Application of a linear ion trap/orbitrap mass spectrometer in metabolite characterization studies: Examination of the human liver microsomal metabolism of the non-tricyclic anti-depressant nefazodone using data-dependent accurate mass measurements

Journal of the American Society for Mass Spectrometry

Volumn 17, Issue 3, 2006, Pages 363-375

  Peterman, Scott M ^a   Duczak Jr , Nicholas ^a   Kalgutkar, Amit S ^b   Lame, Mary E ^b   Soglia, John R ^b  

^a Thermo Fisher Scientific   (United States)

^b PFIZER INC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BIOLOGICAL ORGANS; CELLS; DATA ACQUISITION; DRUG PRODUCTS; MASS SPECTROMETERS;

ION SPECTRA; ION STRUCTURE; MASS MEASUREMENT;

METABOLISM;

DRUG METABOLITE; NEFAZODONE; TRICYCLIC ANTIDEPRESSANT AGENT;

ACCURACY; ANALYTICAL ERROR; ARTICLE; CALCULATION; CHEMICAL BOND; COMPUTER PROGRAM; CONTROLLED STUDY; DRUG METABOLISM; FLOW KINETICS; HUMAN; HUMAN TISSUE; ION TRAP MASS SPECTROMETRY; LINEAR SYSTEM; LIVER MICROSOME METABOLISM; MASS SPECTROMETRY; PREDICTION; SPECTRAL SENSITIVITY; SPECTROMETER; STRUCTURE ANALYSIS;

ANTIDEPRESSIVE AGENTS; CELLS, CULTURED; HUMANS; MICROSOMES, LIVER; REPRODUCIBILITY OF RESULTS; SENSITIVITY AND SPECIFICITY; SPECTROMETRY, MASS, ELECTROSPRAY IONIZATION; TRIAZOLES;

EID: 33344464424     PISSN: 10440305     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jasms.2005.11.014     Document Type: Article

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