-
1
-
-
0842327199
-
Integration of knowledge-based metabolic predictions with liquid chromatography data-dependent tandem mass spectrometry for drug metabolism studies: App lication to studies on the biotransformation of indinavir
-
Anari MR, Sanchez RI, Bakhtiar R, et al. (2004). Integration of knowledge-based metabolic predictions with liquid chromatography data-dependent tandem mass spectrometry for drug metabolism studies: App lication to studies on the biotransformation of indinavir. Anal Chem 76:823-832.
-
(2004)
Anal Chem
, vol.76
, pp. 823-832
-
-
Anari, M.R.1
Sanchez, R.I.2
Bakhtiar, R.3
-
2
-
-
84896483950
-
Reflecting on a decade of metabolite screening and monitoring
-
Aubry AF, Christopher LJ, Wang J, et al. (2014). Reflecting on a decade of metabolite screening and monitoring. Bioanalysis 6:651-664.
-
(2014)
Bioanalysis
, vol.6
, pp. 651-664
-
-
Aubry, A.F.1
Christopher, L.J.2
Wang, J.3
-
3
-
-
62249135160
-
Approaches to the assessment of stable and chemically reactive drug metabolites in early clinical trials
-
Baillie TA. (2009). Approaches to the assessment of stable and chemically reactive drug metabolites in early clinical trials. Chem Res Toxicol 22:263-266.
-
(2009)
Chem Res Toxicol
, vol.22
, pp. 263-266
-
-
Baillie, T.A.1
-
4
-
-
0027205012
-
Mass spectrometry in the analysis of glutathione conjugates
-
Baillie TA, Davis MR. (1993). Mass spectrometry in the analysis of glutathione conjugates. Biol Mass Spectrom 22:319-325.
-
(1993)
Biol Mass Spectrom
, vol.22
, pp. 319-325
-
-
Baillie, T.A.1
Davis, M.R.2
-
5
-
-
0024849826
-
The use of mass spectrometry in the study of chemically-reactive drug metabolites. Application of MS/MS and LC/MS to the analysis of glutathione-and related S-linked conjugates of N-methylformamide
-
Baillie TA, Pearson PG, Rashed MS, Howald WN. (1989). The use of mass spectrometry in the study of chemically-reactive drug metabolites. Application of MS/MS and LC/MS to the analysis of glutathione-and related S-linked conjugates of N-methylformamide. J Pharm Biomed Anal 7:1351-1360.
-
(1989)
J Pharm Biomed Anal
, vol.7
, pp. 1351-1360
-
-
Baillie, T.A.1
Pearson, P.G.2
Rashed, M.S.3
Howald, W.N.4
-
6
-
-
18844408578
-
Study of chemistry in droplets with net charge before and after Coulomb explosion: Ion-induced nucleation in solution and implications for ion production in an electrospray
-
Ba khoum SF, Agnes GR. (2005). Study of chemistry in droplets with net charge before and after Coulomb explosion: Ion-induced nucleation in solution and implications for ion production in an electrospray. Anal Chem 77:3189-3197.
-
(2005)
Anal Chem
, vol.77
, pp. 3189-3197
-
-
Bakhoum, S.F.1
Agnes, G.R.2
-
7
-
-
0002217958
-
Multiple scan modes in the hybrid tandem mass spectrometric screening and characterization of the glutathione conjugate of 2-furamide
-
Ballard KD, Raftery MJ, Jaeschke H, Gaskell SJ. (1991). Multiple scan modes in the hybrid tandem mass spectrometric screening and characterization of the glutathione conjugate of 2-furamide. J Am Soc Mass Spectrom 2:55-68.
-
(1991)
J Am Soc Mass Spectrom
, vol.2
, pp. 55-68
-
-
Ballard, K.D.1
Raftery, M.J.2
Jaeschke, H.3
Gaskell, S.J.4
-
8
-
-
80053232023
-
High-resolution chromatography/time-of-flight MSE with in silico data mining is an information-rich approach to reactive metabolite screening
-
Barbara JE, Castro-Perez JM. (2011). High-resolution chromatography/time-of-flight MSE with in silico data mining is an information-rich approach to reactive metabolite screening. Rapid Commun Mass Spectro m 25:3029-3040.
-
(2011)
Rapid Commun Mass Spectrom
, vol.25
, pp. 3029-3040
-
-
Barbara, J.E.1
Castro-Perez, J.M.2
-
10
-
-
34248572197
-
MSE with mass defect filtering for in vitro and in vivo metabolite identification
-
Bateman KP, Castro-Perez J, Wrona M, et al. (2007). MSE with mass defect filtering for in vitro and in vivo metabolite identification. Rapid Commun Mass Spectrom 21:1485-1496.
-
(2007)
Rapid Commun Mass Spectrom
, vol.21
, pp. 1485-1496
-
-
Bateman, K.P.1
Castro-Perez, J.2
Wrona, M.3
-
11
-
-
49849128566
-
Field desorption mass spectrometry: A technique for the study of thermally unstable substances of low volatility
-
Beckey HD. (1969). Field desorption mass spectrometry: A technique for the study of thermally unstable substances of low volatility. Int J Mass Spectrom Ion Phys 2:500-503.
-
(1969)
Int J Mass Spectrom Ion Phys
, vol.2
, pp. 500-503
-
-
Beckey, H.D.1
-
12
-
-
0023429924
-
Characterizat ion of benzo(a)pyrene metabolites by high performance liquid chromatography-mass spectrometry with a direct liquid introduction interface and using negative chemical ionization
-
Bieri RH, Greaves J. (1987). Characterizat ion of benzo(a)pyrene metabolites by high performance liquid chromatography-mass spectrometry with a direct liquid introduction interface and using negative chemical ionization. Biomed Environ Mass Spectrom 14:555-561.
-
(1987)
Biomed Environ Mass Spectrom
, vol.14
, pp. 555-561
-
-
Bieri, R.H.1
Greaves, J.2
-
13
-
-
0025297376
-
Isolation and characterization of an unusual glucuronide conjugate of rimantadine
-
Brow n SY, Garland WA, Fukuda EK. (1990). Isolation and characterization of an unusual glucuronide conjugate of rimantadine. Drug Metab Dispos 18:546-547.
-
(1990)
Drug Metab Dispos
, vol.18
, pp. 546-547
-
-
Brown, S.Y.1
Garland, W.A.2
Fukuda, E.K.3
-
14
-
-
74049143211
-
ADME optimization and toxicity assessment in early-and late-phase drug discovery
-
Caldwell GW, Yan Z, Tang W, et al. (2009). ADME optimization and toxicity assessment in early-and late-phase drug discovery. Curr Top Med Chem 9:965-980.
-
(2009)
Curr Top Med Chem
, vol.9
, pp. 965-980
-
-
Caldwell, G.W.1
Yan, Z.2
Tang, W.3
-
15
-
-
0025707716
-
Bombardment mass spectrometry
-
Caprioli RM. (1990). Bombardment mass spectrometry. Anal Chem 62: 477A-485A.
-
(1990)
Anal Chem
, vol.62
, pp. 477-485
-
-
Caprioli, R.M.1
-
16
-
-
0025141788
-
On-line analysis of penicillin blood levels in the live rat by combined microdialysis/fast-atom bombardment mass spectrometry
-
Caprioli R M, Lin SN. (1990). On-line analysis of penicillin blood levels in the live rat by combined microdialysis/fast-atom bombardment mass spectrometry. Proc Natl Acad Sci USA 87:240-243.
-
(1990)
Proc Natl Acad Sci USA
, vol.87
, pp. 240-243
-
-
Caprioli, R.M.1
Lin, S.N.2
-
17
-
-
14844293921
-
Increasing throughput and information content for in vitro drug metabolism experiments using ultra-performance liquid chromatography coupled to a quadrupole time-of-flight mass spectrometer
-
Castro-Perez J, Plumb R, Granger JH, et al. (2005). Increasing throughput and information content for in vitro drug metabolism experiments using ultra-performance liquid chromatography coupled to a quadrupole time-of-flight mass spectrometer. Rapid Commun Ma ss Spectrom 19:843-848.
-
(2005)
Rapid Commun Ma Ss Spectrom
, vol.19
, pp. 843-848
-
-
Castro-Perez, J.1
Plumb, R.2
Granger, J.H.3
-
18
-
-
33847212842
-
Current and future trends in the application of HPLC-MS to metabolite-identification studies
-
Castro-Perez JM. 2007. Current and future trends in the application of HPLC-MS to metabolite-identification studies. Drug Discov Today 12 249-256.
-
(2007)
Drug Discov Today
, vol.12
, pp. 249-256
-
-
Castro-Perez, J.M.1
-
19
-
-
34548388291
-
LC-MS-based metabolomics in drug metabolism
-
Chen C, Gonzalez FJ, Idle JR. (2007). LC-MS-based metabolomics in drug metabolism. Drug Metab Rev 39:581-597.
-
(2007)
Drug Metab Rev
, vol.39
, pp. 581-597
-
-
Chen, C.1
Gonzalez, F.J.2
Idle, J.R.3
-
20
-
-
41949134860
-
Identification of novel toxicity-associated metabolites by metabolomics and mass isotopomer analysis of acetaminophen metabolism in wild-type and Cyp2e1-null mice
-
Chen C, Krausz KW, Idle JR, Gonzalez FJ. (2008). Identification of novel toxicity-associated metabolites by metabolomics and mass isotopomer analysis of acetaminophen metabolism in wild-type and Cyp2e1-null mice. J Biol Chem 283:4543-4559.
-
(2008)
J Biol Chem
, vol.283
, pp. 4543-4559
-
-
Chen, C.1
Krausz, K.W.2
Idle, J.R.3
Gonzalez, F.J.4
-
21
-
-
0035699746
-
Reactive metabolite screen for reducing candidate attrition in drug discovery
-
Chen WG, Zhang C, Avery MJ, Fouda HG. (2001). Reactive metabolite screen for reducing candidate attrition in drug discovery. Adv Exp Med Biol 500:521-524.
-
(2001)
Adv Exp Med Biol
, vol.500
, pp. 521-524
-
-
Chen, W.G.1
Zhang, C.2
Avery, M.J.3
Fouda, H.G.4
-
22
-
-
84905216643
-
Liquid chromatogr aphy high-resolution TOF analysis: Investigation of MSE for broad-spectrum drug screening
-
Chindarkar NS, Wakefield MR, Stone JA, Fitzgerald RL. (2014). Liquid chromatogr aphy high-resolution TOF analysis: Investigation of MSE for broad-spectrum drug screening. Clin Chem 60:1115-1125.
-
(2014)
Clin Chem
, vol.60
, pp. 1115-1125
-
-
Chindarkar, N.S.1
Wakefield, M.R.2
Stone, J.A.3
Fitzgerald, R.L.4
-
23
-
-
0035416421
-
Systematic LC/MS metabolite identification in drug discovery
-
Clarke NJ, Rindgen D, Korfmacher WA, Cox KA. (2001). Systematic LC/MS metabolite identification in drug discovery. Anal Chem 73: 430A-439A.
-
(2001)
Anal Chem
, vol.73
, pp. 430-439
-
-
Clarke, N.J.1
Rindgen, D.2
Korfmacher, W.A.3
Cox, K.A.4
-
24
-
-
60149105834
-
Extracting metabolite ions out of a matrix background by combined mass defect, neutral loss and isotope f iltration
-
Cuyckens F, Hurkmans R, Castro-Perez JM, et al. (2009). Extracting metabolite ions out of a matrix background by combined mass defect, neutral loss and isotope f iltration. Rapid Commun Mass Spectrom 23: 327-332.
-
(2009)
Rapid Commun Mass Spectrom
, vol.23
, pp. 327-332
-
-
Cuyckens, F.1
Hurkmans, R.2
Castro-Perez, J.M.3
-
25
-
-
34248552452
-
Gas chromatography-mass spectrometry for residue analysis: Some basic concepts
-
De Brabander HF, De Wasch K, Impens S, et al. (2001). Gas chromatography-mass spectrometry for residue analysis: Some basic concepts. Chromatogr Sci Ser 86:441-454.
-
(2001)
Chromatogr Sci ser
, vol.86
, pp. 441-454
-
-
De Brabander, H.F.1
De Wasch, K.2
Impens, S.3
-
26
-
-
84934435993
-
Detection of polar metabolites through the use of gas chromatography-mass spectrometry
-
De Souza DP. (2013). Detection of polar metabolites through the use of gas chromatography-mass spectrometry. Methods Mol Biol 1055: 29-37.
-
(2013)
Methods Mol Biol
, vol.1055
, pp. 29-37
-
-
De Souza, D.P.1
-
27
-
-
36149017374
-
A new method of positive ray analysis
-
Dempster AJ. (1918). A new method of positive ray analysis. Phys Rev 11:316-325.
-
(1918)
Phys Rev
, vol.11
, pp. 316-325
-
-
Dempster, A.J.1
-
28
-
-
0036709597
-
Cellular glutathione and thiols metabolism
-
Dickinson DA, Forman HJ. (2002). Cellular glutathione and thiols metabolism. Biochem Pharmacol 64:1019-1026.
-
(2002)
Biochem Pharmacol
, vol.64
, pp. 1019-1026
-
-
Dickinson, D.A.1
Forman, H.J.2
-
29
-
-
17644404394
-
Negative ion tandem mass spectrometry for the detection of glutathione conjugates
-
Dieckhaus CM, Fernández-Metzler CL, King R, et al. (2005). Negative ion tandem mass spectrometry for the detection of glutathione conjugates. Chem Res Toxicol 18:630-638.
-
(2005)
Chem Res Toxicol
, vol.18
, pp. 630-638
-
-
Dieckhaus, C.M.1
Fernández-Metzler, C.L.2
King, R.3
-
30
-
-
84875147820
-
Detection and characterization of ticlopidine conjugates in rat bile using high-resolution mass spectrometry: Applications of various data acquisition and processing tools
-
Du F, Ruan Q, Zhu M, Xing J. (2013). Detection and characterization of ticlopidine conjugates in rat bile using high-resolution mass spectrometry: Applications of various data acquisition and processing tools. J Mass Spectrom 48:413-422.
-
(2013)
J Mass Spectrom
, vol.48
, pp. 413-422
-
-
Du, F.1
Ruan, Q.2
Zhu, M.3
Xing, J.4
-
31
-
-
84904961381
-
LC-MS-based metabolomics: An update
-
Fang ZZ, Gonzalez FJ. (2014). LC-MS-based metabolomics: An update. Arch Toxicol 88:1491-1502.
-
(2014)
Arch Toxicol
, vol.88
, pp. 1491-1502
-
-
Fang, Z.Z.1
Gonzalez, F.J.2
-
32
-
-
0041918439
-
Rapid liquid chromatography with tandem mass spectrometry-based screening procedures for studies on the biotransformation of drug candidates
-
Ferná ndez-Metzler CL, Owens KG, Baillie TA, King RC. (1999). Rapid liquid chromatography with tandem mass spectrometry-based screening procedures for studies on the biotransformation of drug candidates. Drug Metab Dispos 27:32-40.
-
(1999)
Drug Metab Dispos
, vol.27
, pp. 32-40
-
-
Fernández-Metzler, C.L.1
Owens, K.G.2
Baillie, T.A.3
King, R.C.4
-
33
-
-
0016054157
-
Direct (non-chromatographic) quantification of drugs and their metabolites from human plasma utilizing chemical ionization mass spectrometry and stable isotope labeling: Quinidine and lidocaine
-
Garland WA, Trager WF, Nelson SD. (1974). Direct (non-chromatographic) quantification of drugs and their metabolites from human plasma utilizing chemical ionization mass spectrometry and stable isotope labeling: Quinidine and lidocaine. Biomed Mass Spectrom 1: 124-129.
-
(1974)
Biomed Mass Spectrom
, vol.1
, pp. 124-129
-
-
Garland, W.A.1
Trager, W.F.2
Nelson, S.D.3
-
34
-
-
84863437164
-
Analysis of synthetic cannabinoids using high-resolution mass spectrometry and mass defect filtering: Implications for nontargeted screening of de signer drugs
-
Grabenauer M, Krol WL, Wiley JL, Thomas BF. (2012). Analysis of synthetic cannabinoids using high-resolution mass spectrometry and mass defect filtering: Implications for nontargeted screening of de signer drugs. Anal Chem 84:5574-5581.
-
(2012)
Anal Chem
, vol.84
, pp. 5574-5581
-
-
Grabenauer, M.1
Krol, W.L.2
Wiley, J.L.3
Thomas, B.F.4
-
35
-
-
0023931506
-
Characterization of glutathione conjugates by fast atom bombardment/tandem mass spectrometry
-
Haroldsen PE, Reilly MH, Hughes H, et al. (1988). Characterization of glutathione conjugates by fast atom bombardment/tandem mass spectrometry. Biomed Environ Mass Spectrom 15:615-621.
-
(1988)
Biomed Environ Mass Spectrom
, vol.15
, pp. 615-621
-
-
Haroldsen, P.E.1
Reilly, M.H.2
Hughes, H.3
-
38
-
-
0037297379
-
Rapid screening and characterization o f drug metabolites using a new quadrupole-linear ion trap mass spectrometer
-
Hopfgartner G, Husser C, Zell M. (2003). Rapid screening and characterization o f drug metabolites using a new quadrupole-linear ion trap mass spectrometer. J Mass Spectrom 38:138-150.
-
(2003)
J Mass Spectrom
, vol.38
, pp. 138-150
-
-
Hopfgartner, G.1
Husser, C.2
Zell, M.3
-
39
-
-
84859107186
-
High-resolution mass spectrometry for integrated qualitative and quantitative analysis of pharmaceuticals in biological matrices
-
Hopfgartner G, Tonoli D, Varesio E. (2012). High-resolution mass spectrometry for integrated qualitative and quantitative analysis of pharmaceuticals in biological matrices. Anal Bioanal Chem 402: 2587-2596.
-
(2012)
Anal Bioanal Chem
, vol.402
, pp. 2587-2596
-
-
Hopfgartner, G.1
Tonoli, D.2
Varesio, E.3
-
40
-
-
4444272971
-
Triple quadrupole linear ion trap mass spec trometer for the analysis of small molecules and macromolecules
-
Hopfgartner G Varesio E Tschäppät V et al. 2004 Triple quadrupole linear ion trap mass spec trometer for the analysis of small molecules and macromolecules.J Mass Spectrom 39 845-855.
-
(2004)
J Mass Spectrom
, vol.39
, pp. 845-855
-
-
Hopfgartner, G.1
Varesio, E.2
Tschäppät, V.3
-
41
-
-
84886468313
-
Use of triple quadrupole-linear ion trap mass spectrometry as a single LC-MS platform in drug metabolism and pharmacokinetics studies
-
In: Lee M, Zhu M, eds London (UK): John Wiley & Sons Ltd. (Chapter 15)
-
Jian W, Yao M, Wen B, Zhu M. (2011). Use of triple quadrupole-linear ion trap mass spectrometry as a single LC-MS platform in drug metabolism and pharmacokinetics studies. In: Lee M, Zhu, M, eds. Mass spectrometry in drug metabolism and disposition: Basic principles and applications. London (UK): John Wiley & Sons Ltd., 483-524 (Chapter 15).
-
(2011)
Mass Spectrometry in Drug Metabolism and Disposition: Basic Principles and Applications
, pp. 483-524
-
-
Jian, W.1
Yao, M.2
Wen, B.3
Zhu, M.4
-
42
-
-
67651007115
-
Rapid detection and characterization of in vitro and urinary N-acetyl-L-cysteine conjugates using quadrupole-linear ion trap mass spectrometry and polarity switching
-
Jian W, Yao M, Zhang D, Zhu M. (2009). Rapid detection and characterization of in vitro and urinary N-acetyl-L-cysteine conjugates using quadrupole-linear ion trap mass spectrometry and polarity switching. Chem Res Tox icol 22:1246-1255.
-
(2009)
Chem Res Tox Icol
, vol.22
, pp. 1246-1255
-
-
Jian, W.1
Yao, M.2
Zhang, D.3
Zhu, M.4
-
44
-
-
33745759450
-
The use of Qtrap technology in drug metabolism
-
King R, Fernandez-Metzler C. (2006). The use of Qtrap technology in drug metabolism. Curr Drug Metab 7:541-545.
-
(2006)
Curr Drug Metab
, vol.7
, pp. 541-545
-
-
King, R.1
Fernandez-Metzler, C.2
-
45
-
-
4344645978
-
Can the pharmaceutical industry reduce attrition rates?
-
Kola I, Landis J. (2004). Can the pharmaceutical industry reduce attrition rates? Nat Rev Drug Discov 3:711-715.
-
(2004)
Nat Rev Drug Discov
, vol.3
, pp. 711-715
-
-
Kola, I.1
Landis, J.2
-
46
-
-
0025084678
-
Preparative highperformance liquid chromatography and preparative thin-layer chromatography isolation of tocainide carbamoyl-O-beta-D-glucuronide: Structural characterization by gas chromatography-mass spectrometry and fast atom bombardment-mass spectrometry
-
Kwok DW, Pillai G, Vaughan R, et al. (1990). Preparative highperformance liquid chromatography and preparative thin-layer chromatography isolation of tocainide carbamoyl-O-beta-D-glucuronide: Structural characterization by gas chromatography-mass spectrometry and fast atom bombardment-mass spectrometry. J Pharm Sci 79: 857-861.
-
(1990)
J Pharm Sci
, vol.79
, pp. 857-861
-
-
Kwok, D.W.1
Pillai, G.2
Vaughan, R.3
-
47
-
-
60749083654
-
Metabolic stability: Main enzymes involved and best tools to assess it
-
Laine R. (2008). Metabolic stability: Main enzymes involved and best tools to assess it. Curr Drug Metab 9:921-927.
-
(2008)
Curr Drug Metab
, vol.9
, pp. 921-927
-
-
Laine, R.1
-
48
-
-
0033128171
-
LC/MS applications in drug development
-
Lee MS, Kerns EH. (1999). LC/MS applications in drug development. Mass Spectrom Rev 18:187-279.
-
(1999)
Mass Spectrom Rev
, vol.18
, pp. 187-279
-
-
Lee, M.S.1
Kerns, E.H.2
-
49
-
-
79953659132
-
Recent developme nt in liquid chromatography/mass spectrometry and emerging technologies for metabolite identification
-
Liang Y, Wang G, Xie L, Sheng L. (2011a). Recent developme nt in liquid chromatography/mass spectrometry and emerging technologies for metabolite identification. Curr Drug Metab 12:329-344.
-
(2011)
Curr Drug Metab
, vol.12
, pp. 329-344
-
-
Liang, Y.1
Wang, G.2
Xie, L.3
Sheng, L.4
-
50
-
-
79957799286
-
Structural identification of the me tabolites for strictosamide in rats bile by an ion trap-TOF mass spectrometer and mass defect filter technique
-
Liang Y, Xiao W, Dai C, et al. (2011b). Structural identification of the me tabolites for strictosamide in rats bile by an ion trap-TOF mass spectrometer and mass defect filter technique. J Chromatogr B Analyt Technol Biomed Life Sci 879:1819-1822.
-
(2011)
J Chromatogr B Analyt Technol Biomed Life Sci
, vol.879
, pp. 1819-1822
-
-
Liang, Y.1
Xiao, W.2
Dai, C.3
-
51
-
-
80055022996
-
Metabolite identification of artemether by data-dependent accurate mass spectrometric analysis using an LTQ-Orbitrap hybrid mass spectrometer in combination with the online hydrogen/deuterium exchange technique
-
Liu T, Du F, Zhu F, Xing J. (2011). Metabolite identification of artemether by data-dependent accurate mass spectrometric analysis using an LTQ-Orbitrap hybrid mass spectrometer in combination with the online hydrogen/deuterium exchange technique. Rapid Commun Mass Spectrom 25:3303-3313.
-
(2011)
Rapid Commun Mass Spectrom
, vol.25
, pp. 3303-3313
-
-
Liu, T.1
Du, F.2
Zhu, F.3
Xing, J.4
-
52
-
-
0023757202
-
Analysis of almitrine and its metabolites in plasma using on-line fast atom bombardment liquid chromatography/mass spectrometry
-
Luijten W, Damien G, Marchand B, Capart J. (1988). Analysis of almitrine and its metabolites in plasma using on-line fast atom bombardment liquid chromatography/mass spectrometry. Biomed Environ Mass Spectrom 16:93-97.
-
(1988)
Biomed Environ Mass Spectrom
, vol.16
, pp. 93-97
-
-
Luijten, W.1
Damien, G.2
Marchand, B.3
Capart, J.4
-
53
-
-
49049114287
-
Rapid screening of glutathionetrapped reactive metabolites by linear ion trap mass spectrometry with isotope pattern-dependent scanning and postacquisi tion data mining
-
Ma L, Wen B, Ruan Q, Zhu M. (2008a ). Rapid screening of glutathionetrapped reactive metabolites by linear ion trap mass spectrometry with isotope pattern-dependent scanning and postacquisi tion data mining. Chem Res Toxicol 21:1477-1483.
-
(2008)
Chem Res Toxicol
, vol.21
, pp. 1477-1483
-
-
Ma, L.1
Wen, B.2
Ruan, Q.3
Zhu, M.4
-
54
-
-
84858391360
-
Application of LC-high-resolution MS with ' intelligent' data mining tools for screening reactive drug metabolites
-
Ma S, Chowdhury SK. (2012). Application of LC-high-resolution MS with ' intelligent' data mining tools for screening reactive drug metabolites. Bioanalysis 4:501-510.
-
(2012)
Bioanalysis
, vol.4
, pp. 501-510
-
-
Ma, S.1
Chowdhury, S.K.2
-
55
-
-
84878501262
-
Data acquisition and data mining techniques for metabolite identification using LC coupled to highresolution MS
-
Ma S, Chowdhury SK. (2013). Data acquisition and data mining techniques for metabolite identification using LC coupled to highresolution MS. Bioanalysis 5:1285-1297.
-
(2013)
Bioanalysis
, vol.5
, pp. 1285-1297
-
-
Ma, S.1
Chowdhury, S.K.2
-
56
-
-
33745758232
-
Application of mass spectrometry for metabolite identification
-
Ma S, Chow dhury SK, Alton KB. (2006). Application of mass spectrometry for metabolite identification. Curr Drug Metab 7:503-523.
-
(2006)
Curr Drug Metab
, vol.7
, pp. 503-523
-
-
Ma, S.1
Chowdhury, S.K.2
Alton, K.B.3
-
57
-
-
78650423579
-
Determination of exposure multip les of human metabolites for MIST assessment in preclinical safety species without using reference standards or radiolabeled compounds
-
Ma S, Li Z, Lee KJ, Chowdhury SK. (2010). Determination of exposure multip les of human metabolites for MIST assessment in preclinical safety species without using reference standards or radiolabeled compounds. Chem Res Toxicol 23:1871-1873.
-
(2010)
Chem Res Toxicol
, vol.23
, pp. 1871-1873
-
-
Ma, S.1
Li, Z.2
Lee, K.J.3
Chowdhury, S.K.4
-
58
-
-
59649106977
-
Recent advances in applications of liquid chromatography-tandem mass spectrometry to the analysis of reactive drug metabolites
-
Ma S, Zhu M. (2009). Recent advances in applications of liquid chromatography-tandem mass spectrometry to the analysis of reactive drug metabolites. Chem Biol Interact 179:25-37.
-
(2009)
Chem Biol Interact
, vol.179
, pp. 25-37
-
-
Ma, S.1
Zhu, M.2
-
59
-
-
41549100628
-
A metabolomic perspective of melatonin metabolism in the mouse
-
Ma X, Chen C, Krausz KW, et al. (2008b ). A metabolomic perspective of melatonin metabolism in the mouse. Endocrinology 149:1869-1879.
-
(2008)
Endocrinology
, vol.149
, pp. 1869-1879
-
-
Ma, X.1
Chen, C.2
Krausz, K.W.3
-
60
-
-
41549150792
-
Dual negative precursor ion scan approach for rapid detection of glutathione conjugates using liquid chromatography/tandem mass spectrometry
-
Mahajan MK Evans CA.2008 Dual negative precursor ion scan approach for rapid detection of glutathione conjugates using liquid chromatography/tandem mass spectrometry. Rapid Commun Mass Spectrom 22 1032-1040.
-
(2008)
Rapid Commun Mass Spectrom
, vol.22
, pp. 1032-1040
-
-
Mahajan, M.K.1
Evans, C.A.2
-
61
-
-
22744442456
-
A strategy for identification of drug metabolites from dried blood spots using triple-quadrupole/linear ion trap hybrid mass spectrometry
-
Mahajan MK, Evans CA. (2008). Dual negative precursor ion scan approach for rapid detection of glutathione conjugates using liquid chromatography/tandem mass spectrometry. Rapid Commun Mass Spectrom 22:1032-1040. Mauriala T, Chauret N, Oballa R, et al. (2005). A strategy for identification of drug metabolites from dried blood spots using triple-quadrupole/linear ion trap hybrid mass spectrometry. Rapid Commun Mass Spectrom 19:1984-1992.
-
(2005)
Rapid Commun Mass Spectrom
, vol.19
, pp. 1984-1992
-
-
Mauriala, T.1
Chauret, N.2
Oballa, R.3
-
62
-
-
84890022116
-
Qualitative metabolism assessment and toxicological detection of xylazine, a veterinary tranquilizer and drug of abuse, in rat and human urine using GC-MS, LC-MSn, and LC-HRMSn
-
Meyer GM, Maurer HH. (2013). Qualitative metabolism assessment and toxicological detection of xylazine, a veterinary tranquilizer and drug of abuse, in rat and human urine using GC-MS, LC-MSn, and LC-HRMSn. Anal Bioanal Chem 405:9779-9789.
-
(2013)
Anal Bioanal Chem
, vol.405
, pp. 9779-9789
-
-
Meyer, G.M.1
Maurer, H.H.2
-
63
-
-
39849101762
-
Comprehensive two-dimensional gas chromatography-mass spectrometry: A review
-
Mondello L, Tranchida PQ, Dugo P, Dugo G. (2008). Comprehensive two-dimensional gas chromatography-mass spectrometry: A review. Mass Spectrom Rev 27:101-124.
-
(2008)
Mass Spectrom Rev
, vol.27
, pp. 101-124
-
-
Mondello, L.1
Tranchida, P.Q.2
Dugo, P.3
Dugo, G.4
-
64
-
-
63449106748
-
Generic dealkylation: A tool for increasing the hit-rate of metabolite rationalization, and automatic customization of mass defect filters
-
Mortishire-Smith RJ, Castro-Perez JM, Yu K, et al. (2009). Generic dealkylation: A tool for increasing the hit-rate of metabolite rationalization, and automatic customization of mass defect filters. Rapid Commu n Mass Spectrom 23:939-948.
-
(2009)
Rapid Commu N Mass Spectrom
, vol.23
, pp. 939-948
-
-
Mortishire-Smith, R.J.1
Castro-Perez, J.M.2
Yu, K.3
-
65
-
-
25144438177
-
Accelerated throughput metabolic route screening in early drug discovery using high-resolution liquid chromatogr aphy/quadrupole time-of-flight mass spectrometry and automated data analysis
-
Mortishire-Smith RJ, O'Connor D, Castro-Perez JM, Kirby J. (2005). Accelerated throughput metabolic route screening in early drug discovery using high-resolution liquid chromatogr aphy/quadrupole time-of-flight mass spectrometry and automated data analysis. Rapid Commun Mass Spectrom 19:2659-2670.
-
(2005)
Rapid Commun Mass Spectrom
, vol.19
, pp. 2659-2670
-
-
Mortishire-Smith, R.J.1
O'Connor, D.2
Castro-Perez, J.M.3
Kirby, J.4
-
66
-
-
33947334687
-
Chemical ionization mass spectrometry I. General introduction
-
Munson MSB, Field FH. (1966). Chemical ionization mass spectrometry I. General introduction. J Am Chem Soc 88:2621-2630.
-
(1966)
J Am Chem Soc
, vol.88
, pp. 2621-2630
-
-
Munson, M.S.B.1
Field, F.H.2
-
67
-
-
0042090318
-
Metabolite characterization in drug discovery utilizing robotic liquid-handling, quadrupole time-of-flight mass spectrometry and in-silico prediction
-
Nassar AE, Adams PE. (2003). Metabolite characterization in drug discovery utilizing robotic liquid-handling, quadrupole time-of-flight mass spectrometry and in-silico prediction. Curr Drug Metab 4: 259-271.
-
(2003)
Curr Drug Metab
, vol.4
, pp. 259-271
-
-
Nassar, A.E.1
Adams, P.E.2
-
68
-
-
79960145301
-
From definition to implementation: A cross-industry perspective of past, current and future MIST strategies
-
Nedderman AN, Dear GJ, North S, et al. (2011). From definition to implementation: A cross-industry perspective of past, current and future MIST strategies. Xenobiotica 41:605-622.
-
(2011)
Xenobiotica
, vol.41
, pp. 605-622
-
-
Nedderman, A.N.1
Dear, G.J.2
North, S.3
-
69
-
-
0004969093
-
The use of chemical ionization mass spectrometry and stable isotope labeling in the analysis of reactive intermediates in drug metabolism
-
In: Frigerio A, Ghisalbe rti EL, eds Plenum Press, New York.
-
Nelson SD, Mitchell JR, Pohl LR. (1977). The use of chemical ionization mass spectrometry and stable isotope labeling in the analysis of reactive intermediates in drug metabolism. In: Frigerio A, Ghisalbe rti EL, eds. Mass spectrometry in drug metabolism, Plenum Press, New York. 237-276.
-
(1977)
Mass Spectrometry in Drug Metabolism
, pp. 237-276
-
-
Nelson, S.D.1
Mitchell, J.R.2
Pohl, L.R.3
-
70
-
-
0344844373
-
The use of deuterium isotope effects to probe the active site properties, mechanism of cytochrome P45 0-catalyzed reactions, and mechanisms of metabolically dependent toxicity
-
Nelson SD, Trager WF. (2003). The use of deuterium isotope effects to probe the active site properties, mechanism of cytochrome P45 0-catalyzed reactions, and mechanisms of metabolically dependent toxicity. Drug Metab Dispos 31:1481-1498.
-
(2003)
Drug Metab Dispos
, vol.31
, pp. 1481-1498
-
-
Nelson, S.D.1
Trager, W.F.2
-
71
-
-
0019796044
-
Comparative electron impact, chemical ionization and field desorption mass spectra of some thioether metabolites of acetaminophen
-
Nelson SD, Vaishnav Y, Kambara H, Baillie TA. (1981). Comparative electron impact, chemical ionization and field desorption mass spectra of some thioether metabolites of acetaminophen. Biomed Mass Spectrom 8:2 44-251.
-
(1981)
Biomed Mass Spectrom
, vol.8
, pp. 244-251
-
-
Nelson, S.D.1
Vaishnav, Y.2
Kambara, H.3
Baillie, T.A.4
-
72
-
-
0022340154
-
Structure of the glutathione adduct of activated 3-methylindole indicates that an imine methide is the electrophilic intermediate
-
Nocerini MR, Yost GS, Carlson JR, et al. (1985). Structure of the glutathione adduct of activated 3-methylindole indicates that an imine methide is the electrophilic intermediate. Drug Metab Dispos 13: 690-694.
-
(1985)
Drug Metab Dispos
, vol.13
, pp. 690-694
-
-
Nocerini, M.R.1
Yost, G.S.2
Carlson, J.R.3
-
73
-
-
0023840566
-
Detection and mechanism of formation of the potent direct-acting mutagen 2-bromoacrolein from 1,2-dibromo-3-chloropropane
-
Omichinski JG, Soderlund EJ, Dybing E, et al. (1988). Detection and mechanism of formation of the potent direct-acting mutagen 2-bromoacrolein from 1,2-dibromo-3-chloropropane. Toxicol Appl Pharmacol 92:286-294.
-
(1988)
Toxicol Appl Pharmacol
, vol.92
, pp. 286-294
-
-
Omichinski, J.G.1
Soderlund, E.J.2
Dybing, E.3
-
74
-
-
0023906007
-
Analysis of glutathione conjugates and related compounds by thermospray mass spectrometry
-
Parker CE, de Wit JS, Smith RW, et al. (1988). Analysis of glutathione conjugates and related compounds by thermospray mass spectrometry. Biomed Environ Mass Spectrom 15:623-633.
-
(1988)
Biomed Environ Mass Spectrom
, vol.15
, pp. 623-633
-
-
Parker, C.E.1
De Wit, J.S.2
Smith, R.W.3
-
77
-
-
0025061975
-
Screening strategy for the detection of derivatized glutathione conjugates by tandem mass spectrometry
-
Pearson PG, Howald WN, Nelson SD. (1990). Screening strategy for the detection of derivatized glutathione conjugates by tandem mass spectrometry. Anal Chem 62:1827-1836.
-
(1990)
Anal Chem
, vol.62
, pp. 1827-1836
-
-
Pearson, P.G.1
Howald, W.N.2
Nelson, S.D.3
-
78
-
-
33344464424
-
Application of a linear ion trap/orbitrap mass spectrometer in metabolite characterization studies: Examinatio n of the human liver microsomal metabolism of the non-tricyclic anti-depressant nefazodone using data-dependent accurate mass measurements
-
Peterman SM, Duczak Jr N, Kalgutkar AS, et al. (2006). Application of a linear ion trap/orbitrap mass spectrometer in metabolite characterization studies: Examinatio n of the human liver microsomal metabolism of the non-tricyclic anti-depressant nefazodone using data-dependent accurate mass measurements. J Am Soc Mass Spectrom 17:363-375.
-
(2006)
J Am Soc Mass Spectrom
, vol.17
, pp. 363-375
-
-
Peterman, S.M.1
Duczak, N.2
Kalgutkar, A.S.3
-
79
-
-
4644265806
-
Ultra-performance liquid chromatography coupled to quadrupole-orthogonal time-offlight mass spectrometry
-
Plumb R, Castro-Perez J, Granger J, et al. (2004). Ultra-performance liquid chromatography coupled to quadrupole-orthogonal time-offlight mass spectrometry. Rapid Commun Mass Spectrom 18: 2331-2337.
-
(2004)
Rapid Commun Mass Spectrom
, vol.18
, pp. 2331-2337
-
-
Plumb, R.1
Castro-Perez, J.2
Granger, J.3
-
80
-
-
0016469776
-
The rapid identification of a new metabolite of warfarin via a chemical ionization mass spectrometry ion doublet technique
-
Pohl LR, Nelson SD, Garland WA, Trager WF. (1975). The rapid identification of a new metabolite of warfarin via a chemical ionization mass spectrometry ion doublet technique. Biomed Mass Spectrom 2:23-30.
-
(1975)
Biomed Mass Spectrom
, vol.2
, pp. 23-30
-
-
Pohl, L.R.1
Nelson, S.D.2
Garland, W.A.3
Trager, W.F.4
-
81
-
-
0023870913
-
A gas chromatogra phic/mass spectrometric assay for catechol estrogens in microsomal incubations: Comparison with a radiometric assay
-
Porubek DJ, Nelson SD. (1988). A gas chromatogra phic/mass spectrometric assay for catechol estrogens in microsomal incubations: Comparison with a radiometric assay. Biomed Environ Mass Spectrom 15:157-161.
-
(1988)
Biomed Environ Mass Spectrom
, vol.15
, pp. 157-161
-
-
Porubek, D.J.1
Nelson, S.D.2
-
83
-
-
0030705215
-
Metabolism and excretion of a novel antianxiety drug candidate, CP-93,393, in Long Evans rats.Differentiation of regioisomeric glucuronides by LC/MS/MS
-
Prakash C, Soliman V. (1997). Metabolism and excretion of a novel antianxiety drug candidate, CP-93,393, in Long Evans rats. Differentiation of regioisomeric glucuronides by LC/MS/MS. Drug Metab Dispos 25:1288-1297.
-
(1997)
Drug Metab Dispos
, vol.25
, pp. 1288-1297
-
-
Prakash, C.1
Soliman, V.2
-
84
-
-
84859501771
-
Drug-drug interactions
-
In Rodrigues AD, ed 2nd ed. New York: Informa Healthcare, USA Inc
-
Rodrigues AD. (2008). Drug-drug interactions, In: Rodrigues AD, ed. Drugs and the pharmaceutical sciences. 2nd ed. New York: Informa Healthcare, USA Inc, 1-719.
-
(2008)
Drugs and the Pharmaceutical Sciences
, pp. 1-719
-
-
Rodrigues, A.D.1
-
85
-
-
39749201504
-
An integrated method for metabolite detection and identification using a linear ion trap/Orbitrap mass spectrometer and multipl e data processing techniques: Application to indinavir metabolite detection
-
Ruan Q, Peterman S, Szewc MA, et al. (2008). An integrated method for metabolite detection and identification using a linear ion trap/Orbitrap mass spectrometer and multipl e data processing techniques: Application to indinavir metabolite detection. J Mass Spectrom 43: 251-261.
-
(2008)
J Mass Spectrom
, vol.43
, pp. 251-261
-
-
Ruan, Q.1
Peterman, S.2
Szewc, M.A.3
-
86
-
-
77952400154
-
Investigation of bioactivation of ticlopidine using linear ion trap/orbitrap mass spe ctrometry and an improved mass defect filtering technique
-
Ruan Q, Zhu M. (2010). Investigation of bioactivation of ticlopidine using linear ion trap/orbitrap mass spe ctrometry and an improved mass defect filtering technique. Chem Res Toxicol 23:909-917.
-
(2010)
Chem Res Toxicol
, vol.23
, pp. 909-917
-
-
Ruan, Q.1
Zhu, M.2
-
87
-
-
0023193612
-
The formation of glutathione conjugate derived from propranolol
-
Sasame HA, Liberato DJ, Gillette JR. (1987). The formation of glutathione conjugate derived from propranolol. Drug Metab Dispos 15:349-355.
-
(1987)
Drug Metab Dispos
, vol.15
, pp. 349-355
-
-
Sasame, H.A.1
Liberato, D.J.2
Gillette, J.R.3
-
88
-
-
0001304095
-
Interface for on-line liquid chromatography-mass spectroscopy analysis
-
Scott RPW, Scott CG, Munroe M, Hess J. (1974). Interface for on-line liquid chromatography-mass spectroscopy analysis. J Chromatogr 99: 395-405.
-
(1974)
J Chromatogr
, vol.99
, pp. 395-405
-
-
Scott, R.P.W.1
Scott, C.G.2
Munroe, M.3
Hess, J.4
-
89
-
-
84863012529
-
Conjugation site modulates the in vivo stability and therapeutic activity of antibody-drug conjugates
-
Shen BQ, Xu K, Liu L, et al. (2012). Conjugation site modulates the in vivo stability and therapeutic activity of antibody-drug conjugates. Nat Biotechnol 30:184-189.
-
(2012)
Nat Biotechnol
, vol.30
, pp. 184-189
-
-
Shen, B.Q.1
Xu, K.2
Liu, L.3
-
90
-
-
84879071414
-
Ion mobility spectrometry-mass spectrometry analysis for the site of aromatic hydroxylation
-
Shimizu A, Chiba M. (2013) . Ion mobility spectrometry-mass spectrometry analysis for the site of aromatic hydroxylation. Drug Metab Dispos 41:1295-1299.
-
(2013)
Drug Metab Dispos
, vol.41
, pp. 1295-1299
-
-
Shimizu, A.1
Chiba, M.2
-
91
-
-
84929468892
-
Adduct ion formation in isobutane chemical ionization of aliphatic olefins
-
Shimizu Y. (1984). Adduct ion formation in isobutane chemical ionization of aliphatic olefins. Mass Spectroscopy, 32:357-364.
-
(1984)
Mass Spectroscopy
, vol.32
, pp. 357-364
-
-
Shimizu, Y.1
-
92
-
-
84901254846
-
Integrated quantification and identification of aldehydes and ketones in biological samples
-
Siegel D, Meinema AC, Permentier H, et al. (2014). Integrated quantification and identification of aldehydes and ketones in biological samples. Anal Chem 86:5089-5100.
-
(2014)
Anal Chem
, vol.86
, pp. 5089-5100
-
-
Siegel, D.1
Meinema, A.C.2
Permentier, H.3
-
94
-
-
0021146055
-
The microsomal metabolism and site of covalent binding to protein of 30-hydroxyacetanilide, a nonhepatotoxic positional isomer of acetaminophen
-
Streeter AJ, Bjorge SM, Axworthy DB, et al. (1984). The microsomal metabolism and site of covalent binding to protein of 30-hydroxyacetanilide, a nonhepatotoxic positional isomer of acetaminophen. Drug Metab Dispos 12:565-576.
-
(1984)
Drug Metab Dispos
, vol.12
, pp. 565-576
-
-
Streeter, A.J.1
Bjorge, S.M.2
Axworthy, D.B.3
-
95
-
-
0036645750
-
Accelerating the drug optimization process: Identification, structure elucidation, and quantification of in vivo metabolites using stable isotopes with LC/MSn and the chemiluminescent nitrogen detector
-
Taylor EW, Jia W, Bush M, Dollinger GD. (2002). Accelerating the drug optimization process: Identification, structure elucidation, and quantification of in vivo metabolites using stable isotopes with LC/MSn and the chemiluminescent nitrogen detector. Anal Chem 74: 3232-3238.
-
(2002)
Anal Chem
, vol.74
, pp. 3232-3238
-
-
Taylor, E.W.1
Jia, W.2
Bush, M.3
Dollinger, G.D.4
-
96
-
-
58149333524
-
Fractional mass filtering as a means to assess circulating metabolites in early human clinical studies
-
Tiller PR, Yu S, Bateman KP, et al. (2008a ). Fractional mass filtering as a means to assess circulating metabolites in early human clinical studies. Rapid Commun Mass Spectrom 22:3510-3516.
-
(2008)
Rapid Commun Mass Spectrom
, vol.22
, pp. 3510-3516
-
-
Tiller, P.R.1
Yu, S.2
Bateman, K.P.3
-
97
-
-
41549139685
-
High-throughput, accurate mass liquid chromatography/tandem mass spectrometry on a quadrupole time-of-flight system as a 'first-line' approach for metabolite identification studies
-
Tiller PR, Yu S, Castro-Perez J, et al. (2008b ). High-throughput, accurate mass liquid chromatography/tandem mass spectrometry on a quadrupole time-of-flight system as a 'first-line' approach for metabolite identification studies. Rapid Commun Mass Spectrom 22:1053-1061.
-
(2008)
Rapid Commun Mass Spectrom
, vol.22
, pp. 1053-1061
-
-
Tiller, P.R.1
Yu, S.2
Castro-Perez, J.3
-
98
-
-
58849124556
-
Liquid chromatography-mass spectrometry in in vitro drug metabolite screening
-
Tolonen A, Turpeinen M, Pelkonen O. (2009). Liquid chromatography-mass spectrometry in in vitro drug metabolite screening. Drug Discov Today 14:120-133.
-
(2009)
Drug Discov Today
, vol.14
, pp. 120-133
-
-
Tolonen, A.1
Turpeinen, M.2
Pelkonen, O.3
-
99
-
-
0024561543
-
Characterization of a carbamic acid ester glucuronide of the secondary amine sertraline
-
Tremaine LM, Stroh JG, Roofed RA. (1989). Characterization of a carbamic acid ester glucuronide of the secondary amine sertraline. Drug Metab Dispos 17:58-63.
-
(1989)
Drug Metab Dispos
, vol.17
, pp. 58-63
-
-
Tremaine, L.M.1
Stroh, J.G.2
Roofed, R.A.3
-
101
-
-
67649410245
-
Metabolic activation of nevirapine in human liver microsomes: Dehydrogenation and inactivation of cytochrome P450 3A4
-
Wen B, Chen Y, Fitch WL. (2009). Metabolic activation of nevirapine in human liver microsomes: Dehydrogenation and inactivation of cytochrome P450 3A4. Drug Metab Dispos 37:1557-1562.
-
(2009)
Drug Metab Dispos
, vol.37
, pp. 1557-1562
-
-
Wen, B.1
Chen, Y.2
Fitch, W.L.3
-
102
-
-
58149101972
-
Comparison of in vitro bioactivation of flutamide and its cyano analogue: Evidence for reductive activation by human NADPH:cytochrome P450 reductase
-
Wen B, Coe KJ, Rademacher P, et al. (2008a ). Comparison of in vitro bioactivation of flutamide and its cyano analogue: Evidence for reductive activation by human NADPH:cytochrome P450 reductase. Chem Res Toxicol 21:2393-2406.
-
(2008)
Chem Res Toxicol
, vol.21
, pp. 2393-2406
-
-
Wen, B.1
Coe, K.J.2
Rademacher, P.3
-
103
-
-
58249118866
-
Screening and characterization of reactive metabolites using glutathione ethyl ester in combination with Q-trap mass spectrometry
-
Wen B, Fitch WL. (2009 a ). Screening and characterization of reactive metabolites using glutathione ethyl ester in combination with Q-trap mass spectrometry. J Mass Spectrom 44:90-100.
-
(2009)
J Mass Spectrom
, vol.44
, pp. 90-100
-
-
Wen, B.1
Fitch, W.L.2
-
104
-
-
66449103559
-
Analytical strategies for the screening and evaluation of chemically reactive drug metabolites
-
Wen B Fitch WL. 2009b. Analytical strategies for the screening and evaluation of chemically reactive drug metabolites. Expert Opin Drug Metab Toxicol 5 39-55.
-
(2009)
Expert Opin Drug Metab Toxicol
, vol.5
, pp. 39-55
-
-
Wen, B.1
Fitch, W.L.2
-
105
-
-
41149180635
-
High-throughput screening and characterizati on of reactive metabolites using polarity switching of hybrid triple quadrupole linear ion trap mass spectrometry
-
Wen B, Ma L, Nelson SD, Zhu M. (2008b ). High-throughput screening and characterizati on of reactive metabolites using polarity switching of hybrid triple quadrupole linear ion trap mass spectrometry. Anal Chem 80:1788-1799.
-
(2008)
Anal Chem
, vol.80
, pp. 1788-1799
-
-
Wen, B.1
Ma, L.2
Nelson, S.D.3
Zhu, M.4
-
106
-
-
42449117632
-
Detection of novel reactive metabolites of trazodone: Evidence for CYP2D6-mediated bioactivation of m-chlorophenylpiperazine
-
Wen B, Ma L, Rodrigues AD, Zhu M. (2008c ). Detection of novel reactive metabolites of trazodone: Evidence for CYP2D6-mediated bioactivation of m-chlorophenylpiperazine. Drug Metab Dispos 36: 841-850.
-
(2008)
Drug Metab Dispos
, vol.36
, pp. 841-850
-
-
Wen, B.1
Ma, L.2
Rodrigues, A.D.3
Zhu, M.4
-
107
-
-
41949120073
-
Bioactivation of the tricyclic antidepressan t amitriptyline and its metabolite nortriptyline to arene oxide intermediates in human liver microsomes and recombinant P450s
-
Wen B, Ma L, Zhu M. (2008d). Bioactivation of the tricyclic antidepressan t amitriptyline and its metabolite nortriptyline to arene oxide intermediates in human liver microsomes and recombinant P450s. Chem Biol Interact 173:59-67.
-
(2008)
Chem Biol Interact
, vol.173
, pp. 59-67
-
-
Wen, B.1
Ma, L.2
Zhu, M.3
-
109
-
-
25144468977
-
All-in-one analysis for metabolite identification using liquid chromatography/hybrid quadrupole time-of-flight mass spectrometry with collision energy switching
-
Wrona M, Mauriala T, Bateman KP, et al. (2005). ' All-in-one' analysis for metabolite identification using liquid chromatography/hybrid quadrupole time-of-flight mass spectrometry with collision energy switching. Rapid Commun Mass Spectrom 19:2597-2602.
-
(2005)
Rapid Commun Mass Spectrom
, vol.19
, pp. 2597-2602
-
-
Wrona, M.1
Mauriala, T.2
Bateman, K.P.3
-
110
-
-
0038361179
-
Use of a quadrupole linear ion trap mass spectrometer in metabolite identification and bioanalysis
-
Xia YQ, Miller JD, Bakhtiar R, et al. (2003). Use of a quadrupole linear ion trap mass spectrometer in metabolite identification and bioanalysis. Rapid Commun Mass Spectrom 17:1137-1145.
-
(2003)
Rapid Commun Mass Spectrom
, vol.17
, pp. 1137-1145
-
-
Xia, Y.Q.1
Miller, J.D.2
Bakhtiar, R.3
-
111
-
-
84860295362
-
Recent advances in metabolite identification and quantitative bioanalysis by LC-Q-TOF MS
-
Xie C, Zhon g D, Yu K, Chen X. (2012). Recent advances in metabolite identification and quantitative bioanalysis by LC-Q-TOF MS. Bioanalysis 4:937-959.
-
(2012)
Bioanalysis
, vol.4
, pp. 937-959
-
-
Xie, C.1
Zhong, D.2
Yu, K.3
Chen, X.4
-
112
-
-
84901024381
-
Metabolomic a nd genomic evidence for compromised bile acid homeostasis by senecionine, a hepatotoxic pyrrolizidine alkaloid
-
Xiong A, Yang F, Fang L, et al. (2014). Metabolomic a nd genomic evidence for compromised bile acid homeostasis by senecionine, a hepatotoxic pyrrolizidine alkaloid. Chem Res Toxicol 27:775-786.
-
(2014)
Chem Res Toxicol
, vol.27
, pp. 775-786
-
-
Xiong, A.1
Yang, F.2
Fang, L.3
-
113
-
-
50049128215
-
Unbiased high-throughput scr eening of reactive metabolites on the linear ion trap mass spectrometer using polarity switch and mass tag triggered datadependent acquisition
-
Yan Z, Caldwell GW, Maher N. (2008). Unbiased high-throughput scr eening of reactive metabolites on the linear ion trap mass spectrometer using polarity switch and mass tag triggered datadependent acquisition. Anal Chem 80:6410-6422.
-
(2008)
Anal Chem
, vol.80
, pp. 6410-6422
-
-
Yan, Z.1
Caldwell, G.W.2
Maher, N.3
-
114
-
-
66149192288
-
Rapid screening and characterization of drug metabolites using multiple ion monitoring dependent product ion scan and postacquisition data mining on a hybrid triple quadrupole-linear ion trap mass spectrometer
-
Yao M, Ma L, Duchoslav E, Zhu M. (2009) . Rapid screening and characterization of drug metabolites using multiple ion monitoring dependent product ion scan and postacquisition data mining on a hybrid triple quadrupole-linear ion trap mass spectrometer. Rapid Commun Mass Spectrom 23:1683-1693.
-
(2009)
Rapid Commun Mass Spectrom
, vol.23
, pp. 1683-1693
-
-
Yao, M.1
Ma, L.2
Duchoslav, E.3
Zhu, M.4
-
115
-
-
55249123849
-
Rapid screening and characterization of drug metabolites using a multiple ion monitoring-dependent MS/MS acquisition method on a hybrid triple quadrupole-lin ear ion trap mass spectrometer
-
Yao M, Ma L, Humphreys WG, Zhu M. (2008). Rapid screening and characterization of drug metabolites using a multiple ion monitoring-dependent MS/MS acquisition method on a hybrid triple quadrupole-lin ear ion trap mass spectrometer. J Mass Spectrom 43: 1364-1375.
-
(2008)
J Mass Spectrom
, vol.43
, pp. 1364-1375
-
-
Yao, M.1
Ma, L.2
Humphreys, W.G.3
Zhu, M.4
-
116
-
-
0033374014
-
Identification of in vitro metabolites of Indinavir by' 'intelligent automated LC-MS/MS'' (INTAMS) utilizing triple quadrupole tandem mass spectrometry
-
Yu X, Cui D, Davis MR. (1999). Identification of in vitro metabolites of Indinavir by ' 'intelligent automated LC-MS/MS'' (INTAMS) utilizing triple quadrupole tandem mass spectrometry. J Am Soc Mass Spectrom 10:175-183.
-
(1999)
J Am Soc Mass Spectrom
, vol.10
, pp. 175-183
-
-
Yu, X.1
Cui, D.2
Davis, M.R.3
-
117
-
-
46849098946
-
Mass defect filtering on high resolution LC/MS data as a methodology fo r detecting metabolites with unpredictable structures: Identification of oxazole-ring opened metabolites of muraglitazar
-
Zhang D, Cheng PT, Zhang H. (2007). Mass defect filtering on high resolution LC/MS data as a methodology fo r detecting metabolites with unpredictable structures: Identification of oxazole-ring opened metabolites of muraglitazar. Drug Metab Lett 1:287-292.
-
(2007)
Drug Metab Lett
, vol.1
, pp. 287-292
-
-
Zhang, D.1
Cheng, P.T.2
Zhang, H.3
-
118
-
-
52649120186
-
An algorithm for thorough background subtraction from high-resolution LC/MS data: Application to the detection of troglitazone metabolites in rat plasma, bile, and urine
-
Zhang H, Ma L, He K, Zhu M. (2008a ). An algorithm for thorough background subtraction from high-resolution LC/MS data: Application to the detection of troglitazone metabolites in rat plasma, bile, and urine. J Mass Spectrom 43:1191-1200.
-
(2008)
J Mass Spectrom
, vol.43
, pp. 1191-1200
-
-
Zhang, H.1
Ma, L.2
He, K.3
Zhu, M.4
-
119
-
-
77951805975
-
Pooled sample strategy in conjunction with high-resolution liquid chromatography-mass spectrometry-based background subtraction to identify toxicological markers in dogs treated with ibipinabant
-
Zhang H, Patrone L, Kozlosky J , et al. (2010). Pooled sample strategy in conjunction with high-resolution liquid chromatography-mass spectrometry-based background subtraction to identify toxicological markers in dogs treated with ibipinabant. Anal Chem 82:383 4-3839.
-
(2010)
Anal Chem
, vol.82
, pp. 3834-3839
-
-
Zhang, H.1
Patrone, L.2
Kozlosky, J.3
-
120
-
-
52649157604
-
An algorithm for thorough background subtraction from high-resolution LC/MS data: Application for detection of glutathione-trapped reactive metabolites
-
Zhang H, Yang Y. (2008). An algorithm for thorough background subtraction from high-resolution LC/MS data: Application for detection of glutathione-trapped reactive metabolites. J Mass Spectrom 43: 1181-1190.
-
(2008)
J Mass Spectrom
, vol.43
, pp. 1181-1190
-
-
Zhang, H.1
Yang, Y.2
-
121
-
-
0242521617
-
A software filter to remove interference ions from drug metabolites in accurate mass liquid chromatography/mass spectrometric analyses
-
Zhang H, Zhang D, Ray K. (2003). A software filter to remove interference ions from drug metabolites in accurate mass liquid chromatography/mass spectrometric analyses. J Mass Spectrom 38: 1110-1112.
-
(2003)
J Mass Spectrom
, vol.38
, pp. 1110-1112
-
-
Zhang, H.1
Zhang, D.2
Ray, K.3
-
122
-
-
67650494794
-
Mass defect filter technique and its applications to drug metabolite identification by highresolution mass spectrometry
-
Zhang H, Zhang D, Ray K, Zhu M. (2009a ). Mass defect filter technique and its applications to drug metabolite identification by highresolution mass spectrometry. J Mass Spectrom 44:999-1016.
-
(2009)
J Mass Spectrom
, vol.44
, pp. 999-1016
-
-
Zhang, H.1
Zhang, D.2
Ray, K.3
Zhu, M.4
-
123
-
-
46849091191
-
Mass defect profiles of biological matrices and the general applicability of mass defect filtering for metabolite detection
-
Zhang H, Zhu M, Ray KL, et al. (2008b ). Mass defect profiles of biological matrices and the general applicability of mass defect filtering for metabolite detection. Rapid Commun Mass Spectrom 22: 2082-2088.
-
(2008)
Rapid Commun Mass Spectrom
, vol.22
, pp. 2082-2088
-
-
Zhang, H.1
Zhu, M.2
Ray, K.L.3
-
124
-
-
84906794536
-
Rapid identification of polymethoxylated flavonoids in traditional chinese medicines with a practical strategy of stepwise mass defect filtering coupled to diagnostic product ions analysi s based on a hybrid LTQ-Orbitrap mass spectrometer
-
Zhang JY, Wang F, Zhang H, et al. (2014). Rapid identification of polymethoxylated flavonoids in traditional chinese medicines with a practical strategy of stepwise mass defect filtering coupled to diagnostic product ions analysi s based on a hybrid LTQ-Orbitrap mass spectrometer. Phytochem Anal 25:405-414.
-
(2014)
Phytochem Anal
, vol.25
, pp. 405-414
-
-
Zhang, J.Y.1
Wang, F.2
Zhang, H.3
-
125
-
-
69249088147
-
Metabolite identification and profiling in drug design: Current practice and future directions
-
Zhang Z Zhu M Tang W. 2009 Metabolite identification and profiling in drug design: Current practice and future directions. Curr Pharm Des.15. 2220-2235.
-
(2009)
Curr Pharm des
, vol.15
, pp. 2220-2235
-
-
Zhang, Z.1
Zhu, M.2
Tang, W.3
-
126
-
-
34250753332
-
Screening and identification of GSH-trapped reactive metabolites using hybrid triple quadrupole linear ion trap mass spectrometry
-
Zheng J, Ma L, Xin B, et al. (2007). Screening and identification of GSH-trapped reactive metabolites using hybrid triple quadrupole linear ion trap mass spectrometry. Chem Res Toxicol 20:757-766.
-
(2007)
Chem Res Toxicol
, vol.20
, pp. 757-766
-
-
Zheng, J.1
Ma, L.2
Xin, B.3
-
127
-
-
33748902567
-
Detection and characterization of metabolites in biological matrices using mass defect filtering of liquid chromatography/high resolution m ass spectrometry data
-
Zhu M, Ma L, Zhang D, et al. (2006). Detection and characterization of metabolites in biological matrices using mass defect filtering of liquid chromatography/high resolution m ass spectrometry data. Drug Metab Dispos 34:1722-1733.
-
(2006)
Drug Metab Dispos
, vol.34
, pp. 1722-1733
-
-
Zhu, M.1
Ma, L.2
Zhang, D.3
-
128
-
-
35848937158
-
Detection and structural characterization of glutathione-trapped reactive metabolites using liquid chro matography-high-resolution mass spectrometry and mass defect filtering
-
Zhu M, Ma L, Zhang H, Humphreys WG. (2007). Detection and structural characterization of glutathione-trapped reactive metabolites using liquid chro matography-high-resolution mass spectrometry and mass defect filtering. Anal Chem 79:8333-8341.
-
(2007)
Anal Chem
, vol.79
, pp. 8333-8341
-
-
Zhu, M.1
Ma, L.2
Zhang, H.3
Humphreys, W.G.4
-
129
-
-
67849134950
-
Integrated strategies for assessment of metabolite exposure in humans during drug development: Analytical challenges and clinical development considerations
-
Zhu M, Zhang D, Zhang H, Shyu WC. (2009a ). Integrated strategies for assessment of metabolite exposure in humans during drug development: Analytical challenges and clinical development considerations. Biopharm Drug Dispos 30:163-184.
-
(2009)
Biopharm Drug Dispos
, vol.30
, pp. 163-184
-
-
Zhu, M.1
Zhang, D.2
Zhang, H.3
Shyu, W.C.4
-
130
-
-
79960431407
-
Drug metabolite profiling and identification by high-resolution mass spectrometry
-
Zhu M, Zhang H, Humphreys WG. (2011). Drug metabolite profiling and identification by high-resolution mass spectrometry. J Biol Chem 2286:25419-25425.
-
(2011)
J Biol Chem
, vol.2286
, pp. 25419-25425
-
-
Zhu, M.1
Zhang, H.2
Humphreys, W.G.3
-
131
-
-
66149168573
-
A retention-time-shift-tolerant background subtraction and noise reduction algorithm (BgS-NoRA) for extraction of drug metabolites in liquid chromatography/mass spectrometry data from bio logical matrices
-
Zhu P, Ding W, Tong W, et al. (2009b ). A retention-time-shift-tolerant background subtraction and noise reduction algorithm (BgS-NoRA) for extraction of drug metabolites in liquid chromatography/mass spectrometry data from bio logical matrices. Rapid Commun Mass Spectrom 23:1563-1572.
-
(2009)
Rapid Commun Mass Spectrom
, vol.23
, pp. 1563-1572
-
-
Zhu, P.1
Ding, W.2
Tong, W.3
-
132
-
-
67650757742
-
An accurate-massbased spectral-averaging isotope-pattern-filtering algorithm for extraction of dr ug metabolites possessing a distinct isotope pattern from LC-MS data
-
Zhu P, Tong W, Alton K, Chowdhury S. (2009c ). An accurate-massbased spectral-averaging isotope-pattern-filtering algorithm for extraction of dr ug metabolites possessing a distinct isotope pattern from LC-MS data. Anal Chem 81:5910-5917.
-
(2009)
Anal Chem
, vol.81
, pp. 5910-5917
-
-
Zhu, P.1
Tong, W.2
Alton, K.3
Chowdhury, S.4
|