Silencing activity of 2′-O-methyl modified anti-MDR1 siRNAs with mismatches in the central part of the duplexes

FEBS Letters

Volumn 585, Issue 14, 2011, Pages 2352-2356

  Petrova, Natalya S ^a   Meschaninova, Mariya I ^a   Venyaminova, Alya G ^a   Zenkova, Marina A ^a   Vlassov, Valentin V ^a   Chernolovskaya, Elena L ^a  

^a INSTITUTE OF CHEMICAL BIOLOGY AND FUNDAMENTAL MEDICINE   (Russian Federation)

Author keywords

2 O Methyl modification; MDR1; RNA interference; siRNA; Thermodynamic stability

Indexed keywords

COMPLEMENTARY RNA; DOUBLE STRANDED RNA; SMALL INTERFERING RNA;

5' UNTRANSLATED REGION; ARTICLE; BASE MISPAIRING; CONTROLLED STUDY; GENE SILENCING; HUMAN; HUMAN CELL; NUCLEIC ACID BASE SUBSTITUTION; PRIORITY JOURNAL; RNA ANALYSIS; RNA INTERFERENCE; RNA STABILITY; RNA STRUCTURE;

ANIMALS; BASE PAIR MISMATCH; GENE SILENCING; HEK293 CELLS; HUMANS; NUCLEOTIDES; P-GLYCOPROTEIN; RNA, SMALL INTERFERING; THERMODYNAMICS;

EID: 79960349939     PISSN: 00145793     EISSN: 18733468     Source Type: Journal    
DOI: 10.1016/j.febslet.2011.06.003     Document Type: Article

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