Modulation of thermal stability can enhance the potency of siRNA

Nucleic Acids Research

Volumn 38, Issue 20, 2010, Pages 7320-7331

  Addepalli, Haripriya ^a   Meena, ^a   Peng, Chang G ^a   Wang, Gang ^a   Fan, Yupeng ^a   Charisse, Klaus ^a   Jayaprakash, K Narayanannair ^a   Rajeev, Kallanthottathil G ^a   Pandey, Rajendra K ^a   Lavine, Gary ^a   Zhang, Ligang ^a   Jahn Hofmann, Kerstin ^a,b   Hadwiger, Philipp ^a,b   Manoharan, Muthiah ^a   Maier, Martin A ^a  

^a ALNYLAM PHARMACEUTICALS   (United States)

^b Roche Kulmbach GmbH   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

2,4 DIFLUOROTOLUENE; PHOSPHATIDYLINOSITOL 3,4,5 TRISPHOSPHATE 3 PHOSPHATASE; SMALL INTERFERING RNA; SUGAR PHOSPHATE; TOLUENE DERIVATIVE; UNCLASSIFIED DRUG;

ARTICLE; BASE MISPAIRING; CONTROLLED STUDY; ENZYME ACTIVITY; FIREFLY; GENE; GENE SILENCING; GENE TARGETING; GENETIC TRANSCRIPTION; HUMAN; HUMAN CELL; IC 50; LUCIFERASE GENE; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN MODIFICATION; RNA CLEAVAGE; RNA STABILITY; THERMODYNAMICS; THERMOSTABILITY;

BASE PAIR MISMATCH; HELA CELLS; HUMANS; RNA INTERFERENCE; RNA STABILITY; RNA, SMALL INTERFERING; THERMODYNAMICS;

EID: 78651281223     PISSN: 03051048     EISSN: 13624962     Source Type: Journal    
DOI: 10.1093/nar/gkq568     Document Type: Article

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