Mass defect filter technique and its applications to drug metabolite identification by high-resolution mass spectrometry

Journal of Mass Spectrometry

Volumn 44, Issue 7, 2009, Pages 999-1016

  Zhang, Haiying ^a   Zhang, Donglu ^a   Ray, Kenneth ^b   Zhu, Mingshe ^a  

^a BRISTOL MYERS SQUIBB   (United States)

^b Novatia   (United States)

Author keywords

Drug metabolites; High resolution mass spectrometry; In vitro and in vivo metabolites; Mass defect filter; Neutral loss filter; Orbitrap; Product ion filter; Reactive metabolites; Time of flight

Indexed keywords

DRUG METABOLITES; HIGH-RESOLUTION MASS SPECTROMETRY; IN VITRO AND IN VIVO METABOLITES; MASS DEFECT FILTER; NEUTRAL LOSS FILTER; ORBITRAP; PRODUCT ION FILTER; REACTIVE METABOLITES; TIME-OF-FLIGHT;

BIOMOLECULES; DEFECTS; HYDROGELS; MASS SPECTROMETERS; MASS SPECTROMETRY; METABOLITES; MOLECULAR MASS; NEGATIVE IONS;

METABOLISM;

DRUG METABOLITE; INDINAVIR;

DATA MINING; DEBROMINATION; DEHYDROGENATION; DRUG IDENTIFICATION; FRAGMENTATION REACTION; IN VITRO STUDY; ION PAIR CHROMATOGRAPHY; LIQUID CHROMATOGRAPHY; MASS SPECTROMETRY; PRIORITY JOURNAL; REVIEW; TANDEM MASS SPECTROMETRY; TIME OF FLIGHT MASS SPECTROMETRY;

ALGORITHMS; ANIMALS; BIOCHEMICAL PROCESSES; HUMANS; MASS SPECTROMETRY; PHARMACEUTICAL PREPARATIONS;

EID: 67650494794     PISSN: 10765174     EISSN: 10969888     Source Type: Journal    
DOI: 10.1002/jms.1610     Document Type: Review

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