An algorithm for thorough background subtraction from high-resolution LC/MS data: Application for detection of glutathione-trapped reactive metabolites

Journal of Mass Spectrometry

Volumn 43, Issue 9, 2008, Pages 1181-1190

  Zhang, Haiying ^a   Yang, Yanou ^a  

^a BRISTOL MYERS SQUIBB   (United States)

Author keywords

Accurate mass; Background subtraction; Glutathione; LC MS; Metabolite profiling; Reactive metabolite

Indexed keywords

ARSENIC COMPOUNDS; BIOMOLECULES; CHLORINE COMPOUNDS; ELECTROLYSIS; IONS; MATRIX ALGEBRA; METABOLITES; SPECTROMETRY; WINDOWS;

ACCURATE MASS; ANALYTE; BACKGROUND SUBTRACTION; CHARGED SPECIES; CLOZAPINE; CONTROL SAMPLES; DICLOFENAC; ERROR TOLERANCE; GLUTATHIONE; HIGH RESOLUTIONS; HUMAN LIVER MICROSOMES; LC/MS; LIQUID CHROMATOGRAPHY/MASS SPECTROMETRY; MASS-SPECTROMETRIC DETECTION; METABOLITE PROFILING; REACTIVE METABOLITE; REACTIVE METABOLITES; SCREENING TECHNIQUES; SUBTRACTION ALGORITHMS; TIME WINDOWS;

ALGORITHMS;

CLOZAPINE; DICLOFENAC; GLUTATHIONE; IMIPRAMINE; TACRINE;

ALGORITHM; ANALYTIC METHOD; ARTICLE; COMPUTER PROGRAM; CONTROLLED STUDY; DRUG STRUCTURE; HUMAN; HUMAN TISSUE; LIQUID CHROMATOGRAPHY; LIVER MICROSOME; MASS SPECTROMETRY; METABOLITE; PRIORITY JOURNAL;

ALGORITHMS; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; CLOZAPINE; DICLOFENAC; GLUTATHIONE; HUMANS; IMIPRAMINE; MICROSOMES, LIVER; SPECTROSCOPY, FOURIER TRANSFORM INFRARED; TACRINE;

EID: 52649157604     PISSN: 10765174     EISSN: 10969888     Source Type: Journal    
DOI: 10.1002/jms.1390     Document Type: Article

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