol. Modifications of low-density lipoprotein that increase its atherogenicity
    • Steinberg D, Parthasarathy S, Carew TE, et al Beyond cholesterol. Modifications of low-density lipoprotein that increase its atherogenicity. N Engl J Med. 1989; 320: 915-24.
    • (1989) N Engl J Med. , vol.320 , pp. 915-24
    • Steinberg, D.1    Parthasarathy, S.2    Carew, T.E.3
  • 3
    • 0029883764 scopus 로고    scopus 로고
    • The role of oxidized lipoproteins in atherogenesis
    • Berliner JA, Heinecke JW. The role of oxidized lipoproteins in atherogenesis. Free Radic Biol Med. 1996; 20: 707-27.
    • (1996) Free Radic Biol Med. , vol.20 , pp. 707-27
    • Berliner, J.A.1    Heinecke, J.W.2
  • 4
    • 48749114764 scopus 로고    scopus 로고
    • Oxidized Low-Density Lipoprotein and Oxidative Stress in the Development of Glomerulosclerosis
    • Lee HS, Song CH. Oxidized Low-Density Lipoprotein and Oxidative Stress in the Development of Glomerulosclerosis. Am J Nephrol. 2009; 29: 62-70.
    • (2009) Am J Nephrol. , vol.29 , pp. 62-70
    • Lee, H.S.1    Song, C.H.2
  • 5
    • 34548396842 scopus 로고    scopus 로고
    • Lipoprotein metabolism in chronic renal insufficiency
    • Saland JM, Ginsberg HN. Lipoprotein metabolism in chronic renal insufficiency. Pediatr Nephrol. 2007; 22: 1095-112.
    • (2007) Pediatr Nephrol. , vol.22 , pp. 1095-112
    • Saland, J.M.1    Ginsberg, H.N.2
  • 6
    • 36148955109 scopus 로고    scopus 로고
    • Mechanisms of progression of chronic kidney disease
    • Fogo AB. Mechanisms of progression of chronic kidney disease. Pediatr Nephrol. 2007; 22: 2011-22.
    • (2007) Pediatr Nephrol. , vol.22 , pp. 2011-22
    • Fogo, A.B.1
  • 7
    • 33748305555 scopus 로고    scopus 로고
    • Dyslipidemia and the progression of renal disease in chronic renal failure patients
    • Cases A, Coll E. Dyslipidemia and the progression of renal disease in chronic renal failure patients. Kidney Int Suppl. 2005; 99: S87-S93.
    • (2005) Kidney Int Suppl. , vol.99
    • Cases, A.1    Coll, E.2
  • 8
    • 28644442748 scopus 로고    scopus 로고
    • Tubularinterstitial interactions in proteinuric renal diseases
    • Kairaitis LK, Harris DCH. Tubularinterstitial interactions in proteinuric renal diseases. Nephrology. 2001; 6: 198-207.
    • (2001) Nephrology. , vol.6 , pp. 198-207
    • Kairaitis, L.K.1    Harris, D.C.H.2
  • 9
    • 17244366954 scopus 로고    scopus 로고
    • Cellular oxidative processes in relation to renal disease
    • Wardle EN. Cellular oxidative processes in relation to renal disease. Am J Nephrol. 2005; 25: 13-22.
    • (2005) Am J Nephrol. , vol.25 , pp. 13-22
    • Wardle, E.N.1
  • 11
    • 44949142269 scopus 로고    scopus 로고
    • The selective detection of mitochondrial superoxide by live cell imaging
    • Robinson KM, Janes MS, Beckman JS. The selective detection of mitochondrial superoxide by live cell imaging. Nat Protoc. 2008; 3: 941-7.
    • (2008) Nat Protoc. , vol.3 , pp. 941-7
    • Robinson, K.M.1    Janes, M.S.2    Beckman, J.S.3
  • 12
    • 0026549468 scopus 로고
    • Control of respiration and ATP synthesis in mammalian mitochondria and cells
    • Brown GC. Control of respiration and ATP synthesis in mammalian mitochondria and cells. Biochem J. 1992; 284: 1-13.
    • (1992) Biochem J. , vol.284 , pp. 1-13
    • Brown, G.C.1
  • 13
    • 44949106317 scopus 로고    scopus 로고
    • Structure, regulation and evolution of Nox-family NADPH oxidases that produce reactive oxygen species
    • Sumimoto H. Structure, regulation and evolution of Nox-family NADPH oxidases that produce reactive oxygen species. FEBS J. 2008; 275: 3249-77.
    • (2008) FEBS J. , vol.275 , pp. 3249-77
    • Sumimoto, H.1
  • 15
    • 0032545445 scopus 로고    scopus 로고
    • Diphenyleneiodonium, an NAD(P)H oxidase inhibitor, also potently inhibits mitochondrial reactive oxygen species production
    • Li Y, Trush MA. Diphenyleneiodonium, an NAD(P)H oxidase inhibitor, also potently inhibits mitochondrial reactive oxygen species production. Biochem Biophys Res Commun. 1998; 253: 295-9.
    • (1998) Biochem Biophys Res Commun. , vol.253 , pp. 295-9
    • Li, Y.1    Trush, M.A.2
  • 16
    • 18544377867 scopus 로고    scopus 로고
    • Inhibition of NADPH oxidase activation in endothelial cells by ortho-methoxy-substituted catechols
    • Johnson DK, Schillinger KJ, Kwait DM, et al Inhibition of NADPH oxidase activation in endothelial cells by ortho-methoxy-substituted catechols. Endothelium. 2002; 9: 191-203.
    • (2002) Endothelium. , vol.9 , pp. 191-203
    • Johnson, D.K.1    Schillinger, K.J.2    Kwait, D.M.3
  • 18
    • 33751072935 scopus 로고    scopus 로고
    • Bioenergetics and the formation of mitochondrial reactive oxygen species
    • Adam-Vizi V, Chinopoulos C. Bioenergetics and the formation of mitochondrial reactive oxygen species. Trends Pharmacol Sci. 2006; 27: 639-45.
    • (2006) Trends Pharmacol Sci. , vol.27 , pp. 639-45
    • Adam-Vizi, V.1    Chinopoulos, C.2
  • 19
    • 34250349160 scopus 로고    scopus 로고
    • Superoxide flux in endothelial cells via the chloride channel-3 mediates intracellular signaling
    • Hawkins BJ, Madesh M, Kirkpatrick CJ, et al Superoxide flux in endothelial cells via the chloride channel-3 mediates intracellular signaling. Mol Biol Cell. 2007; 18: 2002-12.
    • (2007) Mol Biol Cell. , vol.18 , pp. 2002-12
    • Hawkins, B.J.1    Madesh, M.2    Kirkpatrick, C.J.3
  • 20
    • 15544390386 scopus 로고    scopus 로고
    • Function of chloride channels in the kidney
    • Uchida S, Sasaki S. Function of chloride channels in the kidney. Annu Rev Physiol. 2005; 67: 759-78.
    • (2005) Annu Rev Physiol. , vol.67 , pp. 759-78
    • Uchida, S.1    Sasaki, S.2
  • 21
    • 33751185543 scopus 로고    scopus 로고
    • The role of cytosolic phospholipase A2-alfa in regulation of phagocytic functions
    • Levy R. The role of cytosolic phospholipase A2-alfa in regulation of phagocytic functions. Biochim Biophys Acta. 2006; 1761: 1323-34.
    • (2006) Biochim Biophys Acta. , vol.1761 , pp. 1323-34
    • Levy, R.1
  • 22
    • 46649120115 scopus 로고    scopus 로고
    • The versatility of mitochondrial calcium signals: from stimulation of cell metabolism to induction of cell death
    • Rimessi A, Giorgi C, Pinton P, et al The versatility of mitochondrial calcium signals: from stimulation of cell metabolism to induction of cell death. Biochim Biophys Acta. 2008; 1777: 808-16.
    • (2008) Biochim Biophys Acta. , vol.1777 , pp. 808-16
    • Rimessi, A.1    Giorgi, C.2    Pinton, P.3
  • 24
    • 33845977959 scopus 로고    scopus 로고
    • Mitochondrial membrane permeabilization in cell death
    • Kroemer G, Galluzzi L, Brenner C. Mitochondrial membrane permeabilization in cell death. Physiol Rev. 2007; 87: 99-163.
    • (2007) Physiol Rev. , vol.87 , pp. 99-163
    • Kroemer, G.1    Galluzzi, L.2    Brenner, C.3
  • 25
    • 2442693043 scopus 로고    scopus 로고
    • Influence of native and hypochlorite-modified low-density lipoprotein on gene expression in human proximal tubular epithelium
    • Porubsky S, Schmid H, Bonrouhi M, et al Influence of native and hypochlorite-modified low-density lipoprotein on gene expression in human proximal tubular epithelium. Am J Pathol. 2004; 164: 2175-87.
    • (2004) Am J Pathol. , vol.164 , pp. 2175-87
    • Porubsky, S.1    Schmid, H.2    Bonrouhi, M.3
  • 26
    • 0038645852 scopus 로고    scopus 로고
    • Acute tubular injury causes dysreg-ulation of cellular cholesterol transport proteins
    • Zager RA, Johnson ACM, Hanson SY, et al Acute tubular injury causes dysreg-ulation of cellular cholesterol transport proteins. Am J Pathol. 2003; 163: 313-20.
    • (2003) Am J Pathol. , vol.163 , pp. 313-20
    • Zager, R.A.1    Johnson, A.C.M.2    Hanson, S.Y.3
  • 27
    • 33847023386 scopus 로고    scopus 로고
    • 2+ channel subtypes and pharmacology in the kidney
    • 2+ channel subtypes and pharmacology in the kidney. Circ Res. 2007; 100: 342-53.
    • (2007) Circ Res. , vol.100 , pp. 342-53
    • Hayashi, K.1    Wakino, S.2    Sugano, N.3
  • 28
    • 33746839790 scopus 로고    scopus 로고
    • Scavenger receptors in atherosclerosis beyond lipid uptake
    • Kathryn JM, Freeman MW. Scavenger receptors in atherosclerosis beyond lipid uptake. Arterioscler Thromb Vasc Biol. 2006; 26: 1702-11.
    • (2006) Arterioscler Thromb Vasc Biol. , vol.26 , pp. 1702-11
    • Kathryn, J.M.1    Freeman, M.W.2
  • 29
    • 4344669003 scopus 로고    scopus 로고
    • Blockade of Calcium Influx through L-Type Calcium Channels Attenuates Mitochondrial Injury and Apoptosis in Hypoxic Renal Tubular Cells
    • Tanaka T, Nangaku M, Miyata T, et al Blockade of Calcium Influx through L-Type Calcium Channels Attenuates Mitochondrial Injury and Apoptosis in Hypoxic Renal Tubular Cells. J Am Soc Nephrol. 2004; 15: 2320-33.
    • (2004) J Am Soc Nephrol. , vol.15 , pp. 2320-33
    • Tanaka, T.1    Nangaku, M.2    Miyata, T.3
  • 30
    • 16644382118 scopus 로고    scopus 로고
    • Regulatory mechanism and physiological role of cytosolic phospholipase A2
    • Hirabayashi T, Murayama T, Shimizu T. Regulatory mechanism and physiological role of cytosolic phospholipase A2. Biol Pharm Bull. 2004; 27: 1168-73.
    • (2004) Biol Pharm Bull. , vol.27 , pp. 1168-73
    • Hirabayashi, T.1    Murayama, T.2    Shimizu, T.3
  • 31
    • 0041829126 scopus 로고    scopus 로고
    • The requirement of cytosolic phospholipase A2 for the PMA activation of proton efflux through the N-terminal 230-amino acid fragment of gp91phox
    • Mankelow TJ, Pessach E, Levy R, et al The requirement of cytosolic phospholipase A2 for the PMA activation of proton efflux through the N-terminal 230-amino acid fragment of gp91phox. Biochem J. 2003; 374: 315-9.
    • (2003) Biochem J. , vol.374 , pp. 315-9
    • Mankelow, T.J.1    Pessach, E.2    Levy, R.3
  • 32
    • 0037376674 scopus 로고    scopus 로고
    • Oxidant signals and oxidative stress
    • Finkel T. Oxidant signals and oxidative stress. Curr Opin Cell Biol. 2003; 15: 247-54.
    • (2003) Curr Opin Cell Biol. , vol.15 , pp. 247-54
    • Finkel, T.1
  • 33
    • 42249088093 scopus 로고    scopus 로고
    • Reconciling the chemistry and biology of reactive oxygen species
    • Winterbourn CC. Reconciling the chemistry and biology of reactive oxygen species. Nat Chem Biol. 2008; 4: 278-86.
    • (2008) Nat Chem Biol. , vol.4 , pp. 278-86
    • Winterbourn, C.C.1
  • 34
    • 0022555845 scopus 로고
    • Reactive oxygen intermediates in biochemistry
    • Naqui A, Chance B, Cadenas E. Reactive oxygen intermediates in biochemistry. Annu Rev Biochem. 1986; 55: 137-66.
    • (1986) Annu Rev Biochem. , vol.55 , pp. 137-66
    • Naqui, A.1    Chance, B.2    Cadenas, E.3
  • 35
    • 23844558266 scopus 로고    scopus 로고
    • A mitochondrial paradigm of metabolic and degenerative diseases, aging and cancer: a dawn for evolutionary medicine
    • Wallace DC. A mitochondrial paradigm of metabolic and degenerative diseases, aging and cancer: a dawn for evolutionary medicine. Annu Rev Genet. 2005; 39: 359-407.
    • (2005) Annu Rev Genet. , vol.39 , pp. 359-407
    • Wallace, D.C.1
  • 36
    • 33947512416 scopus 로고    scopus 로고
    • Mitochondrial dysfunction in atherosclerosis
    • Madamanchi NR, Runge MS. Mitochondrial dysfunction in atherosclerosis. Circ Res. 2007; 100: 460-73.
    • (2007) Circ Res. , vol.100 , pp. 460-73
    • Madamanchi, N.R.1    Runge, M.S.2
  • 37
    • 0242497269 scopus 로고    scopus 로고
    • Proximal tubular cholesterol loading after mitochondrial, but not glycolytic, blockade
    • Zager RA, Johnson AC, Hanson SY. Proximal tubular cholesterol loading after mitochondrial, but not glycolytic, blockade. Am J Physiol Renal Physiol. 2003; 285: F1092-9.
    • (2003) Am J Physiol Renal Physiol. , vol.285
    • Zager, R.A.1    Johnson, A.C.2    Hanson, S.Y.3
  • 38
    • 0034596947 scopus 로고    scopus 로고
    • Reactive oxygen species (ROS)- induced ROS release: a new phenomenon accompanying induction of the mitochondrial permeability transition in cardiac myocytes
    • Zorov DB, Filburn CR, Klotz LO, et al Reactive oxygen species (ROS)- induced ROS release: a new phenomenon accompanying induction of the mitochondrial permeability transition in cardiac myocytes. J Exp Med. 2000; 192: 1001-14.
    • (2000) J Exp Med. , vol.192 , pp. 1001-14
    • Zorov, D.B.1    Filburn, C.R.2    Klotz, L.O.3
  • 39
    • 33750920827 scopus 로고    scopus 로고
    • A wave of reactive oxygen species (ROS)-induced ROS release in a sea of excitable mitochondria
    • Brady NR, Hamacher-Brady A, Westerhoff HV, Gottlieb RA. A wave of reactive oxygen species (ROS)-induced ROS release in a sea of excitable mitochondria. Antioxid Redox Signal. 2006; 8: 1651-65.
    • (2006) Antioxid Redox Signal. , vol.8 , pp. 1651-65
    • Brady, N.R.1    Hamacher-Brady, A.2    Westerhoff, H.V.3    Gottlieb, R.A.4
  • 40
    • 33745684904 scopus 로고    scopus 로고
    • Mitochondrial ROS-induced ROS release: an update and review
    • Zorov DB, Juhaszova M, Sollott SJ. Mitochondrial ROS-induced ROS release: an update and review. Biochim Biophys Acta. 2006; 1757: 509-17.
    • (2006) Biochim Biophys Acta. , vol.1757 , pp. 509-17
    • Zorov, D.B.1    Juhaszova, M.2    Sollott, S.J.3
  • 41
    • 53449086013 scopus 로고    scopus 로고
    • 2+]i through the mitochondrial ROS-PKCepsilon signaling axis in pulmonary artery smooth muscle cells
    • 2+]i through the mitochondrial ROS-PKCepsilon signaling axis in pulmonary artery smooth muscle cells. Free Radic Biol Med. 2008; 45: 1223-31.
    • (2008) Free Radic Biol Med. , vol.45 , pp. 1223-31
    • Rathore, R.1    Zheng, Y.M.2    Niu, C.F.3
  • 42
    • 65349088460 scopus 로고    scopus 로고
    • Cross-talk between mitochondria and NADPH oxidase: Effects of mild mitochondrial dysfunction on angiotensin II mediated increase in Nox isoform expression and activity in vascular smooth muscle cells
    • Wosniak JJ, Santos CX, Kowaltowski AJ, et al Cross-talk between mitochondria and NADPH oxidase: Effects of mild mitochondrial dysfunction on angiotensin II mediated increase in Nox isoform expression and activity in vascular smooth muscle cells. Antioxid Redox Signal. 2009; 11: 1265-78.
    • (2009) Antioxid Redox Signal. , vol.11 , pp. 1265-78
    • Wosniak, J.J.1    Santos, C.X.2    Kowaltowski, A.J.3
  • 43
    • 11144338185 scopus 로고    scopus 로고
    • Redox active calcium ion channels and cell death
    • Waring P. Redox active calcium ion channels and cell death. Arch Biochem Biophys. 2005; 434: 33-42.
    • (2005) Arch Biochem Biophys. , vol.434 , pp. 33-42
    • Waring, P.1
  • 44
    • 0037745119 scopus 로고    scopus 로고
    • Fluctuation in mitochondrial membrane potential caused by repetitive gating of the permeability transition pore
    • Huser J, Blatter LA. Fluctuation in mitochondrial membrane potential caused by repetitive gating of the permeability transition pore. Biochem J. 1999; 343: 311-17.
    • (1999) Biochem J. , vol.343 , pp. 311-17
    • Huser, J.1    Blatter, L.A.2
  • 46
    • 2942530420 scopus 로고    scopus 로고
    • (2+)-dependent apoptosis through the mitochondrial pathway
    • (2+)-dependent apoptosis through the mitochondrial pathway. J Biol Chem. 2004; 279: 25219-25.
    • (2004) J Biol Chem. , vol.279 , pp. 25219-25
    • Penzo, D.1    Petronilli, V.2    Angelin, A.3
  • 47
    • 31444442215 scopus 로고    scopus 로고
    • Arachidonic acid induces specific membrane permeability increase in heart mitochondria
    • Di Paola M, Zaccagnino P, Oliveros-Celis C, et al Arachidonic acid induces specific membrane permeability increase in heart mitochondria. FEBS Lett. 2006; 580: 775-81.
    • (2006) FEBS Lett. , vol.580 , pp. 775-81
    • Di Paola, M.1    Zaccagnino, P.2    Oliveros-Celis, C.3
  • 48
    • 0344758310 scopus 로고    scopus 로고
    • Arachidonic acid interaction with the mito-chondrial electron transfer chain promotes reactive oxygen species generation
    • Cocco T, Di Paola M, Papa S, et al Arachidonic acid interaction with the mito-chondrial electron transfer chain promotes reactive oxygen species generation. Free Radic Biol Med. 1999; 27: 51-9.
    • (1999) Free Radic Biol Med. , vol.27 , pp. 51-9
    • Cocco, T.1    Di Paola, M.2    Papa, S.3
  • 49
    • 32444446816 scopus 로고    scopus 로고
    • 2+ currents via lysophosphatidylcholineinduced mitochondrial reactive oxygen species (ROS) production
    • 2+ currents via lysophosphatidylcholineinduced mitochondrial reactive oxygen species (ROS) production. Cardiovasc Res. 2006; 69: 855-64.
    • (2006) Cardiovasc Res. , vol.69 , pp. 855-64
    • Fearon, I.M.1
  • 50
    • 33745236658 scopus 로고    scopus 로고
    • Oxidative signaling in renal epithelium: Critical role of cytosolic phospholipase A2 and p38(SAPK)
    • Cui XL, Ding Y, Alexander LD, et al Oxidative signaling in renal epithelium: Critical role of cytosolic phospholipase A2 and p38(SAPK). Free Radic Biol Med. 2006; 41: 213-21.
    • (2006) Free Radic Biol Med. , vol.41 , pp. 213-21
    • Cui, X.L.1    Ding, Y.2    Alexander, L.D.3
  • 51
    • 0035917814 scopus 로고    scopus 로고
    • Mitochondrial permeability transition and oxidative stress
    • Kowaltowski AJ, Castilho RF, Vercesi AE. Mitochondrial permeability transition and oxidative stress. FEBS Lett. 2001; 495: 12-5.
    • (2001) FEBS Lett. , vol.495 , pp. 12-5
    • Kowaltowski, A.J.1    Castilho, R.F.2    Vercesi, A.E.3
  • 52
    • 33646508129 scopus 로고    scopus 로고
    • Activation of Mitogen-Activated Protein Kinases by LysophosphatidylcholineInduced Mitochondrial Reactive Oxygen Species Generation in Endothelial Cells
    • Watanabe N, Zmijewski JW, Takabe W, et al Activation of Mitogen-Activated Protein Kinases by LysophosphatidylcholineInduced Mitochondrial Reactive Oxygen Species Generation in Endothelial Cells. Am J Pathol. 2006; 168: 1737-48.
    • (2006) Am J Pathol. , vol.168 , pp. 1737-48
    • Watanabe, N.1    Zmijewski, J.W.2    Takabe, W.3
  • 53
    • 47549096022 scopus 로고    scopus 로고
    • Superoxide flashes in single mitochondria
    • Wang W, Fang H, Groom L, et al Superoxide flashes in single mitochondria. Cell. 2008; 134: 279-90.
    • (2008) Cell. , vol.134 , pp. 279-90
    • Wang, W.1    Fang, H.2    Groom, L.3
  • 54
    • 33846452528 scopus 로고    scopus 로고
    • 2+ response in human neuroblastoma SH-SY5Y cells
    • 2+ response in human neuroblastoma SH-SY5Y cells. Life Sci. 2007; 80: 886-92.
    • (2007) Life Sci. , vol.80 , pp. 886-92
    • Li, X.H.1    Wu, Y.J.2
  • 55
    • 0035036863 scopus 로고    scopus 로고
    • Arachidonic acid both inhibits and enhances whole cell calcium currents in rat sympathetic neurons
    • Liu L, Barrett CF, Rittenhouse AR. Arachidonic acid both inhibits and enhances whole cell calcium currents in rat sympathetic neurons. Am J Physiol Cell Physiol. 2001; 280: 1293-305.
    • (2001) Am J Physiol Cell Physiol. , vol.280 , pp. 1293-305
    • Liu, L.1    Barrett, C.F.2    Rittenhouse, A.R.3
  • 56
    • 49749144405 scopus 로고    scopus 로고
    • Effects of HMG-CoA reductase inhibitors (statins) on progression of kidney disease
    • Fried LF. Effects of HMG-CoA reductase inhibitors (statins) on progression of kidney disease. Kidney Int. 2008; 74: 571-6.
    • (2008) Kidney Int. , vol.74 , pp. 571-6
    • Fried, L.F.1
  • 57
    • 38049034068 scopus 로고    scopus 로고
    • Pleiotropic effects of statin therapy: molecular mechanisms and clinical results
    • Wang CY, Liu PY, Liao JK. Pleiotropic effects of statin therapy: molecular mechanisms and clinical results. Trends Mol Med. 2008; 14: 37-44.
    • (2008) Trends Mol Med. , vol.14 , pp. 37-44
    • Wang, C.Y.1    Liu, P.Y.2    Liao, J.K.3


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