The use of deuterium isotope effects to probe the active site properties, mechanism of cytochrome P450-catalyzed reactions, and mechanisms of metabolically dependent toxicity

Drug Metabolism and Disposition

Volumn 31, Issue 12, 2003, Pages 1481-1498

  Nelson, Sidney D ^a   Trager, William F ^a  

^a UNIVERSITY OF WASHINGTON   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CYTOCHROME P450; DEUTERIUM;

CHIRALITY; CORRELATION ANALYSIS; CORRELATION COEFFICIENT; ENZYME ACTIVE SITE; ENZYME BINDING; ENZYME DEGRADATION; ENZYME MECHANISM; ENZYME SPECIFICITY; ENZYME SUBSTRATE; ISOTOPE ANALYSIS; MATHEMATICAL COMPUTING; METABOLITE; MICHAELIS CONSTANT; MOLECULAR INTERACTION; PRIORITY JOURNAL; REVIEW; STRUCTURE ANALYSIS; TOXICITY;

ANIMALS; BINDING SITES; CATALYSIS; CYTOCHROME P-450 ENZYME SYSTEM; DEUTERIUM; DRUG TOXICITY; HUMANS; ISOTOPE LABELING; KINETICS; PHARMACEUTICAL PREPARATIONS; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 0344844373     PISSN: 00909556     EISSN: None     Source Type: Journal    
DOI: 10.1124/dmd.31.12.1481     Document Type: Review

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