Combination oral antioxidant supplementation reduces blood pressure

Clinical Science

Volumn 92, Issue 4, 1997, Pages 361-365

  Galley, Helen F ^b   Thornton, Judith ^a   Howdle, Peter D ^a   Walker, Barry E ^a   Webster, Nigel R ^b  

^a ST JAMES S UNIVERSITY HOSPITAL   (United Kingdom)

^b UNIVERSITY OF ABERDEEN   (United Kingdom)

Author keywords

Antioxidants; Carotenoids; Hypertension; Vitamin C; Vitamin E

Indexed keywords

ALPHA TOCOPHEROL; ANTIOXIDANT; ASCORBIC ACID; BETA CAROTENE; NITRIC OXIDE; NITRITE; ZINC SULFATE;

ADULT; AGED; ANTIHYPERTENSIVE ACTIVITY; ANTIOXIDANT ACTIVITY; ARTICLE; BLOOD PRESSURE REGULATION; CARDIOVASCULAR DISEASE; CLINICAL ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; CROSSOVER PROCEDURE; DIET SUPPLEMENTATION; DOUBLE BLIND PROCEDURE; DRUG BLOOD LEVEL; DRUG EFFECT; HUMAN; HYPERTENSION; NITROGEN URINE LEVEL; ORAL DRUG ADMINISTRATION; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; SYSTOLIC BLOOD PRESSURE;

EID: 0030895186     PISSN: 01435221     EISSN: None     Source Type: Journal    
DOI: 10.1042/cs0920361     Document Type: Article

References (25)

1. Haber H. Hypertension - where do we go from here? Hypertension 1985; 7: 311-12.
2. Eicholzer M, Stahelin HB, Gey KF. Inverse correlation between essential antioxidants in plasma and subsequent risk to develop cancer, ischemic heart disease and stroke. EXS 1992; 62: 398-410.
3. Gey KF, Stahelin HB, Eicholzer M. Poor plasma status of carotene and vitamin C is associated with a higher mortality from ischemic heart disease and stroke: Basel prospective study. Clin Invest 1993; 71: 3-6.
4. Gale CR, Martyn CN, Winter PD, Cooper C. Vitamin C and risk of death from stroke and coronary heart disease in cohort of elderly people. Br Med J 1995; 310: 1563-6.
5. Gey KF, Stahelin HB, Ballmer PE. Essential antioxidants in cardiovascular diseases: lessons for Europe. Ther Umsch 1994; 51: 475-82.
6. Palozza P, Krinsky NI. Beta carotene and alpha tocopherol are synergistic antioxidants. Arch Biochem Biophys 1992; 297: 184-7.
7. Packer JE, Slater TL, Willson RL. Direct observation of a free radical interaction between vitamin E and vitamin C. Nature (London) 1979; 278: 737-8.
8. Panza JA, Garcia CE, Kilcoyne CM, Quyyumi AA, Cannon RO. Impaired endothelium dependent vasodilation in patients with essential hypertension. Circulation 1995; 91: 1732-8.
9. Galley HF, Walker BE, Howdle PD, Webster NR. Regulation of nitric oxide synthase activity in cultured human endothelial cells: effect of antioxidants. Free Rad Biol Med 1996; 21: 97-101.
10. Catignami GL, Bieri JG. Simultaneous determination of retinol and α-tocopherol in serum or plasma by liquid chromatography. Clin Chem 1983; 29: 706-12.
11. Phizackerley PRJ, Al-Dabbagh SA. The estimation of nitrate and nitrite in saliva and urine. Anal Biochem 1983; 131: 242-5.
12. Grygelwski RJ, Palmer RMJ, Moncada S. Superoxide anion is involved in the breakdown of endothelium derived vascular relaxing factor. Nature (London) 1986; 320: 454-6.
13. Bulpitt CJ. Vitamin C and blood pressure. J Hypertens 1990; 8: 1071-5.
14. Stampfer MJ, Hennekens CH, Manson JE, Colditz GA, Rosner B, Willett WC. Vitamin E consumption and the risk of coronary heart disease in women. N Engl J Med 1993; 328: 1444-9.
15. Hoffman RM, Garewal HS. Antioxidants and prevention of coronary heart disease. Arch Intern Med 1995; 155: 241-6.
16. Goode HF, Purkins L, Heatley RV, Kelleher J. The effect of vitamin E deficiency on plasma zinc and copper concentrations. Clin Nutr 1991; 10: 233-5.
17. Yoshioka M, Aoyama K, Matsushita T. The effect of ascorbic acid on blood pressure and ascorbic acid. Metabolism in spontaneously hypertensive rats (SH rats). Int J Vitam Nutr Res 1985; 55: 301-7.
18. Koh ET. Effect of vitamin C on blood parameters of hypertensive subjects. J Okla State Med Assoc 1984; 77: 177-182.
19. Osilesi O, Trout DL, Ogunwole J, Glover EE. Blood pressure and plasma lipids during ascorbic acid supplementation in borderline hypertensive and normotensive adults. Nutr Res 1991 ; 11: 405-12.
20. Ceriello A, Giugliano D, Quatraro A, Lefebvre PJ. Anti-oxidants show an anti-hypertensive effect in diabetic and hypertensive subjects. Clin Sci 1991; 81: 739-42.
21. Benjamin N, Copeland M, Smith LM. Reduced nitric oxide synthesis in essential hypertension. J Hypertens 1994; 12: 1322 [Abstract].
22. Cockcroft JR, Chowienczyk PJ, Benjamin N, Ritter JM. Preserved endothelium dependent vasodilatation in patients with essential hypertension. N Engl J Med 1994; 330: 1036-40.
23. Bonnardeaux A, Nadaud S, Charru A, Jeunemaitre X, Corvol P, Soubrier F. Lack of evidence for linkage of the endothelial cell nitric oxide synthase gene to essential hypertension. Circulation 1995; 91: 96-102.
24. G-monomethyl-L-arginine in patients with hypertension. J Hypertens 1992; 10: 1025-31.
25. G-monomethyl-L-arginine in patients with essential hypertension. J Hypertens 1994; 12: 1047-52.