Effect of chronic N-acetylcysteine treatment on the development of spontaneous hypertension

Clinical Science

Volumn 110, Issue 2, 2006, Pages 235-242

  Pecháňová, Olga ^a,b   Zicha, Josef ^b   Kojšová, Stanislava ^a   Dobešová, Zdenka ^b   Jendeková, Lýdia ^a   Kuneš, Jaroslav ^b  

^a INSTITUTE OF CHEMISTRY   (Slovakia)

^b INSTITUTE OF PHYSIOLOGY   (Czech Republic)

Author keywords

Genetic hypertension; N acetylcysteine; Nitric oxide synthase; Nuclear factor B(NF B); Reactive oxygen species (ROS)

Indexed keywords

ACETYLCYSTEINE; ALKADIENE; ENDOTHELIAL NITRIC OXIDE SYNTHASE; GLUTATHIONE; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; NITRIC OXIDE; NITRIC OXIDE SYNTHASE; REACTIVE OXYGEN METABOLITE;

ADOLESCENT; AGED; ANIMAL EXPERIMENT; ANIMAL TISSUE; ANTIOXIDANT ACTIVITY; ARTICLE; BLOOD PRESSURE; CONTROLLED STUDY; ENZYME ACTIVITY; ESSENTIAL HYPERTENSION; HEART LEFT VENTRICLE; KIDNEY; LONG TERM CARE; MALE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; RAT STRAIN; RESISTANCE BLOOD VESSEL;

ACETYLCYSTEINE; AGING; ANIMALS; ANTIOXIDANTS; GLUTATHIONE; HEART VENTRICLES; HYPERTENSION; KIDNEY; MALE; NF-KAPPA B; NITRIC OXIDE SYNTHASE; NITRIC OXIDE SYNTHASE TYPE II; NITRIC OXIDE SYNTHASE TYPE III; RANDOM ALLOCATION; RATS; RATS, INBRED SHR; RATS, INBRED WKY; REACTIVE OXYGEN SPECIES;

EID: 32644441431     PISSN: 01435221     EISSN: None     Source Type: Journal    
DOI: 10.1042/CS20050227     Document Type: Article

References (44)

1. Berry, C., Brosnan, M. J., Fennell, J., Hamilton, C. A. and Dominiczak, A. F. (2001) Oxidative stress and vascular damage in hypertension. Curr. Opin. Nephrol. Hypertens. 10, 247-255
2. Vanhoutte, P. M. (2001) Endothelium-derived free radicals: for worse and for better. J. Clin. Invest. 107, 23-25
3. Wilcox, C. S. (2002) Reactive oxygen species: roles in blood pressure and kidney function. Curr. Hypertens. Rep. 4, 160-164
4. Noll, G., Tschudi, M., Nava, E. and Lüscher, T. F. (1997) Endothelium and high blood pressure. Int. J. Microcirc. Clin. Exp. 17, 273-279
5. Pecháňová, O., Kashiba, M. and Inoue, M. (1999) Role of glutathione in stabilization of nitric oxide during hypertension developed by inhibition of nitric oxide synthase in the rat. Jpn J. Pharmacol. 81, 223-229
6. Zicha, J., Dobešová, Z. and Kuneš, J. (2001) Relative deficiency of nitric oxide-dependent vasodilation in salt-hypertensive Dahl rats: the possible role of superoxide anions. J. Hypertens. 19, 247-254
7. Rajagopalan, S., Kurz, S., Munzel, T. et al. (1996) Angiotensin II-mediated hypertension in the rat increases vascular superoxide production via membrane NADH/NADPH oxidase activation. Contribution to alterations of vasomotor tone. J. Clin. Invest. 97, 1916-1923
8. Dominiczak, A. F. and Bohr, D. F. (1995) Nitric oxide and its putative role in hypertension. Hypertension 25, 1202-1211
9. Nava, E., Farre, A. L., Moreno, C. et al. (1998) Alterations to the nitric oxide pathway in the spontaneously hypertensive rat. J. Hypertens. 16, 609-615
10. Sessa, W. C., Pritchard, K., Seyedi, N., Wang, J. and Hintzc, T. H. (1994) Chronic exercise in dogs increases coronary vascular nitric oxide production and endothelial cell nitric oxide synthase gene expression. Circ. Res. 74, 349-353
11. Briones, A. M., Alonso, M. J., Marin, J., Balfagon, G. and Salaices, M. (2000) Influence of hypertension on nitric oxide synthase expression and vascular effects of lipopolysaccharide in rat mesenteric arteries. Br. J. Pharmacol. 131, 185-194
12. Radaelli, A., Mircoli, L., Mori, I., Mancia, G. and Ferrari, A. U. (1998) Nitric oxide dependent vasodilation in young spontaneously hypertensive rats. Hypertension 32, 735-739
13. Vaziri, N. D., Ni, Z. and Oveisi, F. (1998) Upregulation of renal and vascular nitric oxide synthase in young spontaneously hypertensive rats. Hypertension 31, 1248-1254
14. 1 receptor antagonist combats oxidative stress and restores nitric oxide signaling in the SHR. Kidney Int. 59, 1257-1263
15. Yang, D., Feletou, M., Boulanger, C. M. et al. (2002) Oxygen-derived free radicals mediate endothelium-dependent contractions to acetylcholine in aortas from spontaneously hypertensive rats. Br. J. Pharmacol. 136, 104-110
16. Chabrashvili, T., Tojo, A., Onozato, M. L. et al. (2002) Expression and cellular localization of classic NADPH oxidase subunits in the spontaneously hypertensive rat kidney. Hypertension 39, 269-274
17. Hamilton, C. A., Brosnan, M. J., Al-Benna, S., Berg, G. and Dominiczak, A. F. (2002) NAD(P)H oxidase inhibition improves endothelial function in rat and human blood vessels. Hypertension 40, 755-762
18. Guzik, T. J., West, N. E., Pillai, R., Taggart, D. P. and Channon, K. M. (2002) Nitric oxide modulates superoxide release and peroxynitrite formation in human blood vessels. Hypertension 39, 1088-1094
19. Bouloumie, A., Bauersachs, J., Linz, W. et al. (1997) Endothelial dysfunction coincides with an enhanced nitric oxide synthase expression and superoxide anion production. Hypertension 30, 934-941
20. Lahera, V., Khraibi, A. A. and Romero, J. C. (1993) Sulfhydryl group donors potentiate the hypotensive effect of acetylcholine in rats. Hypertension 22, 156-160
21. Cabassi, A., Dumont, E. C., Girouard, H. et al. (2001) Effects of chronic N-acetylcysteine treatment on the actions of peroxynitrite on aortic vascular reactivity in hypertensive rats. J. Hypertens. 19, 1233-1244
22. Girouard, H., Chulak, C., Wu, L., Lejossec, M. and de Champlain, J. (2003) N-Acetylcysteine improves nitric oxide and alpha-adrenergic pathways in mesenteric beds of spontaneously hypertensive rats. Am. J. Hypertens. 16, 577-584
23. Kogure, K., Watson, R., Busto, R. and Abe, K. (1982) Potentiation of lipid peroxides by ischemia in rat brain. Neurochem. Res. 7, 437-453
24. Ellman, G. L. (1959) Tissue sulfhydryl groups. Arch. Biochem. Biophys. 82, 70-77
25. Bredt, D. S. and Snyder, S. H. (1990) Isolation of nitric oxide synthetase, a calmodulin-requiring enzyme. Proc. Nad. Acad. Sci. U.S.A. 87, 682-685
26. Pecháňová, O., Bernátová, I., Pelouch, V. and Šimko, F. (1997) Protein remodelling of the heart in NO-deficient hypertension: the effect of captopril. J. Mol. Cell. Cardiol. 29, 3365-3374
27. Cabassi, A., Bouchard, J. F., Dumont, E. C. et al. (2000) Effect of antioxidant treatments on nitrate tolerance development in normotensive and hypertensive rats. J. Hypertens. 18, 187-196
28. Sun, Y., Zhang, J., Lu, L., Chen, S. S., Quinn, M. T. and Weber, K. T. (2002) Aldosterone-induced inflammation in the rat heart: role of oxidative stress. Am. J. Pathol. 161, 1773-1781
29. Myers, P. R., Minor, Jr, R. L., Guerra, Jr, R., Bates, J. N. and Harrison, D. G. (1990) Vasorelaxant properties of the endothelium-derived relaxing factor more closely resemble S-nitrosocysteine than nitric oxide. Nature (London) 345, 161-163
30. Ignarro, L. J., Lippton, H., Edwards, J. C. et al. (1981) Mechanism of vascular smooth muscle relaxation by organic nitrates, nitrites, nitroprusside and nitric oxide: evidence for the involvement of S-nitrosothiols as active intermediates, J. Pharmacol. Exp. Ther. 218, 739-749
31. Ramasamy, S., Drummond, G. R., Ahn, J. et al. (1999) Modulation of expression of endothelial nitric oxide synthase by nordihydroguaiaretic acid, a phenolic antioxidant in cultured endothelial cells. Mol. Pharmacol. 56, 116-123
32. Forman, H. J. and Fridovich, I. (1973) Superoxide dismutase: a comparison of rate constants. Arch. Biochem. Biophys. 158, 396-400
33. Afenas'ev, I. (1991) In Superoxide Ion: Chemistry and Biological Implications, CRC Press, Boca Raton, FL
34. Huie, R. E. and Padmaja, S. (1993) The reaction of NO with superoxide. Free Radical Res. Commun. 18, 195-199
35. Koo, J. R. and Vaziri, N. D. (2003) Effects of diabetes, insulin and antioxidants on NO synthase abundance and NO interaction with reactive oxygen species. Kidney Int. 63, 195-201
36. Yoshida, H., Sasaki, K., Namiki, Y., Sato, N. and Tada, N. (2005) Edaravone, a novel radical scavenger, inhibits oxidative modification of low-density lipoprotein (LDL) and reverses oxidized LDL-mediated reduction in the expression of endothelial nitric oxide synthase. Atherosclerosis 179, 97-102
37. Issels, R. D., Nagele, A., Eckert, K. G. and Wilmanns, W. (1988) Promotion of cystine uptake and its utilization for glutathione biosynthesis induced by cysteamine and N-acetylcysteine. Biochem. Pharmacol. 37, 881-888
38. Wu, L. and Juurlink, B. H. (2001) The impaired glutathione system and its up-regulation by sulforaphane in vascular smooth muscle cells from spontaneously hypertensive rats. J. Hypertens. 19, 1819-1825
39. ω-nitro-L-arginine methyl ester-treated rats: the role of reactive oxygen species. Hypertens. Res. 28, 487-494
40. Kuneš, J., Dobešová, Z. and Zicha, J. (2004) Chronic N-acetylcysteine treatment prevents the development of salt hypertension in immature Dahl rats. J. Hypertens. 22(Suppl. 1), S336
41. Xu, H., Fink, G. D. and Galligan, J. J. (2002) Nitric oxide-independent effects of tempol on sympathetic nerve activity and blood pressure in DOCA-salt rats. Am. J. Physiol. Heart Circ. Physiol. 283, H885-H892
42. 2 in DOCA-salt rats. Hypertension 43, 329-334
43. Campese, V. M., Ye, S., Zhong, H., Yanamadala, V., Ye, Z. and Chiu, J. (2004) Reactive oxygen species stimulate central and peripheral sympathetic nervous system activity. Am. J. Physiol. Heart Circ. Physiol. 287, H695-H703
44. Leenen, F. H., Ruzicka, M. and Huang, B. S. (2002) The brain and salt-sensitive hypertension. Curr. Hypertens. Rep. 4, 129-135