Effect of vitamin C on ambulatory blood pressure and plasma lipids in older persons

Journal of Hypertension

Volumn 18, Issue 4, 2000, Pages 411-415

  Fotherby, Martin D ^a,c   Williams, Julie C ^a   Forster, Louise A ^a   Craner, Paul ^a   Ferns, Gordon A ^b  

^a UNIVERSITY OF LEICESTER   (United Kingdom)

^b UNIVERSITY OF SURREY   (United Kingdom)

^c GLENFIELD HOSPITAL   (United Kingdom)

Author keywords

Ambulatory blood pressure; Elderly; Hypertension; Lipids; Vitamin C

Indexed keywords

ASCORBIC ACID; HIGH DENSITY LIPOPROTEIN CHOLESTEROL; LOW DENSITY LIPOPROTEIN CHOLESTEROL; PLACEBO;

ADULT; AGED; ARTICLE; BLOOD PRESSURE; BLOOD PRESSURE MONITORING; CARDIOVASCULAR DISEASE; CHOLESTEROL BLOOD LEVEL; CIRCADIAN RHYTHM; CLINICAL ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; CROSSOVER PROCEDURE; DIASTOLIC BLOOD PRESSURE; DOUBLE BLIND PROCEDURE; DRUG CAPSULE; FEMALE; HUMAN; LIPID BLOOD LEVEL; MALE; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; REGRESSION ANALYSIS; STROKE; SYSTOLIC BLOOD PRESSURE; SYSTOLIC HYPERTENSION; VITAMIN BLOOD LEVEL; VITAMIN SUPPLEMENTATION;

EID: 0034043751     PISSN: 02636352     EISSN: None     Source Type: Journal    
DOI: 10.1097/00004872-200018040-00009     Document Type: Article

References (44)

1. 1 Enstrom JE, Kanim LE, Klein M. Vitamin C intake and mortality among a sample of the United States population. Epidemiology 1992; 3:194-202.
2. 2 Gale CR, Martyn CN, Winter PD, Cooper C. Vitamin C and risk of death from stroke and coronary heart disease in cohort of elderly people. BMJ 1995; 310:1563-1566.
3. 3 Simon JA. Vitamin C and cardiovascular disease: a review. J Am Coll Nutrition 1992; 11(2):107-125.
4. 4 Ness AR, Khaw K-T, Bingham S, Day NE. Vitamin C status and blood pressure. J Hypertens 1996; 14:503-508.
5. 5 Moran JP, Cohen L, Green JM, Xu G, Feldman EB, Hames CG, Feldman DS. Plasma ascorbic acid concentrations relate inversely to blood pressure in human subjects. Am J Clin Nutr 1993; 57:213-217.
6. 6 Dobson H, Muir M, Hume R. The effect of ascorbic acid on the seasonal variations in serum cholesterol levels. Scott Med J 1984; 29:176-182.
7. 7 Shimizu M, Hatta Y, Hayashi H, et al. The effect of ascorbic acid on fibrinolysis. Acta Haematol Jpn 1970; 33:137-148.
8. 8 Bates CJ, Burr MK, St Ledger AS. Vitamin C high density lipoproteins and heart disease in elderly subjects. Age Ageing 1979; 8:177-182.
9. 9 Griffiths ML. Brockelhurst JC, Scott DL, Marks J, Blacklee J. Thiamine and ascorbic levels in the elderly. Gerontol Clin 1967; 9:1-10.
10. 10 Osilesi O, Trout DL, Ogunwole J, Glover EE. Blood pressure and plasma lipids during ascorbic acid supplementation in borderline hypertensive and normotensive adults. Nutr Res 1991; 11:405-412.
11. 11 Lovat LB, Lu Y, Palmer AJ, Edwards R, Fletcher AE, Bulpitt CJ. Double blind trial of vitamin C in elderly hypertensives. J Hum Hypertens 1993; 7:403-405.
12. 12 Ghosh SK, Ekpo EB, IU Shah, AJ Girling, C Jenkins, AJ Sinclair. A double-blind placebo controlled parallel trial of vitamin C treatment in elderly patients with hypertension. Gerontology 1994; 40:268-272.
13. 13 Duffy SJ, Gokce N, Holbrook M, Huang A, Frei B, Keaney JF, et al. Treatment of hypertension with ascorbic acid. Lancet 1999; 354:2048-2049.
14. 14 Lunec J, Blake DR. The determination of dihydroascorbic acid and ascorbic acid in the serum and synovial fluid of patients with rheumatoid arthritis. Free Rad Res Commun 1985; 1:31-39.
15. 15 Fotherby MD, Potter JF. Reproducibility of ambulatory and clinic blood pressure measurements in elderly hypertensive subjects. J Hypertens 1993; 11:573-579.
16. 16 Hills M, Armitage P. The two-period cross-over trial. Br J Clin Pharmacol 1979; 8:7-20.
17. 17 Staessen JA, Bieniaszewski L, et al. What is normal blood pressure on ambulatory monitoring? Neprhol Dial Transplant 1996; 11:241-245.
18. 18 Hemila H. Vitamin C and lowering of blood pressure: need for intervention trials? J Hypertens 1991; 9:1076-1077.
19. 19 Bates CJ, Walmsley CM, Prentice A, Finch S. Does vitamin C reduce blood pressure? Results of a large study of people aged 65 or older. J Hypertens 1998; 16:925-932
20. 20 Yoshioka M, Aoyama K, Matsoshita T. Effects of ascorbic acid on blood pressure and ascorbic acid metabolism in spontaneously hypertensive rats. Int J Vit Nutr Res 1985; 55:301-307.
21. 21 Witte K, Lemmer B. Signal transduction in animal models of normotension and hypertension. Ann New York Acad Sci 1996; 783:71-83.
22. 22 Nakazato T, Shikama T, Toma S, Nakajima Y, Masuda Y. Nocturnal variation in human sympathetic baroreflex sensitivity. J Auton Nerv Syst 1998; 70(1-2): 32-37.
23. 23 Galley HF, Thornton J, Howdle PD, Walker E, Webster NR. Combination oral antioxidant supplementation reduces blood pressure. Clin Sci 1997; 92:361-365.
24. 24 Beetens JR, Herman AG. Ascorbic acid and prostoglandin formation. Int J Vit Nutr Res Suppl 1983; 24:131-143.
25. 25 Toivanen JL. Effects of selenium, vitamin E and vitamin C on human prostacylin and thromboxane synthesis in vitro. Prostaglandins Leukot Med 1987; 26:265-280.
26. 26 Cerna O, Ginter E. Blood lipids and vitmain C status. Lancet 1978; i:1055-1056.
27. 27 Burr ML, Bates CJ, Sweetnam PM, Barasi ME. Plasma ascorbate and HDL-cholesterol in women. Hum Nutr Clin Nutr 1982; 36:399-400.
28. 28 Horsey J, Livesley B, Dickerson JWT. Ischaemic heart disease and aged patients: effects of ascorbic acid on lipoproteins. J Hum Nutr 1981; 35:53-58.
29. 29 Jacques PF, Hartz SC, Mcgandy RB, Jacob RA, Russell RM. Ascorbic acid, HDL and total plasma cholesterol in the elderly. J Am Coll Nutr 1987; 6:169-174.
30. 30 Hallfrisch J, et al. High plasma vitamin C is associated with HDL and HDL II cholesterol. Am J Clin Nutr 1994; 60:100-105.
31. 31 Jackues PF, Sulsky SI, Perrone GE, Schaefei EJ. Ascorbic acid and plasma lipids. Epidemiology 1994; 5:19-26.
32. 32 Toohey L, Harris MA, Allen KG, Melby CL. Plasma ascorbic acid concentrations are related to cardiovascular risk factors in African Americans. J Nutr 1996; 126:121-128.
33. 33 Ness AR, Core KT, Bingham S, Day NE. Vitamin C status and serum lipids. Eur J Clin Nutr 1996; 50:724-729.
34. 34 Greco AM, La Rocca L. Correlation between chronic hypovitaminosis C in old age and plasma levels of cholesterol and triglycerides. Int J Vit Nutr Res 1982; 23(Suppl):129-136.
35. 35 Elwood PC, Hughes RE, Hurley RJ. Ascorbic acid and serum cholesterol. Lancet 1970; ii:1197.
36. 36 Hooper PL, Hooper EM, Hunt WC, Garry PJ, Goodwin JS. Vitamins, lipids and lipoproteins in a healthy elderly population. Int J Vit Nutr Res 1983; 53:412-419.
37. 37 Heine H, Norden C. Vitamin C therapy in hyperlipoproteinemia. Int J Vit Nutr Res 1979; 19(Suppl):45-54.
38. 38 Salonen JT, Salonen R, Seppanen K, et al. Relationship of serum selenium and antioxidants to plasma lipoproteins, platelet aggregability and prevalent ischaemic heart disease in Eastern Finnish men. Atherosclerosis 1988; 70:155-160.
39. 39 Buzzard IM, McRoberts MR, Driscoll DI, Bowering J. Effect of dietary eggs and ascorbic acid on plasma lipid and lipoprotein cholesterol levels in healthy young men. Am J Clin Nutr 1982; 36:94-105.
40. 40 Bishop N, Schorah CJ, Wales JK. The effect of vitamin supplementation on diabetic hyperlipidaemia: a double blind cross over study. Diabetic Med 1985; 2:121-124.
41. 41 Aro A, Kyllastinen M, Kostiaine E, Gref C-G, Elfving S, Uusitalo U. No effect on serum lipids by moderate and high doses of vitamin C in elderly subjects with low plasma ascorbic acid levels. Ann Nutr Metabol 1988; 32:133-137.
42. 42 Ginta E. Cholesterol, vitamin C controls its transformation to bile acids. Science 1973; 179:702-704.
43. 43 Aulinsks TH, Van der Westhuyzen DR, Coetzee GA. Ascorbate increases the number of low density lipoprotein receptors in cultured arterial smooth muscle cells. Atherosclerosis 1983; 47:159-171.
44. 44 Harats D, Ben-Naim M, Dabach Y, et al. Effect of vitamin C and E supplementation on susceptibility of plasma lipoproteins to peroxidation induced by acute smoking. Atherosclerosis 1990; 85:47-54.