Exercise training, NADPH oxidase p22phox gene polymorphisms, and hypertension

Medicine and Science in Sports and Exercise

Volumn 41, Issue 7, 2009, Pages 1421-1428

  Feairheller, Deborah L ^a   Brown, Michael D ^a,b   Park, Joon Young ^b,c   Brinkley, Tina E ^b,d   Basu, Samar ^e   Hagberg, James M ^b   Ferrell, Robert E ^f   Fenty Stewart, Nicola M ^a,b  

^a TEMPLE UNIVERSITY   (United States)

^b UNIVERSITY OF MARYLAND   (United States)

^c NATIONAL HEART LUNG AND BLOOD INSTITUTE   (United States)

^d WAKE FOREST SCHOOL OF MEDICINE   (United States)

^e UPPSALA UNIVERSITY   (Sweden)

^f UNIVERSITY OF PITTSBURGH GRADUATE SCHOOL OF PUBLIC HEALTH   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

8 ISOPROSTAGLANDIN F2 ALPHA; NITRIC OXIDE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE OXIDASE; 8-EPI-PROSTAGLANDIN F2ALPHA; ANTIOXIDANT; CYBA PROTEIN, HUMAN; MULTIENZYME COMPLEX; OXIDOREDUCTASE; PROSTAGLANDIN F2 ALPHA; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE DEHYDROGENASE;

ADULT; AEROBIC EXERCISE; AGED; ARTICLE; BLOOD LEVEL; CONTROLLED STUDY; DEMOGRAPHY; FEMALE; GENE; GENETIC POLYMORPHISM; GENETIC VARIABILITY; GENOTYPE; HOMOZYGOTE; HUMAN; HYPERTENSION; KIDNEY CONCENTRATING CAPACITY; KINESIOTHERAPY; MAJOR CLINICAL STUDY; MALE; OXIDATIVE STRESS; PATHOLOGY; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE OXIDASE P22PHOX GENE; SINGLE NUCLEOTIDE POLYMORPHISM; ANALOGS AND DERIVATIVES; ANALYSIS OF VARIANCE; COMPARATIVE STUDY; ENZYMOLOGY; EXERCISE; FITNESS; GENETICS; METABOLISM; MIDDLE AGED; OXYGEN CONSUMPTION; URINE;

ADULT; AGED; ANALYSIS OF VARIANCE; ANTIOXIDANTS; DINOPROST; EXERCISE; EXERCISE THERAPY; FEMALE; HUMANS; HYPERTENSION; MALE; MIDDLE AGED; MULTIENZYME COMPLEXES; NADH, NADPH OXIDOREDUCTASES; NADPH OXIDASE; NITRIC OXIDE; OXIDATIVE STRESS; OXYGEN CONSUMPTION; PHYSICAL FITNESS; POLYMORPHISM, GENETIC;

EID: 67650046463     PISSN: 01959131     EISSN: 15300315     Source Type: Journal    
DOI: 10.1249/MSS.0b013e318199cee8     Document Type: Article

References (40)

1. Adams V, Linke A, Krankel N, et al. Impact of regular physical activity on the NAD(P)H oxidase and angiotensin receptor system in patients with coronary artery disease. Circulation. 2005;111: 555-62.
2. Attipoe S, Park JY, Fenty N, Phares D, Brown M. Oxidative stress levels are reduced in postmenopausal women with exercise training regardless of hormone replacement therapy status. J Women Aging. 2008;20:31-45.
3. Basu S. Isoprostanes: novel bioactive products of lipid peroxidation. Free Radic Res. 2004;38:105-22.
4. 2alpha: an index for oxidative injury via free radical catalysed lipid peroxidation. Prostaglandins Leukot Essent Fatty Acids. 1998;58:319-25.
5. Bolad I, Delafontaine P. Endothelial dysfunction: its role in hypertensive coronary disease. Curr Opin Cardiol. 2005;20:270-4.
6. Brown MD, Srinivasan M, Hogikyan RV, et al. Nitric oxide biomarkers increase during exercise-induced vasodilation in the forearm. Int J Sports Med. 2000;21:83-9.
7. Cahilly C, Ballantyne CM, Lim DS, Gotto A, Marian AJ. A variant of p22(phox), involved in generation of reactive oxygen species in the vessel wall, is associated with progression of coronary atherosclerosis. Circ Res. 2000;86:391-5.
8. Cai H, Griendling KK, Harrison DG. The vascular NAD(P)H oxidases as therapeutic targets in cardiovascular diseases. Trends Pharmacol Sci. 2003;24:471-8.
9. Chien S, Li S, Shyy YJ. Effects of mechanical forces on signal transduction and gene expression in endothelial cells. Hypertension. 1998;31:162-9.
10. Chrysohoou C, Panagiotakos DB, Pitsavos C, et al. The association between pre-hypertension status and oxidative stress markers related to atherosclerotic disease: the ATTICA study. Atherosclerosis. 2007;192:169-76.
11. Cracowski JL, Durand T, Bessard G. Isoprostanes as a biomarker of lipid peroxidation in humans: physiology, pharmacology and clinical implications. Trends Pharmacol Sci. 2002;23:360-6.
12. Dinauer MC, Pierce EA, Bruns GA, Curnutte JT, Orkin SH. Human neutrophil cytochrome b light chain (p22-phox). Gene structure, chromosomal location, and mutations in cytochrome- negative autosomal recessive chronic granulomatous disease. J Clin Invest. 1990;86:1729-37.
13. Duerrschmidt N, Stielow C, Muller G, Pagano PJ, Morawietz H. NO-mediated regulation of NAD(P)H oxidase by laminar shear stress in human endothelial cells. J Physiol. 2006;576:557-67.
14. Escobales N, Crespo MJ. Oxidative-nitrosative stress in hypertension. Curr Vasc Pharmacol. 2005;3:231-46.
15. Gardemann A, Mages P, Katz N, Tillmanns H, Haberbosch W. The p22phox A640G gene polymorphism but not the C242T gene variation is associated with coronary heart disease in younger individuals. Atherosclerosis. 1999;145:315-23.
16. Goto C, Higashi Y, Kimura M, et al. Effect of different intensities of exercise on endothelium-dependent vasodilation in humans. Circulation. 2004;108:530-5.
17. Gruetter CA, Barry BK, McNamara DB, Gruetter DY, Kadowitz PJ, Ignarro L. Relaxation of bovine coronary artery and activation of coronary arterial guanylate cyclase by nitric oxide, nitroprusside and a carcinogenic nitrosoamine. J Cyclic Nucleotide Res. 1979;5:211-24.
18. x isoform expression in human coronary artery disease. Arterioscler Thromb Vasc Biol. 2006;26:333-9.
19. Guzik TJ, West NE, Black E, et al. Functional effect of the C242T polymorphism in the NAD(P)H oxidase p22phox gene on vascular superoxide production in atherosclerosis. Circulation. 2000;102:1744-7.
20. Guzik TJ, West NE, Pillai R, Taggart DP, Channon KM. Nitric oxide modulates superoxide release and peroxynitrite formation in human blood vessels. Hypertension. 2002;39:1088-94.
21. Hagberg JM, Park JJ, Brown MD. The role of exercise training in the treatment of hypertension: an update. Sports Med. 2000;30: 193-206.
22. Inoue N, Kawashima S, Kanazawa K, Yamada S, Akita H, Yokoyama M. Polymorphism of the NADH/NADPH oxidase p22 phox gene in patients with coronary artery disease. Circulation. 1998;97:135-7.
23. Kojda G, Hambrecht R. Molecular mechanisms of vascular adaptations to exercise. Physical activity as an effective antioxi- dant therapy? Cardiovasc Res. 2005;67:187-97.
24. Landmesser U, Drexler H. Endothelial function and hypertension. Curr Opin Cardiol. 2007;22:316-20.
25. Lassegue B, Clempus RE. Vascular NAD(P)H oxidases: specific features, expression, and regulation. Am J Physiol Regul Integr Comp Physiol. 2003;285:R277-97.
26. Moreno MU, Jose GS, Fortuno A, Beloqui O, Diez J, Zalba G. The C242T CYBA polymorphism of NADPH oxidase is associated with essential hypertension. J Hypertens. 2006;24:1299-306.
27. Morrow JD. The isoprostanes: their quantification as an index of oxidant stress status in vivo. Drug Metab Rev. 2000;32:377-85.
28. Ogita H, Liao J. Endothelial function and oxidative stress. Endothelium. 2004;11:123-32.
29. Ohta M, Nanri H, Matsushima Y, Sato Y, Ikeda M. Blood pressure-lowering effects of lifestyle modification: possible involvement of nitric oxide bioavailability. Hypertens Res. 2005; 28:779-86.
30. Ohura N, Yamamoto K, Ichioka S, et al. Global analysis of shear stress-responsive genes in vascular endothelial cells. JAtheroscler Thromb. 2003;10:304-13.
31. Park JY, Ferrell RE, Park JJ, et al. NADPH oxidase p22phox gene variants are associated with systemic oxidative stress biomarker responses to exercise training. J Appl Physiol. 2005;99:1905-11.
32. Rice-Evans C, Miller NJ. Total antioxidant status in plasma and body fluids. Methods Enzymol. 1994;234:279-93.
33. Roberts LJ, Morrow JD. Measurement of F(2)-isoprostanes as an index of oxidative stress in vivo. Free Radic Biol Med. 2000;28: 505-13.
34. Schneider CD, Barp J, Ribeiro JL, Bello-Klein A, Oliveira AR. Oxidative stress after three different intensities of running. Can Appl Physiol. 2005;30:723-34.
35. Ushio-Fukai M, Zafari AM, Fukui T, Ishizaka N, Griendling KK. p22phox is a critical component of the superoxide-generating NADH/NADPH oxidase system and regulates angiotensin II- induced hypertrophy in vascular smooth muscle cells. Biol Chem. 1996;271:23317-21.
36. Wang JS, Lin CC, Chen JK, Wong MK. Role of chronic exercise in decreasing oxidized LDL-potentiated platelet activation by enhancing platelet-derived no release and bioactivity in rats. Life Sci. 2000;66:1937-48.
37. Weiss EP, Park JJ, McKenzie JA, et al. Plasma nitrate/nitrite response to an oral glucose load and the effect of endurance training. Metabolism. 2004;53:673-79.
38. Wyche KE, Wang SS, Griendling KK, et al. C242T CYBA polymorphism of the NADPH oxidase is associated with reduced respiratory burst in human neutrophils. Hypertension. 2004;43: 1246-51.
39. Zalba G, Beaumont FJ, San Jose G, et al. Vascular NADH/ NADPH oxidase is involved in enhanced superoxide production in spontaneously hypertensive rats. Hypertension. 2000;35:1055-61.
40. Zalba G, San Jose G, Moreno MU, Fortuno A, Diez J. NADPH oxidase-mediated oxidative stress: genetic studies of the p22(phox) gene in hypertension. Antioxid Redox Signal. 2005;7:1327-36.