The G·U wobble base pair: A fundamental building block of RNA structure crucial to RNA function in diverse biological systems

EMBO Reports

Volumn 1, Issue 1, 2000, Pages 18-23

  Varani, Gabriele ^a   McClain, William H ^b  

^a MRC LABORATORY OF MOLECULAR BIOLOGY   (United Kingdom)

^b UNIVERSITY OF WISCONSIN MADISON   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

GUANINE; RNA; URACIL;

BASE PAIRING; CHEMICAL STRUCTURE; CHEMISTRY; CONFORMATION; GENETICS; HYDROGEN BOND; METABOLISM; REVIEW; THERMODYNAMICS;

BASE PAIRING; GUANINE; HYDROGEN BONDING; MODELS, MOLECULAR; MOLECULAR STRUCTURE; NUCLEIC ACID CONFORMATION; RNA; THERMODYNAMICS; URACIL;

EID: 0034232357     PISSN: 1469221X     EISSN: None     Source Type: Journal    
DOI: 10.1093/embo-reports/kvd001     Document Type: Article

References (21)

1. Abramovitz, D.L., Friedman, R.A. and Pyle, A.M. (1996) Catalytic role of 2′-hydroxyl groups within a group II intron active site. Science, 271, 1410-1413.
2. Allain, F.H.-T. and Varani, G. (1995a) Divalent metal ion binding to a conserved wobble pair defining the upstream site of cleavage of group I self-splicing introns. Nucleic Acids Res., 23, 341-350.
3. Allain, F.H.-T. and Varani, G. (1995b) Structure of the PI helix from group I self splicing introns. J. Mol. Biol., 250, 333-353.
4. Bénard, L., Mathy, N., Grunberg-Magnago, M., Ehresmann, B., Ehresmann, C. and Portier, C. (1998) Identification in a pseudoknot of a U·G motif essential for the regulation of the expression of ribosomal protein S15. Proc. Natl Acad. Sci. USA, 95, 2564-2567.
5. Cate, J.H. and Doudna, J.A. (1996) Metal-binding sites in the major groove of a large ribozyme domain. Structure, 4, 1221-1229.
6. Chang, K.Y., Varani, G., Bhattacharya, S., Choi, H. and McClain, W.H. (1999) Correlation of deformability at a tRNA recognition site and aminoacylation specificity. Proc. Natl Acad. Sci. USA, 96, 11764-11769.
7. Ciesolka, J. and Yarus, M. (1996) Small RNA-divalent domains. RNA, 2, 785-793.
8. Clark, B.F.C. and Klug, A. (1975) Structure and function of tRNA with special reference to the three dimensional structure of yeast phenylalanine tRNA. Proc. Tenth FEBS Meet., 39, 183-206.
9. Crick, F.H.C. (1966) Codon-anticodon pairing: The wobble hypothesis. J. Mol. Biol., 19, 548-555.
10. Doudna, J.A., Cormack, B.P. and Szostak, J.W. (1989) RNA structure, not sequence, determines the 5′ splice-site specificity of a group I intron. Proc. Natl Acad. Sci. USA, 86, 7402-7406.
11. Ferre-D'Amare, A., Zhou, K. and Doudna, J.A. (1998) Crystal structure of a hepatitis delta ribozyme. Nature, 395, 567-574.
12. Ala by alanyl-tRNA synthetase. Science, 271, 195-197.
13. Gautheret, D., Konings, D. and Gutell, R.R. (1995) G·U base pairing motifs in ribosomal RNA. RNA, 1, 807-814.
14. Pyle, A.M. (1993) Ribozymes: A distinct class of metalloenzymes. Science, 261, 709-714.
15. Pyle, A.-M., Moran, S., Strobel, S.A., Chapman, T., Turner, D.H. and Cech, T.R. (1994) Replacement of the conserved G·U with a G-C pair at the cleavage site of the Tetrahymena ribozyme decreases binding, reactivity and fidelity. Biochemistry, 33, 13856-13863.
16. Quigley, G.J. and Rich, A.R. (1975) Structural domains of transfer RNA molecules. Science, 194, 796-806.
17. Ala: Role of the G3·U70 base pair in synthetase recognition. Nucleic Acids Res., 25, 2083-2090.
18. Sec hinder its recognition by prokaryotic elongation factor Tu. EMBO J., 15, 650-657.
19. Asp. Science, 252, 1682-1689.
20. Sprinzl, M., Horn, C., Brown, M., Ioudovitch, A. and Steinberg, S. (1996) Compilation of tRNA sequences and sequences of tRNA genes. Nucleic Acids Res., 26, 148-153.
21. Strazewski, P., Biala, E., Gabriel, K. and McClain, W.H. (1999) The relationship of thermodynamic stability at a G-U recognition site to tRNA aminoacylation specificity. RNA, 5, 1490-1494.