An algorithm for thorough background subtraction from high-resolution LC/MS data: Application to the detection of troglitazone metabolites in rat plasma, bile, and urine

Journal of Mass Spectrometry

Volumn 43, Issue 9, 2008, Pages 1191-1200

  Zhang, Haiying ^a   Ma, Li ^a   He, Kan ^a   Zhu, Mingshe ^a  

^a BRISTOL MYERS SQUIBB   (United States)

Author keywords

Accurate mass; Background subtraction; In vivo; LC MS; Mass defect filter; Metabolite profiling; Troglitazone

Indexed keywords

AGRICULTURAL ENGINEERING; ALGORITHMS; BODY FLUIDS; CHEMOTHERAPY; CHLORINE COMPOUNDS; DATA ACQUISITION; DRUG DELIVERY; DRUG DOSAGE; ERROR ANALYSIS; IDENTIFICATION (CONTROL SYSTEMS); MATRIX ALGEBRA; METABOLITES; PEST CONTROL; PLASMA (HUMAN); PLASMAS; RAT CONTROL; SULFATE MINERALS; WINDOWS;

ACCURATE MASS; ANALYTE; BACKGROUND SUBTRACTION; BIOLOGICAL MATRIXES; DRUG METABOLITES; ERROR TOLERANCE; FRAGMENTATION PATTERNS; GENERIC DATA; HIGH RESOLUTIONS; IN VIVO; LC/MS; LIQUID CHROMATOGRAPHY/MASS SPECTROMETRY; MASS DEFECT FILTER; MASS DEFECTS; METABOLITE IDENTIFICATION; METABOLITE PROFILING; NOVEL ALGORITHMS; RAT PLASMAS; RAT URINE; SIMPLE ALGORITHMS; TIME WINDOWS; TROGLITAZONE;

BIOMOLECULES;

DRUG METABOLITE; TROGLITAZONE;

ALGORITHM; ANALYTIC METHOD; ANALYTICAL EQUIPMENT; ANIMAL EXPERIMENT; ARTICLE; CONTROLLED STUDY; DRUG BILE LEVEL; DRUG BLOOD LEVEL; DRUG METABOLISM; DRUG URINE LEVEL; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; LIQUID CHROMATOGRAPHY; MALE; MASS SPECTROMETER; MASS SPECTROMETRY; NONHUMAN; PLASMA; PRIORITY JOURNAL; RAT;

ADMINISTRATION, ORAL; ALGORITHMS; ANIMALS; BILE; CHROMANS; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; MALE; METABOLISM; PLASMA; RATS; RATS, SPRAGUE-DAWLEY; THIAZOLIDINEDIONES; URINE; VASODILATOR AGENTS;

RATTUS;

EID: 52649120186     PISSN: 10765174     EISSN: 10969888     Source Type: Journal    
DOI: 10.1002/jms.1432     Document Type: Article

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